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<section id="main" class="wrapper">
<div class="container">
<header class="major special">
<h2>The goals</h2>
</header>
<div class="-2u 6u">
<span class="image fit"><img src="images/team/worldLamps.png" alt="" /></span>
</div>
<section>
<div class="box alt">
<div class="row 100% uniform">
<div class="-2u 6u">
<h3>The challenges</h3>
<p>Performing Metabolomics in Latin America, and research in general, comes with some additional challenges for researchers and lab managers:
</p>
<h4>CHALLENGE 1) INSTRUMENT CHOICE (ROBUSTNESS OF INSTRUMENTATION TO LESS CONTROLLED CONDITIONS)</h4>
<p>Latin America isn't producing research equipment thus instrumentation has to be imported. Although Latin America is a growing research market, it is still very small when compared to the big nations of research, meaning that only a few companies/vendors have their own teams in Latin America, but not in all countries.
</p>
<h4>CHALLENGE 2) ACCOMMODATING VARIABILITY IN PHYSICAL AND FINANCIAL CLIMATES</h4>
<p>
Research is still underrated in almost all Latin American countries, as well as their budgets dedicated to science and innovation. This systematic underfunding impacts negatively on the sciences policies, mainly resulting in a lack of stable priorities and long-term investment strategies. This is a major obstacle to building a robust research infrastructure in our region.
</p>
<h4>CHALLENGE 3) RESTRICTED MATERIALS AND SUPPLIES</h4>
In the same vein, little has been done by weak or inexistent Ministries of Science to improve the importation process of research equipment. As a result, the purchase of research gears is more expensive and takes more time than it should. Typically, both importation and nationalization processes increase the price by at least 30% up to 200%, and a simple replacement or maintenance kit may take 3 to 6 months to be purchased.
<p>
</p>
<h4>CHALLENGE 4) OPEN SOURCE SOFTWARE AND DATA REPOSITORIES</h4>
<p>
The access to resources behind paywall is a major obstacle for underfunded researchers. This includes research papers, dataset or any database or software that is under a commercial license. Interestingly, Latin America is not a leading actor in open science and open data movements. On the contrary, the systematically underfunded Ministries of Science stays way behind their counterparts when it comes to negotiating national agreements or to draft new open policies that would ultimately benefit their researchers.
</p>
<h4>CHALLENGE 5) CORPORATE RECOGNITION OF THE BENEFITS OF SUPPORTING RESOURCE-LIMITED LABORATORIES AND INSTITUTIONS</h4>
<p>
The Latin American research market is not attractive enough for vendors and manufacturers to offer competitive support according to the different requirements, such as delayed payments schemes, corporate discounts and maintenance strategies that would effectively compensate for the lack of coherent national policies.
</p>
<h4>CHALLENGE 6) TRANSFER OF TECHNOLOGY AND EXPERTISE</h4>
<p>
The high upfront cost of setting up a metabolomic profiling infrastructure led to the concentration of equipment and skilled researchers in a handful of international hubs. These hubs are attractive for new talented researchers allowing for sustainable formation programs, i.e., a balanced inbound and outbound flow of researchers whose contributions outweigh the efforts required to train them. Conversely, Latin American "hubs" send their researchers abroad for training and then are struggling to match operative conditions in the lab. While this leads to a constant transfer of skills, which is positive, it also increases the pressure to match the experimental conditions, and leaves no possibility to build a national critical mass. Altogether this adds to the costs of running a facility in Latin America.
</p>
<h3>The goals</h3>
<p>
The LAMPS seeks to find sustainable solutions to grow a robust and stable capacity for metabolomics in Latin America, that includes joint-training camp, continent-wide collaborative projects, sharing experiences and practices relevant to Latin America, unified participation in international networking activities, among other things.
