diff --git a/drivers/ieee802154/Kconfig.nrf5 b/drivers/ieee802154/Kconfig.nrf5
index 1705ccd42039599..bf4bcd1be8cf46f 100644
--- a/drivers/ieee802154/Kconfig.nrf5
+++ b/drivers/ieee802154/Kconfig.nrf5
@@ -96,6 +96,7 @@ config IEEE802154_NRF5_MULTIPLE_CCA
 
 config IEEE802154_NRF5_CST_ENDPOINT
 	bool "Support for OpenThread CST Endpoint extension in the ieee802154_nrf5."
+	default y if OPENTHREAD_WAKEUP_COORDINATOR
 	help
 	  Enable support for OpenThread CST (Coordinated Sampled Transmitter) Endpoint
 	  with CST IE injection as an extension to ieee802154_nrf5 driver.
diff --git a/modules/openthread/CMakeLists.txt b/modules/openthread/CMakeLists.txt
index 977b7e5921f1e6e..b0dfd8baf18a69e 100644
--- a/modules/openthread/CMakeLists.txt
+++ b/modules/openthread/CMakeLists.txt
@@ -128,6 +128,7 @@ kconfig_to_ot_option(CONFIG_OPENTHREAD_TX_QUEUE_STATISTICS OT_TX_QUEUE_STATS "En
 kconfig_to_ot_option(CONFIG_OPENTHREAD_UDP_FORWARD OT_UDP_FORWARD "Enable UDP forward feature")
 kconfig_to_ot_option(CONFIG_OPENTHREAD_UPTIME OT_UPTIME "Enable support for tracking OpenThread instance's uptime")
 kconfig_to_ot_option(CONFIG_OPENTHREAD_VERHOEFF_CHECKSUM OT_VERHOEFF_CHECKSUM "Verhoeff checksum")
+kconfig_to_ot_option(CONFIG_OPENTHREAD_WAKEUP_COORDINATOR OT_WAKEUP_COORDINATOR "Enable Wake-up Coordinator role")
 
 if(CONFIG_OPENTHREAD_COPROCESSOR_VENDOR_HOOK_SOURCE)
   set(OT_NCP_VENDOR_HOOK_SOURCE ${CONFIG_OPENTHREAD_COPROCESSOR_VENDOR_HOOK_SOURCE} CACHE STRING "NCP vendor hook source file name" FORCE)
diff --git a/modules/openthread/Kconfig.features b/modules/openthread/Kconfig.features
index f4cbfb3551a2a36..44cd3cc7adaf90e 100644
--- a/modules/openthread/Kconfig.features
+++ b/modules/openthread/Kconfig.features
@@ -128,6 +128,10 @@ config OPENTHREAD_DEVICE_PROP_LEADER_WEIGHT
 config OPENTHREAD_DATASET_UPDATER
 	bool "Dataset updater"
 
+config OPENTHREAD_WAKEUP_COORDINATOR
+	bool "Wake-up Coordinator support"
+	select OPENTHREAD_CSL_RECEIVER
+
 config OPENTHREAD_DHCP6_CLIENT
 	bool "DHCPv6 client support"
 
diff --git a/modules/openthread/platform/radio.c b/modules/openthread/platform/radio.c
index 70b17e7708e40ad..34725f70dbac8c8 100644
--- a/modules/openthread/platform/radio.c
+++ b/modules/openthread/platform/radio.c
@@ -1396,6 +1396,65 @@ void otPlatRadioUpdateCslSampleTime(otInstance *aInstance, uint32_t aCslSampleTi
 }
 #endif /* CONFIG_OPENTHREAD_CSL_RECEIVER */
 
+#if defined(CONFIG_OPENTHREAD_WAKEUP_COORDINATOR)
+otError otPlatRadioEnableCst(otInstance *aInstance, uint32_t aCstPeriod, otShortAddress aShortAddr,
+			     const otExtAddress *aExtAddr)
+{
+	struct ieee802154_config config;
+	int result;
+	uint8_t header_ie[OT_IE_HEADER_SIZE + OT_THREAD_IE_SIZE + OT_CST_IE_SIZE] = { 0 };
+	size_t index = 0;
+
+	ARG_UNUSED(aInstance);
+
+	/* Configure the CST period first to give drivers a chance to validate
+	 * the IE for consistency if they wish to.
+	 */
+	config.cst_period = aCstPeriod;
+	result = radio_api->configure(radio_dev, IEEE802154_OPENTHREAD_CONFIG_CST_PERIOD, &config);
+	if (result) {
+		return OT_ERROR_FAILED;
+	}
+
+	/* Configure the CST IE. */
+	header_ie[index++] = OT_THREAD_IE_SIZE + OT_CST_IE_SIZE;
+	header_ie[index++] = 0;
+	sys_put_le24(THREAD_IE_VENDOR_OUI, &header_ie[index]);
+	index += 3;
+	header_ie[index++] = THREAD_IE_SUBTYPE_CST;
+	/* Leave CST Phase empty intentionally */
+	index += 2;
+	sys_put_le16(aCstPeriod, &header_ie[index]);
+	index += 2;
+
+	config.ack_ie.header_ie = aCstPeriod > 0 ? (struct ieee802154_header_ie *)header_ie : NULL;
+	config.ack_ie.short_addr = aShortAddr;
+	config.ack_ie.ext_addr = aExtAddr != NULL ? aExtAddr->m8 : NULL;
+	config.ack_ie.purge_ie = false;
+
+	result = radio_api->configure(radio_dev, IEEE802154_CONFIG_ENH_ACK_HEADER_IE, &config);
+
+	return result ? OT_ERROR_FAILED : OT_ERROR_NONE;
+}
+
+void otPlatRadioUpdateCstSampleTime(otInstance *aInstance, uint32_t aCstSampleTime)
+{
+	int result;
+
+	ARG_UNUSED(aInstance);
+
+	struct ieee802154_config config = {
+		.expected_tx_time = convert_32bit_us_wrapped_to_64bit_ns(
+			aCstSampleTime - PHR_DURATION_US),
+	};
+
+	result = radio_api->configure(radio_dev, IEEE802154_OPENTHREAD_CONFIG_EXPECTED_TX_TIME,
+					&config);
+	__ASSERT_NO_MSG(result == 0);
+	(void)result;
+}
+#endif /* CONFIG_OPENTHREAD_WAKEUP_COORDINATOR */
+
 uint8_t otPlatRadioGetCslAccuracy(otInstance *aInstance)
 {
 	ARG_UNUSED(aInstance);