diff --git a/cmake/compilers/Clang.cmake b/cmake/compilers/Clang.cmake
index 15f2a39684..1b81540e84 100644
--- a/cmake/compilers/Clang.cmake
+++ b/cmake/compilers/Clang.cmake
@@ -52,8 +52,10 @@ if (NOT TBB_STRICT AND COMMAND tbb_remove_compile_flag)
 endif()
 
 # Enable Intel(R) Transactional Synchronization Extensions (-mrtm) and WAITPKG instructions support (-mwaitpkg) on relevant processors
-if (CMAKE_SYSTEM_PROCESSOR MATCHES "(AMD64|amd64|i.86|x86)")
-    set(TBB_COMMON_COMPILE_FLAGS ${TBB_COMMON_COMPILE_FLAGS} -mrtm $<$<NOT:$<VERSION_LESS:${CMAKE_CXX_COMPILER_VERSION},12.0>>:-mwaitpkg>)
+if(NOT EMSCRIPTEN)
+  if (CMAKE_SYSTEM_PROCESSOR MATCHES "(AMD64|amd64|i.86|x86)")
+      set(TBB_COMMON_COMPILE_FLAGS ${TBB_COMMON_COMPILE_FLAGS} -mrtm $<$<NOT:$<VERSION_LESS:${CMAKE_CXX_COMPILER_VERSION},12.0>>:-mwaitpkg>)
+  endif()
 endif()
 
 # Clang flags to prevent compiler from optimizing out security checks