-
Notifications
You must be signed in to change notification settings - Fork 1
/
Copy pathBioCCP_Interactive_Notebook.jl
1587 lines (1279 loc) · 57.1 KB
/
BioCCP_Interactive_Notebook.jl
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
### A Pluto.jl notebook ###
# v0.16.1
using Markdown
using InteractiveUtils
# This Pluto notebook uses @bind for interactivity. When running this notebook outside of Pluto, the following 'mock version' of @bind gives bound variables a default value (instead of an error).
macro bind(def, element)
quote
local el = $(esc(element))
global $(esc(def)) = Core.applicable(Base.get, el) ? Base.get(el) : missing
el
end
end
# ╔═╡ 56571409-a81d-4772-98fd-e85e883aa4e4
using Plots, PlutoUI, BioCCP
# ╔═╡ 20ce43cd-7634-4c94-afdf-d243415525cb
md" $(@bind date DateField())"
# ╔═╡ 4d246460-af05-11eb-382b-590e60ba61f5
md"## Collecting Coupons in combinatorial biotechnology
This notebook provides functions and corresponding visualizations to determine expected minimum sample sizes for combinatorial biotechnology experiments, based on the mathematical framework of the Coupon Collector Problem (references see [^1], [^2]).
"
# ╔═╡ 6183795b-62a0-4ed4-b8f9-ea522da956e2
begin
begin
function tocsv(raw)
t = string(raw)
t = split(t, "[")[2]
t = split(t, "]")[1]
return t
end
end
md""
end
# ╔═╡ a8c81622-194a-443a-891b-bfbabffccff1
begin
md"""
👇 **COMPLETE THE FIELDS BELOW** 👇\
*First, fill in the input parameters of your problem setting. Then, click outside the text field to update the report.*"""
end
# ╔═╡ e1b554a6-db6c-4d2a-9dd3-0a35095f4d8c
Show(MIME"image/png"(), read("BioCCP_scheme.png"))
# ╔═╡ 36a09fff-8b14-4d91-84e0-9ecabefa810a
# ╔═╡ 40ac5be1-6fc2-4fbc-b0ca-a021266b2247
begin
vec_n = [];
md"""🔹 **№ modules in design space** (`n`): $(@bind n_string TextField(default = "100")) $(@bind help_n Button("❓"))"""
end
# ╔═╡ 7b05669c-7abe-42a7-838c-61c06b261256
begin
help_n
switch_n = rem(length(vec_n), 2)
push!(vec_n, 1)
if switch_n == 1
md"""
= *How many different modules or building blocks are available to construct designs?*"""
end
end
# ╔═╡ 123d5b94-5772-42dc-bf74-d964d023b209
begin
vec_r = []
md"""
🔹 **Expected № modules per design** (`r`): $(@bind r NumberField(1:20)) $(@bind help_r Button("❓")) """
end
# ╔═╡ 30cb2ab3-ad67-405e-95a1-8feea223938a
begin
help_r
switch_r = rem(length(vec_r), 2)
push!(vec_r, 1)
if switch_r == 1
md"""
= *How many modules are combined in a single design, on average?*"""
end
end
# ╔═╡ c8164a38-fcf9-4f1b-b697-46c8ce978fce
begin
vec_m = []
md"""
**🔹 № times you want to observe each module** (`m`): $(@bind m NumberField(1:20)) $(@bind help_m Button("❓")) """
end
# ╔═╡ a5c3153f-0946-4af8-871c-634a71e8b7f1
begin
help_m
switch_m = rem(length(vec_m), 2)
push!(vec_m, 1)
if switch_m == 1
md"""
= *How many times do you want to observe each of the available modules in the total set of designs?*"""
end
end
# ╔═╡ d6c6be55-fc94-480a-bc58-ca67b0c44568
begin
vec_p = []
md"""🔹 **Abundances of modules during library generation** (`p`): $(@bind ps Select(["Equal", "Unequal"], default = "Equal")) $(@bind help_p Button("❓"))"""
end
# ╔═╡ b88fab57-9f78-4450-90af-62ab860620a0
begin
help_p
switch_p = rem(length(vec_p), 2)
push!(vec_p, 1)
if switch_p == 1
md"""
= *How are the abundances of the modules distributed during combinatorial generation of designs?
