diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index a5c322fc23834..21b74f446f7ab 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -134,10 +134,6 @@ jobs:
 
     env:
       CCACHE_MAXSIZE: '200M'
-      CI_CCACHE_VERSION: '4.7.5'
-      CI_QT_CONF: '-release -silent -opensource -confirm-license -opengl desktop -static -static-runtime -mp -qt-zlib -qt-pcre -qt-libpng -nomake examples -nomake tests -nomake tools -no-angle -no-dbus -no-gif -no-gtk -no-ico -no-icu -no-libjpeg -no-libudev -no-sql-sqlite -no-sql-odbc -no-sqlite -no-vulkan -skip qt3d -skip qtactiveqt -skip qtandroidextras -skip qtcharts -skip qtconnectivity -skip qtdatavis3d -skip qtdeclarative -skip doc -skip qtdoc -skip qtgamepad -skip qtgraphicaleffects -skip qtimageformats -skip qtlocation -skip qtlottie -skip qtmacextras -skip qtmultimedia -skip qtnetworkauth -skip qtpurchasing -skip qtquick3d -skip qtquickcontrols -skip qtquickcontrols2 -skip qtquicktimeline -skip qtremoteobjects -skip qtscript -skip qtscxml -skip qtsensors -skip qtserialbus -skip qtserialport -skip qtspeech -skip qtsvg -skip qtvirtualkeyboard -skip qtwayland -skip qtwebchannel -skip qtwebengine -skip qtwebglplugin -skip qtwebsockets -skip qtwebview -skip qtx11extras -skip qtxmlpatterns -no-openssl -no-feature-bearermanagement -no-feature-printdialog -no-feature-printer -no-feature-printpreviewdialog -no-feature-printpreviewwidget -no-feature-sql -no-feature-sqlmodel -no-feature-textbrowser -no-feature-textmarkdownwriter -no-feature-textodfwriter -no-feature-xml'
-      CI_QT_DIR: 'qt-everywhere-src-5.15.11'
-      CI_QT_URL: 'https://download.qt.io/official_releases/qt/5.15/5.15.11/single/qt-everywhere-opensource-src-5.15.11.zip'
       PYTHONUTF8: 1
       TEST_RUNNER_TIMEOUT_FACTOR: 40
 
@@ -145,6 +141,10 @@ jobs:
       - name: Checkout
         uses: actions/checkout@v4
 
+      - name: Remove non-MSVC tool installations
+        run: |
+          Remove-Item -Path "$env:ProgramFiles/CMake" -Recurse -Force
+
       - name: Configure Developer Command Prompt for Microsoft Visual C++
         # Using microsoft/setup-msbuild is not enough.
         uses: ilammy/msvc-dev-cmd@v1
@@ -153,98 +153,25 @@ jobs:
 
       - name: Get tool information
         run: |
+          cmake --version | Out-File -FilePath "cmake_version"
+          Get-Content -Path "cmake_version"
+          Write-Output "---"
           msbuild -version | Out-File -FilePath "$env:GITHUB_WORKSPACE\msbuild_version"
           Get-Content -Path "$env:GITHUB_WORKSPACE\msbuild_version"
           $env:VCToolsVersion | Out-File -FilePath "$env:GITHUB_WORKSPACE\toolset_version"
           Write-Host "VCToolsVersion $(Get-Content -Path "$env:GITHUB_WORKSPACE\toolset_version")"
-          $env:CI_QT_URL | Out-File -FilePath "$env:GITHUB_WORKSPACE\qt_url"
-          $env:CI_QT_CONF | Out-File -FilePath "$env:GITHUB_WORKSPACE\qt_conf"
           py -3 --version
           Write-Host "PowerShell version $($PSVersionTable.PSVersion.ToString())"
 
-      - name: Restore static Qt cache
-        id: static-qt-cache
-        uses: actions/cache/restore@v4
-        with:
-          path: C:\Qt_static
-          key: ${{ github.job }}-static-qt-${{ hashFiles('msbuild_version', 'qt_url', 'qt_conf') }}
-
-      - name: Build static Qt. Download
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        shell: cmd
-        run: |
-          curl --location --output C:\qt-src.zip %CI_QT_URL%
-          choco install --yes --no-progress jom
-
-      - name: Build static Qt. Expand source archive
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        shell: cmd
-        run: tar -xf C:\qt-src.zip -C C:\
-
-      - name: Build static Qt. Create build directory
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        run: |
-          Rename-Item -Path "C:\$env:CI_QT_DIR" -NewName "C:\qt-src"
-          New-Item -ItemType Directory -Path "C:\qt-src\build"
-
-      - name: Build static Qt. Configure
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        working-directory: C:\qt-src\build
-        shell: cmd
-        run: ..\configure %CI_QT_CONF% -prefix C:\Qt_static
-
-      - name: Build static Qt. Build
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        working-directory: C:\qt-src\build
-        shell: cmd
-        run: jom
-
-      - name: Build static Qt. Install
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        working-directory: C:\qt-src\build
-        shell: cmd
-        run: jom install
-
-      - name: Save static Qt cache
-        if: steps.static-qt-cache.outputs.cache-hit != 'true'
-        uses: actions/cache/save@v4
-        with:
-          path: C:\Qt_static
-          key: ${{ github.job }}-static-qt-${{ hashFiles('msbuild_version', 'qt_url', 'qt_conf') }}
-
-      - name: Ccache installation cache
-        id: ccache-installation-cache
-        uses: actions/cache@v4
-        with:
-          path: |
-            C:\ProgramData\chocolatey\lib\ccache
-            C:\ProgramData\chocolatey\bin\ccache.exe
-            C:\ccache\cl.exe
-          key: ${{ github.job }}-ccache-installation-${{ env.CI_CCACHE_VERSION }}
-
       - name: Install Ccache
-        if: steps.ccache-installation-cache.outputs.cache-hit != 'true'
         run: |
-          choco install --yes --no-progress ccache --version=$env:CI_CCACHE_VERSION
-          New-Item -ItemType Directory -Path "C:\ccache"
-          Copy-Item -Path "$env:ChocolateyInstall\lib\ccache\tools\ccache-$env:CI_CCACHE_VERSION-windows-x86_64\ccache.exe" -Destination "C:\ccache\cl.exe"
-
-      - name: Restore Ccache cache
-        id: ccache-cache
-        uses: actions/cache/restore@v4
-        with:
-          path: ~/AppData/Local/ccache
-          key: ${{ github.job }}-ccache-${{ github.run_id }}
-          restore-keys: ${{ github.job }}-ccache-
+          choco install --yes --no-progress ccache
 
