diff --git a/Cargo.lock b/Cargo.lock
index 5eea72d..8e16e36 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -386,6 +386,7 @@ version = "0.1.0"
 dependencies = [
  "deadpool-diesel",
  "diesel",
+ "itertools",
  "thiserror",
 ]
 
@@ -703,6 +704,15 @@ version = "1.70.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f8478577c03552c21db0e2724ffb8986a5ce7af88107e6be5d2ee6e158c12800"
 
+[[package]]
+name = "itertools"
+version = "0.13.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "413ee7dfc52ee1a4949ceeb7dbc8a33f2d6c088194d9f922fb8318faf1f01186"
+dependencies = [
+ "either",
+]
+
 [[package]]
 name = "itoa"
 version = "1.0.11"
@@ -1416,6 +1426,7 @@ dependencies = [
  "http",
  "http-body-util",
  "index",
+ "itertools",
  "paste",
  "serde",
  "serde_json",
diff --git a/README.md b/README.md
index 1b1ec41..13320a0 100644
--- a/README.md
+++ b/README.md
@@ -52,4 +52,4 @@ Follow these steps in order to easily work on the Unipept API in the devcontaine
 
 * You first have to build the binaries by running `cargo build --release`.
 * Then, you should start the mariadb server: `sudo service mariadb start`
-* Finally, the Unipept API can be started with this command: `./target/release/unipept-api -i "/unipept-index-data" -d "mysql://root:unipept@127.0.0.1:3306/unipept" -p 80`.
+* Finally, the Unipept API can be started with this command: `./target/release/unipept-api -i "/unipept-index-data" -d "mysql://root:root_pass@localhost:3306/unipept" -p 80`.
diff --git a/api/Cargo.toml b/api/Cargo.toml
index e840d74..bef0020 100644
--- a/api/Cargo.toml
+++ b/api/Cargo.toml
@@ -25,3 +25,4 @@ urlencoding = "2.1.3"
 http = "1.1.0"
 tower-layer = "0.3.2"
 tower-service = "0.3.2"
+itertools = "0.13.0"
diff --git a/api/src/controllers/api/pept2prot.rs b/api/src/controllers/api/pept2prot.rs
index 78bb50f..7c8b945 100644
--- a/api/src/controllers/api/pept2prot.rs
+++ b/api/src/controllers/api/pept2prot.rs
@@ -1,4 +1,6 @@
+use std::collections::HashSet;
 use axum::{extract::State, Json};
+use itertools::Itertools;
 use database::get_accessions_map;
 use serde::{Deserialize, Serialize};
 
@@ -55,7 +57,7 @@ async fn handler(
 
     let result = index.analyse(&input, equate_il, None);
 
-    let accession_numbers: Vec<String> = result
+    let accession_numbers: HashSet<String> = result
         .iter()
         .flat_map(|item| item.proteins.iter().map(|protein| protein.uniprot_accession.clone()))
         .collect();
diff --git a/api/src/controllers/api/protinfo.rs b/api/src/controllers/api/protinfo.rs
index c00b2d3..4300d34 100644
--- a/api/src/controllers/api/protinfo.rs
+++ b/api/src/controllers/api/protinfo.rs
@@ -1,3 +1,4 @@
+use std::collections::HashSet;
 use axum::{extract::State, Json};
 use database::get_accessions;
 use serde::{Deserialize, Serialize};
@@ -58,6 +59,7 @@ async fn handler(
     version: LineageVersion
 ) -> Result<Vec<ProtInformation>, ApiError> {
     let input = sanitize_proteins(input);
+    let input = HashSet::from_iter(input.into_iter());
 
     let connection = database.get_conn().await?;
 
diff --git a/api/src/controllers/private_api/proteins.rs b/api/src/controllers/private_api/proteins.rs
index 750ce1d..a2dddbc 100644
--- a/api/src/controllers/private_api/proteins.rs
+++ b/api/src/controllers/private_api/proteins.rs
@@ -1,3 +1,4 @@
+use std::collections::HashSet;
 use axum::{extract::State, Json};
 use database::get_accessions_map;
 use serde::{Deserialize, Serialize};
@@ -57,7 +58,7 @@ async fn handler(
         return Ok(ProteinInformation::default());
     }
 
-    let accession_numbers: Vec<String> =
+    let accession_numbers: HashSet<String> =
         result[0].proteins.iter().map(|protein| protein.uniprot_accession.clone()).collect();
 
     let accessions_map = connection.interact(move |conn| get_accessions_map(conn, &accession_numbers)).await??;
diff --git a/database/Cargo.toml b/database/Cargo.toml
index 29ab330..2b03cf6 100644
--- a/database/Cargo.toml
+++ b/database/Cargo.toml
@@ -6,4 +6,5 @@ edition = "2021"
 [dependencies]
 deadpool-diesel = { version = "0.4.1", features = ["mysql"] }
 diesel = { version = "2", features = ["mysql"] }
+itertools = "0.13.0"
 thiserror = "1.0"
diff --git a/database/src/lib.rs b/database/src/lib.rs
index 3db0349..af65ff1 100644
--- a/database/src/lib.rs
+++ b/database/src/lib.rs
@@ -1,10 +1,11 @@
 use std::{collections::HashMap, ops::Deref};
-
+use std::collections::HashSet;
 use deadpool_diesel::mysql::{Manager, Object, Pool};
 pub use deadpool_diesel::InteractError;
 use diesel::{prelude::*, MysqlConnection, QueryDsl};
 pub use errors::DatabaseError;
 use models::UniprotEntry;
+use itertools::Itertools;
 
 mod errors;
 mod models;
@@ -36,16 +37,29 @@ impl Deref for Database {
 
 pub fn get_accessions(
     conn: &mut MysqlConnection,
-    accessions: &Vec<String>
+    accessions: &HashSet<String>
 ) -> Result<Vec<UniprotEntry>, DatabaseError> {
     use schema::uniprot_entries::dsl::*;
 
-    Ok(uniprot_entries.filter(uniprot_accession_number.eq_any(accessions)).load(conn)?)
+    let mut result: Vec<UniprotEntry> = Vec::new();
+
+    accessions
+        .into_iter()
+        .chunks(1000)
+        .into_iter()
+        .for_each(|chunk| {
+            let data = uniprot_entries.filter(uniprot_accession_number.eq_any(chunk)).load(conn);
+            if data.is_ok() {
+                result.extend(data.unwrap());
+            }
+        });
+
+    Ok(result)
 }
 
 pub fn get_accessions_map(
     conn: &mut MysqlConnection,
-    accessions: &Vec<String>
+    accessions: &HashSet<String>
 ) -> Result<HashMap<String, UniprotEntry>, DatabaseError> {
     Ok(get_accessions(conn, accessions)?
         .into_iter()