Is each module equally likely to be included in a design?*"""
end
end
# ╔═╡ 45507d48-d75d-41c9-a018-299e209f900e
begin
vec_p_unequal = []
n = parse(Int64, n_string);
if ps == "Equal"
distribution = "Equal"
end
if ps == "Unequal"
md""" ↳ **Specify distribution**:
$(@bind distribution Select(["Bell curve", "Zipf's law", "Custom vector"], default = " "))"""
end
end
# ╔═╡ a937e514-4c4a-4f76-b8e5-3c2031afd416
if ps == "Unequal"
md"""
*If the exact module probabilities are known, choose "Custom vector".*
*Otherwise, select:*
- *"Zipf's law" (when you expect a small number of modules to occur quite often, and a very large number of modules to occur at the statistical equivalent of zero, but, they do occur.)*
- *"Bell curve" (when you expect a large number of modules to occur at an average probability and a smaller number of modules to occur with a small or large probability)* """
end
# ╔═╡ b17f3b8a-61ee-4563-97cd-19ff049a8e1e
begin
if distribution == "Zipf's law" || distribution == "Bell curve"
md""" ↳ **Specify pₘₐₓ/pₘᵢₙ**: $(@bind pmaxpmin_string TextField(default = "4")) = *The ratio of the largest and smallest module probability*"""
end
end
# ╔═╡ 2639e3fb-ccbb-44de-bd15-1c5dbf6c1539
begin
if distribution == "Custom vector"
md""" **↳ Enter/load your custom abundances by changing the cell below 👇**"""
end
end
# ╔═╡ 464b67be-2dad-4315-a144-0b475414366f
if distribution == "Custom vector"
md""" $(@bind abundances_str TextField((30, 10), default=join(string.(rand(200:1:400, n)), "\n")))
*Make sure the number of abundances is equal to n!*"""
end
# ╔═╡ 1220c75b-303c-4b0a-84c4-a12ee834a5af
begin
function tonumbers(text)
text = split(text, "\n")
text = rstrip.(text)
text = text[text .!= ""]
text = parse.(Float64,text)
return text
end
if distribution == "Custom vector"
abundances = (tonumbers(abundances_str))
end
md""
end
# ╔═╡ f6ebf9fb-0a29-4cb4-a544-6c6e32bedcc4
md"""
🎯 **REPORT** 🎯
**💻 Module probabilities** $(@bind show_modprobs Select(["🔻 SHOW ", "🔺 HIDE "], default="🔻 SHOW ") ) \
*How the abundances of the modules are distributed during combinatorial library generation.*
"""
# ╔═╡ b0291e05-776e-49ce-919f-4ad7de4070af
begin
function p_power(n, k)
p = (1:n) .^ -k
return p ./ sum(p)
end
if ps == "Equal"
p_vec = ones(n)./sum(ones(n));
elseif ps == "Unequal"
if distribution == "Bell curve"
ratio = parse(Float64, pmaxpmin_string)
ab1 = 1
ab2 = ratio*ab1
μ = (ab1+ab2)/2
σ = (ab2-ab1)/6
#create fixed distribution of abundances according to percentiles of bell curve
n_perc_1 = Int(floor(n*0.34));
n_perc_2 = Int(floor(n*0.135));
n_perc_3 = Int(floor(n*0.0215));
#n_perc_4 = Int(floor(n*0.0013));
n_perc_rest = n - 2*n_perc_1 - 2*n_perc_2 - 2*n_perc_3 ;
p_vec_unnorm = vcat(fill(μ,2*n_perc_1+n_perc_rest), fill(μ+1.5*σ, n_perc_2), fill(μ-1.5*σ, n_perc_2), fill(μ+3*σ, n_perc_3), fill(μ-3*σ, n_perc_3) )
# normalize sum to 1
p_vec = sort(p_vec_unnorm ./ sum(p_vec_unnorm))
end
if distribution == "Custom vector"
p_vec_unnorm = abundances
p_vec = abundances ./ sum(abundances)
end
if distribution == "Zipf's law"
ratio = parse(Float64, pmaxpmin_string)
p_vec = p_power(n, log(ratio)/log(n))
p_vec = p_vec ./ sum(p_vec)
end
end
if show_modprobs == "🔻 SHOW "
scatter(p_vec, title = "Probability mass function", ylabel = "module probability pⱼ", xlabel = "module j", label="", size = (700, 400))
ylims!((0,2*maximum(p_vec)), titlefont=font(10), xguidefont=font(9), yguidefont=font(9))
end
end
# ╔═╡ 87c3f5cd-79bf-4ad8-b7f8-3e98ec548a9f
begin
if show_modprobs == "🔻 SHOW " && distribution == "Bell curve"
histogram(p_vec, normalize=:probability, bar_edges=false, size = (550, 320), orientation=:v, bins=[(μ - 3*σ)/sum(p_vec_unnorm), (μ - 2*σ)/sum(p_vec_unnorm), (μ-σ)/sum(p_vec_unnorm), (μ + σ)/sum(p_vec_unnorm), (μ + 2*σ)/sum(p_vec_unnorm), (μ + 3.2*σ)/sum(p_vec_unnorm)], titlefont=font(10), xguidefont=font(9), yguidefont=font(9), label="")
# if distribution == "Normally distributed"
# plot!(x->pdf(Normal(μ, σ), x), xlim=xlims())
# xlabel!("Abundance"); ylabel!("probability"); title!("Distribution of module abundances")
# end
xlabel!("Probability"); ylabel!("Relative frequency"); title!("Distribution of module probabilities")
end
end
# ╔═╡ 2313198e-3ac9-407b-b0d6-b79e02cefe35
begin
if show_modprobs == "🔻 SHOW " && distribution == "Bell curve"
md"""For $n_string modules of which the probabilities form a bell curve with ratio pₘₐₓ/pₘᵢₙ = $pmaxpmin_string , we follow the percentiles of a normal distribution to generate the probability vector.
We consider μ to be the mean module probability and σ to be the standard deviation of the module probabilities.
According to the percentiles
- 68% of the module probabilities lies in the interval [μ - σ, μ + σ],
- 95% of falls into the range [μ - 2σ, μ + 2σ] and
- 99.7% lies in [μ - 3σ, μ +3σ].
We use the ratio pₘₐₓ/pₘᵢₙ to fix the width of the interval [μ - 3σ, μ +3σ]. (We assume that pₘₐₓ = μ +3σ and pₘᵢₙ = μ - 3σ and calculate μ and σ from this assumption). In addition, we make sure the sum of the probability vector sums up to 1.
