A methylation toolset designed for sequence-level DNA methylation data management. It is a command-line C program capable of performing sequence-level enrichment testing, row operations (such as merging pseudobulks), downsampling, and other related tasks with ultra fast speed.
David Goldberg, Hongxiang Fu, Daniel Atkins, Ethan Moyer, Wanding Zhou, KnowYourCG: supervised learning of sparse DNA methylomes.
A User Guide has been created to provide detailed documentation of YAME. The guide can be found at: https://zhou-lab.github.io/YAME/.