       - name: Using vcpkg with MSBuild
         run: |
           Set-Location "$env:VCPKG_INSTALLATION_ROOT"
-          Add-Content -Path "triplets\x64-windows-static.cmake" -Value "set(VCPKG_BUILD_TYPE release)"
-          Add-Content -Path "triplets\x64-windows-static.cmake" -Value "set(VCPKG_PLATFORM_TOOLSET_VERSION $env:VCToolsVersion)"
-          .\vcpkg.exe --vcpkg-root "$env:VCPKG_INSTALLATION_ROOT" integrate install
-          git rev-parse HEAD | Out-File -FilePath "$env:GITHUB_WORKSPACE\vcpkg_commit"
-          Get-Content -Path "$env:GITHUB_WORKSPACE\vcpkg_commit"
+          Add-Content -Path "triplets\x64-windows.cmake" -Value "set(VCPKG_BUILD_TYPE release)"
+          Add-Content -Path "triplets\x64-windows.cmake" -Value "set(VCPKG_PLATFORM_TOOLSET_VERSION $env:VCToolsVersion)"
 
       - name: vcpkg tools cache
         uses: actions/cache@v4
@@ -252,23 +179,41 @@ jobs:
           path: C:/vcpkg/downloads/tools
           key: ${{ github.job }}-vcpkg-tools
 
-      - name: vcpkg binary cache
-        uses: actions/cache@v4
+      - name: Restore vcpkg binary cache
+        uses: actions/cache/restore@v4
+        id: vcpkg-binary-cache
         with:
           path: ~/AppData/Local/vcpkg/archives
-          key: ${{ github.job }}-vcpkg-binary-${{ hashFiles('vcpkg_commit', 'msbuild_version', 'toolset_version', 'build_msvc/vcpkg.json') }}
+          key: ${{ github.job }}-vcpkg-binary-${{ hashFiles('cmake_version', 'msbuild_version', 'toolset_version', 'vcpkg.json') }}
+
+      - name: Generate build system
+        run: |
+          cmake -B build --preset vs2022 -DCMAKE_TOOLCHAIN_FILE="$env:VCPKG_INSTALLATION_ROOT\scripts\buildsystems\vcpkg.cmake" -DWERROR=ON
 
-      - name: Generate project files
-        run: py -3 build_msvc\msvc-autogen.py
+      - name: Save vcpkg binary cache
+        uses: actions/cache/save@v4
+        if: github.event_name != 'pull_request' && steps.vcpkg-binary-cache.outputs.cache-hit != 'true'
+        with:
+          path: ~/AppData/Local/vcpkg/archives
+          key: ${{ github.job }}-vcpkg-binary-${{ hashFiles('cmake_version', 'msbuild_version', 'toolset_version', 'vcpkg.json') }}
+
+      - name: Restore Ccache cache
+        id: ccache-cache
+        uses: actions/cache/restore@v4
+        with:
+          path: ~/AppData/Local/ccache
+          key: ${{ github.job }}-ccache-
 
       - name: Build
-        shell: cmd
+        working-directory: build
         run: |
           ccache --zero-stats
-          msbuild build_msvc\bitcoin.sln -property:CLToolPath=C:\ccache;CLToolExe=cl.exe;UseMultiToolTask=true;Configuration=Release -maxCpuCount -verbosity:minimal -noLogo
+          cmake --build . -j $env:NUMBER_OF_PROCESSORS --config Release
 
       - name: Ccache stats
-        run: ccache --show-stats
+        run: |
+          ccache --version | head -n 1
+          ccache --show-stats --verbose
 
       - name: Save Ccache cache
         uses: actions/cache/save@v4
@@ -278,20 +223,18 @@ jobs:
           # https://github.com/actions/cache/blob/main/tips-and-workarounds.md#update-a-cache
           key: ${{ github.job }}-ccache-${{ github.run_id }}
 
-      - name: Run unit tests
-        run: src\test_bitcoin.exe -l test_suite
-
-      - name: Run benchmarks
-        run: src\bench_bitcoin.exe -sanity-check
-
-      - name: Run util tests
-        run: py -3 test\util\test_runner.py
-
-      - name: Run rpcauth test
-        run: py -3 test\util\rpcauth-test.py
+      - name: Run test suite
+        working-directory: build
+        run: |
+          ctest -j $env:NUMBER_OF_PROCESSORS -C Release
 
