GPCRchimeraDB

Main repository of the database GPCRchimeraDB (https://www.bio2byte.be/gpcrchimeradb/).

Format the Data

In the folder Notebooks, the following Jupyter notebooks are available:

Format a chimera's data: Identify parents, cutting sites, and mutations based on its sequence.
Generate entry file for chimeric GPCRs.
Generate entry file for natural GPCRs.

The Data

Available on Zedodo :

Entry files (JSON, 1 per entry).
FASTA sequences.
Structures (PDB, AF2, AF2 MS, ESMFold).
Master alignment (MSA).
Activation state structures (GPCRdb).
Classification.
G-protein and B-arrestin coupling (GPCRdb).
Limits TM regions (TMbed).
Endogenous ligands (GPCRdb).
Variants (GPCRdb).
Scientific to common names organisms (UniProt).

The Database

Explore your favorite chimeric or natural GPCR at the sequence, structural, and biophysical levels and design new chimeras!

Visit GPCRchimeraDB: https://www.bio2byte.be/gpcrchimeradb/.

The Database's Documentation

GitHub repository for GPCRchimeraDB's documentation: https://github.com/Bio2Byte/gpcrchimeradb-docs.

The Paper

Contact Us

[email protected]

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.