As a result, we get:
- $(n_perc_1+n_perc_rest) modules with a probability of $(µ/sum(p_vec_unnorm))
- $(n_perc_2) modules with a probability of $((μ+1.5*σ)/sum(p_vec_unnorm))
- $(n_perc_2) modules with a probability of $((μ-1.5*σ)/sum(p_vec_unnorm))
- $(n_perc_3) modules with a probability of $((μ+2.5*σ)/sum(p_vec_unnorm))
- $(n_perc_3) modules with a probability of $((μ-2.5*σ)/sum(p_vec_unnorm))"""
end
end
# ╔═╡ f098570d-799b-47e2-b692-476a4d95825b
if show_modprobs == "🔻 SHOW "
md"Each biological design in the design space is built by choosing $r module(s) (with replacement) out of a set of $n_string modules according to the module probabilities visualized above."
end
# ╔═╡ 85bfc3d5-447d-4078-af14-e3f369adfa71
# ╔═╡ caf67b2f-cc2f-4d0d-b619-6e1969fabc1a
md""" **💻 Expected minimum sample size** $(@bind show_E Select(["🔻 SHOW ", "🔺 HIDE "], default="🔺 SHOW "))
\
*The expected minimum number of designs to observe each module at least $m time(s) in the sampled set of designs.* """
# ╔═╡ 6f14a72c-51d3-4759-bb8b-10db1dc260f0
begin
if show_E == "🔻 SHOW "
E = Int(ceil(expectation_minsamplesize(n; p = p_vec, m=m, r = r)))
sd = Int(ceil(std_minsamplesize(n; p = p_vec, m=m, r = r)))
md"""
`Expected minimum sample size ` = **$E designs**\
`Standard deviation ` = **$sd designs** """
end
end
# ╔═╡ f1e180e5-82a7-4fab-b894-75be4627af5d
# ╔═╡ 22fe8006-0e81-4e0a-a460-28610a55cd97
md""" **💻 Success probability** $(@bind show_success Select(["🔻 SHOW ", "🔺 HIDE "], default="🔻 SHOW ") )\
*The probability that the minimum number of designs T is smaller than or equal to a given sample size t.* """
# ╔═╡ db4371e4-7f86-4db3-b076-12f6cd220b89
begin
if show_success == "🔻 SHOW "
sample_size_95 = 1
while 0.95 - success_probability(n, sample_size_95; p = p_vec,
r = r, m = m) > 0.00005
global sample_size_95 += Int(ceil(n/10))
end
md""" 👉 Enter your sample size of interest: $(@bind sample_size_1_string TextField(default=string(sample_size_95)))"""
end
#genereer tabel + download knop
end
# ╔═╡ 317995ed-bdf4-4f78-bd66-a39ffd1dc452
begin
if show_success == "🔻 SHOW "
sample_size_1 = parse(Int64, sample_size_1_string);
p_success = Float64(success_probability(n, sample_size_1; p = p_vec, m = m, r = r))
md"""
↳ `Success probability F(t)` = **$p_success**\
"""
end
end
# ╔═╡ 3039ac2b-656e-4c2b-9036-cb1d9cdc0790
# ╔═╡ ca5a4cef-df67-4a5e-8a86-75a9fe8c6f37
if show_success == "🔻 SHOW "
md"*A curve describing the success probability in function of sample size.*"
end
# ╔═╡ 9616af0e-810c-4e6a-bc67-cb70e5e620f5
# ╔═╡ 24f7aae7-d37a-4db5-ace0-c910b178da88
begin
if show_success == "🔻 SHOW "
sample_size_initial = 5
while (1 - success_probability(n, sample_size_initial; p = p_vec, r = r, m = m)) > 0.0005
global sample_size_initial += Int(ceil(n/10))
end
sample_sizes = Int.(ceil.(0:n/10:sample_size_initial))
successes = success_probability.(n, sample_sizes; p = p_vec, r = r, m = m)
plot(sample_sizes, successes, title = "Success probability in function of sample size",
xlabel = "sample size s",
ylabel="P(minimum sample size <= s)", label = "", legend=:bottomright, size=(600,400), seriestype=:scatter, titlefont=font(10),xguidefont=font(9), yguidefont=font(9))
end
end
# ╔═╡ 4902d817-3967-45cd-a283-b2872cf1b49c
if show_success == "🔻 SHOW "
DownloadButton(string("sample_size,", tocsv(sample_sizes), "\n", "success_probability,", tocsv(successes)), "successprobability_$date.csv")
end
# ╔═╡ 37f951ee-885c-4bbe-a05f-7c5e48ff4b6b
begin
#following one-sided version of Chebyshev's inequality.
function chebyshev_onesided_larger(X, μ, σ)
X_μ = X - μ
return σ^2 / (σ^2 + X_μ^2)
end
function chebyshev_onesided_smaller(X, μ, σ)
X_μ = μ - X
return σ^2 / (σ^2 + X_μ^2)
end
if show_success == "🔻 SHOW "
if sample_size_1 < E
compare = "smaller"
if sample_size_1 <= n/r
print_sentence = "P(minimum sample size ≤ $sample_size_1) = 0."
else
prob_chebyshev = chebyshev_onesided_smaller(sample_size_1, E, sd)
print_sentence = "P(minimum sample size ≤ $sample_size_1) ≤ $prob_chebyshev. "
end
elseif sample_size_1 > E
compare = "greater"
prob_chebyshev = chebyshev_onesided_larger(sample_size_1, E, sd)
print_sentence = "P(minimum sample size ≥ $sample_size_1) ≤ $prob_chebyshev. "
elseif sample_size_1==E
print_sentence = "P(minimum sample size ≤ $sample_size_1 OR minimum sample size ≥ $sample_size_1) ≤ 1."