       - name: Run functional tests
+        working-directory: build
         env:
+          BITCOIND: '${{ github.workspace }}\build\src\Release\bitcoind.exe'
+          BITCOINCLI: '${{ github.workspace }}\build\src\Release\bitcoin-cli.exe'
+          BITCOINUTIL: '${{ github.workspace }}\build\src\Release\bitcoin-util.exe'
+          BITCOINWALLET: '${{ github.workspace }}\build\src\Release\bitcoin-wallet.exe'
           TEST_RUNNER_EXTRA: ${{ github.event_name != 'pull_request' && '--extended' || '' }}
         shell: cmd
         run: py -3 test\functional\test_runner.py --jobs %NUMBER_OF_PROCESSORS% --ci --quiet --tmpdirprefix=%RUNNER_TEMP% --combinedlogslen=99999999 --timeout-factor=%TEST_RUNNER_TIMEOUT_FACTOR% %TEST_RUNNER_EXTRA%
@@ -304,7 +247,8 @@ jobs:
           git log -1
 
       - name: Run fuzz binaries
+        working-directory: build
         env:
-          BITCOINFUZZ: "${{ github.workspace}}\\src\\fuzz.exe"
+          BITCOINFUZZ: '${{ github.workspace }}\build\src\test\fuzz\Release\fuzz.exe'
         shell: cmd
         run: py -3 test\fuzz\test_runner.py --par %NUMBER_OF_PROCESSORS% --loglevel DEBUG %RUNNER_TEMP%\qa-assets\fuzz_seed_corpus
diff --git a/ci/test/00_setup_env.sh b/ci/test/00_setup_env.sh
index b9e6818afbccd..2a7ae923e615b 100755
--- a/ci/test/00_setup_env.sh
+++ b/ci/test/00_setup_env.sh
@@ -62,7 +62,7 @@ export CCACHE_DIR=${CCACHE_DIR:-$BASE_SCRATCH_DIR/.ccache}
 # Folder where the build result is put (bin and lib).
 export BASE_OUTDIR=${BASE_OUTDIR:-$BASE_SCRATCH_DIR/out}
 # Folder where the build is done (dist and out-of-tree build).
-export BASE_BUILD_DIR=${BASE_BUILD_DIR:-$BASE_SCRATCH_DIR/build}
+export BASE_BUILD_DIR=${BASE_BUILD_DIR:-$BASE_SCRATCH_DIR/build-$HOST}
 # The folder for previous release binaries.
 # This folder exists only on the ci guest, and on the ci host as a volume.
 export PREVIOUS_RELEASES_DIR=${PREVIOUS_RELEASES_DIR:-$BASE_ROOT_DIR/prev_releases}
diff --git a/ci/test/00_setup_env_arm.sh b/ci/test/00_setup_env_arm.sh
index c80036164fd47..e6cf9644b51aa 100755
--- a/ci/test/00_setup_env_arm.sh
+++ b/ci/test/00_setup_env_arm.sh
@@ -17,4 +17,4 @@ export RUN_FUNCTIONAL_TESTS=false
 export GOAL="install"
 # -Wno-psabi is to disable ABI warnings: "note: parameter passing for argument of type ... changed in GCC 7.1"
 # This could be removed once the ABI change warning does not show up by default
-export BITCOIN_CONFIG="--enable-reduce-exports CXXFLAGS=-Wno-psabi"
+export BITCOIN_CONFIG="-DREDUCE_EXPORTS=ON -DCMAKE_CXX_FLAGS=-Wno-psabi"
diff --git a/ci/test/00_setup_env_i686_centos.sh b/ci/test/00_setup_env_i686_centos.sh
index 5f8391c5dacfd..881f006732575 100755
--- a/ci/test/00_setup_env_i686_centos.sh
+++ b/ci/test/00_setup_env_i686_centos.sh
@@ -13,5 +13,5 @@ export CI_BASE_PACKAGES="gcc-c++ glibc-devel.x86_64 libstdc++-devel.x86_64 glibc
 export PIP_PACKAGES="pyzmq"
 export GOAL="install"
 export NO_WERROR=1  # Suppress error: #warning _FORTIFY_SOURCE > 2 is treated like 2 on this platform [-Werror=cpp]
-export BITCOIN_CONFIG="--enable-zmq --with-gui=qt5 --enable-reduce-exports"
+export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DBUILD_GUI=ON -DREDUCE_EXPORTS=ON"
 export CONFIG_SHELL="/bin/dash"
diff --git a/ci/test/00_setup_env_i686_multiprocess.sh b/ci/test/00_setup_env_i686_multiprocess.sh
index f6463438d3959..521c82c3ef0e5 100755
--- a/ci/test/00_setup_env_i686_multiprocess.sh
+++ b/ci/test/00_setup_env_i686_multiprocess.sh
@@ -13,6 +13,6 @@ export PACKAGES="llvm clang g++-multilib"
 export DEP_OPTS="DEBUG=1 MULTIPROCESS=1"
 export GOAL="install"
 export TEST_RUNNER_EXTRA="--v2transport"
-export BITCOIN_CONFIG="--enable-debug CC='clang -m32' CXX='clang++ -m32' \
-CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' CXXFLAGS='-Wno-error=documentation'"
+export BITCOIN_CONFIG="-DCMAKE_BUILD_TYPE=Debug -DCMAKE_C_COMPILER='clang;-m32' -DCMAKE_CXX_COMPILER='clang++;-m32' \
+-DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -Wno-error=documentation'"
 export BITCOIND=bitcoin-node  # Used in functional tests
diff --git a/ci/test/00_setup_env_mac_cross.sh b/ci/test/00_setup_env_mac_cross.sh
index 31c4bff6aeae0..98d85ddf6221e 100755
--- a/ci/test/00_setup_env_mac_cross.sh
+++ b/ci/test/00_setup_env_mac_cross.sh
@@ -17,4 +17,4 @@ export XCODE_BUILD_ID=15A240d
 export RUN_UNIT_TESTS=false
 export RUN_FUNCTIONAL_TESTS=false
 export GOAL="deploy"
-export BITCOIN_CONFIG="--with-gui --enable-reduce-exports"
+export BITCOIN_CONFIG="-DBUILD_GUI=ON -DREDUCE_EXPORTS=ON"
diff --git a/ci/test/00_setup_env_mac_native.sh b/ci/test/00_setup_env_mac_native.sh
index c47f13f96ed30..6076740887024 100755
--- a/ci/test/00_setup_env_mac_native.sh
+++ b/ci/test/00_setup_env_mac_native.sh
@@ -11,7 +11,7 @@ export HOST=x86_64-apple-darwin
 # Therefore, `--break-system-packages` is needed.
 export PIP_PACKAGES="--break-system-packages zmq"
 export GOAL="install"
-export BITCOIN_CONFIG="--with-gui --with-miniupnpc --with-natpmp --enable-reduce-exports"
+export BITCOIN_CONFIG="-DBUILD_GUI=ON -DWITH_MINIUPNPC=ON -DWITH_NATPMP=ON -DREDUCE_EXPORTS=ON"
 export CI_OS_NAME="macos"
 export NO_DEPENDS=1
 export OSX_SDK=""
diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
index 668e9ecc8a96f..cae3906ae17a6 100755
--- a/ci/test/00_setup_env_native_asan.sh
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -17,10 +17,11 @@ else
 fi
 
