Figure3.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "This notebook allows to reproduce **Figure 3** of the paper \"Covering the Combinatorial Design Space of Multiplex CRISPR/Cas Experiments in Plants\" by Kirsten Van Huffel, Michiel Stock, Tom Ruttink and Bernard De Baets."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### Load packages"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "\n",
      "(process:4344): GLib-GIO-WARNING **: 10:22:27.662: Unexpectedly, UWP app `HaukeGtze.7-ZipFileManagerUnofficial_1.2107.2.0_x64__6bk20wvc8rfx2' (AUMId `HaukeGtze.7-ZipFileManagerUnofficial_6bk20wvc8rfx2!zFM.exe') supports 36 extensions but has no verbs\n"
     ]
    }
   ],
   "source": [
    "using Random \n",
    "using Plots  \n",
    "using Distributions \n",
    "using LinearAlgebra\n",
    "using Combinatorics\n",
    "using BioCCP"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### Load BioCCP- and simulation-based framework"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "include(\"MultiplexCrisprDOE.jl\");"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### Set seed for reproducibility"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "TaskLocalRNG()"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Random.seed!(1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "include(\"DefaultParameters_k=2.jl\");"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "- Figure 3A: Distribution of the abundances of the gRNAs in the construct library"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
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     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Random.seed!(1)\n",
    "p_gRNA_freq = gRNA_frequency_distribution(m, sd, l, u, n_gRNA_total; normalize = false, visualize=false)\n",
    "histogram(p_gRNA_freq, label=\"\", \n",
    "            xlabel=\"Number of reads per gRNA\", \n",
    "            linecolor=\"white\", \n",
    "            normalize=:probability,\n",
    "            xtickfontsize=10,ytickfontsize=10,\n",
    "            color=:mediumturquoise, size=(500,350), bins = 25,\n",
    "            xlim=((25, 125)),\n",
    "            ylabel=\"Relative frequency\", \n",
    "            title=\"gRNA frequency distribution\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "- Figure 3B: Distribution of genome editing efficiencies of the gRNAs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
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     "execution_count": 6,
     "metadata": {},
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   ],
   "source": [
    "Random.seed!(1)\n",
    "gRNA_edit_distribution(f_act, ϵ_edit_act, ϵ_edit_inact, sd_act, n_gRNA_total; visualize = true)"
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  }
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