Skip to content

Commit

Permalink
Merge branch 'master' of github.com:ComputationalProteomics/NormalyzerDE
Browse files Browse the repository at this point in the history
  • Loading branch information
Jakob37 committed Feb 7, 2021
2 parents 330bc13 + c51320c commit 73c59fa
Showing 1 changed file with 7 additions and 5 deletions.
12 changes: 7 additions & 5 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -9,6 +9,13 @@ NormalyzerDE is a software designed to ease the process of selecting an optimal

NormalyzerDE includes several normalization approaches, a empirical Bayes-based statistical approach implemented as part of Limma and a newly implemented retention-time segmented normalization approach inspired by previously outlined approaches. The emprical-based based statistics has been shown to increase sensitivity over ANOVA when detecting differentially expressed features.

# Cite NormalyzerDE

NormalyzerDE is published [here](https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00523)

Willforss, J., Chawade, A., Levander, F.
NormalyzerDE: Online tool for improved normalization of omics expression data and high-sensitivity differential expression analysis. *Journal of Proteome Research* **2018**, 10.1021/acs.jproteome.8b00523.

# Installation

Currently, the easiest way is to install directly from GitHub. It is recommended that you use
Expand Down Expand Up @@ -48,11 +55,6 @@ Rscript -e 'NormalyzerDE::normalyzer(jobName="rscript_norm", designPath="test_de
Rscript -e 'NormalyzerDE::normalyzerDE(jobName="rscript_de", designPath="test_design.tsv", dataPath="test_data.tsv", comparisons=c("1-2", "1-3"))'
```

# Cite NormalyzerDE

Willforss, J., Chawade, A., Levander, F.
NormalyzerDE: Online tool for improved normalization of omics expression data and high-sensitivity differential expression analysis. *Journal of Proteome Research* **2018**, 10.1021/acs.jproteome.8b00523.

# References

(1) Bolstad, B. preprocessCore: A collection of pre-processing functions. **2018**; https://github.com/bmbolstad/preprocessCore.
Expand Down

0 comments on commit 73c59fa

Please sign in to comment.