 export CONTAINER_NAME=ci_native_asan
-export PACKAGES="systemtap-sdt-dev clang-18 llvm-18 libclang-rt-18-dev python3-zmq qtbase5-dev qttools5-dev-tools libevent-dev libboost-dev libdb5.3++-dev libminiupnpc-dev libnatpmp-dev libzmq3-dev libqrencode-dev libsqlite3-dev ${BPFCC_PACKAGE}"
+export PACKAGES="systemtap-sdt-dev clang-18 llvm-18 libclang-rt-18-dev python3-zmq qtbase5-dev qttools5-dev qttools5-dev-tools libevent-dev libboost-dev libdb5.3++-dev libminiupnpc-dev libnatpmp-dev libzmq3-dev libqrencode-dev libsqlite3-dev ${BPFCC_PACKAGE}"
 export NO_DEPENDS=1
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-usdt --enable-zmq --with-incompatible-bdb --with-gui=qt5 \
-CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER' \
---with-sanitizers=address,float-divide-by-zero,integer,undefined \
-CC='clang-18 -ftrivial-auto-var-init=pattern' CXX='clang++-18 -ftrivial-auto-var-init=pattern'"
+export BITCOIN_CONFIG="-DWITH_USDT=ON -DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=ON \
+-DSANITIZERS=address,float-divide-by-zero,integer,undefined \
+-DCMAKE_C_COMPILER=clang-18 -DCMAKE_CXX_COMPILER=clang++-18 \
+-DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
+-DCMAKE_CXX_FLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -ftrivial-auto-var-init=pattern'"
diff --git a/ci/test/00_setup_env_native_fuzz.sh b/ci/test/00_setup_env_native_fuzz.sh
index f50561f875078..bb35778fed776 100755
--- a/ci/test/00_setup_env_native_fuzz.sh
+++ b/ci/test/00_setup_env_native_fuzz.sh
@@ -15,7 +15,9 @@ export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=true
 export GOAL="install"
 export CI_CONTAINER_CAP="--cap-add SYS_PTRACE"  # If run with (ASan + LSan), the container needs access to ptrace (https://github.com/google/sanitizers/issues/764)
-export BITCOIN_CONFIG="--enable-fuzz --with-sanitizers=fuzzer,address,undefined,float-divide-by-zero,integer \
-CC='clang-18 -ftrivial-auto-var-init=pattern' CXX='clang++-18 -ftrivial-auto-var-init=pattern'"
+export BITCOIN_CONFIG="-DFUZZ=ON -DSANITIZERS=fuzzer,address,undefined,float-divide-by-zero,integer \
+-DCMAKE_C_COMPILER=clang-18 -DCMAKE_CXX_COMPILER=clang++-18 \
+-DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
+-DCMAKE_CXX_FLAGS='-ftrivial-auto-var-init=pattern'"
 export CCACHE_MAXSIZE=200M
 export LLVM_SYMBOLIZER_PATH="/usr/bin/llvm-symbolizer-18"
diff --git a/ci/test/00_setup_env_native_fuzz_with_msan.sh b/ci/test/00_setup_env_native_fuzz_with_msan.sh
index f1c358082d5c1..b8cd372c0c603 100755
--- a/ci/test/00_setup_env_native_fuzz_with_msan.sh
+++ b/ci/test/00_setup_env_native_fuzz_with_msan.sh
@@ -18,7 +18,8 @@ export PACKAGES="ninja-build"
 export DEP_OPTS="DEBUG=1 NO_BDB=1 NO_QT=1 CC=clang CXX=clang++ CFLAGS='${MSAN_FLAGS}' CXXFLAGS='${MSAN_AND_LIBCXX_FLAGS}'"
 export GOAL="install"
 # _FORTIFY_SOURCE is not compatible with MSAN.
-export BITCOIN_CONFIG="--enable-fuzz --with-sanitizers=fuzzer,memory CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -U_FORTIFY_SOURCE'"
+export BITCOIN_CONFIG="-DFUZZ=ON -DSANITIZERS=fuzzer,memory -DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' \
+-DAPPEND_CPPFLAGS='-U_FORTIFY_SOURCE'"
 export USE_MEMORY_SANITIZER="true"
 export RUN_UNIT_TESTS="false"
 export RUN_FUNCTIONAL_TESTS="false"
diff --git a/ci/test/00_setup_env_native_fuzz_with_valgrind.sh b/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
index bf4d1573e3ccf..233d36ca44f25 100755
--- a/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
+++ b/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
@@ -15,5 +15,5 @@ export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=true
 export FUZZ_TESTS_CONFIG="--valgrind"
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-fuzz --with-sanitizers=fuzzer CC=clang-16 CXX=clang++-16"
