Notebooks/json_GPCRchimeraDB_chimera.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import requests, sys\n",
    "import json\n",
    "import os\n",
    "import urllib.request\n",
    "from Bio import SeqIO\n",
    "from Bio import AlignIO\n",
    "import re\n",
    "import html\n",
    "from collections import defaultdict"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "170\n",
      "{'OPSD_BOVIN_AA2AR_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVAIRIPLRYNGLVTENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARILAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS', 'OPSD_BOVIN_ADRB2_MESAU_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVAITSPFKYQSLLTENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALKTLIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMRSPDFRIAFQELLCLRRSSSKAYGNGYSSNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPL', 'OPSD_BOVIN_ADRB2_MESAU_2': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCLRRSSSKAYGNGYSSNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPLTETSQVAPA', 'OPSD_BOVIN_ACM2_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIKVNRHLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTKPLTYPVKRTTKMAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKTFKHLLMCHYKNIGATRTETSQVAPA', 'OPSD_BOVIN_ACM3_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFKVNKQLKTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTRPLTYRAKRTTKRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQALTETSQVAPA', 'OPSD_BOVIN_ACM1_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFKVNTELKTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTRPLSYRAKRTPRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQCTETSQVAPA', 'OPSD_BOVIN_DRD2_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVSREKALQTTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAMPMLYNTRYSSKRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKAFMKILHCTETSQVAPA', 'OPSD_BOVIN_DRD1_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVIRFRHLRSKVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVSSPFQYERKMTPKAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHSTTETSQVAPA', 'OPSD_BOVIN_AA2AR_HUMAN_2': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVWLNSNLQNVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRIPLRYNGLVTGTRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIFLAARRQLKQMESQPLPGERARSTLQKEVHARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVSTETSQVAPA', 'OPSD_BOVIN_FFAR3_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFVGKLQRRPVALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHPLWYKTRPRLGQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRLVWILGRGGSHRRQRRVARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAESTETSQVAPA', 'OPSD_BOVIN_ADA1A_RAT_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVACHRHLHSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVSYPLRYPTIVTQRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEVTETSQVAPA', 'OPSD_BOVIN_ADRB2_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCLRRSSSKAYGNGYSSNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPLTETSQVAPA', 'OPSD_BOVIN_GP183_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIVQNRKKINSLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHPLRYNKIKRIEHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQICCKLFRTAKQNPLTEKSGVNKKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGKTETSQVAPA', 'OPSD_BOVIN_GP182_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVNWRGSGRAGLLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSASPSWQRYQHRVRRAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLTACRLRQPGQPKSRRHCRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPSTETSQVAPA', 'OPSD_BOVIN_GP176_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTCRTTVFKSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLYPLERKISDAKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKCLIGTLVQLHHRYSRRNVVSTGSGMAEASLEPSIRSGSQLLEMFHIGQQQIFKPTEDEEESEAKYIGSADFQAKEIFSTCLEGEQGPQFAPSAPPLSTVDSVSQVAPAAPVEPETFPDKYSLQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPKVGRVERKMSRNNKVSIFPKVDSTETSQVAPA', 'OPSD_BOVIN_GP174_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFYGYMKETKRLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVMYPFRFHDCKQKYDAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKTVLSLQDKYPMAQDLGEKQKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELCTETSQVAPA', 'OPSD_BOVIN_GP173_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVLKERALHKALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHHRFYAKRMTLWTAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKCLRTHAPCWGTGGAPAPREPYCVMTETSQVAPA', 'OPSD_BOVIN_GP171_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFIQKNTNHRCLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTHSCKIYRIQEPGFAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLVIRQLYRNKDNENYPNVKKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRSKVTETFASPKETKAQKEKLRCENNATETSQVAPA', 'OPSD_BOVIN_GP162_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVISAKQQKHKPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRWPVNYRLSNAKKQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGTLWARPRRARQARRVGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLDGSESAKTSLQRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRADVRTVWEQCVAIMSEEDGDDDGGCDDYAEGRVCKVRFDANGATGPGSRDPAQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIFSTPREPGSFLHKWSSSDDIRVLPAQSRALGGPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGHSPRRPRPLGLSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGGEESARAWGGSWGPGNPIFPQLTLTETSQVAPA', 'OPSD_BOVIN_GP161_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLYKKSYLLTLLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLYPMVYPMKITGNRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQRTETSQVAPA', 'OPSD_BOVIN_GP153_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVGAKQKKWKPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCWPVNYRLSNAKKQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGTLAVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSLQRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRADLKAVREKCMALMANDEESDDETSLEGGISPDLVLERSLDYGYGGDFVALDRMAKYEISALEGGLPQLYPLRPLQEDKMQYLQVPPTRRFSHDDADVWAAVPLPAFLPRWGSGEDLAALAHLVLPAGPERRRASLLAFAEDAPPSRARRRSAESLLSLRPSALDSGPRGARDSPPGSPRRRPGPGPRSASASLLPDAFALTAFECEPQALRRPPGPFPAAPAAPDGADPGEAPTPPSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATLHSDSLGSASTETSQVAPA', 'OPSD_BOVIN_GP152_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVAGSQARHGAGTRLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLCPHWYPGHRPVRLAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLTQATACRTCHRQQQPAACRGFARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRTLLRSVLSSFAAALCEERPGSFTPTEPQTQLDSEGPTLPEPMAEAQSQMDPVAQPQVNPTLQPRSDPTAQPQLNPTAQPQSDPTAQPQLNLMAQPQSDSVAQPQADTNVQTPAPAASSVPSPCDEASPTPSSHPTPGALEDPATPPASEGESPSSTPPEAAPGAGPTTETSQVAPA', 'OPSD_BOVIN_GP151_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLLHNAWKGKPSMLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVSDPAKQVSIHNYAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRAYDQCKKRGTKTQNLRNQIRSKQVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFREGLKGVWKWMITKKPPTVSESQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHERDTVPSVQDNDPIPWEHEDQETGEGVKTETSQVAPA', 'OPSD_BOVIN_GP150_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLCGGGGPWAGPKRRKLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRLPHGRPLPAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHLLSVWWRHRPQAPAAAAPWSASPGRAPAPSALPRAKVQSRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRQLRKRLGSLCCAPQGGAEDEEGPRGHQALYRQRWPHPHYHHARREPLDEGGLRPPPPRPRPLPCSCESAFTETSQVAPA', 'OPSD_BOVIN_GP149_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLLKMQNRTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVHRGVGSQTASRRSGAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGEISRGASIPGTPPTAGRVVSLSPEDAPGPSLRRSGGCSPSSDTVFGPGAPAAAGAEACRRENRGTLYGTRSFTVSVAQKRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRLSFQKSYGIYKIAHEDYYDDDENSIFYHNLMNSECETTKDPQRDNRNIFNAIKVEISTTPSLDSSTQRGINKCTNTDITEAKQDSNNKKDAFSDKTGGDINYEETTFSEGPERRLSHEESQKPDLSDWEWCRSKSERTPRQRSGYALAIPLCAFQGTVSLHAPTGKTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEDSSSTFVDTSVKIHLEVLEICDNEEALDTVSIISNISQSSTQVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSNPDGDINISIPDTVEAHRQNSKRQHQERDGYQEEIQLLNKAYRKREEESKGSTETSQVAPA', 'OPSD_BOVIN_GP148_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVILRNQRLRQELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVIHPLRYLSFMSHGAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIYAEAKTSGIWGQGYSRARGTLRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQLLGMVRGHLPSRRHQAIFTISTETSQVAPA', 'OPSD_BOVIN_GP146_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVNLHSKASMTMLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVALPRTYMASVYNAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLLSRVRREDTPLDRDTGRLEPSAHRRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRSKLQRLMKKLPCGDRHCSPDHMGVQQVLATETSQVAPA', 'OPSD_BOVIN_GP142_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLARLATRTRRPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCHPLHHRAASSPGRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGAIIHRLRRRGRSGLQPRVGKSTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEVTETSQVAPA', 'OPSD_BOVIN_GP141_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLVKMNTRSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVFKCKDKVEFYRKLAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGIIMLMVQKLRHSLLSHQEFWAQRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQKIIGLWNCVLCRTETSQVAPA', 'OPSD_BOVIN_GP139_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLSQLVARRQKLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCHPLKYHTVSYPARAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGIIVYKLRRKSNFRLRGYSTGKTTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSPTETSQVAPA', 'OPSD_BOVIN_GP135_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIVKHRQLRTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVRPPREKIGRRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHICKTVRLSDVRVRPVNTYARVLRFFSEVRTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSLTETSQVAPA', 'OPSD_BOVIN_GP132_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVALLQVLQGNVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVYALESRGRRRRRTAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIFRSIKQSMGLSAAQKAKVKRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESCTETSQVAPA', 'OPSD_BOVIN_FFAR4_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVARRRRRGALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHLQRGVRGPGRRAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRWKKIFCCFWFPEKGAILTDTSVKRNDLSIISGTETSQVAPA', 'OPSD_BOVIN_GP119_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVLLLIHKNDGLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVKQPFRYLKIMSGFVAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDGTETSQVAPA', 'OPSD_BOVIN_GPR88_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVSSFRKLQTTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRAPATYQALYQRRHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGIVRRVRVSVKRVSVLNFHLLHQLPGCARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHWTETSQVAPA', 'OPSD_BOVIN_GPR87_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFFHIRNKTSLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVKPFGDSRMYSITFAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGAISRYIHKSSRQFISQSSRKRKHNRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRRLFKKSNIRTRSESIRSLQSVRRSEVRIYYDYTDVTETSQVAPA', 'OPSD_BOVIN_GPR85_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLVKDKTLHRALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHHRFYTKRLTFWTAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRCFSTTLLYCRKSRLPREPYCVITETSQVAPA', 'OPSD_BOVIN_GPR84_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLAIQPKLRTRLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHPKLFPQVFSAKGAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQAYGSILKRGPRSFHRLHTETSQVAPA', 'OPSD_BOVIN_GPR83_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIFKNQRMHSALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVMHPLKPRISITKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVAKKLWLCNMIGDVTTEQYFALRRKKKKTIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIELKALLSMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIVTMSTETSQVAPA', 'OPSD_BOVIN_GPR82_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFLTKIGKKTSLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCYEKIFYGHLLKKFRQPNFAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGSFVSHLRKIRTCTSIMEKDLTYSSVRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKTLYNLFTKSNSAHMQSYGTETSQVAPA', 'OPSD_BOVIN_GPR78_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVCAYSAELRTRALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVGFPLRYAGRLRPRYAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTHTETSQVAPA', 'OPSD_BOVIN_GPR75_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFFDPAFRKFRTNLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLGKQPNRTASFPCAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRKVLWCLQYIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSVTETSQVAPA', 'OPSD_BOVIN_OGR1_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVGYLQIKARNELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHPFRFHQFRTLKAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGILRAVRRSHGTQKSRKDQIQRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLATETSQVAPA', 'OPSD_BOVIN_PSYR_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVSFLQAKKESELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVYPLKFFFLRTRRFAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKVYQAVRHNKATENKEKKRIIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRYDMWNILKFCTGRCNTSQRQRKRILSVSTKDTMELEVLETETSQVAPA', 