</p>
</div>
</div>
</div>
</section>
<!--
<section>
<header class="major special">
<h2>School Program</h2>
<p>
<a href="#monday">Monday May 21</a>|
<a href="#tuesday">Tuesday May 22</a>
</p>
</header>
</section>
-->
</div>
</section>
<section >
<div class="container">
<header class="major special">
<h2>The team</h2>
</header>
</div>
<div class="container">
<section>
<div class="box alt">
<div class="row 50% uniform">
<div class="8u">
<span class="image left"><img src="images/team/Maria Eugenia Monge.jpg" alt="" /></span>
<header>
<h3>Maria Eugenia Monge</h3>
<b><bold><a href="https://orcid.org/0000-0001-6517-5301">ORCID</a></bold></b>
<h4>The research</h4>
Dr. María Eugenia Monge is an Independent Researcher of CONICET, the National Scientific and Technical Research Council of Argentina. In 2006, she obtained her Ph.D. in Inorganic, Analytical, and Physical Chemistry from the University of Buenos Aires, Argentina. In 2007, she conducted a postdoctoral stance in the research group of Pier Luigi San Biagio at the Biophysical Institute of Palermo-CNR, Italy, to analyze gas-phase fingerprints obtained with electronic noses comprised of semiconductor-based chemical sensors using chemometric tools and GC-MS. Between 2008 and 2011 she held a postdoctoral position in the research group of Christian George at IRCELYON-CNRS, France, to study photoinduced transformations of atmospheric aerosol particles and the effect of light in heterogeneous reactions between trace gases and different substrates. In 2012, she joined the group of Facundo Fernández as a research scientist at the Georgia Institute of Technology, USA to work in the field of mass spectrometry-based metabolomics for biomarker discovery, and in the development of quantitative methods for biological and pharmaceutical sample analysis. In 2014, she was recruited by CONICET to set-up a new laboratory at CIBION, a recently founded research center of CONICET, where she leads the Bioanalytical Mass Spectrometry (MS) <a href="https://cibion.conicet.gov.ar/mass-spectrometry/?lan=en">Group</a> and the MS facility. Her research group applies MS for biomarker discovery and early disease detection, with special emphasis on untargeted metabolomics-based diagnostics. The applications her group is currently working on include biomarker discovery studies for renal cell carcinoma and prostate cancer detection in collaboration with Argentine biobanking systems and hospitals. Her group is also involved in collaborative studies applying metabolomics workflows to address health-related scientific questions in the fields of cancer metabolism, molecular neurobiology, and dengue disease, using in vitro and in vivo models. As well, the Monge lab has participated in a H2020-MSCA-RISE network to investigate marine chemical environments with ambient MS-based untargeted metabolomics strategies. Her group is also developing free and open source tools for preprocessing LC-MS data for quality control procedures in untargeted metabolomics workflows. Since her return to Argentina, Dr. Monge has coordinated metabolomics courses in CIBION for South American students, and has participated in promoting awareness of metabolomics and its advantages throughout Argentina, Brazil, and Colombia with the hope of broadening and strengthening the South American metabolomics community. She was an invited speaker in the last two meetings of the Latin American Metabolic Profiling Society (LAMPS). Since 2019, she has been a member of the Metabolomics Society and the Metabolomics Quality Assurance and Quality Control Consortium (mQACC), where she participates on the Defining Best Practices working group; and she serves as a member of the Metabolomics Society Membership Committee. Dr. Monge also served as guest editor for the journal Metabolites; and she is an editorial board member of GigaByte.
</br></br>
</header>
<h4>The lab</h4>
<span class="image right"><img src="images/labs/cibion/cibion.png" alt="" /></span>
<p>
<ul>
<li>Direct Real Time Analysis ionization source (DART, Ionsense Inc.) coupled to the a Xevo G2-S QTof mass spectrometer (Waters Corp.)</li>
<li>ACQUITY UPLC I-Class system coupled to a Xevo G2-S QTof mass spectrometer (Waters Corp.)</li>
<li>ALLIANCE e2695 HPLC Separation Module coupled to 2998 Photodiode Array Detector and SQ D2, a bench-top quadrupole API mass spectrometer (Waters Corp.)
