diff --git a/.github/workflows/build-and-test.yaml b/.github/workflows/build-and-test.yaml
index 9e778fe..8d80eb4 100644
--- a/.github/workflows/build-and-test.yaml
+++ b/.github/workflows/build-and-test.yaml
@@ -112,6 +112,23 @@ jobs:
               libva2 libva-drm2 \
               nodejs npm xvfb
 
+      - name: Install Chromium (non-Snap, arm64 Linux only)
+        if: runner.os == 'Linux' && matrix.target_arch == 'arm64'
+        run: |
+          sudo add-apt-repository ppa:xtradeb/apps -y
+          sudo apt update
+          sudo apt -y install chromium
+
+          # Running inside a Docker container, we need to kill the sandbox.
+          # Heredocs interpolate variables, so escape the dollar sign below.
+          cat >/usr/local/bin/chromium <<EOF
+          #!/bin/bash
+          exec /usr/bin/chromium --no-sandbox "\$@"
+          EOF
+
+          chmod 755 /usr/local/bin/chromium
+          echo "CHROME_BIN=/usr/local/bin/chromium" >> $GITHUB_ENV
+
       - name: Install Python deps
         run: |
           python3 -m pip install -r requirements.txt
@@ -142,8 +159,20 @@ jobs:
           else
             WRAPPER=""
           fi
+
+          if [[ '${{ runner.os }}' == 'Linux' && '${{ matrix.target_arch }}' == 'arm64' ]]; then
+            # There is no Widevine CDM for Linux arm64 at this time.
+            # By setting this here instead of probing during the test, we can
+            # be sure to notice failures if Widevine disappears from our
+            # testing environment on platforms where this would not be
+            # expected.
+            EXTRA_ARGS="--no-test-widevine"
+          else
+            EXTRA_ARGS=""
+          fi
+
           # Use the "spec" reporter for clearer logs in GitHub Actions
-          $WRAPPER python3 run_end_to_end_tests.py --reporters spec
+          $WRAPPER python3 run_end_to_end_tests.py --reporters spec $EXTRA_ARGS
 
       - name: Debug on failure
         uses: mxschmitt/action-tmate@v3.6
diff --git a/build-matrix.json b/build-matrix.json
index 83d1ca7..b914c64 100644
--- a/build-matrix.json
+++ b/build-matrix.json
@@ -29,7 +29,6 @@
   "comment2": "runners hosted by the owner, enabled by the ENABLE_SELF_HOSTED variable being set on the repo",
   "selfHosted": [
     {
-      "DISABLED": "Disabled because there is no Chrome build for arm64 Linux to run the test cases.  Need support for another browser through Karma.",
       "os": "self-hosted-linux-arm64",
       "os_name": "linux",
       "target_arch": "arm64"
diff --git a/run_end_to_end_tests.py b/run_end_to_end_tests.py
index c5e5c04..5d55aab 100755
--- a/run_end_to_end_tests.py
+++ b/run_end_to_end_tests.py
@@ -322,6 +322,12 @@ def main():
                       help='Random seed to reproduce failures')
   parser.add_argument('--filter',
                       help='Plain text or regex filter for test cases')
+  parser.add_argument('--test-widevine', default=True,
+                      action='store_true',
+                      help='Test Widevine (the default)')
+  parser.add_argument('--no-test-widevine', dest='test_widevine',
+                      action='store_false',
+                      help='Do not test Widevine')
   parser.add_argument('--debug',
                       action='store_true',
                       help='Dump information about the configs and the ' +
@@ -378,6 +384,8 @@ def main():
     test_args += [ '--seed', args.seed ]
   if args.debug:
     test_args += [ '--debug', 'true' ]
+  if args.test_widevine:
+    test_args += [ '--testWidevine', 'true' ]
 
   for i in range(trials):
     # If the exit code was not 0, the tests in karma failed or crashed.
diff --git a/tests/karma.conf.js b/tests/karma.conf.js
index 3c1ea0f..705f607 100644
--- a/tests/karma.conf.js
+++ b/tests/karma.conf.js
@@ -22,6 +22,7 @@ module.exports = function(config) {
       filter: config.filter,
       seed: config.seed,
       debug: !!config.debug,
+      testWidevine: !!config.testWidevine,
     },
     frameworks: ['jasmine'],
     files: [
diff --git a/tests/tests.js b/tests/tests.js
index e5b4d3e..10db879 100644
--- a/tests/tests.js
+++ b/tests/tests.js
@@ -20,6 +20,7 @@ const TEST_DIR = 'test_assets/';
 let player;
 let video;
 let doDebug = false;
+let testWidevine = true;
 
 const jasmineEnv = jasmine.getEnv();
 const originalJasmineExecute = jasmineEnv.execute.bind(jasmineEnv);
@@ -37,6 +38,9 @@ jasmineEnv.execute = () => {
   // If the user asked us to debug, we can print manifest/playlist contents.
   doDebug = __karma__.config.debug;
 
+  // True if we're testing Widevine (the default).
+  testWidevine = __karma__.config.testWidevine;
+
   // Set jasmine config.
   jasmineEnv.configure({
     random,
@@ -558,13 +562,16 @@ function liveTests(manifestUrl, format) {
 }
 
 function drmTests(manifestUrl, format) {
-  it('has widevine encryption enabled ' + format, async () => {
+  it('has Widevine encryption enabled ' + format, async () => {
     if (manifestUrl.includes('hls.m3u8')) {
       // https://github.com/shaka-project/shaka-packager/issues/1439
       // Inappropriate key material in HLS outputs causes this test to fail.
       // Until this bug is resolved, skip this test for HLS.
       pending('Skipped due to shaka-packager#1439');
     }
+    if (!testWidevine) {
+      pending('Skipped due to command line flag');
+    }
 
     const inputConfigDict = {
       'inputs': [