'OPSD_BOVIN_GPR63_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVYQKAAMRSALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVQRQDKLNPYRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGILNTLRHNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRDACLDMMPKSFKFLPQLPGHTKRRIRPSAVYVCGEHRTVVTETSQVAPA', 'OPSD_BOVIN_GPR62_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVLRTPGLRDLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHPLRPGSRPPAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLSTETSQVAPA', 'OPSD_BOVIN_GPR61_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKTPALRKLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHPMRYEVRMTLGLAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLESTETSQVAPA', 'OPSD_BOVIN_GPR55_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFSTFLKNRWPDYAALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRYPLLVSHLRSPRKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRSIHILLGRRDHTQDWVQQKACIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRMNIRAHRPSRVQLVLQDTTISRGTETSQVAPA', 'OPSD_BOVIN_GPR52_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFHCAPLLHHYTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTKPLSYNQLVTPCRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSITETSQVAPA', 'OPSD_BOVIN_MTR1L_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVTKNKKLRNSLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCHSLQYERIFSVRNAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIWTKVLAARDPAGQNPDNQLAEVRNFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAVTETSQVAPA', 'OPSD_BOVIN_GPR45_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVYQRPAMRSALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVQRQDKLNPRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAVTETSQVAPA', 'OPSD_BOVIN_GPR42_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFVGKLRCRPVALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHPLWYKTRPRLGQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRLVWILGRGGSHRRQRRVARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAENTETSQVAPA', 'OPSD_BOVIN_GPR39_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLQKKGYLQKELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCHPFRYKAVSGPCQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEVTETSQVAPA', 'OPSD_BOVIN_G37L1_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVWHSYYLKSALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSTLPKVRPIERCQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGVTWRVRGPPGRKSECRASKHEQCESQLNRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPCTETSQVAPA', 'OPSD_BOVIN_GPR37_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVCHNYYMRSILNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTNVQMYYEMIENCSAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGVTARKIRKAEKACTRGNKRQIQLESQMNRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHCTETSQVAPA', 'OPSD_BOVIN_GPR35_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFCCRMQQWTELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVRHPLRARGLRSPRQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKVVTALAQRPPTDVGQAEATRKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFREASALAVAPSAKAHKSQDSLCVTLATETSQVAPA', 'OPSD_BOVIN_GPR34_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFLGIHRKRNSLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVNRSIQQRKAITTKQAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKIGKNLLRISKRRSKFPNSGKYATTARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKSTTETSQVAPA', 'OPSD_BOVIN_GPR33_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLRFKMKQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLHPVWSQQHRTPRWAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVASKVKERSLFKSSKPFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKVFKKSILALFESTFSEDSSVERTQTTETSQVAPA', 'OPSD_BOVIN_GPR32_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVFRMARTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVLYPVWALNHRTVQRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLIRAKLLREGWVHANRPKRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFREKFFQSLTSALARAFGEEEFLSSCPRGNAPRETETSQVAPA', 'OPSD_BOVIN_GPR31_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFLFRVRVWKPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHPRLKVNLLSPQAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGIIRALQKRLREPEKQPKLQRAQRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYSTETSQVAPA', 'OPSD_BOVIN_GPR27_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIVRERSLHRALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHHRFYAERLAGWPCAAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRDCFRAQFPCCQSPRTTQATHPCDLKGIGLTETSQVAPA', 'OPSD_BOVIN_GPR26_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLLHSADIRRQALNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVFPLSYRAKMRLRDAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSETETSQVAPA', 'OPSD_BOVIN_GPR25_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLAGRRGPRRLLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVKLLEARPLRTPRCAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRISRRLRRPPHVGRARRNSLRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASWTETSQVAPA', 'OPSD_BOVIN_GPR22_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVYCMKSNLINSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVKPANRILTMGRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSEIREKCLVPQVVTDTETSQVAPA', 'OPSD_BOVIN_GPR21_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFHCAPLLNHHTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTKPLTYNTLVTPWRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGNIFRICQQHTKDISERQARFSSQSGETGEVQACPDKRYARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHITETSQVAPA', 'OPSD_BOVIN_GPR20_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFCCRTRAKTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVRPEGSRRCRQPACAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRIMCALSRPGLLHQGRQRRVRAMRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRATVRGLFGQHGEREPSSGDVVSMHRSSKGSGRHHILSAGPHALTQALANGPEATETSQVAPA', 'OPSD_BOVIN_GPR19_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIHRSRRTQSTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVYPLSFKVSREKAKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFVTETSQVAPA', 'OPSD_BOVIN_GPR18_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFSCTTKKRTTLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVQPKYAKELKNTCKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGVIIHNLLHGRTSKLKPKVKEKSIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEMLTETSQVAPA', 'OPSD_BOVIN_GPR17_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVFIRDHKSGTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVHPVKSLKLRRPLYAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGLIIRSLRQGLRVEKRLKTKAVRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSELTETSQVAPA', 'OPSD_BOVIN_GPR15_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVLHFKPGSRRLLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVVWPVVSRKFRRTDCAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGCIARKLCAHYQQSGKHNKKLKKSIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFARRRKRSVSLTETSQVAPA', 'OPSD_BOVIN_GPR12_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIFHNPSLRAPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVYYALTYHSERTVTFAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQICKIVMRHAHQIALQHHFLATSHYVTTRKGVRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKALCLICCGCIPSSLAQRARSPSDVTETSQVAPA', 'OPSD_BOVIN_GPR6_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIASTPALRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVYNALTYYSRRTLLGAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRICQVVWRHAHQIALQQHCLAPPHLAATRKGVRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRRALWLLLCGCFQSKVPFRSRSPSEVTETSQVAPA', 'OPSD_BOVIN_GPR4_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVAYRQVQQRNELNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVAHPLRFARLRRVKTAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGGILRAVRGSVSTERQEKAKIKRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQTETSQVAPA', 'OPSD_BOVIN_GPR3_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIVGTPAFRAPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVYNALTYYSETTVTRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQICRIVCRHAQQIALQRHLLPASHYVATRKGIRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKVLWAVCCCCSSSKIPFRSRSPSDVTETSQVAPA', 'OPSD_BOVIN_CML2_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTGFKWKKTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVIHPVLSHRHRTLKNAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGCLIFKVKKRSILISSRHFRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQTETSQVAPA', 'GPR27_HUMAN_ADRB2_HUMAN_1': 'MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVDRYFAITSPFKYQSLLTWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL', 'GPR27_HUMAN_ADRB2_HUMAN_2': 'MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVDRYFAITSPFKYQSLLTWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRGRFHVQNLSQVEQDGRTGHGLRRSLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL', 'GPR27_HUMAN_ADRB2_HUMAN_3': 'MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIAKFERLQTVPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVDRYFAITSPFKYQSLLTWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRGRFHVQNLSQVEQDGRTGHGLRRSLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL', 'GPR27_HUMAN_ADRB2_HUMAN_4': 'MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIAKFERLQTVPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVDRYFAITSPFKYQSLLTWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRGRFHVQNLSQVEQDGRTGHGLRRSLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVYFLFNRELRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'GPR27_HUMAN_ADRB2_HUMAN_5': 'MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRGRFHVQNLSQVEQDGRTGHGLRRSLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL', 'OPSD_BOVIN_ADRB2_HUMAN_2': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_HUMAN_3': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMSPDFRIAFQELLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ACM1_HUMAN_2': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRDTFRLLLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_HUMAN_4': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMSPDFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADA1A_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVVACHRHLHSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVSYPLRYPTIVTQRRAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAARMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEVTETSQVAPA', 'OPSD_HUMAN_ADRB2_HUMAN_1': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLLASTETSQVAPA', 'OPSD_HUMAN_ADRB2_HUMAN_2': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLLASTETSQVAPA', 'OPSD_HUMAN_ADRB2_HUMAN_3': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLLASTETSQVAPA', 'OPSD_HUMAN_OPRM_HUMAN_1': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVIVRYTKMKTALNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCHPVKALDFRTPRNAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP', 'OPSD_BOVIN_CXCR4_HUMAN_1': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVMGYQKKLRSPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVIVHATNSQRPRKLHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGIIISKLSHSKGHQKRKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS', 'OPSD_RAT_OPRM_RAT_1': 'MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVIVRYTKMKTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCHPVKALDFRTPRNAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLPTETSQVAPA', 'OPSD_HUMAN_OPN4_HUMAN_1': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQIFRAIRETGRALQTFGACKGNGESLWQRQRLQSEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPAASTTVSKTETSQVAPA', 'OPSD_HUMAN_OPN4_HUMAN_2': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTRPLATFGVASKNHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQIFRAIRETGRALQTFGACKGNGESLWQRQRLQSEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPAASTTVSKTETSQVAPA', 'OPSD_HUMAN_OPN4_HUMAN_3': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQSRSLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTRPLATFGVASKNHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQIFRAIRETGRALQTFGACKGNGESLWQRQRLQSEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPAASTTVSKTETSQVAPA', 'OPSD_HUMAN_OPN4_HUMAN_4': 'MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQSRSLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTRPLATFGVASKNHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQIFRAIRETGRALQTFGACKGNGESLWQRQRLQSEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRMASTTVSKTETSQVAPA', 'ACM3_HUMAN_ACM4_HUMAN_1': 'MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSIKVNRQLQTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFCVTKPLTYPARRTTKMAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNATFKKTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL', 'ACM4_HUMAN_ACM3_HUMAN_1': 'MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSFKVNKQLKTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFSITRPLTYRAKRTTKRAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNKTFRTTFRHLLLCQYRNIGTAR', '5HT2A_HUMAN_OPRK_HUMAN_1': 'MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKVRLLSGSREKDRNLRRITRLVLVVVAVFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV', 'EDNRA_HUMAN_OPRK_HUMAN_1': 'METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVLCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN', '5HT4R_HUMAN_OPRK_HUMAN_1': 'MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT', '5HT5A_HUMAN_OPRK_HUMAN_1': 'MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKALKSVRLLSGSREKDRNLRRAARMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH', 'DRD1_HUMAN_OPRK_HUMAN_1': 'MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT', 'NTR1_RAT_OPRK_HUMAN_1': 'MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILYTLMILRLKSVRLLSGSREKDRNLRRITRLVLAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY', 'GP149_HUMAN_OPRK_HUMAN_1': 'MSLFLSNLSTNDSSLWKENHNSTDLLNPPGTLNIYLFCLTCLMTFAALVGSIYSLISLLKMQNRTVVSMLVASWSVDDLMSVLSVTIFMFLQWPNEVPGYFQFLCTTSALMYLCQGLSSNLKATLLVSYNFYTMHRGVGSQTASRRSGQVLGVVLTVWAASLLLSALPLCGWGAFVRTPWGCLVDCSSSYVLFLSIVYALAFGLLVGLSVPLTHRLLCVTLVYTLMILRLKSVRLLSGSREKDRNLRRITRLVLILALTKVVLWLPMMMHMVVQNVVGFQSLPLETFSFLLTLLATTVTPVFVLSKRWTHLPCGCIINCRQNAYAVASDGKKIKRKGFEFNLSFQKSYGIYKIAHEDYYDDDENSIFYHNLMNSECETTKDPQRDNRNIFNAIKVEISTTPSLDSSTQRGINKCTNTDITEAKQDSNNKKDAFSDKTGGDINYEETTFSEGPERRLSHEESQKPDLSDWEWCRSKSERTPRQRSGYALAIPLCAFQGTVSLHAPTGKTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEDSSSTFVDTSVKIHLEVLEICDNEEALDTVSIISNISQSSTQVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSNPDGDINISIPDTVEAHRQNSKRQHQERDGYQEEIQLLNKAYRKREEESKGS', 'GP151_HUMAN_OPRK_HUMAN_1': 'MLAAAFADSNSSSMNVSFAHLHFAGGYLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKSVWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIHNYTIWSVLVAIWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGKLYPLLAFGLPLFFASFYVTLVYTLMILRLKSVRLLSGSREKDRNLRRITRLVLSIAIISALLWLPEWVAWLWVWHLKAAGPAPPQGFIALSQVLMFSISSANPLIFLVMSEEFREGLKGVWKWMITKKPPTVSESQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHERDTVPSVQDNDPIPWEHEDQETGEGVK', 'OPRM_MOUSE_OPRK_HUMAN_1': 'MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRLLSGSREKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP', 'NTR1_HUMAN_OPRK_HUMAN_1': 'MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLYTLMILRLKSVRLLSGSREKDRNLRRITRLVLAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY', 'SSR2_HUMAN_OPRK_HUMAN_1': 'MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSVRLLSGSREKDRNLRRVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI', 'HRH2_HUMAN_OPRK_HUMAN_1': 'MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR', 'MC4R_HUMAN_CNR1_HUMAN_1': 'MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFRPLAYKRIVTRPKVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY', 'MC4R_HUMAN_CNR1_HUMAN_2': 'MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFRPLAYKRIVTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY', 'MC4R_HUMAN_CNR1_HUMAN_3': 'MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYISIHRPLAYKRIVTRPKVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY', 'MC4R_HUMAN_CNR1_HUMAN_4': 'MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYISIHRPLAYKRIVTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY', 'ADA1A_HUMAN_OPRK_HUMAN_1': 'MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTARIWGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYLMILRLKSVRLLSGSREKDRNLRRITRLVLVREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV', 'CXCR3_HUMAN_OPRK_HUMAN_1': 'MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILARLKSVRLLSGSREKDRNLRRITRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL', 'ADA1B_MESAU_ADRB2_HUMAN_1': 'MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVFQEAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF', 'ADA1B_MESAU_ADRB2_HUMAN_2': 'MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVLQKIDKSEGLTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF', 'ADA1B_MESAU_ADRB2_HUMAN_3': 'MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELEGRFHVQNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF', 'ADA1B_MESAU_ADRB2_HUMAN_4': 'MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHQVEQDGTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF', 'ADA1B_MESAU_ADRB2_HUMAN_5': 'MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSKEHKALKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF', 'ADRB2_HUMAN_ADA1B_MESAU_1': 'MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'ADA1A_RAT_ADA1B_MESAU_1': 'MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV', 'ACM1_HUMAN_ACM2_HUMAN_1': 'MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC', 'ACM2_HUMAN_ACM1_HUMAN_1': 'MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR', 'DRD3_HUMAN_DRD2_HUMAN_1': 'MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC', 'DRD3_MOUSE_DRD2_MOUSE_1': 'MAPLSQISSHINSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC', 'DRD2_MOUSE_DRD3_MOUSE_1': 'MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVARIYMVLRQRRRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKPYPQKCQDPLLSHLQPLSPGQTHGELKRYYSICQDTALRHPNFEGGGGMSQVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC', 'ACM2_HUMAN_ACM3_RAT_1': 'MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR', 'ACM2_HUMAN_ACM3_RAT_2': 'MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWRIYKETEKRTKELAGLQVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR', 'ADRB3_HUMAN_ADRB2_HUMAN_1': 'MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', '5HT2A_HUMAN_5HT2C_HUMAN_1': 'MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV', '5HT2B_HUMAN_5HT2C_HUMAN_1': 'MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYVAIRNPIEHSRFNSRTKAIMKIAVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV', 'ADRB2_HUMAN_HRH2_HUMAN_1': 'MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYCAVMDPLRYPVLVTPVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'ADRB2_HUMAN_HRH2_HUMAN_2': 'MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRIFKVARDQAKRINHISSWKAATIREHKATVTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'ADRB2_HUMAN_HRH2_HUMAN_3': 'MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR', 'ADRB2_HUMAN_HRH2_HUMAN_4': 'MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYCAVMDPLRYPVLVTPVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRIFKVARDQAKRINHISSWKAATIREHKATVTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'ADA2A_HUMAN_ADA2C_HUMAN_1': 'MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV', 'ADA2C_HUMAN_ADA2A_HUMAN_1': 'MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ', 'AA2AR_CANLF_AA1R_HUMAN_1': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD', 'AA2AR_CANLF_AA1R_HUMAN_2': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'OPSD_BOVIN_ADRB2_MESAU_6': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCSPFKYQSLLTENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQEGRFHSPNLGQVEQDGRSGHGLRRSSKFCATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCLRRSSSKAYGNGYSSNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPL', 'ACKR3_HUMAN_CXCR4_HUMAN_1': 'MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLAIVHATNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK', 'OPSD_BOVIN_ADRB2_MESAU_7': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_8': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_9': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_10': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLVITAIAKFERLQTVTNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYIAITSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYSRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALKTLGIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_11': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLVITAIAKFERLQTVTNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYIAITSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_12': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA', 'ACM3_RAT_ACM2_HUMAN_1': 'MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL', 'ACM3_RAT_ACM2_HUMAN_2': 'MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWHISRASKSRIKKDKKEQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL', 'V2R_HUMAN_V1AR_RAT_1': 'MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRYIAVCHPLKTLQQPARRSRLMILVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS', 'V2R_HUMAN_V1AR_RAT_2': 'MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS', 'V1AR_RAT_V2R_HUMAN_1': 'MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALARRGRRGHWAPIHVFIGHLCLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST', 'V1AR_RAT_V2R_HUMAN_2': 'MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAICRPMLAYRHGSGAHWNRPVLTSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST', 'V1AR_RAT_V2R_HUMAN_3': 'MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST', 'AA2AR_CANLF_AA1R_HUMAN_3': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLEVFYLIRKQLNKKVSASERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_4': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERAQKYYQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_5': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESKVSASERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_6': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERAQKYYGKELKIAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_7': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYLRVKIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_8': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYKMVVTPRRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_9': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYKMVVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA2AR_CANLF_AA1R_HUMAN_10': 'MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTPRRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS', 'AA1R_HUMAN_AA2AR_CANLF_1': 'MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD', 'AA1R_HUMAN_AA2AR_CANLF_2': 'MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLRIFLAARRQLKQMESSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD', 'OPSD_BOVIN_ADRB2_MESAU_4': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVFNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERGVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCAGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCLRRSSSKAYGNGYSSNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPLTETSQVAPA', 'OPSD_BOVIN_ADRB2_MESAU_5': 'MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVIAKFERLQTVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVTSPFKYQSLLTKNKAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVFQVAKRQLQKIDKSEGRFHSPNLGQVEQDGRSGHGLRRSSKFCLKEHKALRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRIAFQELLCLRRSSSKAYGNGYAGNSNGKTDYMGEASGCQLGQEKESERLCEDPPGTESFVNCQGTVPSLSLDSQGRNCSTNDSPLTETSQVAPA', 'ACM3_HUMAN_ADRB2_HUMAN_1': 'MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSIAKFERLQTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDCVASNASVMNLLVISFDRYFSITSPFKYQSLLTKNKAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAGFYMPVTIMTILYWRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL', 'ACM3_HUMAN_PSYR_HUMAN_1': 'MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSSFLQAKKESENNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDCVASNASVMNLLVISFDRYFSIVYPLKFFFLRTRRFAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAGFYMPVTIMTILYWKVYQAVRHNKATENKEKKRIIQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRYDMWNILKFCTGRCNTSQRQRKRILSVSTKDTMELEVLE', 'ACM3_HUMAN_HCAR2_HUMAN_1': 'MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFCFHLKSWKSNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDCVASNASVMNLLVISFDRYFSIVHPHHALNKISNRTAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAGFYMPVTIMTILYWRIIWSLRQRQMDRHAKIKRAIQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP'}\n"
     ]
    }
   ],
   "source": [
    "#upload data\n",
    "of_interest=['']\n",
    "\n",
    "naturals_entry_data = \"../data/all_designs.fasta\"\n",
    "entry_uniprotID_seq = {}\n",
    "for record in SeqIO.parse(naturals_entry_data,\"fasta\"):\n",
    "    # if record.id in of_interest:\n",
    "        entry_uniprotID_seq[record.id]=str(record.seq)\n",
    "\n",
    "print(len(entry_uniprotID_seq))\n",
    "print(entry_uniprotID_seq)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Download file with classification info\n",
    "filename_listGPCRdb = \"../data/240923_Classification_GPCRdb.xlsx\"\n",
    "listGPCRdb_df = pd.read_excel(filename_listGPCRdb)\n",
    "\n",
    "#chimeric design info\n",
    "filename_chimeric_designs = \"../data/previous_designs.xlsx\"\n",
    "chimeric_design_df = pd.read_excel(filename_chimeric_designs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [],
   "source": [
    "def calculate_sq_atom_distance(i, j):\n",
    "    \"\"\"Squared euclidean distance between two 3d points\"\"\"\n",
    "    return (i[0] - j[0]) * (i[0] - j[0]) + \\\n",
    "            (i[1] - j[1]) * (i[1] - j[1]) + \\\n",
    "            (i[2] - j[2]) * (i[2] - j[2])\n",
    "\n",
    "def identify_gaps(pdb_file, chain_pdb, offset, end): #code modified from pdb_gap.py file from pdbtools Copyright 2018 João Pedro Rodrigues\n",
    "    fhandle = open(pdb_file, 'r')\n",
    "    centroid = ' CA '  # respect spacing. 'CA  ' != ' CA '\n",
    "    distance_threshold = 4.0 * 4.0\n",
    "    prev_at = (None, None, None, None, (None, None, None))\n",
    "    model = 0\n",
    "    n_gaps = 0\n",
    "    gap = []\n",
    "    for line in fhandle:\n",
    "\n",
    "        if line.startswith('MODEL'):\n",
    "            model = int(line[10:14])\n",
    "\n",
    "        elif line.startswith('ATOM'):\n",
    "            atom_name = line[12:16]\n",
    "            if atom_name != centroid:\n",
    "                continue\n",
    "\n",
    "            resn = line[17:20]\n",
    "            resi = int(line[22:26])\n",
    "            chain = line[21]\n",
    "            x = float(line[30:38])\n",
    "            y = float(line[38:46])\n",
    "            z = float(line[46:54])\n",
    "\n",
    "            at_uid = (model, chain, resi, resn, atom_name, (x, y, z))\n",
    "            if prev_at[0] == at_uid[0] and prev_at[1] == at_uid[1]:\n",
    "                d = calculate_sq_atom_distance(at_uid[5], prev_at[5])\n",
    "                if d > distance_threshold:\n",
    "                    gap.append([prev_at[1],prev_at[2],at_uid[1],at_uid[2]])\n",
    "                    # sys.stdout.write(fmt_GAPd.format(prev_at, at_uid, d**0.5))\n",
    "                    n_gaps += 1\n",
    "                elif prev_at[2] + 1 != at_uid[2]:\n",
    "                    # sys.stdout.write(fmt_GAPs.format(prev_at, at_uid))\n",