</li>
</ul>
</p>
<hr>
<span class="image left"><img src="images/speakers/pablo.hoijemberg.jpg" alt="" /></span>
<header>
<h3>Pablo hoijemberg</h3>
<b><bold><a href="https://orcid.org/0000-0002-4870-3309">ORCID</a></bold></b>
<h4>The research</h4>
Pablo Hoijemberg an Associate Researcher of CONICET, the National Scientific and Technical Research Council of Argentina. He leads the Bioanalytical NMR Group since 2015 at the "Centro de Investigaciones en Bionanociencias (CIBION-CONICET)", Center for Bionanosciences Research, in Buenos Aires, Argentina. He received his PhD in Chemistry from the Universidad de Buenos Aires (Buenos Aires, Argentina) in 2009, performing research in photochemistry. He remained in the field of photochemistry for about 4 years as a Postdoctoral Researcher at the Université de Haute Alsace in Mulhouse, France, and at Rutgers University, New Jersey, USA. Then, in August 2013 Pablo switched fields to Nuclear Magnetic Resonance (NMR) based Metabolomics, working as a Postdoctoral Researcher with Dr. István Pelczer, at the Department of Chemistry at Princeton University. He conducted research on NMR metabolomics on biological samples, as well as chemometric analyses on complex mixtures.
At CIBION Pablo is finishing the setup of the NMR laboratory, which will soon have a Bruker Avance NEO 500 MHz system installed, with a SmartProbe and Sample Case Cooled sampling system, to focus on metabolomics studies. The first projects involve studies on renal cell carcinoma and prostate cancer, in collaboration with local hospitals and a biobank, for potential biomarker discovery and early disease diagnostics. In addition, the system will have the first HR-MAS probe in Argentina, aiming at metabolomics studies on biopsy tissues in the near future. Together with Dr. María Eugenia Monge, his metabolomics partner at CIBION (specialized in mass spectrometry), he coordinated and taught hands-on metabolomics courses at CIBION for students from the region. Pablo was an invited speaker in the Latin American Metabolic Profiling Symposium held in Rosario in 2016, and was going to be an invited speaker for the 2020 meeting, postponed due to the pandemic.
During these past years the Bioanalytical NMR Group developed bioinformatics methodologies based on JRES spectra to improve speed and accuracy in metabolite identification, by surpassing the intrinsic “limitations” of statistical correlation (STOCSY) in 1D spectral sets, namely peak overlap, peak misalignment, low intensity signals and biological correlation. COCOA-POD deals mainly with peak overlap by performing the statistical correlation analysis on the 2D JRES matrix and projecting from the nontilted JRES-STOCSY spectrum to obtain 1D traces that can be peak picked for database queries, free of overlap from non-correlated peaks at the same f2 values. Then, the CSMDB with ConQuer ABC presents the first searchable database for multiplets with scoring, allowing for f1 trace comparison for multiplet matching and ambiguity detection, incorporating also consecutive queries to assess biologically correlated metabolites through the integration with the metabolite identification.
</br></br>
</header>
</div>
<div class="-2u 8u">
<span class="image right"><img src="images/team/Monica Cala_small.jpg" alt="" /></span>
<header>
<h3>Monica Cala</h3>
<h4>The research</h4>
Mónica Cala is currently the Head of Metabolomics Core Facility – MetCore at Universidad de los Andes in Bogotá, Colombia. She obtained her PhD in Chemical Sciences at Universidad de los Andes in 2017. She has extensive experience in Analytical Chemistry, particularly in separation techniques such as gas chromatography (GC), liquid chromatography (LC) and capillary electrophoresis (CE) coupled with high-resolution mass spectrometry. Since 2012, She has been working in the application of analytical tools in non-targeted metabolomics based on mass spectrometry, particularly in biomedical applications, performing non-targeted metabolomics multiplatform by GC-MS, LC-MS and CE-MS. At Metcore, she is currently leading research projects applying non-targeted and targeted metabolomics in different areas such as health, nutrition and agriculture.