+export BITCOIN_CONFIG="-DFUZZ=ON -DSANITIZERS=fuzzer -DCMAKE_C_COMPILER=clang-16 -DCMAKE_CXX_COMPILER=clang++-16"
 export CCACHE_MAXSIZE=200M
diff --git a/ci/test/00_setup_env_native_msan.sh b/ci/test/00_setup_env_native_msan.sh
index dd465cac2e295..85a1d3bd48e0a 100755
--- a/ci/test/00_setup_env_native_msan.sh
+++ b/ci/test/00_setup_env_native_msan.sh
@@ -18,7 +18,7 @@ export PACKAGES="ninja-build"
 export DEP_OPTS="DEBUG=1 NO_BDB=1 NO_QT=1 CC=clang CXX=clang++ CFLAGS='${MSAN_FLAGS}' CXXFLAGS='${MSAN_AND_LIBCXX_FLAGS}'"
 export GOAL="install"
 # _FORTIFY_SOURCE is not compatible with MSAN.
-export BITCOIN_CONFIG="--with-sanitizers=memory CPPFLAGS='-U_FORTIFY_SOURCE'"
+export BITCOIN_CONFIG="-DSANITIZERS=memory -DAPPEND_CPPFLAGS='-U_FORTIFY_SOURCE'"
 export USE_MEMORY_SANITIZER="true"
 export RUN_FUNCTIONAL_TESTS="false"
 export CCACHE_MAXSIZE=250M
diff --git a/ci/test/00_setup_env_native_nowallet_libbitcoinkernel.sh b/ci/test/00_setup_env_native_nowallet_libbitcoinkernel.sh
index 6425120afb896..c38cc5e0ff2f8 100755
--- a/ci/test/00_setup_env_native_nowallet_libbitcoinkernel.sh
+++ b/ci/test/00_setup_env_native_nowallet_libbitcoinkernel.sh
@@ -12,4 +12,4 @@ export CI_IMAGE_NAME_TAG="docker.io/ubuntu:22.04"
 export PACKAGES="python3-zmq clang-15 llvm-15 libc++abi-15-dev libc++-15-dev"
 export DEP_OPTS="NO_WALLET=1 CC=clang-15 CXX='clang++-15 -stdlib=libc++'"
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-reduce-exports --enable-experimental-util-chainstate --with-experimental-kernel-lib --enable-shared"
+export BITCOIN_CONFIG="-DREDUCE_EXPORTS=ON -DBUILD_UTIL_CHAINSTATE=ON -DBUILD_KERNEL_LIB=ON -DBUILD_SHARED_LIBS=ON"
diff --git a/ci/test/00_setup_env_native_previous_releases.sh b/ci/test/00_setup_env_native_previous_releases.sh
index 9da3b18999c24..5ef53f4a19f74 100755
--- a/ci/test/00_setup_env_native_previous_releases.sh
+++ b/ci/test/00_setup_env_native_previous_releases.sh
@@ -16,5 +16,6 @@ export RUN_UNIT_TESTS_SEQUENTIAL="true"
 export RUN_UNIT_TESTS="false"
 export GOAL="install"
 export DOWNLOAD_PREVIOUS_RELEASES="true"
-export BITCOIN_CONFIG="--enable-zmq --with-gui=qt5 --enable-reduce-exports --enable-debug \
-CFLAGS=\"-g0 -O2 -funsigned-char\" CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' CXXFLAGS=\"-g0 -O2 -funsigned-char\""
+export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DBUILD_GUI=ON -DREDUCE_EXPORTS=ON -DCMAKE_BUILD_TYPE=Debug \
+-DCMAKE_C_FLAGS='-funsigned-char' -DCMAKE_C_FLAGS_DEBUG='-g0 -O2' \
+-DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -funsigned-char' -DCMAKE_CXX_FLAGS_DEBUG='-g0 -O2'"
diff --git a/ci/test/00_setup_env_native_tidy.sh b/ci/test/00_setup_env_native_tidy.sh
index 5f422bbdb6e02..760323c90d3b4 100755
--- a/ci/test/00_setup_env_native_tidy.sh
+++ b/ci/test/00_setup_env_native_tidy.sh
@@ -9,12 +9,14 @@ export LC_ALL=C.UTF-8
 export CI_IMAGE_NAME_TAG="docker.io/ubuntu:24.04"
 export CONTAINER_NAME=ci_native_tidy
 export TIDY_LLVM_V="18"
-export PACKAGES="clang-${TIDY_LLVM_V} libclang-${TIDY_LLVM_V}-dev llvm-${TIDY_LLVM_V}-dev libomp-${TIDY_LLVM_V}-dev clang-tidy-${TIDY_LLVM_V} jq bear libevent-dev libboost-dev libminiupnpc-dev libnatpmp-dev libzmq3-dev systemtap-sdt-dev qtbase5-dev qttools5-dev qttools5-dev-tools libqrencode-dev libsqlite3-dev libdb++-dev"
+export PACKAGES="clang-${TIDY_LLVM_V} libclang-${TIDY_LLVM_V}-dev llvm-${TIDY_LLVM_V}-dev libomp-${TIDY_LLVM_V}-dev clang-tidy-${TIDY_LLVM_V} jq libevent-dev libboost-dev libminiupnpc-dev libnatpmp-dev libzmq3-dev systemtap-sdt-dev qtbase5-dev qttools5-dev qttools5-dev-tools libqrencode-dev libsqlite3-dev libdb++-dev"
 export NO_DEPENDS=1
 export RUN_UNIT_TESTS=false
 export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=false
 export RUN_TIDY=true
 export GOAL="install"