    "                    gap.append([prev_at[1],prev_at[2],at_uid[1],at_uid[2]])\n",
    "                    n_gaps += 1\n",
    "\n",
    "            prev_at = at_uid\n",
    "\n",
    "    gaps_cleaned = []\n",
    "    start = offset\n",
    "    for section in gap:\n",
    "        if section[0] == chain_pdb and section[2] == chain_pdb:\n",
    "            stop = section[1]\n",
    "            if start < 1000 and stop < 1000:\n",
    "                gaps_cleaned.append([start,stop])\n",
    "            start = section[3]\n",
    "    gaps_cleaned.append([start,end])\n",
    "    return gaps_cleaned"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "def merge_duplicates(dicts):\n",
    "    # Step 1: Group dictionaries by the 'start' key\n",
    "    grouped = defaultdict(list)\n",
    "    for d in dicts:\n",
    "        grouped[d['start']].append(d)\n",
    "    \n",
    "    result = []\n",
    "    conflicts = []\n",
    "\n",
    "    # Step 2: Process each group\n",
    "    for start, items in grouped.items():\n",
    "        if len(items) > 1:\n",
    "            # Check if all 'type' values are the same\n",
    "            types = set(d['type'] for d in items)\n",
    "            if len(types) == 1:\n",
    "                # Merge 'reference' values\n",
    "                merged_references = \"PDBePISA \"\n",
    "                for d in items:\n",
    "                    merged_references += d['description'].split('.')[0] + \" \"\n",
    "                    merged_references += d['description'].split(' ')[-1] + \" \"\n",
    "                # Create a new dictionary with merged references\n",
    "                new_dict = items[0].copy()\n",
    "                new_dict['description'] = merged_references[:-1]\n",
    "                new_dict['reference'] = \"https://www.ebi.ac.uk/pdbe/pisa/\"\n",
    "                result.append(new_dict)\n",
    "            else:\n",
    "                # Print dictionaries with different 'type' values\n",
    "                for d in items:\n",
    "                    conflicts.append(d)\n",
    "        else:\n",
    "            result.append(items[0])\n",
    "    \n",
    "    return result, conflicts\n",
    "\n",
    "def retrieve_interacting_residues_PDB(pdb_id, chain_pdb,uniprot_pdb_start,pdb_start):\n",
    "    # retrieve the interacting residues in the PDBs from PISA, need to make sure it doesn't take into accound the interactions between 2 sym GPCRs\n",
    "    # interacting residues is defined by a bsa > 0\n",
    "    #https://github.com/PDBe-KB/pdbe-pisa-json/blob/main/PISA-APIs.ipynb\n",
    "\n",
    "\n",
    "    interacting_residues = []\n",
    "    chain_interacting_molecule = \"\"\n",
    "    try: #when its just 1 chain or 1 chain and a ligand PISA doesn't work\n",
    "        difference_pdb_uniprot_start = pdb_start-uniprot_pdb_start\n",
    "        response = requests.get(f\"https://www.ebi.ac.uk/pdbe/api/pisa/assembly/{pdb_id.lower()}/1\")\n",
    "        interface_count = response.json()[pdb_id.lower()][\"assembly\"][\"interface_count\"]\n",
    "        for i in range(1,interface_count+1):\n",
    "            response_single_interface = requests.get(f\"https://www.ebi.ac.uk/pdbe/api/pisa/interface/{pdb_id.lower()}/1/{i}/\")\n",
    "            data = response_single_interface.json()\n",
    "            if \"/\" in chain_pdb:\n",
    "                chain_pdb = chain_pdb.split(\"/\")\n",
    "            for j in range(len(data[\"molecules\"])):\n",
    "                if isinstance(chain_pdb,str):\n",
    "                    if data[\"molecules\"][j][\"chain_id\"]==chain_pdb:\n",
    "                        for bsa,position in zip(data[\"molecules\"][j][\"buried_surface_areas\"],data[\"molecules\"][j]['residue_seq_ids']):\n",
    "                            if bsa >0.0:\n",
    "                                interacting_residues.append(int(position)-difference_pdb_uniprot_start)\n",
    "                        if j == 0: #there is supposed to be only 2 molecules, the GPCR and the interacting molecule\n",
    "                            chain_interacting_molecule = data[\"molecules\"][1][\"chain_id\"]\n",
    "                        else: \n",
    "                            chain_interacting_molecule = data[\"molecules\"][0][\"chain_id\"]\n",
    "                elif isinstance(chain_pdb,list):\n",
    "                    if chain_pdb[0] in data[\"molecules\"][j][\"chain_id\"] and chain_pdb[1] in data[\"molecules\"][j+1][\"chain_id\"]:\n",
    "                        break\n",
    "                    else:\n",
    "                        if chain_pdb[0] in data[\"molecules\"][j][\"chain_id\"] or chain_pdb[1] in data[\"molecules\"][j][\"chain_id\"]:\n",
    "                            for bsa,position in zip(data[\"molecules\"][j][\"buried_surface_areas\"],data[\"molecules\"][j]['residue_seq_ids']):\n",
    "                                if bsa >0.0:\n",
    "                                    interacting_residues.append(int(position)-difference_pdb_uniprot_start)\n",
    "                        if j == 0: #there is supposed to be only 2 molecules, the GPCR and the interacting molecule\n",
    "                            chain_interacting_molecule = data[\"molecules\"][1][\"chain_id\"]\n",
    "                        else: \n",
    "                            chain_interacting_molecule = data[\"molecules\"][0][\"chain_id\"]\n",
    "    except:\n",
    "        pass\n",
    "\n",
    "\n",
    "    return interacting_residues,chain_interacting_molecule\n",
    "\n",
    "def extract_name_binders(chain_of_interest,pdb_file_path):\n",
    "\n",
    "    molecule_name = None\n",
    "    current_molecule = \"\"\n",
    "    reading_molecule = False\n",
    "    found_chain = False\n",
    "    \n",
    "    # Open and read the PDB file\n",
    "    with open(pdb_file_path, 'r') as file:\n",
    "        lines = file.readlines()\n",
    "    \n",
    "    for line in lines:\n",
    "        if line.startswith(\"COMPND\"):\n",
    "            # Start reading the molecule name if \"MOLECULE\" is in the line\n",
    "            if \"MOLECULE\" in line:\n",
    "                reading_molecule = True\n",
    "                current_molecule = line.split(\":\")[1].strip().rstrip(\";\")  # Extract initial part of the molecule name\n",
    "            # If the molecule name is being read and it continues on the next line\n",
    "            elif reading_molecule and \"CHAIN\" not in line:\n",
    "                pattern = r\"\\d+\\s+(.+)\"\n",
    "                match = re.search(pattern, line)\n",
    "                current_molecule += \" \"+match.group(1).strip().rstrip(\";\")\n",
    "            # Once we reach the chain of interest\n",
    "            if f\"CHAIN: {chain_of_interest}\" in line:\n",
    "                found_chain = True\n",
    "            # If molecule and chain have been found, stop reading\n",
    "            if found_chain and current_molecule and \";\" in line:\n",
    "                molecule_name = current_molecule\n",
    "                break\n",
    "    return molecule_name\n",
    " \n",
    "    \n",
    "def translate_interacting_residues_IC_EC(interacting_residues,binders,pdb_list,all_regions):\n",
    "    interactions_pdb_list_EC = []\n",
    "    interactions_pdb_list_IC = []\n",
    "    for residues,binder,pdb_id in zip(interacting_residues,binders,pdb_list):\n",
    "        for residue in residues:\n",
    "            for region in all_regions:\n",
    "                if residue >= region[\"start\"] and residue <= region[\"end\"]:\n",
    "                    if region[\"name\"] in [\"Nterm\",\"ECL1\",\"ECL2\",\"ECL3\"]:\n",
    "                        region_residue = \"EC\"\n",
    "                    elif region[\"name\"] in [\"Cterm\",\"ICL1\",\"ICL2\",\"ICL3\"]:\n",
    "                        region_residue = \"IC\"\n",
    "                    elif region[\"name\"] in [\"TM1\",\"TM3\",\"TM5\",\"TM7\"]:\n",
    "                        if residue <= region[\"start\"] + round(((region[\"end\"]-region[\"start\"])/2)):\n",
    "                            region_residue = \"EC\"\n",
    "                        else:\n",
    "                            region_residue = \"IC\"\n",
    "                    elif region[\"name\"] in [\"TM2\",\"TM4\",\"TM6\"]:\n",
    "                        if residue <= region[\"start\"] + round(((region[\"end\"]-region[\"start\"])/2)):\n",
    "                            region_residue = \"IC\"\n",
    "                        else:\n",
    "                            region_residue = \"EC\"\n",
    "\n",
    "                    interactions_pdb = {}\n",
    "                    interactions_pdb[\"start\"]=int(residue)\n",
    "                    interactions_pdb[\"end\"]=int(residue)\n",
    "                    if region_residue == \"IC\":\n",
    "                        interactions_pdb[\"type\"]=\"Intracellular binding pocket residue\"\n",
    "                    else:\n",
    "                        interactions_pdb[\"type\"]=\"Extracellular binding pocket residue\"\n",
    "                    \n",
    "                    interactions_pdb[\"description\"]=f\"{binder}. Inferred from {pdb_id}\"\n",
    "                    interactions_pdb[\"reference\"]=\"https://www.ebi.ac.uk/pdbe/pisa/\"\n",
    "\n",
    "                    if region_residue == \"IC\":\n",
    "                        interactions_pdb_list_IC.append(interactions_pdb)\n",
    "                    else:\n",
    "                        interactions_pdb_list_EC.append(interactions_pdb)\n",
    "\n",
    "    #merge duplicates\n",
    "    interactions_pdb_list_IC_no_duplicates,_ = merge_duplicates(interactions_pdb_list_IC)\n",
    "    interactions_pdb_list_EC_no_duplicates,_ = merge_duplicates(interactions_pdb_list_EC)\n",
    "\n",
    "    return interactions_pdb_list_IC_no_duplicates, interactions_pdb_list_EC_no_duplicates"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {},
   "outputs": [],
   "source": [
    "def pad_line(line):\n",
    "    \"\"\"Helper function to pad line to 80 characters in case it is shorter\"\"\"\n",
    "    size_of_line = len(line)\n",
    "    if size_of_line < 80:\n",
    "        padding = 80 - size_of_line + 1\n",
    "        line = line.strip('\\n') + ' ' * padding + '\\n'\n",
    "    return line[:81]  # 80 + newline character\n",
    "\n",
    "def check_first_residue_pdb_uniprot(pdb_file,chain_interest,sequence):\n",
    "    #SIFT mapping identifies 1st residue from PDB in uniprot. But that 1st residue is not necessarly the first residue that is resolved in the PDB\n",
    "    #Here check if the first residue that is resolved corresponds to a residue at the same position in sequence\n",
    "    #if yes, no need to renumber\n",
    "    Three_to_One_AA = {'CYS': 'C', 'ASP': 'D', 'SER': 'S', 'GLN': 'Q', 'LYS': 'K',\n",
    "     'ILE': 'I', 'PRO': 'P', 'THR': 'T', 'PHE': 'F', 'ASN': 'N', \n",
    "     'GLY': 'G', 'HIS': 'H', 'LEU': 'L', 'ARG': 'R', 'TRP': 'W', \n",
    "     'ALA': 'A', 'VAL':'V', 'GLU': 'E', 'TYR': 'Y', 'MET': 'M'}\n",
    "\n",
    "    fhandle = open(pdb_file, 'r')\n",
    "    _pad_line = pad_line\n",
    "    for line in fhandle:\n",
    "        line = _pad_line(line)\n",
    "        if line.startswith(\"ATOM\") and line[21]==chain_interest:\n",
    "            residue = Three_to_One_AA[line[17:20].upper()]\n",
    "            pos = int(line[24:27])\n",
    "            break\n",
    "    if sequence[pos-1] == residue:\n",
    "        return True\n",
    "    else:\n",
    "        return False"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [],
   "source": [
    "def SIFT_mapping(pdb_id,uniprot_id):\n",
    "    #find equivalence start uniprot and pdb \n",
    "    # https://www.ebi.ac.uk/pdbe/api/doc/sifts.html\n",
    "    response = requests.get(f\"https://www.ebi.ac.uk/pdbe/api/mappings/uniprot/{pdb_id}\")\n",
    "    data = response.json()\n",
    "    uniprot_pdb_start = data[pdb_id.lower()]['UniProt'][uniprot_id]['mappings'][0]['unp_start']\n",
    "    pdb_start = data[pdb_id.lower()]['UniProt'][uniprot_id]['mappings'][0]['start']['author_residue_number']\n",
    "    if not pdb_start:\n",
    "        pdb_start = data[pdb_id.lower()]['UniProt'][uniprot_id]['mappings'][0]['start']['residue_number']\n",
    "    return uniprot_pdb_start, pdb_start\n",
    "\n",
    "def renumber_pdb_uniprot_start(pdb_file,pdb_id,chain,uniprot_id,sequence):\n",
    "    uniprot_pdb_start, pdb_start=SIFT_mapping(pdb_id,uniprot_id)\n",
    "    new_pdb_file_path = f\"../examples/3Dstructures/pdb_renumbered/{pdb_id}.pdb\"\n",
    "    modify = False\n",
    "    if not check_first_residue_pdb_uniprot(pdb_file,chain,sequence) and uniprot_pdb_start != pdb_start :\n",
    "    #if both SIFT and the manually matching with th e sequence doesn't work, renumber\n",
    "        modify = True\n",
    "    if modify:\n",
    "        !python pdb_reres.py -$uniprot_pdb_start -$chain $pdb_file > $new_pdb_file_path\n",
    "    else:\n",
    "        uniprot_pdb_start, pdb_start = 0, 0\n",
    "    return new_pdb_file_path, uniprot_pdb_start, pdb_start"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "def retrieve_pdb_dsbonds_chimera_info(structures_pdb,uniprot_id_ref,sequence):\n",
    "    structures = []\n",
    "    ds_bonds = []\n",
    "    pdbs = []\n",
    "    chains = []\n",
    "    uniprot_pdb_starts = []\n",
    "    pdb_starts = []\n",
    "    binders_list= []\n",
    "    interacting_residues_list = []\n",
    "\n",
    "    for pdb_info in structures_pdb:\n",
    "        pdb_id = pdb_info[\"PDB id\"]\n",
    "        chain_pdb = pdb_info[\"chain\"]\n",
    "        state = pdb_info[\"state\"]\n",
    "        pdb_file_path = f'../data/tmp/{pdb_id}.pdb'\n",