</br></br>
</header>
<h4>The lab</h4>
<span class="image left"><img src="images/labs/metcore/metcore.png" alt="" /></span>
<p><bold>Contact: metcore_at_uniandes.edu.co</bold></p>
<p>
<a href="https://metcore.uniandes.edu.co/en/">MetCore</a> the first Metabolomics Core Facility in Colombia providing access to cutting-edge technology in MS-based metabolite analysis. Metcore offer active cooperation to conduct innovative and multidisciplinary research projects, as well as metabolomics services in health, agroindustrial, biotechnological and environmental sectors.
</p>
<hr>
</div>
<div class="8u">
<span class="image left"><img src="images/team/Julien Wist.jpg" alt="" /></span>
<header>
<h3>Julien Wist</h3>
<b><bold><a href="https://orcid.org/0000-0002-3416-2572">ORCID</a></bold></b>
<h4>The research</h4>
Our main research interest is to use NMR and cheminformatics to help unravel complex mixtures. Our tools are available at <a href="https://www.cheminfo.org">cheminfo.org</a> as demo. A repository for small molecules can be found at <a href="https://c6h6.org">c6h6.org</a>. All our developments are open source and can be found at <a href="http://github.com/cheminfo">github.com/cheminfo</a>. Have a look at <a href="https://nmrdb.org">nmrdb.org</a> and our new project <a href="https://nmrium.org">nmrium.org</a> for exercises and to <a href="https://nmredata.org">NMReData.org</a> for more information about NMReRecords. Aside from cheminformatics we also apply NMR to <a href="https://www.cheminfo.org/flavor/metabolomics/index">metabolomics</a> and have fun playing with diffusion experiment.
</br></br>
</header>
<h4>The lab</h4>
<span class="image right"><img src="images/labs/cibion.png" alt="" /></span>
<p><bold>Contact: https://sigelab.univalle.edu.co/ (buscar RMN)</bold></p>
<p>
The NMR LAb consists of a Bruker Avance II 400MHz Spectrometer with BCU and sampleXpress and several high performance workstations and servers for developing cheminformatics pipelines. Although we have access to a QTOF X500R QTOF, we are instead collaborating with Metcore Lab that is MS only to offer together a comprehensive metabolic profiling platform for all agroindustrial applications. For human health projects, our laboratory may count with an international collaboration (Australian National Phenome Center, Perth, Australia) for access to higher fields.
</p>
<hr>
</div>
<div class="-2u 8u">
<span class="image right"><img src="images/team/Martin Arán.jpg" alt="" /></span>
<header>
<h3>Martin Arán</h3>
<b><bold><a href="https://orcid.org/0000-0002-4004-6295?lang=en">ORCID</a></bold></b>
<h4>The research</h4>
Martin Arán, PhD
Director of NMR Facility at Fundación Instituto Leloir-IIBBA-CONICET (Buenos Aires, Argentina).
Our laboratory works collaboratively with groups from scientific centers and industries in Argentina. We participate in projects and provide services in NMR of proteins (dynamics, structure) and metabolomics. (https://www.inis-biotech.com.ar/es/STAN2616)
Our lab uses NMR to understand the structural basis of protein activity and the chemical basis of cell metabolism. Our primary organism is Bizionia argentinensis, a psicrotolerant bacterium isolated from the sea surface in Antarctica. We are interested in the structural and functional characterization of proteins, the search for new low-temperature active enzymes and the discovery of natural bioactive products produced by Bizionia argentinensis. The magnitude of the true chemical potential of marine bacteria is still far from being established and NMR represents a valuable tool to determine the identity and structure of these compounds. We also are very interested in other marine bacteria, including pathogenic species. Dr. Arán got his start in NMR as a postdoc working with Dr. Daniel Cicero (FIL-IIBBA, Buenos Aires and University Tor Vergata, Rome) and specialized in metabolomics with Dr. Arthur Edison (Southeast Center for Integrated Metabolomics, Florida).
