Should sequencing depth be considered？

[Yunliang81]

It seems that the sequencing depth was not considered in the .py code. The sequencing depth could affect alpha and beta diversity. Should the sequencing depth be considered?

[matbeale]

This is a really good point - any plans to add in rarefaction options to allow for this?

[mars188]

would be great if rarefaction option is added to consider seq depth