    "        urllib.request.urlretrieve(f'https://files.rcsb.org/download/{pdb_id}.pdb', pdb_file_path)\n",
    "\n",
    "        #get SIFTS mapping PDB seq > UniProt mapping and renumber pdb. New pdb being written\n",
    "        new_pdb_file_path, uniprot_pdb_start, pdb_start=renumber_pdb_uniprot_start(pdb_file_path,pdb_id,chain_pdb,uniprot_id_ref,sequence)\n",
    "        if os.path.exists(new_pdb_file_path):\n",
    "            path_DB_pdb = f\"file:///examples/3Dstructures/pdb_renumbered/{pdb_id}.pdb\"\n",
    "        else:\n",
    "            path_DB_pdb = f\"https://files.rcsb.org/download/{pdb_id}.pdb\"\n",
    "            new_pdb_file_path = pdb_file_path\n",
    "        \n",
    "        # #this is needed to find the interactions within the pdb file\n",
    "        pdbs.append(pdb_id)\n",
    "        chains.append(chain_pdb)\n",
    "        uniprot_pdb_starts.append(uniprot_pdb_start)\n",
    "        pdb_starts.append(pdb_start)\n",
    "\n",
    "        #get offset and gaps in structure\n",
    "        offset = 0\n",
    "        start_found = False\n",
    "        gaps = []\n",
    "        gap = False\n",
    "        with open(new_pdb_file_path, 'r') as f:\n",
    "            for line in f:\n",
    "                line_list = line.split()\n",
    "                if not start_found:\n",
    "                    if line_list[0]==\"ATOM\" and line_list[4]==chain_pdb:\n",
    "                        if int(line_list[5]) >= 1:\n",
    "                            offset = int(line_list[5]) - 1 #line_list[5] gives the 1st position so the offset is line_list[5] -1\n",
    "                            start_found = True\n",
    "                else:\n",
    "                    if line_list[0]==\"ATOM\" and line_list[4]==chain_pdb:\n",
    "                        end = int(line_list[5])\n",
    "                \n",
    "                \n",
    "        gaps = identify_gaps (new_pdb_file_path, chain_pdb, offset+1, end)\n",
    "        structures.append({\"value\":pdb_id,\"chain\": chain_pdb, \"state\":state, \"offset\":  offset, \"gaps\": gaps, \"url\":path_DB_pdb, \"reference\":f\"https://www.rcsb.org/structure/{pdb_id.upper()}\"})\n",
    "\n",
    "        #Look for disulfide bridges in PDB files\n",
    "        with open(new_pdb_file_path, 'r') as f:\n",
    "            for line in f:\n",
    "                line_list = line.split()\n",
    "                if line_list[0]==\"SSBOND\":\n",
    "                    if line_list[3] == chain_pdb and line_list[6] == chain_pdb:\n",
    "                        ssbond = {}\n",
    "                        ssbond[\"start\"] = int(line_list[4])\n",
    "                        ssbond[\"end\"]= int(line_list[7])\n",
    "                        ssbond[\"description\"] = \"Disulfide bond\"\n",
    "                        ssbond[\"reference\"] = \"Extracted from PDB files\"\n",
    "                        ds_bonds.append(ssbond)\n",
    "\n",
    "        #find interacting residues at ligand binding site and G protein binding site\n",
    "        interacting_residues,binder_chain = retrieve_interacting_residues_PDB(pdb_id,chain_pdb,uniprot_pdb_start,pdb_start)\n",
    "\n",
    "        interacting_residues_list.append(list(set(interacting_residues)))\n",
    "        binder = extract_name_binders(binder_chain,pdb_file_path)\n",
    "        if binder != None:\n",
    "            binders_list.append(binder)\n",
    "\n",
    "        #remove pdb file\n",
    "        os.remove(pdb_file_path)\n",
    "    \n",
    "    #Keep only the DS bonds that are in every PDB file (sometimes add DS bond to stabilize structure to be crystalized)\n",
    "    ds_bonds_noduplicates=[dict(t) for t in {tuple(d.items()) for d in ds_bonds}]\n",
    "    for single in ds_bonds_noduplicates:\n",
    "        count = 0\n",
    "        for multiple in ds_bonds:\n",
    "            if single == multiple:\n",
    "                count +=1\n",
    "        if count != len(structures):\n",
    "            ds_bonds_noduplicates.remove(single)   \n",
    "            \n",
    "    return structures, ds_bonds_noduplicates, interacting_residues_list, binders_list, pdbs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#find TM regions based on TMbed predictions\n",
    "#find the TM regions\n",
    "\n",
    "def TMbed_retrieve_allregions(TM_regions_file,abbreviated_name):\n",
    "    \n",
    "    regions = []\n",
    "    region_names = ['Nterm','TM1', 'ICL1', 'TM2', 'ECL1', 'TM3', 'ICL2', 'TM4', 'ECL2', 'TM5', 'ICL3', 'TM6', 'ECL3', 'TM7','Cterm']\n",
    "\n",
    "    with open(TM_regions_file, 'r') as f:\n",
    "        count = 0\n",
    "        TM_counter = 1\n",
    "        name =\"\"\n",
    "        ok=False\n",
    "        error = False\n",
    "        for line in f:\n",
    "            line=line.replace('\\n',\"\").replace('\\t',\" \")\n",
    "            line=list(line.split())\n",
    "            count +=1\n",
    "            if \">\" in line[0]:\n",
    "                try:\n",
    "                    name = line[0].split('|')[1]\n",
    "                except:\n",
    "                    name = line[0][1:]\n",
    "                count = 1\n",
    "            if name == abbreviated_name and (count%3==0):\n",
    "                counter_region = 0\n",
    "                start = False\n",
    "                \n",
    "                previous = 1\n",
    "                for idx,element in enumerate(line[0]):\n",
    "                    if start == False:\n",
    "                        if element == \"H\" or element == \"h\":\n",
    "                            start = True\n",
    "                            lower_lim_TM = idx+1 #human readble limits\n",
    "                            region = {}\n",
    "                            region[\"name\"] = region_names[counter_region]\n",
    "                            region[\"start\"] = previous\n",
    "                            region[\"end\"] = lower_lim_TM-1\n",
    "                            region[\"reference\"] = \"TMbed\"\n",
    "                            regions.append(region)\n",
    "                            counter_region +=1\n",
    "                    else:\n",
    "                        if element != \"H\" and element != \"h\":\n",
    "                            upper_lim_TM = idx  #human readble limits\n",
    "                            start = False\n",
    "                            region = {}\n",
    "                            region[\"name\"] = region_names[counter_region]\n",
    "                            region[\"start\"] = lower_lim_TM\n",
    "                            region[\"end\"] = upper_lim_TM\n",
    "                            region[\"reference\"] = \"TMbed\"\n",
    "                            regions.append(region)\n",
    "                            counter_region +=1\n",
    "                            previous=upper_lim_TM+1\n",
    "                region = {}\n",
    "                region[\"name\"] = region_names[counter_region]\n",
    "                region[\"start\"] = previous\n",
    "                region[\"end\"] = len(line[0])\n",
    "                region[\"reference\"] = \"TMbed\"\n",
    "                regions.append(region)\n",
    "                break\n",
    "\n",
    "    return regions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "def cutting_pts_2_ss_region(dict_regions,all_regions=None):\n",
    "    translated_regions = []\n",
    "    if isinstance(dict_regions,dict):\n",
    "        for region in dict_regions.keys():\n",
    "            lower_lim = dict_regions[region][0]\n",
    "            upper_lim = dict_regions[region][1]\n",
    "            for ss_region in all_regions:\n",
    "                if lower_lim >= ss_region[\"start\"] and lower_lim <= ss_region[\"end\"]:\n",
    "                    ss_lower_lim = ss_region[\"name\"]\n",
    "                if upper_lim >= ss_region[\"start\"] and upper_lim <= ss_region[\"end\"]:\n",
    "                    ss_upper_lim = ss_region[\"name\"]\n",
    "            translated_regions.append(str(lower_lim)+\"-\"+str(upper_lim)+f\" ({ss_lower_lim}-{ss_upper_lim})\")\n",
    "\n",
    "    elif isinstance(dict_regions,list):\n",
    "        if all_regions:\n",
    "            for section in dict_regions:\n",
    "                info = []\n",
    "                for pos in section:\n",
    "                    for ss_region in all_regions:\n",
    "                        if int(pos) >= ss_region[\"start\"] and int(pos) <= ss_region[\"end\"]:\n",
    "                            ss_pos = ss_region[\"name\"]\n",
    "                            break\n",
    "                    info.append(pos)\n",
    "                    info.append(ss_pos)\n",
    "                translated_regions.append(str(info[0])+\"-\"+str(info[2])+f\" ({info[1]}-{info[3]})\")\n",
    "        else:\n",
    "            for region in dict_regions:\n",
    "                lower_lim = region[0]\n",
    "                upper_lim = region[1]\n",
    "                translated_regions.append(str(lower_lim)+\"-\"+str(upper_lim))\n",
    "    return translated_regions\n",
    "\n",
    "\n",
    "def sections_coloring_chimera(info_specific_chimera,allregions):\n",
    "    coloring = {\"Nterm\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM1\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM1-Loop-TM2\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM2\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM2-Loop-TM3\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM3\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM3-Loop-TM4\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM4\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM4-Loop-TM5\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM5\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM5-Loop-TM6\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM6\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM6-Loop-TM7\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"TM7\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"},\n",
    "                \"Cterm\":{0:\"\",1:\"\",2:\"\",3:\"\",4:\"\"}}\n",
    "\n",
    "    cutting_pts_with_ss = info_specific_chimera[\"cutting_point_chimera\"]\n",
    "    for parent,region in enumerate(cutting_pts_with_ss):\n",
    "        positions=region.split(\" \")[0]\n",
    "        name=region.split(\" \")[1][1:-1]\n",
    "        info = []\n",
    "        for i in range(1):\n",
    "            position = int(positions.split(\"-\")[i])\n",
    "            name_region= name.split(\"-\")[i]\n",
    "            lower_lim = [d for d in allregions if d.get(\"name\") == name_region][0][\"start\"]\n",
    "            upper_lim = [d for d in allregions if d.get(\"name\") == name_region][0][\"end\"]\n",
    "            a_fifth = round((upper_lim-lower_lim)/5)\n",
    "            if position < (lower_lim + a_fifth):\n",
    "                idx = 0\n",
    "            elif position < (lower_lim + 2*a_fifth):\n",
    "                idx = 1\n",
    "            elif position < (lower_lim + 3*a_fifth):\n",
    "                idx = 2\n",
    "            elif position < (lower_lim + 4*a_fifth):\n",
    "                idx = 3\n",
    "            else:\n",
    "                idx = 4\n",
    "\n",
    "            #make names match\n",
    "            name_loops = {\"ICL1\":\"TM1-Loop-TM2\",\"ECL1\":\"TM2-Loop-TM3\",\n",
    "                            \"ICL2\":\"TM3-Loop-TM4\",\"ECL2\":\"TM4-Loop-TM5\",\n",
    "                            \"ICL3\":\"TM5-Loop-TM6\",\"ECL3\":\"TM6-Loop-TM7\"}\n",
    "            if \"IC\" in name_region or \"EC\" in name_region:\n",
    "                name_region = name_loops[name_region]\n",
    "\n",
    "            if (parent % 2)==0:\n",
    "                parent_name = \"EC\"\n",
    "            else:\n",
    "                parent_name = \"IC\"\n",
    "\n",
    "            if len(coloring[name_region][idx]) != 0:\n",
    "                coloring[name_region][idx+1]=parent_name\n",
    "            else:\n",
    "                coloring[name_region][idx]=parent_name\n",
    "            \n",
    "    content = \"EC\"\n",
    "    for region_coloring, idx_coloring in coloring.items():\n",
    "            for idx in idx_coloring.keys():\n",
    "                if len(idx_coloring[idx]) == 0:\n",
    "                    idx_coloring[idx] = content\n",
    "                else:\n",
    "                    content = idx_coloring[idx]\n",
    "               \n",
    "    return coloring\n",
    "\n",
    "def retrieve_involvement_natural_chimeric_design(uniprot_id,all_regions):\n",
    "\n",
    "    involvement = []\n",
    "\n",
    "    for parent_column_id in ['Reference_id','Target_id']:\n",
    "\n",
    "        #find rows that have uniprot as ref id or target id\n",
    "        designs_parent = chimeric_design_df[chimeric_design_df[parent_column_id] == uniprot_id]\n",
    "\n",
    "        #Info from rows\n",
    "        names_chimeras = designs_parent['Chimera_name'].tolist()\n",
    "        ids_chimeras = designs_parent['Chimera_name_ids'].tolist()\n",
    "        regions_chimera = designs_parent['Chimera_parts'].tolist()\n",
    "        name_target_chimeras = designs_parent['Target_name'].tolist()\n",
    "        id_target_chimeras = designs_parent['Target_id'].tolist()\n",
    "\n",
    "        name_ref_chimeras = designs_parent['Reference_name'].tolist()\n",
    "        id_ref_chimeras = designs_parent['Reference_id'].tolist()\n",
    "\n",
    "        regions_ref_chimeras = designs_parent['Reference_cutting_points'].tolist()\n",
    "        regions_target_chimeras = designs_parent['Target_cutting_points'].tolist()\n",
    "\n",
    "        expression = designs_parent['Expression binary'].tolist()\n",