end
md"""*Upper bound on probability that minimum sample size is smaller than given sample size t, according to Chebychev's inequality.*:
$print_sentence"""
end
end
# ╔═╡ 702b158b-4f1c-453f-9e70-c00ec22226c3
# ╔═╡ dc696281-7a5b-4568-a4c2-8dde90af43f0
md""" **💻 Expected observed fraction of the total number of modules** $(@bind show_satur Select(["🔻 SHOW ", "🔺 HIDE "], default="🔺 HIDE "))\
*The fraction of the total number of available modules that is expected to be observed after collecting a given number of designs.*"""
# ╔═╡ eb92ff7c-0140-468c-8b32-f15d1cf15913
if show_satur == "🔻 SHOW "
md"""
👉 Enter your sample size of interest: $(@bind sample_size_2_string TextField(default="50")) """
end
# ╔═╡ f0eaf96b-0bc0-4194-9a36-886cb1d66e00
begin
if show_satur == "🔻 SHOW "
sample_size_2 = Int(ceil(parse(Int64, sample_size_2_string)))
E_fraction = expectation_fraction_collected(n, sample_size_2; p = p_vec, r = r)
md""" ↳ `Expected fraction observed` = **$E_fraction**
"""
end
end
# ╔═╡ 8ce0d3d7-8081-4d08-9189-595e3dc1814f
# ╔═╡ 0099145a-5460-4549-9513-054bc1b04eea
if show_satur == "🔻 SHOW "
md""" *A curve describing the expected fraction of modules observed in function of sample size.* """
end
# ╔═╡ 7968de5e-5ae8-4ab4-b089-c3d33475af2f
begin
if show_satur == "🔻 SHOW "
global sample_size_initial_frac = 5
while (1 - expectation_fraction_collected(n, sample_size_initial_frac; p = p_vec, r = r)) > 0.0005
global sample_size_initial_frac += Int(ceil(n/10))
end
sample_sizes_frac = Int.(ceil.(collect(0 : n/10 : sample_size_initial_frac)))
fracs = expectation_fraction_collected.(n, sample_sizes_frac; p = p_vec, r = r)
plot(sample_sizes_frac, fracs, title = "Expected observed fraction of the total number of modules",
xlabel = "sample size", seriestype=:scatter,
ylabel= "Expected observed fraction", label = "", size=(700,400), xguidefont=font(9), yguidefont=font(9), titlefont=font(10))
end
end
# ╔═╡ 0b95ccff-4c7b-400d-be61-8ea056ccc87f
if show_satur == "🔻 SHOW "
DownloadButton(string("sample_size,", tocsv(sample_sizes_frac), "\n", "expected_observed_fraction,", tocsv(fracs)), "expectedobservedfraction_$date.csv")
end
# ╔═╡ 09fb9f1d-16e4-447c-a5c0-d153cec22665
# ╔═╡ f92a6b6e-a556-45cb-a1ae-9f5fe791ffd2
md""" **💻 Occurrence of a specific module** $(@bind show_occ Select(["🔻 SHOW ", "🔺 HIDE "], default="🔺 HIDE "))\
*How many times one can expect to have collected a specific module in a sample of a given size.*"""
# ╔═╡ ec2a065f-0dc7-44d4-a18b-6c6a228b3ffc
if show_occ == "🔻 SHOW " && distribution != "Zipf's law"
md""" 👉 Enter the probability of the module of interest: $(@bind p_string TextField(default="0.005"))\
"""
end
# ╔═╡ 0e39a993-bb2f-4897-bfe2-5128ec62bef9
if show_occ == "🔻 SHOW " && distribution == "Zipf's law"
md""" 👉 Enter the rank of the module of interest: $(@bind rank_string TextField(default="5"))\
"""
end
# ╔═╡ f3329934-d69b-48a0-9cf1-e9a5920cf414
if show_occ == "🔻 SHOW "
md""" 👉 Enter the sample size of interest: $(@bind sample_size_3_string TextField(default="500"))"""
end
# ╔═╡ a041652b-365e-4594-9c48-c63d547b3295
# ╔═╡ 6acb0a97-6469-499f-a5cf-6335d6aa909a
begin
if show_occ == "🔻 SHOW "
sample_size_3 = parse(Int64, sample_size_3_string)
if distribution != "Zipf's law"
pᵢ = parse(Float64, p_string)
ed = Int(floor(sample_size_3*pᵢ*r))
j = collect(0:1:3*ed)
x = prob_occurrence_module.(pᵢ, sample_size_3, r, j)
plot(j,x, seriestype=[:scatter, :line], xlabel="occurrences in sample",
ylabel="probability",
title="Probability on number of occurrences for specific module
(for sample size = $sample_size_3)",
size=((600,300)), label="",titlefont=font(10),
xguidefont=font(9), yguidefont=font(9))
else
rank = parse(Int64, rank_string)
pᵢ = p_vec[rank]
ed = Int(floor(sample_size_3*pᵢ*r))
j = collect(0:1:3*ed)
x = prob_occurrence_module.(pᵢ, sample_size_3, r, j)
plot(j,x, seriestype=[:scatter, :line], xlabel="occurrences in sample",
ylabel="probabilityS",
title="Probability on number of occurrences for specific module
(for sample size = $sample_size_3)",
size=((600,300)), label="",titlefont=font(10),
xguidefont=font(9), yguidefont=font(9))
end
end
end
# ╔═╡ 595423df-728b-43b1-ade4-176785c54be3
begin
if show_occ == "🔻 SHOW "
md""" ↳ `Expected number of times observed` ≈ **$ed**
"""
end
end
# ╔═╡ a2bf1368-20a9-42cd-af58-67397644d725
if show_occ == "🔻 SHOW "
DownloadButton(string("number_of_occurence,", tocsv(j), "\n", "probability,", tocsv(x)), "occurrencemodule_$date.csv")
end
# ╔═╡ fbffaab6-3154-49df-a226-d5810d0b7c38
md"""## References"""
# ╔═╡ 1f48143a-2152-4bb9-a765-a25e70c281a3
md"""[^1]: Doumas, A. V., & Papanicolaou, V. G. (2016). *The coupon collector’s problem revisited: generalizing the double Dixie cup problem of Newman and Shepp.* ESAIM: Probability and Statistics, 20, 367-399.