-export BITCOIN_CONFIG="CC=clang-${TIDY_LLVM_V} CXX=clang++-${TIDY_LLVM_V} --with-incompatible-bdb --disable-hardening CFLAGS='-O0 -g0' CXXFLAGS='-O0 -g0'"
+export BITCOIN_CONFIG="-DWARN_INCOMPATIBLE_BDB=OFF -DHARDENING=OFF \
+-DCMAKE_C_COMPILER=clang-${TIDY_LLVM_V} -DCMAKE_CXX_COMPILER=clang++-${TIDY_LLVM_V} \
+-DCMAKE_C_FLAGS_RELWITHDEBINFO='-O0 -g0' -DCMAKE_CXX_FLAGS_RELWITHDEBINFO='-O0 -g0'"
 export CCACHE_MAXSIZE=200M
diff --git a/ci/test/00_setup_env_native_tsan.sh b/ci/test/00_setup_env_native_tsan.sh
index 3fcaa8c6c69d3..519575dcd4f06 100755
--- a/ci/test/00_setup_env_native_tsan.sh
+++ b/ci/test/00_setup_env_native_tsan.sh
@@ -11,4 +11,5 @@ export CI_IMAGE_NAME_TAG="docker.io/ubuntu:24.04"
 export PACKAGES="clang-18 llvm-18 libclang-rt-18-dev libc++abi-18-dev libc++-18-dev python3-zmq"
 export DEP_OPTS="CC=clang-18 CXX='clang++-18 -stdlib=libc++'"
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-zmq CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -DDEBUG_LOCKCONTENTION' --with-sanitizers=thread"
+export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DSANITIZERS=thread \
+-DCMAKE_CXX_FLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -DDEBUG_LOCKCONTENTION'"
diff --git a/ci/test/00_setup_env_native_valgrind.sh b/ci/test/00_setup_env_native_valgrind.sh
index ebef590c0a9e0..f697b3d7c78af 100755
--- a/ci/test/00_setup_env_native_valgrind.sh
+++ b/ci/test/00_setup_env_native_valgrind.sh
@@ -13,4 +13,4 @@ export USE_VALGRIND=1
 export NO_DEPENDS=1
 export TEST_RUNNER_EXTRA="--exclude feature_init,rpc_bind,feature_bind_extra"  # feature_init excluded for now, see https://github.com/bitcoin/bitcoin/issues/30011 ; bind tests excluded for now, see https://github.com/bitcoin/bitcoin/issues/17765#issuecomment-602068547
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-zmq --with-incompatible-bdb --with-gui=no CC=clang-16 CXX=clang++-16" # TODO enable GUI
+export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=OFF -DCMAKE_C_COMPILER=clang-16 -DCMAKE_CXX_COMPILER=clang++-16" # TODO enable GUI
diff --git a/ci/test/00_setup_env_s390x.sh b/ci/test/00_setup_env_s390x.sh
index 2fd94e253cac7..eb12bc6fd179b 100755
--- a/ci/test/00_setup_env_s390x.sh
+++ b/ci/test/00_setup_env_s390x.sh
@@ -13,4 +13,4 @@ export CI_IMAGE_NAME_TAG="docker.io/s390x/ubuntu:24.04"
 export TEST_RUNNER_EXTRA="--exclude rpc_bind,feature_bind_extra"  # Excluded for now, see https://github.com/bitcoin/bitcoin/issues/17765#issuecomment-602068547
 export RUN_FUNCTIONAL_TESTS=true
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-reduce-exports"
+export BITCOIN_CONFIG="-DREDUCE_EXPORTS=ON"
diff --git a/ci/test/00_setup_env_win64.sh b/ci/test/00_setup_env_win64.sh
index bf80d5d435f0e..15b9e407b6051 100755
--- a/ci/test/00_setup_env_win64.sh
+++ b/ci/test/00_setup_env_win64.sh
@@ -16,4 +16,5 @@ export GOAL="deploy"
 # Prior to 11.0.0, the mingw-w64 headers were missing noreturn attributes, causing warnings when
 # cross-compiling for Windows. https://sourceforge.net/p/mingw-w64/bugs/306/
 # https://github.com/mingw-w64/mingw-w64/commit/1690994f515910a31b9fb7c7bd3a52d4ba987abe
-export BITCOIN_CONFIG="--enable-reduce-exports --disable-gui-tests CXXFLAGS='-Wno-return-type -Wno-error=maybe-uninitialized -Wno-error=array-bounds'"
+export BITCOIN_CONFIG="-DREDUCE_EXPORTS=ON -DBUILD_GUI_TESTS=OFF \
+-DCMAKE_CXX_FLAGS='-Wno-error=return-type -Wno-error=maybe-uninitialized -Wno-error=array-bounds'"
diff --git a/ci/test/03_test_script.sh b/ci/test/03_test_script.sh
index f5da7bc55d3a7..37b7e3b0e557d 100755
--- a/ci/test/03_test_script.sh
+++ b/ci/test/03_test_script.sh
@@ -99,17 +99,20 @@ if [ "$DOWNLOAD_PREVIOUS_RELEASES" = "true" ]; then
   test/get_previous_releases.py -b -t "$PREVIOUS_RELEASES_DIR"
 fi
 