    "        fct = designs_parent['Function binary'].tolist()\n",
    "\n",
    "        application = designs_parent['Application'].tolist()\n",
    "        type_chimera = designs_parent['Chimera Type (1/2/3)'].tolist()\n",
    "        Gprot = designs_parent['G-protein'].tolist()\n",
    "        Ligand =designs_parent['Ligand'].tolist()\n",
    "        structures = designs_parent['3D structure PDB'].tolist()\n",
    "        biblio = designs_parent['DOI'].tolist()\n",
    "\n",
    "        for i,name in enumerate(names_chimeras):\n",
    "            \n",
    "            cutting_pt_chimera = cutting_pts_2_ss_region(eval(regions_chimera[i]),all_regions) \n",
    "\n",
    "            all_regions_ref = TMbed_retrieve_allregions(\"../data/Uniprot_TMbed.txt\",id_ref_chimeras[i])\n",
    "            cutting_pt_ref = cutting_pts_2_ss_region(eval(regions_ref_chimeras[i]),all_regions_ref)\n",
    "\n",
    "            all_regions_target = TMbed_retrieve_allregions(\"../data/Uniprot_TMbed.txt\",id_target_chimeras[i])\n",
    "            cutting_pt_target = cutting_pts_2_ss_region(eval(regions_target_chimeras[i]),all_regions_target)\n",
    "\n",
    "            pharma_name_ref = html.unescape(get_pharma_name(id_ref_chimeras[i],name_ref_chimeras[i]))\n",
    "            pharma_name_target = html.unescape(get_pharma_name(id_target_chimeras[i], name_target_chimeras[i]))\n",
    "\n",
    "            pharma_name_ref_ = pharma_name_ref\n",
    "            pharma_name_target_ = pharma_name_target\n",
    "            if \"receptor\" in pharma_name_ref.lower():\n",
    "                pharma_name_ref_ = pharma_name_ref.replace(\" receptor\",\"\")\n",
    "            if \"receptor\" in pharma_name_target.lower():\n",
    "                pharma_name_target_ = pharma_name_target.replace(\" receptor\",\"\")\n",
    "            pharma_name = pharma_name_ref_ + \" \" + pharma_name_target_ + \" receptor\"\n",
    "            if \"adrenoceptor\" in pharma_name:\n",
    "                pharma_name = pharma_name.replace(\" receptor\",\"\")\n",
    "\n",
    "            if isinstance(structures[i],str):\n",
    "                pdb = structures[i]\n",
    "            else:\n",
    "                pdb = \"\"\n",
    "\n",
    "            if isinstance(Gprot[i],str):\n",
    "                gprot=Gprot[i]\n",
    "            else:\n",
    "                gprot=\"\"\n",
    "\n",
    "            if isinstance(Ligand[i],str):\n",
    "                ligand=Ligand[i]\n",
    "            else:\n",
    "                ligand=\"\"\n",
    "\n",
    "            chimera={\n",
    "            \"name\":name,\n",
    "            \"name_pharma\":pharma_name,\n",
    "            \"id\":ids_chimeras[i],\n",
    "            \"ref\": name_ref_chimeras[i],\n",
    "            \"ref_pharma_name\": pharma_name_ref,\n",
    "            \"target\": name_target_chimeras[i],\n",
    "            \"target_pharma_name\":pharma_name_target,\n",
    "            \"cutting_point_chimera\": cutting_pt_chimera,\n",
    "            \"cutting_point_ref\": cutting_pt_ref,\n",
    "            \"cutting_point_target\": cutting_pt_target,\n",
    "            \"expression_function\": fct[i],\n",
    "            \"type\": type_chimera[i],\n",
    "            \"GprotLigand\": gprot+\" \"+ligand,\n",
    "            \"application\": application[i]+\" \"+pdb,\n",
    "            \"reference\": biblio[i]\n",
    "            }\n",
    "            involvement.append(chimera)\n",
    "\n",
    "    return involvement\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [],
   "source": [
    "def retrieve_3D_structure_info(info_3Dstructure):\n",
    "    structures_pdb = []\n",
    "    for pdb_info in info_3Dstructure.split(\",\"):\n",
    "        pdb_id = pdb_info.split('(')[0]\n",
    "        chain = pdb_info.split('(')[1].split(' ')[0]\n",
    "        state = pdb_info.split('(')[1].split(' ')[1][:-1]\n",
    "        pdb_dict={\"PDB id\":pdb_id,\"chain\":chain,\"state\":state}\n",
    "        structures_pdb.append(pdb_dict)\n",
    "    return structures_pdb\n",
    "\n",
    "def split_string(input_string):\n",
    "    match = re.match(r\"([a-zA-Z]?)(-?)(\\d*)(-?)([a-zA-Z]?)\", input_string)\n",
    "    if match:\n",
    "        return list(filter(None, match.groups()))\n",
    "    return []\n",
    "\n",
    "def retrieve_mutations_vs_parents_info(mutations,biblio):\n",
    "    mutations_list = []\n",
    "    if len(mutations)>=4:\n",
    "        for mut in mutations.split(\",\"):\n",
    "            if len(mut)>3:\n",
    "                split_mut = split_string(mut)\n",
    "                position = split_mut[1]\n",
    "                parent_res = split_mut[0]\n",
    "                chimera_res = split_mut[2]\n",
    "                mut_dict = {\"start\":int(position),\"end\":int(position),\"original residue\":parent_res, \"alternative residue\":chimera_res,\"reference\":biblio}\n",
    "                mutations_list.append(mut_dict)\n",
    "        return mutations_list\n",
    "    return TypeError\n",
    "\n",
    "def retrieve_chimera_design_info(abb_name):\n",
    "\n",
    "    all_info = chimeric_design_df[chimeric_design_df[\"Chimera_name\"] == abb_name]\n",
    "\n",
    "    uniprot_id = all_info[\"Chimera_name_ids\"].values[0]\n",
    "    given_name = all_info[\"Given name\"].values[0]\n",
    "    cutting_points = eval(all_info[\"Chimera_parts\"].values[0])\n",
    "    ref_parent_name = all_info[\"Reference_name\"].values[0]\n",
    "    ref_parent_id = all_info[\"Reference_id\"].values[0]\n",
    "    target_parent_name = all_info[\"Target_name\"].values[0]\n",
    "    target_parent_id = all_info[\"Target_id\"].values[0]\n",
    "    Gprot = all_info['G-protein'].values[0]\n",
    "\n",
    "    if isinstance(Gprot,str):\n",
    "        gprot=Gprot\n",
    "    else:\n",
    "        gprot=\"\"  \n",
    "    \n",
    "    biblio = all_info['DOI'].values[0]\n",
    "    try:\n",
    "        structures_pdb =  retrieve_3D_structure_info(all_info[\"3D structure PDB\"].values[0])\n",
    "    except:\n",
    "        structures_pdb = []\n",
    "    try:\n",
    "        mutations_vs_parents = retrieve_mutations_vs_parents_info(all_info[\"Mutations\"].values[0],biblio)\n",
    "    except:\n",
    "        mutations_vs_parents = []\n",
    "\n",
    "    return uniprot_id,given_name,cutting_points,ref_parent_name,ref_parent_id,target_parent_name,target_parent_id,structures_pdb,mutations_vs_parents,gprot,biblio"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "def familly_subclass_parents(ref_parent_name,ref_parent_id,target_parent_name,target_parent_id):\n",
    "    #find classfication based on human classification in GPCRdb\n",
    "    #find human ortholog\n",
    "    family_chimera = []\n",
    "    subclass_ligand_chimera = []\n",
    "    subclass_phylo_chimera = []\n",
    "\n",
    "    for abbreviated_name,uniprotID in zip([ref_parent_name,target_parent_name],[ref_parent_id,target_parent_id]):\n",
    "        try:\n",
    "            if listGPCRdb_df[listGPCRdb_df['Uniprot ID'] == uniprotID][\"Phylogenetically-based\"].values[0] == \"A-other\":\n",
    "                if not abbreviated_name.endswith(\"HUMAN\"):\n",
    "                    abbreviated_name_human = (abbreviated_name.split('_')[0]+\"_\"+\"HUMAN\").lower()\n",
    "                    uniprot_id_human = listGPCRdb_df[listGPCRdb_df['Name'] == abbreviated_name_human]['Uniprot ID'].values[0] \n",
    "            else:\n",
    "                uniprot_id_human = uniprotID\n",
    "\n",
    "\n",
    "            family = listGPCRdb_df[listGPCRdb_df['Uniprot ID'] == uniprot_id_human][\"Subclass\"].values[0].rstrip() #need to change this to interpro API for those not on GPCRdb\n",
    "\n",
    "\n",
    "            if \"Class A\" in family:\n",
    "                family = family.replace(\"Class A \",\"\")\n",
    "                family = family[0].upper()+family[1:]\n",
    "            if \"receptors\" in family:\n",
    "                family = family.replace(\"receptors\",\"\").rstrip()\n",
    "            elif \"receptor\" in family:\n",
    "                family = family.replace(\"receptor\",\"\").rstrip()\n",
    "            subclass_ligand = listGPCRdb_df[listGPCRdb_df['Uniprot ID'] == uniprot_id_human][\"Ligand-based\"].values[0].rstrip() #need to change so it works for all mammals (put same as what we have for humans? What with those not on GPCRdb?)\n",
    "\n",
    "            \n",
    "            if \"receptors\" in subclass_ligand:\n",
    "                subclass_ligand = subclass_ligand.replace(\"receptors\",\"\").rstrip()\n",
    "            elif \"receptor\" in subclass_ligand:\n",
    "                subclass_ligand = subclass_ligand.replace(\"receptor\",\"\").rstrip()\n",
    "            subclass_phylo = listGPCRdb_df[listGPCRdb_df['Uniprot ID'] == uniprot_id_human][\"Phylogenetically-based\"].values[0]\n",
    "            if \"A-\" in subclass_phylo:\n",
    "                subclass_phylo = subclass_phylo.split('-')[1].rstrip()\n",
    "                subclass_phylo = subclass_phylo[0].upper()+subclass_phylo[1:]\n",
    "\n",
    "        except:\n",
    "                family = \"Olfactory\"\n",
    "                subclass_ligand = \"Olfactory\"\n",
    "                subclass_phylo = \"Olfactory\"\n",
    "\n",
    "        family_chimera.append(family)\n",
    "        subclass_ligand_chimera.append(subclass_ligand)\n",
    "        subclass_phylo_chimera.append(subclass_phylo)\n",
    "    \n",
    "    family_chimera_str = \" & \".join(family_chimera)\n",
    "    subclass_ligand_chimera_str = \" & \".join(subclass_ligand_chimera)\n",
    "    subclass_phylo_chimera_str = \" & \".join(subclass_phylo_chimera)\n",
    "    \n",
    "    return family_chimera_str,subclass_ligand_chimera_str,subclass_phylo_chimera_str"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 31,
   "metadata": {},
   "outputs": [],
   "source": [
    "def write_cutting_point_region(cutting_points,ref_parent_name,target_parent_name,biblio):\n",
    "    cutting_points_regions_parent = []\n",
    "    for i,region in enumerate(cutting_points):\n",
    "        if (i%2)==0:\n",
    "            parent = ref_parent_name\n",
    "            parent_type = \"EC side parent\"\n",
    "        else:\n",
    "            parent = target_parent_name\n",
    "            parent_type = \"IC side parent\"\n",
    "\n",
    "        region_parent =  {\n",
    "        \"name\": f\"{parent} ({parent_type})\",\n",
    "        \"start\": region[0],\n",
    "        \"end\": region[1],\n",
    "        \"reference\": biblio\n",
    "        }\n",
    "        cutting_points_regions_parent.append(region_parent)\n",
    "    return cutting_points_regions_parent"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {},
   "outputs": [],
   "source": [
    "#convert scientific name UniProt to common name\n",
    "def parse_species_file(file_path):\n",
    "    species_dict = {}\n",
    "    \n",
    "    with open(file_path, 'r') as file:\n",
    "        lines = file.readlines()\n",
    "    \n",
    "    scientific_name = None\n",
    "    \n",
    "    for line in lines:\n",
    "        if \"N=\" in line:\n",
    "            scientific_name = line.split(\"N=\")[1].strip()\n",
    "        elif \"C=\" in line and scientific_name:\n",
    "            common_name = line.split(\"C=\")[1].strip()\n",
    "            species_dict[scientific_name] = common_name\n",
    "            scientific_name = None  # Reset for the next entry\n",
    "    \n",
    "    return species_dict\n",
    "\n",
    "def species_uniprot(ref_parent_id,target_parent_id):\n",
    "    species_parents = []\n",
    "    for prot_id in [ref_parent_id,target_parent_id]:\n",
    "        requestURL = f\"https://rest.uniprot.org/uniprotkb/{prot_id}.json\"\n",
    "        r = requests.get(requestURL, headers={ \"Accept\" : \"application/json\"})\n",
    "        if not r.ok:\n",
    "            r.raise_for_status()\n",
    "            sys.exit()\n",
    "        uniprot_json = json.loads(r.text)\n",
    "        species = uniprot_json['organism']['scientificName']\n",
    "        species_parents.append(species)\n",
    "\n",
    "    #convert scientific names to common names\n",
    "    uniprot_names = \"../data/UniProt_names_scientific_common.txt\"\n",
    "    species_dict = parse_species_file(uniprot_names)\n",
    "    species_parents_common_name = []\n",
    "    for species in species_parents:\n",
    "        species_parents_common_name.append(species_dict[species])\n",
    "    return \" & \".join(species_parents_common_name)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "metadata": {},
   "outputs": [],
   "source": [
    "def retrieve_seq_parents(ref_parent_id,target_parent_id):\n",
    "    proteins_mammalians = SeqIO.index(\"/Users/charlottecrauwels/Library/CloudStorage/OneDrive-VrijeUniversiteitBrussel/PhD/WP1/Data/Sequence/all_mammals_classA/240923_cleaned_all_mammals_classA.fasta\", \"fasta\")\n",
    "    ref_seq = str(proteins_mammalians[ref_parent_id].seq)\n",
    "    target_seq = str(proteins_mammalians[target_parent_id].seq)\n",
    "    return ref_seq,target_seq"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {},
   "outputs": [],
   "source": [
    "#equivalence between positions in sequence and in MSA\n",
    "#dictionary with list of list. In every sublist, 2 elements, 1st is the position in sequence, the 2nd the position in MSA\n",
    "def map_seq_MSA(sequence_aligned):\n",
    "    previous = 0\n",
    "    translate = {}\n",
    "    sequence_nogaps = sequence_aligned.replace(\"-\",\"\")\n",
    "    for res in range(len(sequence_nogaps)):\n",
    "        idx_msa = previous + sequence_aligned[previous:].index(sequence_nogaps[res])\n",
    "        translate[res+1]=idx_msa+1\n",