[^2]: Boneh, A., & Hofri, M. (1997). *The coupon-collector problem revisited—a survey of engineering problems and computational methods.* Stochastic Models, 13(1), 39-66.
"""
# ╔═╡ 00000000-0000-0000-0000-000000000001
PLUTO_PROJECT_TOML_CONTENTS = """
[deps]
BioCCP = "79e6b149-e254-49fe-a721-3c4960de1574"
Plots = "91a5bcdd-55d7-5caf-9e0b-520d859cae80"
PlutoUI = "7f904dfe-b85e-4ff6-b463-dae2292396a8"
[compat]
BioCCP = "~0.1.1"
Plots = "~1.22.4"
PlutoUI = "~0.7.16"
"""
# ╔═╡ 00000000-0000-0000-0000-000000000002
PLUTO_MANIFEST_TOML_CONTENTS = """
# This file is machine-generated - editing it directly is not advised
[[Adapt]]
deps = ["LinearAlgebra"]
git-tree-sha1 = "84918055d15b3114ede17ac6a7182f68870c16f7"
uuid = "79e6a3ab-5dfb-504d-930d-738a2a938a0e"
version = "3.3.1"
[[ArgTools]]
git-tree-sha1 = "bdf73eec6a88885256f282d48eafcad25d7de494"
uuid = "0dad84c5-d112-42e6-8d28-ef12dabb789f"
version = "1.1.1"
[[Artifacts]]
deps = ["Pkg"]
git-tree-sha1 = "c30985d8821e0cd73870b17b0ed0ce6dc44cb744"
uuid = "56f22d72-fd6d-98f1-02f0-08ddc0907c33"
version = "1.3.0"
[[Base64]]
uuid = "2a0f44e3-6c83-55bd-87e4-b1978d98bd5f"
[[BioCCP]]
deps = ["Distributions"]
git-tree-sha1 = "4293935cfb1576a783192e81d965addff4d1b47a"
uuid = "79e6b149-e254-49fe-a721-3c4960de1574"
version = "0.1.1"
[[Bzip2_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "c3598e525718abcc440f69cc6d5f60dda0a1b61e"
uuid = "6e34b625-4abd-537c-b88f-471c36dfa7a0"
version = "1.0.6+5"
[[Cairo_jll]]
deps = ["Artifacts", "Bzip2_jll", "Fontconfig_jll", "FreeType2_jll", "Glib_jll", "JLLWrappers", "LZO_jll", "Libdl", "Pixman_jll", "Pkg", "Xorg_libXext_jll", "Xorg_libXrender_jll", "Zlib_jll", "libpng_jll"]
git-tree-sha1 = "e2f47f6d8337369411569fd45ae5753ca10394c6"
uuid = "83423d85-b0ee-5818-9007-b63ccbeb887a"
version = "1.16.0+6"
[[ChainRulesCore]]
deps = ["Compat", "LinearAlgebra", "SparseArrays"]
git-tree-sha1 = "a325370b9dd0e6bf5656a6f1a7ae80755f8ccc46"
uuid = "d360d2e6-b24c-11e9-a2a3-2a2ae2dbcce4"
version = "1.7.2"
[[ColorSchemes]]
deps = ["ColorTypes", "Colors", "FixedPointNumbers", "Random"]
git-tree-sha1 = "a851fec56cb73cfdf43762999ec72eff5b86882a"
uuid = "35d6a980-a343-548e-a6ea-1d62b119f2f4"
version = "3.15.0"
[[ColorTypes]]
deps = ["FixedPointNumbers", "Random"]
git-tree-sha1 = "024fe24d83e4a5bf5fc80501a314ce0d1aa35597"
uuid = "3da002f7-5984-5a60-b8a6-cbb66c0b333f"
version = "0.11.0"
[[Colors]]
deps = ["ColorTypes", "FixedPointNumbers", "Reexport"]
git-tree-sha1 = "417b0ed7b8b838aa6ca0a87aadf1bb9eb111ce40"
uuid = "5ae59095-9a9b-59fe-a467-6f913c188581"
version = "0.12.8"
[[Compat]]
deps = ["Base64", "Dates", "DelimitedFiles", "Distributed", "InteractiveUtils", "LibGit2", "Libdl", "LinearAlgebra", "Markdown", "Mmap", "Pkg", "Printf", "REPL", "Random", "SHA", "Serialization", "SharedArrays", "Sockets", "SparseArrays", "Statistics", "Test", "UUIDs", "Unicode"]
git-tree-sha1 = "31d0151f5716b655421d9d75b7fa74cc4e744df2"
uuid = "34da2185-b29b-5c13-b0c7-acf172513d20"
version = "3.39.0"
[[CompilerSupportLibraries_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "8e695f735fca77e9708e795eda62afdb869cbb70"
uuid = "e66e0078-7015-5450-92f7-15fbd957f2ae"
version = "0.3.4+0"
[[Contour]]
deps = ["StaticArrays"]
git-tree-sha1 = "9f02045d934dc030edad45944ea80dbd1f0ebea7"
uuid = "d38c429a-6771-53c6-b99e-75d170b6e991"
version = "0.5.7"
[[DataAPI]]
git-tree-sha1 = "cc70b17275652eb47bc9e5f81635981f13cea5c8"
uuid = "9a962f9c-6df0-11e9-0e5d-c546b8b5ee8a"
version = "1.9.0"
[[DataStructures]]
deps = ["Compat", "InteractiveUtils", "OrderedCollections"]