-BITCOIN_CONFIG_ALL="--disable-dependency-tracking"
+BITCOIN_CONFIG_ALL=""
 if [ -z "$NO_DEPENDS" ]; then
-  BITCOIN_CONFIG_ALL="${BITCOIN_CONFIG_ALL} CONFIG_SITE=$DEPENDS_DIR/$HOST/share/config.site"
+  BITCOIN_CONFIG_ALL="${BITCOIN_CONFIG_ALL} -DCMAKE_TOOLCHAIN_FILE=$DEPENDS_DIR/$HOST/toolchain.cmake"
 fi
 if [ -z "$NO_WERROR" ]; then
-  BITCOIN_CONFIG_ALL="${BITCOIN_CONFIG_ALL} --enable-werror"
+  BITCOIN_CONFIG_ALL="${BITCOIN_CONFIG_ALL} -DWERROR=ON"
 fi
 
 ccache --zero-stats
 PRINT_CCACHE_STATISTICS="ccache --version | head -n 1 && ccache --show-stats"
 
+mkdir -p "${BASE_BUILD_DIR}"
+cd "${BASE_BUILD_DIR}"
+
 if [ -n "$ANDROID_TOOLS_URL" ]; then
   make distclean || true
   ./autogen.sh
@@ -119,40 +122,21 @@ if [ -n "$ANDROID_TOOLS_URL" ]; then
   exit 0
 fi
 
-BITCOIN_CONFIG_ALL="${BITCOIN_CONFIG_ALL} --enable-external-signer --prefix=$BASE_OUTDIR"
-
-if [ -n "$CONFIG_SHELL" ]; then
-  "$CONFIG_SHELL" -c "./autogen.sh"
-else
-  ./autogen.sh
-fi
-
-mkdir -p "${BASE_BUILD_DIR}"
-cd "${BASE_BUILD_DIR}"
-
-bash -c "${BASE_ROOT_DIR}/configure --cache-file=config.cache $BITCOIN_CONFIG_ALL $BITCOIN_CONFIG" || ( (cat config.log) && false)
-
-make distdir VERSION="$HOST"
-
-cd "${BASE_BUILD_DIR}/bitcoin-$HOST"
-
-bash -c "./configure --cache-file=../config.cache $BITCOIN_CONFIG_ALL $BITCOIN_CONFIG" || ( (cat config.log) && false)
+BITCOIN_CONFIG_ALL="$BITCOIN_CONFIG_ALL -DWITH_EXTERNAL_SIGNER=ON -DCMAKE_INSTALL_PREFIX=$BASE_OUTDIR"
 
 if [[ "${RUN_TIDY}" == "true" ]]; then
-  MAYBE_BEAR="bear --config src/.bear-tidy-config"
-  MAYBE_TOKEN="--"
+  BITCOIN_CONFIG_ALL="$BITCOIN_CONFIG_ALL -DCMAKE_EXPORT_COMPILE_COMMANDS=ON"
 fi
 
-bash -c "${MAYBE_BEAR} ${MAYBE_TOKEN} make $MAKEJOBS $GOAL" || ( echo "Build failure. Verbose build follows." && make "$GOAL" V=1 ; false )
+bash -c "cmake -S $BASE_ROOT_DIR $BITCOIN_CONFIG_ALL $BITCOIN_CONFIG || ( (cat CMakeFiles/CMakeOutput.log CMakeFiles/CMakeError.log) && false)"
+
+bash -c "make $MAKEJOBS all $GOAL" || ( echo "Build failure. Verbose build follows." && make all "$GOAL" V=1 ; false )
 
 bash -c "${PRINT_CCACHE_STATISTICS}"
 du -sh "${DEPENDS_DIR}"/*/
 du -sh "${PREVIOUS_RELEASES_DIR}"
 
 if [[ $HOST = *-mingw32 ]]; then
-  # Generate all binaries, so that they can be wrapped
-  make "$MAKEJOBS" -C src/secp256k1 VERBOSE=1
-  make "$MAKEJOBS" -C src minisketch/test.exe VERBOSE=1
   "${BASE_ROOT_DIR}/ci/test/wrap-wine.sh"
 fi
 
@@ -161,7 +145,7 @@ if [ -n "$USE_VALGRIND" ]; then
 fi
 
 if [ "$RUN_UNIT_TESTS" = "true" ]; then
-  DIR_UNIT_TEST_DATA="${DIR_UNIT_TEST_DATA}" LD_LIBRARY_PATH="${DEPENDS_DIR}/${HOST}/lib" make "${MAKEJOBS}" check VERBOSE=1
+  DIR_UNIT_TEST_DATA="${DIR_UNIT_TEST_DATA}" LD_LIBRARY_PATH="${DEPENDS_DIR}/${HOST}/lib" CTEST_OUTPUT_ON_FAILURE=ON ctest "${MAKEJOBS}"
 fi
 
 if [ "$RUN_UNIT_TESTS_SEQUENTIAL" = "true" ]; then
@@ -179,7 +163,7 @@ if [ "${RUN_TIDY}" = "true" ]; then
   cmake --build /tidy-build --target bitcoin-tidy-tests "$MAKEJOBS"
 
