GPCRchimeraDB

Main repository of the database GPCRchimeraDB (https://www.bio2byte.be/gpcrchimeradb/).

Format the Data

In the folder Notebooks, the following Jupyter notebooks are available:

• Format a chimera's data: Identify parents, cutting sites, and mutations based on its sequence.
• Generate entry file for chimeric GPCRs.
• Generate entry file for natural GPCRs.

The Data

Available on Zedodo :

• Entry files (JSON, 1 per entry).
• FASTA sequences.
• Structures (PDB, AF2, AF2 MS, ESMFold).
• Master alignment (MSA).
• Activation state structures (GPCRdb).
• Classification.
• G-protein and B-arrestin coupling (GPCRdb).
• Limits TM regions (TMbed).
• Endogenous ligands (GPCRdb).
• Variants (GPCRdb).
• Scientific to common names organisms (UniProt).

The Database

Explore your favorite chimeric or natural GPCR at the sequence, structural, and biophysical levels and design new chimeras!

Visit GPCRchimeraDB: https://www.bio2byte.be/gpcrchimeradb/.

The Database's Documentation

GitHub repository for GPCRchimeraDB's documentation: https://github.com/Bio2Byte/gpcrchimeradb-docs.

The Paper

Contact Us

[email protected]

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.