git-tree-sha1 = "7d9d316f04214f7efdbb6398d545446e246eff02"
uuid = "864edb3b-99cc-5e75-8d2d-829cb0a9cfe8"
version = "0.18.10"
[[DataValueInterfaces]]
git-tree-sha1 = "bfc1187b79289637fa0ef6d4436ebdfe6905cbd6"
uuid = "e2d170a0-9d28-54be-80f0-106bbe20a464"
version = "1.0.0"
[[Dates]]
deps = ["Printf"]
uuid = "ade2ca70-3891-5945-98fb-dc099432e06a"
[[DelimitedFiles]]
deps = ["Mmap"]
uuid = "8bb1440f-4735-579b-a4ab-409b98df4dab"
[[Distributed]]
deps = ["Random", "Serialization", "Sockets"]
uuid = "8ba89e20-285c-5b6f-9357-94700520ee1b"
[[Distributions]]
deps = ["ChainRulesCore", "FillArrays", "LinearAlgebra", "PDMats", "Printf", "QuadGK", "Random", "SparseArrays", "SpecialFunctions", "Statistics", "StatsBase", "StatsFuns"]
git-tree-sha1 = "e13d3977b559f013b3729a029119162f84e93f5b"
uuid = "31c24e10-a181-5473-b8eb-7969acd0382f"
version = "0.25.19"
[[DocStringExtensions]]
deps = ["LibGit2"]
git-tree-sha1 = "a32185f5428d3986f47c2ab78b1f216d5e6cc96f"
uuid = "ffbed154-4ef7-542d-bbb7-c09d3a79fcae"
version = "0.8.5"
[[Downloads]]
deps = ["ArgTools", "LibCURL", "NetworkOptions"]
git-tree-sha1 = "135bf1896be424235eadb17474b2a78331567f08"
uuid = "f43a241f-c20a-4ad4-852c-f6b1247861c6"
version = "1.5.1"
[[EarCut_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "92d8f9f208637e8d2d28c664051a00569c01493d"
uuid = "5ae413db-bbd1-5e63-b57d-d24a61df00f5"
version = "2.1.5+1"
[[Expat_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "1402e52fcda25064f51c77a9655ce8680b76acf0"
uuid = "2e619515-83b5-522b-bb60-26c02a35a201"
version = "2.2.7+6"
[[FFMPEG]]
deps = ["FFMPEG_jll"]
git-tree-sha1 = "b57e3acbe22f8484b4b5ff66a7499717fe1a9cc8"
uuid = "c87230d0-a227-11e9-1b43-d7ebe4e7570a"
version = "0.4.1"
[[FFMPEG_jll]]
deps = ["Artifacts", "Bzip2_jll", "FreeType2_jll", "FriBidi_jll", "JLLWrappers", "LAME_jll", "LibVPX_jll", "Libdl", "Ogg_jll", "OpenSSL_jll", "Opus_jll", "Pkg", "Zlib_jll", "libass_jll", "libfdk_aac_jll", "libvorbis_jll", "x264_jll", "x265_jll"]
git-tree-sha1 = "3cc57ad0a213808473eafef4845a74766242e05f"
uuid = "b22a6f82-2f65-5046-a5b2-351ab43fb4e5"
version = "4.3.1+4"
[[FillArrays]]
deps = ["LinearAlgebra", "Random", "SparseArrays", "Statistics"]
git-tree-sha1 = "8756f9935b7ccc9064c6eef0bff0ad643df733a3"
uuid = "1a297f60-69ca-5386-bcde-b61e274b549b"
version = "0.12.7"
[[FixedPointNumbers]]
deps = ["Statistics"]
git-tree-sha1 = "335bfdceacc84c5cdf16aadc768aa5ddfc5383cc"
uuid = "53c48c17-4a7d-5ca2-90c5-79b7896eea93"
version = "0.8.4"
[[Fontconfig_jll]]
deps = ["Artifacts", "Bzip2_jll", "Expat_jll", "FreeType2_jll", "JLLWrappers", "Libdl", "Libuuid_jll", "Pkg", "Zlib_jll"]
git-tree-sha1 = "35895cf184ceaab11fd778b4590144034a167a2f"
uuid = "a3f928ae-7b40-5064-980b-68af3947d34b"
version = "2.13.1+14"
[[Formatting]]
deps = ["Printf"]
git-tree-sha1 = "8339d61043228fdd3eb658d86c926cb282ae72a8"
uuid = "59287772-0a20-5a39-b81b-1366585eb4c0"
version = "0.4.2"
[[FreeType2_jll]]
deps = ["Artifacts", "Bzip2_jll", "JLLWrappers", "Libdl", "Pkg", "Zlib_jll"]
git-tree-sha1 = "cbd58c9deb1d304f5a245a0b7eb841a2560cfec6"
uuid = "d7e528f0-a631-5988-bf34-fe36492bcfd7"
version = "2.10.1+5"
[[FriBidi_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "0d20aed5b14dd4c9a2453c1b601d08e1149679cc"
uuid = "559328eb-81f9-559d-9380-de523a88c83c"
version = "1.0.5+6"
[[GLFW_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Libglvnd_jll", "Pkg", "Xorg_libXcursor_jll", "Xorg_libXi_jll", "Xorg_libXinerama_jll", "Xorg_libXrandr_jll"]
git-tree-sha1 = "a199aefead29c3c2638c3571a9993b564109d45a"