</br></br>
</header>
<h4>The lab</h4>
<span class="image left"><img src="images/labs/LNMR.jpg" alt="" /></span>
<p><bold>Contact: maran_at_leloir.org.ar / <a href="https://www.inis-biotech.com.ar/es/STAN2616">https://www.inis-biotech.com.ar/es/STAN2616</a></bold></p>
<p>
600 MHz AV III NMR Spectrometer (Bruker), with Sample Case.
</p>
<hr>
</div>
<div class="8u">
<span class="image left"><img src="images/team/paula.burdisso2.jpg" alt="" /></span>
<header>
<h3>Paula Burdisso</h3>
<b><bold><a href="https://orcid.org/0000-0002-8845-1345">ORCID</a></bold></b>
<h4>The research</h4>
Paula Burdisso is a project manager of the metabolomics facility at the Argentine Platform of Structural Biology and Metabolomics (PlaBEM) at IBR-CONICET in Rosario, Argentina. She has a degree in Biotechnology and a PhD in Biological Sciences graduated from the National University of Rosario where she was trained in the field of structural biology. Later, she specialized in the study of metabolic profiles by Nuclear Magnetic Resonance and Multivariate Data Analysis at Imperial College London advised by Professor Elaine Holmes and Dr. Isabel García-Perez. In 2015, she set up the metabolomics lab at PlaBEM where she currently leads interdisciplinary and collaborative NMR metabolomics projects and provides services to several research groups and companies in Latin America.
</br></br>
</header>
<h4>The lab</h4>
<span class="image right"><img src="images/labs/plabem/plabem.png" alt="" /></span>
<p><bold>Contact: <a href="http://www.plabem.gob.ar/index.php">http://www.plabem.gob.ar/index.php</a></bold></p>
<p>
PlaBEM is a core facility focused on innovation providing high quality services in structural biology and NMR metabolomics to the research community and companies from the regional productive sector applied to different areas such as biotechnology, translational medicine and food quality control.
</p>
<p>
<ul>
<li>700 MHz , AVANCE III</li>
<li>600 MHz, AVANCE II</li>
</ul>
</p>
<hr>
</div>
<div class="-2u 8u">
<span class="image right"><img src="images/speakers/guillermo.moyna.jpg" alt="" /></span>
<header>
<h3>Guillermo Moyna</h3>
<b><bold><a href="https://orcid.org/0000-0002-0727-1079">ORCID</a></bold></b>
<h4>The research</h4>
Dr. Guillermo Moyna Borthagaray is a professor at the Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República (UdelaR), in Paysandú, Uruguay. He obtained his Ph.D. in Organic Chemistry form Texas A&M University under the direction of Prof. A. I. Scott (F.R.S.) in 1998. His graduate work dealt with the conformational analysis of biologically-active compounds using a combination of synthesis, NMR spectroscopy, and computational chemistry. Following a short postdoctoral stay in the group of Prof. Randy Zauhar at the University of the Sciences in Philadelphia (USciences), he joined the faculty of the same institution. During his tenure at USciences, Guillermo pursued several research endeavors in areas that ranged from synthetic and medicinal chemistry to NMR spectroscopy and material science. He also directed the institutional NMR facility, and helped establish the West Center for Computer Aided Drug Design and Discovery (WC2D3). As part of a university-wide decentralization project of the UdelaR, he returned to Uruguay in 2011 to head the Departamento de Química del Litoral (DQL) of the CENUR Litoral Norte. In addition to the research activities developed while at USciences, his group began to work on the application of NMR-based metabolomic analysis to a variety of problems of the health and agroindustrial sectors. These include the development of chemometric tools for the diagnosis of kidney disease, the monitoring of health markers in dairy cattle and other production animals, and the selection of pest-resistant cultivar varieties of barley and other crops. Throughout his career in Uruguay and abroad, Guillermo has participated in more than 20 funded research projects, mentored two postdoctoral, 13 graduate, and 28 undergraduate students, and authored 76 peer-reviewed publications and 7 book chapters.