   set -eo pipefail
-  cd "${BASE_BUILD_DIR}/bitcoin-$HOST/src/"
+  cd "${BASE_BUILD_DIR}/src/"
   if ! ( run-clang-tidy-"${TIDY_LLVM_V}" -quiet -load="/tidy-build/libbitcoin-tidy.so" "${MAKEJOBS}" | tee tmp.tidy-out.txt ); then
     grep -C5 "error: " tmp.tidy-out.txt
     echo "^^^ ⚠️ Failure generated from clang-tidy"
@@ -189,12 +173,12 @@ if [ "${RUN_TIDY}" = "true" ]; then
   # accepted in src/.bear-tidy-config
   # Filter out:
   # * qt qrc and moc generated files
-  jq 'map(select(.file | test("src/qt/qrc_.*\\.cpp$|/moc_.*\\.cpp$") | not))' ../compile_commands.json > tmp.json
-  mv tmp.json ../compile_commands.json
-  cd "${BASE_BUILD_DIR}/bitcoin-$HOST/"
+  jq 'map(select(.file | test("src/qt/qrc_.*\\.cpp$|/moc_.*\\.cpp$") | not))' "${BASE_BUILD_DIR}/compile_commands.json" > tmp.json
+  mv tmp.json "${BASE_BUILD_DIR}/compile_commands.json"
+  cd "${BASE_ROOT_DIR}"
   python3 "/include-what-you-use/iwyu_tool.py" \
-           -p . "${MAKEJOBS}" \
-           -- -Xiwyu --cxx17ns -Xiwyu --mapping_file="${BASE_BUILD_DIR}/bitcoin-$HOST/contrib/devtools/iwyu/bitcoin.core.imp" \
+           -p "${BASE_BUILD_DIR}" "${MAKEJOBS}" \
+           -- -Xiwyu --cxx17ns -Xiwyu --mapping_file="${BASE_BUILD_DIR}/contrib/devtools/iwyu/bitcoin.core.imp" \
            -Xiwyu --max_line_length=160 \
            2>&1 | tee /tmp/iwyu_ci.out
   cd "${BASE_ROOT_DIR}/src"
diff --git a/ci/test/wrap-wine.sh b/ci/test/wrap-wine.sh
index 90e53887bc4b8..a0d32a93a3f9c 100755
--- a/ci/test/wrap-wine.sh
+++ b/ci/test/wrap-wine.sh
@@ -6,7 +6,7 @@
 
 export LC_ALL=C.UTF-8
 
-for b_name in {"${BASE_OUTDIR}/bin"/*,src/secp256k1/*tests,src/minisketch/test{,-verify},src/univalue/{test_json,unitester,object}}.exe; do
+for b_name in {"${BASE_OUTDIR}/bin"/*,src/univalue/{test_json,unitester,object}}.exe; do
     # shellcheck disable=SC2044
     for b in $(find "${BASE_ROOT_DIR}" -executable -type f -name "$(basename "$b_name")"); do
       if (file "$b" | grep "Windows"); then
diff --git a/cmake/leveldb.cmake b/cmake/leveldb.cmake
index 61ebcd835d253..46421fd4ca4cb 100644
--- a/cmake/leveldb.cmake
+++ b/cmake/leveldb.cmake
@@ -99,3 +99,7 @@ target_link_libraries(leveldb PRIVATE
   nowarn_leveldb_interface
   crc32c
 )
+
+set_target_properties(leveldb PROPERTIES
+  EXPORT_COMPILE_COMMANDS OFF
+)
diff --git a/cmake/minisketch.cmake b/cmake/minisketch.cmake
index c3b90a6ff2f5d..2573b2b1b2bee 100644
--- a/cmake/minisketch.cmake
+++ b/cmake/minisketch.cmake
@@ -57,6 +57,9 @@ if(HAVE_CLMUL)
       core_base_interface
       minisketch_common
   )
+  set_target_properties(minisketch_clmul PROPERTIES
+    EXPORT_COMPILE_COMMANDS OFF
+  )
 endif()
 
 add_library(minisketch STATIC EXCLUDE_FROM_ALL
@@ -82,3 +85,7 @@ target_link_libraries(minisketch
     minisketch_common
     $<TARGET_NAME_IF_EXISTS:minisketch_clmul>
 )
+
+set_target_properties(minisketch PROPERTIES
+  EXPORT_COMPILE_COMMANDS OFF
+)
diff --git a/cmake/module/WarnAboutGlobalProperties.cmake b/cmake/module/WarnAboutGlobalProperties.cmake
index 1cf3a6be86742..faa56a2a7f191 100644
--- a/cmake/module/WarnAboutGlobalProperties.cmake
+++ b/cmake/module/WarnAboutGlobalProperties.cmake
@@ -29,6 +29,7 @@ endif()
 # Instead, prefer the target-specific target_link_libraries() one.
 file(WRITE ${CMAKE_CURRENT_BINARY_DIR}/dummy_cxx_source.cpp "#error")
 add_library(check_loose_linked_libraries OBJECT EXCLUDE_FROM_ALL ${CMAKE_CURRENT_BINARY_DIR}/dummy_cxx_source.cpp)
+set_target_properties(check_loose_linked_libraries PROPERTIES EXPORT_COMPILE_COMMANDS OFF)
 get_target_property(global_linked_libraries check_loose_linked_libraries LINK_LIBRARIES)
 if(global_linked_libraries)
   message(AUTHOR_WARNING "There are libraries linked with `link_libraries` commands: ${global_linked_libraries}")