uuid = "0656b61e-2033-5cc2-a64a-77c0f6c09b89"
version = "3.3.4+0"
[[GR]]
deps = ["Base64", "DelimitedFiles", "GR_jll", "HTTP", "JSON", "Libdl", "LinearAlgebra", "Pkg", "Printf", "Random", "Serialization", "Sockets", "Test", "UUIDs"]
git-tree-sha1 = "c2178cfbc0a5a552e16d097fae508f2024de61a3"
uuid = "28b8d3ca-fb5f-59d9-8090-bfdbd6d07a71"
version = "0.59.0"
[[GR_jll]]
deps = ["Artifacts", "Bzip2_jll", "Cairo_jll", "FFMPEG_jll", "Fontconfig_jll", "GLFW_jll", "JLLWrappers", "JpegTurbo_jll", "Libdl", "Libtiff_jll", "Pixman_jll", "Pkg", "Qt5Base_jll", "Zlib_jll", "libpng_jll"]
git-tree-sha1 = "d59e8320c2747553788e4fc42231489cc602fa50"
uuid = "d2c73de3-f751-5644-a686-071e5b155ba9"
version = "0.58.1+0"
[[GeometryBasics]]
deps = ["EarCut_jll", "IterTools", "LinearAlgebra", "StaticArrays", "StructArrays", "Tables"]
git-tree-sha1 = "58bcdf5ebc057b085e58d95c138725628dd7453c"
uuid = "5c1252a2-5f33-56bf-86c9-59e7332b4326"
version = "0.4.1"
[[Gettext_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Libiconv_jll", "Pkg", "XML2_jll"]
git-tree-sha1 = "8c14294a079216000a0bdca5ec5a447f073ddc9d"
uuid = "78b55507-aeef-58d4-861c-77aaff3498b1"
version = "0.20.1+7"
[[Glib_jll]]
deps = ["Artifacts", "Gettext_jll", "JLLWrappers", "Libdl", "Libffi_jll", "Libiconv_jll", "Libmount_jll", "PCRE_jll", "Pkg", "Zlib_jll"]
git-tree-sha1 = "04690cc5008b38ecbdfede949220bc7d9ba26397"
uuid = "7746bdde-850d-59dc-9ae8-88ece973131d"
version = "2.59.0+4"
[[Grisu]]
git-tree-sha1 = "53bb909d1151e57e2484c3d1b53e19552b887fb2"
uuid = "42e2da0e-8278-4e71-bc24-59509adca0fe"
version = "1.0.2"
[[HTTP]]
deps = ["Base64", "Dates", "IniFile", "Logging", "MbedTLS", "NetworkOptions", "Sockets", "URIs"]
git-tree-sha1 = "14eece7a3308b4d8be910e265c724a6ba51a9798"
uuid = "cd3eb016-35fb-5094-929b-558a96fad6f3"
version = "0.9.16"
[[Hyperscript]]
deps = ["Test"]
git-tree-sha1 = "8d511d5b81240fc8e6802386302675bdf47737b9"
uuid = "47d2ed2b-36de-50cf-bf87-49c2cf4b8b91"
version = "0.0.4"
[[HypertextLiteral]]
git-tree-sha1 = "f6532909bf3d40b308a0f360b6a0e626c0e263a8"
uuid = "ac1192a8-f4b3-4bfe-ba22-af5b92cd3ab2"
version = "0.9.1"
[[IOCapture]]
deps = ["Logging", "Random"]
git-tree-sha1 = "f7be53659ab06ddc986428d3a9dcc95f6fa6705a"
uuid = "b5f81e59-6552-4d32-b1f0-c071b021bf89"
version = "0.2.2"
[[IniFile]]
deps = ["Test"]
git-tree-sha1 = "098e4d2c533924c921f9f9847274f2ad89e018b8"
uuid = "83e8ac13-25f8-5344-8a64-a9f2b223428f"
version = "0.5.0"
[[InteractiveUtils]]
deps = ["Markdown"]
uuid = "b77e0a4c-d291-57a0-90e8-8db25a27a240"
[[IrrationalConstants]]
git-tree-sha1 = "f76424439413893a832026ca355fe273e93bce94"
uuid = "92d709cd-6900-40b7-9082-c6be49f344b6"
version = "0.1.0"
[[IterTools]]
git-tree-sha1 = "05110a2ab1fc5f932622ffea2a003221f4782c18"
uuid = "c8e1da08-722c-5040-9ed9-7db0dc04731e"
version = "1.3.0"
[[IteratorInterfaceExtensions]]
git-tree-sha1 = "a3f24677c21f5bbe9d2a714f95dcd58337fb2856"
uuid = "82899510-4779-5014-852e-03e436cf321d"
version = "1.0.0"
[[JLLWrappers]]
deps = ["Preferences"]
git-tree-sha1 = "642a199af8b68253517b80bd3bfd17eb4e84df6e"
uuid = "692b3bcd-3c85-4b1f-b108-f13ce0eb3210"
version = "1.3.0"
[[JSON]]
deps = ["Dates", "Mmap", "Parsers", "Unicode"]
git-tree-sha1 = "8076680b162ada2a031f707ac7b4953e30667a37"
uuid = "682c06a0-de6a-54ab-a142-c8b1cf79cde6"
version = "0.21.2"
[[JpegTurbo_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "9aff0587d9603ea0de2c6f6300d9f9492bbefbd3"
uuid = "aacddb02-875f-59d6-b918-886e6ef4fbf8"
version = "2.0.1+3"