<a href="https://exportcvuy.anii.org.uy/cv/?2cebe78e18fa760a7d79dd8a0021057dde02e9333677a6c5fcca4cd9f2ebc8ff20700be3044d46d4a23ffbe14bb8f73a516209099e443241db3b37bd796008fb">More information.</a>
</br></br>
</header>
<h4>The lab</h4>
<span class="image left"><img src="images/labs/paysandu/AVANCE-400-Paysandu.jpeg" alt="" /></span>
<p>
<ul>
<li>Three-channel Bruker AVANCE III 500 with 1H/13C/15N and 1H/13C/31P TXI probes.</li>
<li>Two-channel Bruker AVANCE III 400 with BBOF and 1H/13C SEI probes and SampleXpress 60.</li>
<li>Access to two-channel Bruker AVANCE NEO 400 with BBI probe.</li>
</ul>
</p>
<hr>
</div>
<div class="8u">
<span class="image left"><img src="images/speakers/ian.castro.jpg" alt="" /></span>
<header>
<h3>Ian Castro-Gamboa</h3>
<b><bold><a href="https://orcid.org/0000-0002-2353-0181">ORCID</a></bold></b>
<h4>The research</h4>
Dr. Ian Castro-Gamboa is a professor and researcher at São Paulo State University (UNESP). In 2000 he obtained his Ph.D in natural products chemistry at the Federal University of São Carlos (UFSCar), researching chemosystematics and secondary metabolite vertical transference from grafted trees of economic importance. From 2000 to 2002 he conducted a postdoctoral research at NuBBE (Nuclei of Bioassays, Biosynthesis and Natural Products Ecophysiology) researching electrochemical active molecules from crude extract using HPLC-EQD and creating a database aiming antioxidant metabolites from plants from the Brazilian Atlantic rainforest and Cerrado. In 2003 he joined the Institute of Chemistry faculty at IQ-UNESP, starting the qualitative analysis of a bank of extract from Brazilian plants using MS and NMR. He joined Art Edison’s research group at the University of Florida (UF) from 2009-2010, developing dereplications analysis of high complexity extracts using NMR. He has mentored 15 masters dissertations and 10 Ph.D thesis aiming metabolomics and the understanding the chemical composition from plants and microorganisms from Brazilian biodiversity. For the past decade, his research group has endeavor significant efforts to study a collection of microorganisms isolated from the rhizosphere of Senna spectabilis, aiming the isolation of molecular precursors from piperidine alkaloids. Through several joint projects, his team was able to study fungal biotransformation of selected molecules, enhanced chemical and biological diversity by co-culture, as well as inducing cryptic antimicrobial secondary metabolites. In addition, this fascinating journey allowed the development of novel dereplication strategies using MS and NMR in order to understand the complexity of fungal interactions in this intriguing biological niche. Additionally, Prof. Castro-Gamboa has published 75 manuscripts in diverse scientific journals as we as authored 2 book chapters and 4 patents. He has been selected as a speaker and plenary lecturer at The American Society og Pharmacognosy (ASP), Gesellschaft für Arzneipflanzen und Naturstoff-Forschung (GA), Brazilian Society of Chemistry (SBQ), Brazilian Conference on Natural Products (BCNP), amongst other scientific societies. He also has been invited as lecturer in short courses using NMR as a tool in the metabolomic scenario in Brazil, Costa Rica, Colombia and Argentina. Since 2013 Prof. Castro-Gamboa coordinates the NMR platform at IQ-UNESP and from 2018-2022 is the head of the Department of Biochemistry and Organic Chemistry at IQ-UNESP. <a href="http://lattes.cnpq.br/9032973705204320">More information.</a>
</br></br>
</header>
<h4>The lab</h4>
<span class="image right"><img src="images/labs/unesp/unesp.png" alt="" /></span>
<p><bold>Contact: <a href="https://nubbe.iq.unesp.br">https://nubbe.iq.unesp.br</a></bold></p>
<p>
Available Instrumentation at NuBBE:
<ul>
<li>Chromatography and Mass Spectrometry systems: 11</li>
<li>8 HPLC-DAD</li>
<li>2 LC-MS (1 HPLC-QToF-MS; 1 UPLC-QToF-MS); 1 MALDI-TOF</li>
<li>600 MHz (with cryoprobe)</li>
<li>600 MHz (smart probe)</li>
<li>400 MHz WB</li>
<li>300 MHz FT</li>
</ul>
</p>
<hr>
</div>
</div>
</div>
</section>
</div>
</section>