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I have been using enrico to carry out a batch analysis for hundreds of sources with the same analysis parameters (different ROIs but same time interval, energy selection, zenith angle cut etc). In this case, one should generate only one livetime cube and then reuse it in all ROIs. In my experience, this greatly sped up my analysis.
I modified the source code just a little bit in order to be able to reuse livetime cubes. Then one only needs to provide the ltcube filename in the field 'config[file][ltcube]’.