05.Synapse_and_Receptors.md

layout	title	date	author	summary	weight
notes	05.Synapse and receptor	2016-03-28	ErbB4	Synapse and receptor	5

Synapse and receptor

What is left from last section: calcium-activated potassium channels, low-threshold and high-threshold calcium-activated potassium channels, are responsible for post-inhibitory-rebound and adaptation respectively.

Calcium dynamics

Calcium concentration varies in different parts of neuron: soma, dendrite and spines, enabling neurotransmitter release, action potential generation and synapse stabilization.

$$\mathrm{\frac{d[Ca^{2+}]i}{dt}}=\mathrm{-\tau{Ca}^{-1}[Ca^{2+}]i+\phi{Ca}I_{Ca}}$$

Synapse

Synapses could be classified as inhibitory synapses (mainly using GABA as neurotransmitter) and excitatory synapses (adopting glutamate as neurotransmitter).

The activation of post-synaptic element is realized by binding of neurotransmitter and receptor, ion channel opening and post-synaptic current (or potential) generation, or other intracellular cascade. The amount of current pass through a specific synapse could be described as a function of synaptic conductance $\mathrm{g_{syn}}$ and driving potential.

$$\mathrm{I_{syn}}(t)=\mathrm{g_{syn}}(t)(u-\mathrm{E_{syn})}$$

The conductance of synapse is an exponential decay function:

$$\mathrm{g_{syn}}(t)=\sum_f\bar{g}_\mathrm{syn}e^{-(t-t^f)/\tau}\Theta(t-t^f).$$

for inhibitory synapse, which has two types of current components:

$$\mathrm{g_{syn}}(t)=\sum_f(\bar{g}\mathrm{fast}e^{-(t-t^f)/\tau\mathrm{fast})}+\bar{g}\mathrm{slow}e^{-(t-t^f)/\tau\mathrm{slow})})\Theta(t-t^f).$$

for excitatory synapse, which adapts two types of receptors: NMDA (slow) and AMPA (fast):

$$\mathrm{g_{AMPS}}(t)=\bar{g}\mathrm{AMPA} N [e^{-(t-t^f)/\tau\mathrm{decay}}-e^{-(t-t^f)/\tau_\mathrm{rise}}]\Theta(t-t^f).$$

$$\mathrm{g_{NMDA}}(t)=\bar{g}\mathrm{NMDA} N [e^{-(t-t^f)/\tau\mathrm{decay}}-e^{-(t-t^f)/\tau_\mathrm{rise}}]g_\mathrm{\infty}\Theta(t-t^f),$$ with $g_{\infty} = (1+e^{\alpha u}[\mathrm{Mg}^{2+}]_o/\beta)^{-1}.$

Receptors

See this reference for differences between AMPA and NMDA receptor. http://www.sumanasinc.com/webcontent/animations/content/receptors.html

Spatial structure of dendritic tree

Cable equations based on Kirchhoff's law. See Green's function solving the stationary solution of cable equations in next section.