[[LAME_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "df381151e871f41ee86cee4f5f6fd598b8a68826"
uuid = "c1c5ebd0-6772-5130-a774-d5fcae4a789d"
version = "3.100.0+3"
[[LZO_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "f128cd6cd05ffd6d3df0523ed99b90ff6f9b349a"
uuid = "dd4b983a-f0e5-5f8d-a1b7-129d4a5fb1ac"
version = "2.10.0+3"
[[LaTeXStrings]]
git-tree-sha1 = "c7f1c695e06c01b95a67f0cd1d34994f3e7db104"
uuid = "b964fa9f-0449-5b57-a5c2-d3ea65f4040f"
version = "1.2.1"
[[Latexify]]
deps = ["Formatting", "InteractiveUtils", "LaTeXStrings", "MacroTools", "Markdown", "Printf", "Requires"]
git-tree-sha1 = "a4b12a1bd2ebade87891ab7e36fdbce582301a92"
uuid = "23fbe1c1-3f47-55db-b15f-69d7ec21a316"
version = "0.15.6"
[[LibCURL]]
deps = ["LibCURL_jll", "MozillaCACerts_jll"]
git-tree-sha1 = "cdbe7465ab7b52358804713a53c7fe1dac3f8a3f"
uuid = "b27032c2-a3e7-50c8-80cd-2d36dbcbfd21"
version = "0.6.3"
[[LibCURL_jll]]
deps = ["LibSSH2_jll", "Libdl", "MbedTLS_jll", "Pkg", "Zlib_jll", "nghttp2_jll"]
git-tree-sha1 = "897d962c20031e6012bba7b3dcb7a667170dad17"
uuid = "deac9b47-8bc7-5906-a0fe-35ac56dc84c0"
version = "7.70.0+2"
[[LibGit2]]
deps = ["Printf"]
uuid = "76f85450-5226-5b5a-8eaa-529ad045b433"
[[LibSSH2_jll]]
deps = ["Libdl", "MbedTLS_jll", "Pkg"]
git-tree-sha1 = "717705533148132e5466f2924b9a3657b16158e8"
uuid = "29816b5a-b9ab-546f-933c-edad1886dfa8"
version = "1.9.0+3"
[[LibVPX_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "85fcc80c3052be96619affa2fe2e6d2da3908e11"
uuid = "dd192d2f-8180-539f-9fb4-cc70b1dcf69a"
version = "1.9.0+1"
[[Libdl]]
uuid = "8f399da3-3557-5675-b5ff-fb832c97cbdb"
[[Libffi_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "a2cd088a88c0d37eef7d209fd3d8712febce0d90"
uuid = "e9f186c6-92d2-5b65-8a66-fee21dc1b490"
version = "3.2.1+4"
[[Libgcrypt_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Libgpg_error_jll", "Pkg"]
git-tree-sha1 = "b391a18ab1170a2e568f9fb8d83bc7c780cb9999"
uuid = "d4300ac3-e22c-5743-9152-c294e39db1e4"
version = "1.8.5+4"
[[Libglvnd_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg", "Xorg_libX11_jll", "Xorg_libXext_jll"]
git-tree-sha1 = "7739f837d6447403596a75d19ed01fd08d6f56bf"
uuid = "7e76a0d4-f3c7-5321-8279-8d96eeed0f29"
version = "1.3.0+3"
[[Libgpg_error_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "ec7f2e8ad5c9fa99fc773376cdbc86d9a5a23cb7"
uuid = "7add5ba3-2f88-524e-9cd5-f83b8a55f7b8"
version = "1.36.0+3"
[[Libiconv_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "cba7b560fcc00f8cd770fa85a498cbc1d63ff618"
uuid = "94ce4f54-9a6c-5748-9c1c-f9c7231a4531"
version = "1.16.0+8"
[[Libmount_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "51ad0c01c94c1ce48d5cad629425035ad030bfd5"
uuid = "4b2f31a3-9ecc-558c-b454-b3730dcb73e9"
version = "2.34.0+3"
[[Libtiff_jll]]
deps = ["Artifacts", "JLLWrappers", "JpegTurbo_jll", "Libdl", "Pkg", "Zlib_jll", "Zstd_jll"]
git-tree-sha1 = "291dd857901f94d683973cdf679984cdf73b56d0"
uuid = "89763e89-9b03-5906-acba-b20f662cd828"
version = "4.1.0+2"
[[Libuuid_jll]]
deps = ["Artifacts", "JLLWrappers", "Libdl", "Pkg"]
git-tree-sha1 = "f879ae9edbaa2c74c922e8b85bb83cc84ea1450b"
uuid = "38a345b3-de98-5d2b-a5d3-14cd9215e700"
version = "2.34.0+7"
[[LinearAlgebra]]
deps = ["Libdl"]
uuid = "37e2e46d-f89d-539d-b4ee-838fcccc9c8e"
[[LogExpFunctions]]
deps = ["ChainRulesCore", "DocStringExtensions", "IrrationalConstants", "LinearAlgebra"]
git-tree-sha1 = "34dc30f868e368f8a17b728a1238f3fcda43931a"
uuid = "2ab3a3ac-af41-5b50-aa03-7779005ae688"
version = "0.3.3"
[[Logging]]
uuid = "56ddb016-857b-54e1-b83d-db4d58db5568"