    "        previous = idx_msa + 1\n",
    "    return translate\n",
    "\n",
    "#Microswitches/motifs - identify them based on their defined columns in mammalian MSA\n",
    "def motifs_microswitches_literature(MSA,uniprot_id):\n",
    "    #GPCRdb finds sodium pockets\n",
    "    #As microswitches are well defined in literature we can check ourselves if these well knwon microswitches are present in our gpcrs\n",
    "    #All known microswitches in literature for class A\n",
    "    E_DRY_W = {\"positions\":[\"3.49\", \"3.50\", \"3.51\"],\"residues\":[\"ED\", \"R\", \"WY\"], \"name\": \"E/DRY/W motif (ionic lock switch)\"}\n",
    "    CWxP = {\"positions\":[\"6.47\", \"6.48\", \"6.50\"], \"residues\":[\"C\", \"W\", \"P\"], \"name\": \"CWxP motif (transmission toggle switch)\"}\n",
    "    NPxxY = {\"positions\":[\"7.49\", \"7.50\", \"7.53\"], \"residues\":[\"N\",\"P\",\"Y\"], \"name\": \"NPxxY motif (tyr toggle switch)\"}\n",
    "    PIF = {\"positions\": [\"5.50\", \"3.40\", \"6.44\"], \"residues\":[\"P\",\"I\",\"F\"], \"name\": \"PIF motif\"}\n",
    "    hydrophobic_lock = {\"positions\":[\"3.43\",\"6.40\"], \"residues\":[\"LVIM\", \"LVIM\"], \"name\": \"hydrophobic lock\"}\n",
    "    ionic_lock = {\"positions\":[\"6.30\"], \"residues\":[\"DE\"], \"name\": \"ionic lock\"}\n",
    "    #disulfide bond between TM3 and ECL2 is already identified by Uniprot in the \"Disulfide bonds\" section\n",
    "    #Sodium binding pocket (allosteric action): middle of the 7TMs. Identified by GPCRdb but are the identified ones all of them???\n",
    "\n",
    "    #the positions are in human readable format (not pyton - starts at 0)\n",
    "    MSA_E_DRY_W = {\"positions\":[694,695,696],\"residues\":[\"ED\", \"R\", \"WY\"], \"name\": \"E/DRY/W motif (ionic lock switch)\"}\n",
    "    MSA_CWxP = {\"positions\":[1211,1212,1214], \"residues\":[\"C\", \"W\", \"P\"], \"name\": \"CWxP motif (transmission toggle switch)\"}\n",
    "    MSA_NPxxY = {\"positions\":[1290,1291,1294], \"residues\":[\"N\",\"P\",\"Y\"], \"name\": \"NPxxY motif (tyr toggle switch)\"}\n",
    "    MSA_PIF = {\"positions\": [947,685,1204], \"residues\":[\"P\",\"I\",\"F\"], \"name\": \"PIF motif\"}\n",
    "    MSA_hydrophobic_lock = {\"positions\":[688,1200], \"residues\":[\"LVIM\", \"LVIM\"], \"name\": \"Hydrophobic lock\"}\n",
    "    MSA_ionic_lock = {\"positions\":[1190], \"residues\":[\"DE\"], \"name\": \"Ionic lock\"}\n",
    "    MSA_sodium_pocket = {\"positions\":[619,684], \"residues\":[\"D\",\"S\"], \"name\": \"Sodium binding pocket\"}\n",
    "\n",
    "    TM1x50={\"positions\":[579],\"residues\":[\"N\"], \"name\": \"1.50 (BW numbering)\"}\n",
    "    TM2x50={\"positions\":[619],\"residues\":[\"D\"], \"name\": \"2.50 (BW numbering)\"}\n",
    "    TM3x50={\"positions\":[695],\"residues\":[\"R\"], \"name\": \"3.50 (BW numbering)\"}\n",
    "    TM4x50={\"positions\":[751],\"residues\":[\"P\"], \"name\": \"4.50 (BW numbering)\"}\n",
    "    TM5x50={\"positions\":[947],\"residues\":[\"P\"], \"name\": \"5.50 (BW numbering)\"}\n",
    "    TM6x50={\"positions\":[1214],\"residues\":[\"P\"], \"name\": \"6.50 (BW numbering)\"}\n",
    "    TM7x50={\"positions\":[1291],\"residues\":[\"P\"], \"name\": \"7.50 (BW numbering)\"}\n",
    "\n",
    "    alignment = AlignIO.read(open(MSA), \"fasta\")\n",
    "    len_MSA=alignment.get_alignment_length()\n",
    "    record_dict = SeqIO.index(MSA, \"fasta\")\n",
    "    aligned_seq_interest = str(record_dict[uniprot_id].seq)\n",
    "    translate_seq_MSA = map_seq_MSA(aligned_seq_interest) #gives position of a unaligned res in msa\n",
    "    translate_MSA_seq = {v: k for k, v in translate_seq_MSA.items()} #gives position of a aligned res in unaligned seq\n",
    "    microswitch_types = [MSA_E_DRY_W, MSA_CWxP, MSA_NPxxY, MSA_PIF, MSA_hydrophobic_lock, MSA_ionic_lock,\n",
    "                         TM1x50,TM2x50,TM3x50,TM4x50,TM5x50,TM6x50,TM7x50]\n",
    "    microswitches = []\n",
    "    microswitches_residues = []\n",
    "\n",
    "    for microswitch_type in microswitch_types:\n",
    "        are_there = []\n",
    "        for position, residue in zip(microswitch_type[\"positions\"], microswitch_type[\"residues\"]):\n",
    "            if aligned_seq_interest[position-1] in residue:\n",
    "                are_there.append(True)\n",
    "            else:\n",
    "                are_there.append(False)\n",
    "        for i, (position, residue) in enumerate(zip(microswitch_type[\"positions\"], microswitch_type[\"residues\"])):\n",
    "            microswitch_residue = {}\n",
    "\n",
    "            #take into account the possibility that there is a gap at that position in the MSA\n",
    "            if position in translate_MSA_seq:\n",
    "                microswitch_residue[\"start\"] = translate_MSA_seq[position]\n",
    "                microswitch_residue[\"end\"] = translate_MSA_seq[position]\n",
    "                residue_motif = aligned_seq_interest[position-1]\n",
    "            else:\n",
    "                for next in range(position+1,len_MSA):\n",
    "                    if next in translate_MSA_seq:\n",
    "                        microswitch_residue[\"start\"] = translate_MSA_seq[next]\n",
    "                        microswitch_residue[\"end\"] = translate_MSA_seq[next]\n",
    "                        residue_motif = aligned_seq_interest[next-1]\n",
    "                        break\n",
    "                                    \n",
    "            if not all(are_there) and not are_there[i]:\n",
    "                if residue_motif == \"F\" and microswitch_type[\"name\"]==\"PIF motif\":\n",
    "                    microswitch_residue[\"description\"] = residue_motif + \" instead of \"+ residue+ \" from \" + \" (part of \" + microswitch_type[\"name\"]+ \")\"\n",
    "                elif residue_motif == \"R\" and microswitch_type[\"name\"]==\"E/DRY/W motif (ionic lock switch)\":\n",
    "                    microswitch_residue[\"description\"] = residue_motif + \" instead of \"+ residue + \" (part of \" + microswitch_type[\"name\"]+ \")\"\n",
    "                elif \"(BW numbering)\" in microswitch_type[\"name\"]:\n",
    "                    microswitch_residue[\"description\"] = residue_motif+ \" instead of \"+ residue + \" \" + microswitch_type[\"name\"]\n",
    "                else:\n",
    "                    microswitch_residue[\"description\"] = residue_motif + \" instead of \"+ residue + \" (part of \" + microswitch_type[\"name\"]+ \")\"\n",
    "            else:\n",
    "                if residue_motif == \"F\" and microswitch_type[\"name\"]==\"PIF motif\":\n",
    "                    microswitch_residue[\"description\"] = residue_motif + \" part of \" + microswitch_type[\"name\"] +\" and hydrophobic lock\"\n",
    "                elif residue_motif == \"R\" and microswitch_type[\"name\"]==\"E/DRY/W motif (ionic lock switch)\":\n",
    "                    microswitch_residue[\"description\"] = residue_motif+ \" part of \" + microswitch_type[\"name\"] +\" and ionic lock\"\n",
    "                elif \"(BW numbering)\" in microswitch_type[\"name\"]:\n",
    "                    microswitch_residue[\"description\"] = residue_motif+ \" \" + microswitch_type[\"name\"]\n",
    "                else:\n",
    "                    microswitch_residue[\"description\"] = residue_motif+ \" part of \" + microswitch_type[\"name\"]\n",
    "            if are_there[i]:\n",
    "                microswitch_residue[\"conserved\"] = \"yes\"\n",
    "            else:\n",
    "                microswitch_residue[\"conserved\"] = \"no\"\n",
    "            microswitch_residue[\"reference\"] = \"Based on alignment\"\n",
    "            microswitches_residues.append(microswitch_residue)\n",
    "\n",
    "    return microswitches_residues\n",
    "\n",
    "def find_motifs_parent_chimera(cutting_points_parent,microswitches_to_look_at,cutting_points_chimera,counter):\n",
    "    microswitches_found = []\n",
    "    for region_parent in cutting_points_parent:\n",
    "        region_chimera = cutting_points_chimera[counter]\n",
    "        start_region_chimera = int(region_chimera.split(' ')[0].split('-')[0])\n",
    "        stop_region_chimera = int(region_chimera.split(' ')[0].split('-')[1])\n",
    "\n",
    "        start_region_parent = int(region_parent.split(' ')[0].split('-')[0])\n",
    "        stop_region_parent = int(region_parent.split(' ')[0].split('-')[1])\n",
    "\n",
    "        if start_region_parent > start_region_chimera:\n",
    "            difference = start_region_parent - start_region_chimera\n",
    "        else:\n",
    "            difference = start_region_chimera - start_region_parent\n",
    "\n",
    "        for position in range(start_region_parent,stop_region_parent+1):\n",
    "            motifs_associated_pos = []\n",
    "                    \n",
    "            motifs_associated_pos = [item for item in microswitches_to_look_at if item[\"start\"] == position]\n",
    "            if len(motifs_associated_pos)>0:\n",
    "                if start_region_parent > start_region_chimera:\n",
    "                    position_chimera = position - difference\n",
    "                else:\n",
    "                    position_chimera = position + difference\n",
    "                for motif in motifs_associated_pos:\n",
    "                    motif_chimera = motif.copy()\n",
    "                    motif_chimera[\"start\"] = position_chimera\n",
    "                    motif_chimera[\"end\"] = position_chimera\n",
    "                    microswitches_found.append(motif_chimera)\n",
    "    \n",
    "\n",
    "        counter +=2\n",
    "    return microswitches_found\n",
    "\n",
    "def motifs_microswitches_chimera(ref_parent_id,target_parent_id,info_specific_chimera):\n",
    "    #find motifs chimera based on motifs parents. For every region coming from a particular parent, look if the parent has motifs in that region. If yes, chimera also has it.\n",
    "\n",
    "    cutting_points_chimera = info_specific_chimera[\"cutting_point_chimera\"]\n",
    "    cutting_points_ref = info_specific_chimera[\"cutting_point_ref\"]\n",
    "    cutting_points_target = info_specific_chimera[\"cutting_point_target\"]\n",
    "\n",
    "    MSA = \"../data/MSA_all_mammalian.fasta\"\n",
    "    microswitches_ref = motifs_microswitches_literature(MSA,ref_parent_id)\n",
    "    microswitches_target = motifs_microswitches_literature(MSA,target_parent_id)\n",
    "    microswitches_chimera_ref = find_motifs_parent_chimera(cutting_points_ref,microswitches_ref,cutting_points_chimera,0)\n",
    "    microswitches_chimera_target = find_motifs_parent_chimera(cutting_points_target,microswitches_target,cutting_points_chimera,1)\n",
    "\n",
    "    microswitches_residues = microswitches_chimera_ref + microswitches_chimera_target\n",
    "    return microswitches_residues"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [],
   "source": [
    "def get_pharma_name(uniprotID,abb_name):\n",
    "    #GtoP or gpcrdb_name or pharmacological name\n",
    "    try:\n",
    "        requestURL = f\"https://gpcrdb.org/services/protein/accession/{uniprotID}\"\n",
    "\n",
    "        r = requests.get(requestURL, headers={ \"Accept\" : \"application/json\"})\n",
    "        if not r.ok:\n",
    "            info_entry = None\n",
    "        else:\n",
    "            info_entry = json.loads(r.text)\n",
    "    except:\n",
    "        info_entry = None\n",
    "\n",
    "    if not info_entry is None:\n",
    "        clean_html_tags = re.compile('<.*?>')\n",
    "        pharma_name = re.sub(clean_html_tags, '', info_entry[\"name\"])\n",
    "    else:\n",
    "        pharma_name = abb_name\n",
    "\n",
    "    return pharma_name\n",
    "\n",
    "def retrieve_pharma_name_parents(ref_parent_name,ref_parent_id,target_parent_name,target_parent_id):\n",
    "    pharma_name_ref = get_pharma_name(ref_parent_id,ref_parent_name)\n",
    "    pharma_name_target = get_pharma_name(target_parent_id,target_parent_name)\n",
    "\n",
    "    if \"receptor\" in pharma_name_ref.lower():\n",
    "        pharma_name_ref = pharma_name_ref.replace(\" receptor\",\"\")\n",
    "    if \"receptor\" in pharma_name_target.lower():\n",
    "        pharma_name_target = pharma_name_target.replace(\" receptor\",\"\")\n",
    "    \n",
    "    pharma_name = pharma_name_ref + \" \" + pharma_name_target + \" receptor\"\n",
    "\n",
    "    if \"adrenoceptor\" in pharma_name:\n",
    "        pharma_name = pharma_name.replace(\" receptor\",\"\")\n",
    "\n",
    "    return pharma_name_ref,pharma_name_target,pharma_name"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "OPSD_BOVIN_AA2AR_HUMAN_1\n",
      "OPSD_BOVIN_ADRB2_MESAU_1\n",
      "OPSD_BOVIN_ADRB2_MESAU_2\n",
      "OPSD_BOVIN_ACM2_HUMAN_1\n",
      "OPSD_BOVIN_ACM3_HUMAN_1\n",
      "OPSD_BOVIN_ACM1_HUMAN_1\n",
      "OPSD_BOVIN_DRD2_HUMAN_1\n",
      "OPSD_BOVIN_DRD1_HUMAN_1\n",
      "OPSD_BOVIN_AA2AR_HUMAN_2\n",
      "OPSD_BOVIN_FFAR3_HUMAN_1\n",
      "OPSD_BOVIN_ADA1A_RAT_1\n",
      "OPSD_BOVIN_ADRB2_HUMAN_1\n",
      "OPSD_BOVIN_GP183_HUMAN_1\n",
      "OPSD_BOVIN_GP182_HUMAN_1\n",
      "OPSD_BOVIN_GP176_HUMAN_1\n",
      "OPSD_BOVIN_GP174_HUMAN_1\n",
      "OPSD_BOVIN_GP173_HUMAN_1\n",
      "OPSD_BOVIN_GP171_HUMAN_1\n",
      "OPSD_BOVIN_GP162_HUMAN_1\n",
      "OPSD_BOVIN_GP161_HUMAN_1\n",
      "OPSD_BOVIN_GP153_HUMAN_1\n",
      "OPSD_BOVIN_GP152_HUMAN_1\n",
      "OPSD_BOVIN_GP151_HUMAN_1\n",
      "OPSD_BOVIN_GP150_HUMAN_1\n",
      "OPSD_BOVIN_GP149_HUMAN_1\n",
      "OPSD_BOVIN_GP148_HUMAN_1\n",
      "OPSD_BOVIN_GP146_HUMAN_1\n",
      "OPSD_BOVIN_GP142_HUMAN_1\n",
      "OPSD_BOVIN_GP141_HUMAN_1\n",
      "OPSD_BOVIN_GP139_HUMAN_1\n",
      "OPSD_BOVIN_GP135_HUMAN_1\n",
      "OPSD_BOVIN_GP132_HUMAN_1\n",
