The list of tags is case-sensitive

[benfulton]

The first few dozen tags are all the ones that have capital letters, leading a user searching for, e.g. "bioinformatics" to conclude that there aren't any projects with that tag. The lower-case bioinformatics tag is buried deeper in the list.

[vsoch]

Those are tags that come exactly from their respective repos. If you wanted to normalize (all lowercase) you'd need to do that in the automation

good-first-issues/.github/scripts/generate-first-issues.py

Line 133 in 2257085

for issue in issues:

and retroactively update all the current issues here.