03 Sepsis Dataset

Sepsis dataset

See Introduction.

Sepsis dataset is a simulated clinical trial with two groups treatment about sepsis desease. See details. This dataset is taken from SIDES method

Sepsis contains simulated data on 470 subjects with a binary outcome survival, that stores survival status for patient after 28 days of treatment, value of 1 for subjects who died after 28 days and 0 otherwise. There are 11 covariates, listed below, all of which are numerical variables.

Note that contrary to the original dataset used in SIDES, missing values have been imputed by random forest randomForest::rfImpute(). See file data-raw/sepsis.R for more details.

True subgroup is PRAPACHE <= 26 & AGE <= 49.80. NOTE: This subgroup is defined with the lower event rate (survival = 1) in treatement arm.

470 patients and 13 variables:

• survival : binary outcome
• THERAPY : 1 for active treatment, 0 for control treatment
• TIMFIRST : Time from first sepsis-organ fail to start drug
• AGE : Patient age in years
• BLLPLAT : Baseline local platelets
• blSOFA : Sum of baselin sofa (cardiovascular, hematology, hepaticrenal, and respiration scores)
• BLLCREAT : Base creatinine
• ORGANNUM : Number of baseline organ failures
• PRAPACHE : Pre-infusion apache-ii score
• BLGCS : Base GLASGOW coma scale score
• BLIL6 : Baseline serum IL-6 concentration
• BLADL : Baseline activity of daily living score
• BLLBILI : Baseline local bilirubin

Source: http://biopharmnet.com/subgroup-analysis-software/