      "OPSD_BOVIN_FFAR4_HUMAN_1\n",
      "OPSD_BOVIN_GP119_HUMAN_1\n",
      "OPSD_BOVIN_GPR88_HUMAN_1\n",
      "OPSD_BOVIN_GPR87_HUMAN_1\n",
      "OPSD_BOVIN_GPR85_HUMAN_1\n",
      "OPSD_BOVIN_GPR84_HUMAN_1\n",
      "OPSD_BOVIN_GPR83_HUMAN_1\n",
      "OPSD_BOVIN_GPR82_HUMAN_1\n",
      "OPSD_BOVIN_GPR78_HUMAN_1\n",
      "OPSD_BOVIN_GPR75_HUMAN_1\n",
      "OPSD_BOVIN_OGR1_HUMAN_1\n",
      "OPSD_BOVIN_PSYR_HUMAN_1\n",
      "OPSD_BOVIN_GPR63_HUMAN_1\n",
      "OPSD_BOVIN_GPR62_HUMAN_1\n",
      "OPSD_BOVIN_GPR61_HUMAN_1\n",
      "OPSD_BOVIN_GPR55_HUMAN_1\n",
      "OPSD_BOVIN_GPR52_HUMAN_1\n",
      "OPSD_BOVIN_MTR1L_HUMAN_1\n",
      "OPSD_BOVIN_GPR45_HUMAN_1\n",
      "OPSD_BOVIN_GPR42_HUMAN_1\n",
      "OPSD_BOVIN_GPR39_HUMAN_1\n",
      "OPSD_BOVIN_G37L1_HUMAN_1\n",
      "OPSD_BOVIN_GPR37_HUMAN_1\n",
      "OPSD_BOVIN_GPR35_HUMAN_1\n",
      "OPSD_BOVIN_GPR34_HUMAN_1\n",
      "OPSD_BOVIN_GPR33_HUMAN_1\n",
      "OPSD_BOVIN_GPR32_HUMAN_1\n",
      "OPSD_BOVIN_GPR31_HUMAN_1\n",
      "OPSD_BOVIN_GPR27_HUMAN_1\n",
      "OPSD_BOVIN_GPR26_HUMAN_1\n",
      "OPSD_BOVIN_GPR25_HUMAN_1\n",
      "OPSD_BOVIN_GPR22_HUMAN_1\n",
      "OPSD_BOVIN_GPR21_HUMAN_1\n",
      "OPSD_BOVIN_GPR20_HUMAN_1\n",
      "OPSD_BOVIN_GPR19_HUMAN_1\n",
      "OPSD_BOVIN_GPR18_HUMAN_1\n",
      "OPSD_BOVIN_GPR17_HUMAN_1\n",
      "OPSD_BOVIN_GPR15_HUMAN_1\n",
      "OPSD_BOVIN_GPR12_HUMAN_1\n",
      "OPSD_BOVIN_GPR6_HUMAN_1\n",
      "OPSD_BOVIN_GPR4_HUMAN_1\n",
      "OPSD_BOVIN_GPR3_HUMAN_1\n",
      "OPSD_BOVIN_CML2_HUMAN_1\n",
      "GPR27_HUMAN_ADRB2_HUMAN_1\n",
      "GPR27_HUMAN_ADRB2_HUMAN_2\n",
      "GPR27_HUMAN_ADRB2_HUMAN_3\n",
      "GPR27_HUMAN_ADRB2_HUMAN_4\n",
      "GPR27_HUMAN_ADRB2_HUMAN_5\n",
      "OPSD_BOVIN_ADRB2_HUMAN_2\n",
      "OPSD_BOVIN_ADRB2_HUMAN_3\n",
      "OPSD_BOVIN_ACM1_HUMAN_2\n",
      "OPSD_BOVIN_ADRB2_HUMAN_4\n",
      "OPSD_BOVIN_ADA1A_HUMAN_1\n",
      "OPSD_HUMAN_ADRB2_HUMAN_1\n",
      "OPSD_HUMAN_ADRB2_HUMAN_2\n",
      "OPSD_HUMAN_ADRB2_HUMAN_3\n",
      "OPSD_HUMAN_OPRM_HUMAN_1\n",
      "OPSD_BOVIN_CXCR4_HUMAN_1\n",
      "OPSD_RAT_OPRM_RAT_1\n",
      "OPSD_HUMAN_OPN4_HUMAN_1\n",
      "OPSD_HUMAN_OPN4_HUMAN_2\n",
      "OPSD_HUMAN_OPN4_HUMAN_3\n",
      "OPSD_HUMAN_OPN4_HUMAN_4\n",
      "ACM3_HUMAN_ACM4_HUMAN_1\n",
      "ACM4_HUMAN_ACM3_HUMAN_1\n",
      "5HT2A_HUMAN_OPRK_HUMAN_1\n",
      "EDNRA_HUMAN_OPRK_HUMAN_1\n",
      "5HT4R_HUMAN_OPRK_HUMAN_1\n",
      "5HT5A_HUMAN_OPRK_HUMAN_1\n",
      "DRD1_HUMAN_OPRK_HUMAN_1\n",
      "NTR1_RAT_OPRK_HUMAN_1\n",
      "GP149_HUMAN_OPRK_HUMAN_1\n",
      "GP151_HUMAN_OPRK_HUMAN_1\n",
      "OPRM_MOUSE_OPRK_HUMAN_1\n",
      "NTR1_HUMAN_OPRK_HUMAN_1\n",
      "SSR2_HUMAN_OPRK_HUMAN_1\n",
      "HRH2_HUMAN_OPRK_HUMAN_1\n",
      "MC4R_HUMAN_CNR1_HUMAN_1\n",
      "MC4R_HUMAN_CNR1_HUMAN_2\n",
      "MC4R_HUMAN_CNR1_HUMAN_3\n",
      "MC4R_HUMAN_CNR1_HUMAN_4\n",
      "ADA1A_HUMAN_OPRK_HUMAN_1\n",
      "CXCR3_HUMAN_OPRK_HUMAN_1\n",
      "ADA1B_MESAU_ADRB2_HUMAN_1\n",
      "ADA1B_MESAU_ADRB2_HUMAN_2\n",
      "ADA1B_MESAU_ADRB2_HUMAN_3\n",
      "ADA1B_MESAU_ADRB2_HUMAN_4\n",
      "ADA1B_MESAU_ADRB2_HUMAN_5\n",
      "ADRB2_HUMAN_ADA1B_MESAU_1\n",
      "ADA1A_RAT_ADA1B_MESAU_1\n",
      "ACM1_HUMAN_ACM2_HUMAN_1\n",
      "ACM2_HUMAN_ACM1_HUMAN_1\n",
      "DRD3_HUMAN_DRD2_HUMAN_1\n",
      "DRD3_MOUSE_DRD2_MOUSE_1\n",
      "DRD2_MOUSE_DRD3_MOUSE_1\n",
      "ACM2_HUMAN_ACM3_RAT_1\n",
      "ACM2_HUMAN_ACM3_RAT_2\n",
      "ADRB3_HUMAN_ADRB2_HUMAN_1\n",
      "5HT2A_HUMAN_5HT2C_HUMAN_1\n",
      "5HT2B_HUMAN_5HT2C_HUMAN_1\n",
      "ADRB2_HUMAN_HRH2_HUMAN_1\n",
      "ADRB2_HUMAN_HRH2_HUMAN_2\n",
      "ADRB2_HUMAN_HRH2_HUMAN_3\n",
      "ADRB2_HUMAN_HRH2_HUMAN_4\n",
      "ADA2A_HUMAN_ADA2C_HUMAN_1\n",
      "ADA2C_HUMAN_ADA2A_HUMAN_1\n",
      "AA2AR_CANLF_AA1R_HUMAN_1\n",
      "AA2AR_CANLF_AA1R_HUMAN_2\n",
      "OPSD_BOVIN_ADRB2_MESAU_6\n",
      "ACKR3_HUMAN_CXCR4_HUMAN_1\n",
      "OPSD_BOVIN_ADRB2_MESAU_7\n",
      "OPSD_BOVIN_ADRB2_MESAU_8\n",
      "OPSD_BOVIN_ADRB2_MESAU_9\n",
      "OPSD_BOVIN_ADRB2_MESAU_10\n",
      "OPSD_BOVIN_ADRB2_MESAU_11\n",
      "OPSD_BOVIN_ADRB2_MESAU_12\n",
      "ACM3_RAT_ACM2_HUMAN_1\n",
      "ACM3_RAT_ACM2_HUMAN_2\n",
      "V2R_HUMAN_V1AR_RAT_1\n",
      "V2R_HUMAN_V1AR_RAT_2\n",
      "V1AR_RAT_V2R_HUMAN_1\n",
      "V1AR_RAT_V2R_HUMAN_2\n",
      "V1AR_RAT_V2R_HUMAN_3\n",
      "AA2AR_CANLF_AA1R_HUMAN_3\n",
      "AA2AR_CANLF_AA1R_HUMAN_4\n",
      "AA2AR_CANLF_AA1R_HUMAN_5\n",
      "AA2AR_CANLF_AA1R_HUMAN_6\n",
      "AA2AR_CANLF_AA1R_HUMAN_7\n",
      "AA2AR_CANLF_AA1R_HUMAN_8\n",
      "AA2AR_CANLF_AA1R_HUMAN_9\n",
      "AA2AR_CANLF_AA1R_HUMAN_10\n",
      "AA1R_HUMAN_AA2AR_CANLF_1\n",
      "AA1R_HUMAN_AA2AR_CANLF_2\n",
      "OPSD_BOVIN_ADRB2_MESAU_4\n",
      "OPSD_BOVIN_ADRB2_MESAU_5\n",
      "ACM3_HUMAN_ADRB2_HUMAN_1\n",
      "ACM3_HUMAN_PSYR_HUMAN_1\n",
      "ACM3_HUMAN_HCAR2_HUMAN_1\n"
     ]
    }
   ],
   "source": [
    "for abbreviated_name, prot_seq in entry_uniprotID_seq.items():\n",
    "    print(abbreviated_name)\n",
    "    if not os.path.exists(f'../examples/json_entries/updated_chimeras/{abbreviated_name.upper()}.json'):\n",
    "    # if \"a\" == \"a\":\n",
    "\n",
    "        class_ = 'A & A' #always class A for now\n",
    "        uniprotID,given_name,cutting_points,ref_parent_name,ref_parent_id,target_parent_name,target_parent_id,structures_pdb,mutations_vs_parents,gprot,biblio = retrieve_chimera_design_info(abbreviated_name)\n",
    "\n",
    "        ref_parent_seq,target_parent_seq = retrieve_seq_parents(ref_parent_id,target_parent_id)\n",
    "\n",
    "        #pharma name based on pharma name parents\n",
    "        pharma_name_ref,pharma_name_target,pharma_name = retrieve_pharma_name_parents(ref_parent_name,ref_parent_id,target_parent_name,target_parent_id)\n",
    "        \n",
    "        species = species_uniprot(ref_parent_id,target_parent_id)\n",
    "        \n",
    "        family,subclass_ligand,subclass_phylo=familly_subclass_parents(ref_parent_name,ref_parent_id,target_parent_name,target_parent_id)\n",
    "\n",
    "        #Secondary structure info\n",
    "        TM_regions_file = \"../data/TM_regions_chimeras_TMbed.txt\"\n",
    "        allregions = TMbed_retrieve_allregions(TM_regions_file,abbreviated_name)\n",
    "\n",
    "        #structures\n",
    "        structures, ds_bonds_noduplicates, interacting_residues_list, binders, pdbs = retrieve_pdb_dsbonds_chimera_info(structures_pdb,ref_parent_id,prot_seq)\n",
    "        #AlphaFold2\n",
    "        af_model_path = f\"file:///examples/3Dstructures/AF_chimera/{uniprotID}.pdb\"\n",
    "        structures.append({\"value\":f\"AlphaFold2\",\"chain\": \"A\",  \"state\":\"Undetermined\", \"offset\":  0, \"gaps\": [], \"url\": af_model_path, \"reference\":\"AlphaFold2\"})\n",
    "        \n",
    "        #AlphaFold multistate. Don't have a AF ms for every GPCR (only humans). Need to check if file exist:\n",
    "        af_ms_active = f\"../examples/3Dstructures/AFms/Active/{uniprotID}.pdb\"\n",
    "        af_ms_inactive = f\"../examples/3Dstructures/AFms/Inactive/{uniprotID}.pdb\"\n",
    "        esmf = f\"../examples/3Dstructures/ESMF_chimera/{uniprotID}.pdb\"\n",
    "        if os.path.exists(af_ms_active):\n",
    "            af_ms_active = f\"file:///examples/3Dstructures/AFms/Active/{uniprotID}.pdb\"\n",
    "            structures.append({\"value\":f\"AlphaFold2 Active\",\"chain\": \"A\",  \"state\":\"Active\", \"offset\":  0, \"gaps\": [], \"url\": af_ms_active, \"reference\":\"AlphaFold multistate\"})\n",
    "        if os.path.exists(af_ms_inactive):\n",
    "            af_ms_inactive = f\"file:///examples/3Dstructures/AFms/Inactive/{uniprotID}.pdb\"\n",
    "            structures.append({\"value\":f\"AlphaFold2 Inactive\",\"chain\": \"A\",  \"state\":\"Inactive\", \"offset\":  0, \"gaps\": [], \"url\": af_ms_inactive, \"reference\":\"AlphaFold multistate\"})\n",
    "        if os.path.exists(esmf):\n",
    "            esmf = f\"file:///examples/3Dstructures/ESMF_chimera/{uniprotID}.pdb\"\n",
    "            structures.append({\"value\":f\"ESMFold\",\"chain\": \"A\",  \"state\":\"Undetermined\", \"offset\":  0, \"gaps\": [], \"url\": esmf, \"reference\":\"ESMFold\"})\n",
    "\n",
    "        #retrieve the residues interacting with ligand/Gprot/Nb/Ab in PDB and link it to region\n",
    "        #Add manually extra IC and EC contacts\n",
    "        #should follow the following structure: list regrouping all dictionaries with 1 dict per contact\n",
    "        #in dictionary: {\"start\":,\"end\",\"type\",\"description\",\"reference\"}\n",
    "        #for the EC contacts the types can be \"orthosteric\",\"allosteric\",\"VHH EC\"\n",
    "        #for the IC contacts the types can be \"G-protein\",\"VHH IC\"\n",
    "        manual_ICs,manual_ECs = translate_interacting_residues_IC_EC(interacting_residues_list,binders,pdbs,allregions)\n",
    "\n",
    "        #chimeric info\n",
    "        chimeras_ref_involved = retrieve_involvement_natural_chimeric_design(ref_parent_id,allregions)\n",
    "        chimeras_target_involved = retrieve_involvement_natural_chimeric_design(target_parent_id,allregions)  \n",
    "        chimeras = chimeras_ref_involved + chimeras_target_involved\n",
    "        chimeras_no_duplicates = {}\n",
    "        for d in chimeras:\n",
    "            chimeras_no_duplicates[d['name']] = d\n",
    "        chimeras_no_duplicates = list(chimeras_no_duplicates.values())\n",
    "\n",
    "        confo_biosensor = []\n",
    "\n",
    "        #chimeric info specfic design being studied\n",
    "        for d in chimeras_no_duplicates:\n",
    "            if d.get(\"name\") == abbreviated_name:\n",
    "                info_specific_chimera = d.copy()\n",
    "        info_specific_chimera[\"mutations vs parents\"] = mutations_vs_parents\n",
    "        info_specific_chimera[\"ref parent seq\"] = ref_parent_seq\n",
    "        info_specific_chimera[\"target parent seq\"] = target_parent_seq\n",
    "        info_specific_chimera[\"coloring\"] =sections_coloring_chimera(info_specific_chimera,allregions)\n",
    "\n",
    "        #microswitches based on microswitches/motifs in parents\n",
    "        microswitches = motifs_microswitches_chimera(ref_parent_id,target_parent_id,info_specific_chimera)\n",
    "        info = {}\n",
    "        #standard needed in json chimera for DB\n",
    "        info[\"chimera\"] = True\n",
    "        info[\"ancestors\"] = [ref_parent_name,target_parent_name]\n",
    "\n",
    "        info[\"info specific chimera\"]=info_specific_chimera\n",
    "\n",
    "        #Abbreviated name\n",
    "        info[\"Abbreviated name\"] = [{\"value\": abbreviated_name.upper(), \"reference\": \"GPCRchimeraDB\"}]\n",
    "\n",
    "        #pharma name\n",
    "        info[\"Pharmacological name\"] = [{\"value\": pharma_name, \"reference\": \"GPCRdb\"}]\n",
    "\n",
    "        #Name\n",
    "        info[\"Name(s)\"] = [{\"value\": given_name, \"reference\": \"GPCRchimeraDB\"}]\n",
    "\n",
    "        #Uniprot ID\n",
    "        info[\"Uniprot ID\"] = [{\"value\": uniprotID, \"reference\": \"GPCRchimeraDB\"}]\n",
    "\n",
    "        #Species\n",
    "        info[\"Organism\"] =  [{\"value\":species, \"reference\": \"UniProt\"}]\n",
    "\n",
    "        #Class\n",
    "        info[\"Class\"] = [{\"value\":class_, \"reference\": \"GPCRdb\"}]\n",
    "\n",
    "        #Family\n",
    "        info[\"Family\"] = [{\"value\": family, \"reference\": \"GPCRdb\"}]\n",
    "\n",
    "        #Subclass\n",
    "        #Phylogenetically based & Ligand based\n",
    "        info[\"Subclass\"] = {\"Phylogenetically based\": [{\"value\": subclass_phylo, \"reference\": \"10.1124/mol.63.6.1256\"}],\n",
    "                            \"Ligand based\": [{\"value\":subclass_ligand, \"reference\": \"GPCRdb\"}]}\n",
    "\n",
    "        #endogenous ligand\n",
    "        info[\"Endogenous ligand\"]= []\n",
    "        \n",
    "        #Gport and Barr coupling data\n",
    "        if len(gprot)>0:\n",
    "            info[\"G-protein coupling\"]= [{\"value\":gprot, \"reference\": biblio}]\n",
    "        else:\n",
    "            info[\"G-protein coupling\"]= []\n",
    "        info[\"Beta-arrestin coupling\"] = []\n",
    "\n",
    "        #Structures\n",
    "        info[\"Structures\"] = structures\n",
    "\n",
    "        #Info related to chimeric design\n",
    "        info[\"Conformational biosensor\"] = confo_biosensor\n",
    "        info[\"Involvement in chimeric design\"] = chimeras_no_duplicates\n",
    "        info[\"Cutting point values\"] = write_cutting_point_region(cutting_points,ref_parent_name,target_parent_name,biblio)\n",
    "\n",
    "        features = {}\n",
    "        features['Microswitches'] = microswitches\n",
    "        features['PTMs'] = []\n",
    "        features['Disulfide bonds'] = ds_bonds_noduplicates\n",
    "        features['Mutagenesis'] = []\n",
    "        features['Pharmacological mutagenesis'] = []\n",
    "        features[\"Contacts\"] = manual_ECs +  manual_ICs\n",
    "        info[\"Features\"] = features\n",
    "\n",
    "        #Sequence\n",
    "        info[\"Sequence\"] = [{\"value\":prot_seq, \"reference\": biblio}]\n",
    "\n",
    "        #Secondary structure info\n",
    "        info[\"Limits regions\"] = allregions\n",
    "\n",
    "        #Gather info that could be useful for chimeric design: for chimera put just yes chimera so that filter can be used on DB?\n",
    "        known_info = [{\"value\": \"Yes chimera\"}]\n",
    "        info[\"Known info chimeric design\"] = known_info\n",
    "\n",
    "        json.dump(info, open(f'../examples/json_entries/updated_chimeras/{abbreviated_name.upper()}.json', 'w'), indent=2)"
   ]
  }
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