This presentation showcases a collaborative effort between Nir's Lab at UTMB and Akdemir Lab at UTMDACC, focusing on the intricate analysis of genome structures using cutting-edge super-resolution microscopy. The high-resolution images, obtained through state-of-the-art microscopy techniques in Nir's Lab, provide unprecedented insights into cellular processes. These images capture cellular details at the nanoscale, offering a glimpse into the complexity of cellular structures.Cell lines, meticulously produced in Akdemir Lab, serve as the foundation for this comprehensive analysis. The data analysis, a crucial aspect of this collaborative endeavor, unveils hidden patterns and structures within the microscopic images.