diff --git a/tools/lastz/lastz.xml b/tools/lastz/lastz.xml
index 96e081cf43e..35e46a149ee 100644
--- a/tools/lastz/lastz.xml
+++ b/tools/lastz/lastz.xml
@@ -6,7 +6,7 @@
     <expand macro="bio_tools"/>
     <requirements>
         <requirement type="package" version="@TOOL_VERSION@">lastz</requirement>
-        <requirement type="package" version="1.14">samtools</requirement>
+        <requirement type="package" version="1.21">samtools</requirement>
         <requirement type="package" version="3.6.3">r-base</requirement>
         <requirement type="package" version="1.0.8">bzip2</requirement>
     </requirements>
diff --git a/tools/lastz/lastz_macros.xml b/tools/lastz/lastz_macros.xml
index b1478c0267e..0e921f49432 100644
--- a/tools/lastz/lastz_macros.xml
+++ b/tools/lastz/lastz_macros.xml
@@ -1,5 +1,5 @@
 <macros>
-    <token name="@TOOL_VERSION@">1.04.22</token>
+    <token name="@TOOL_VERSION@">1.04.41</token>
     <token name="@VERSION_SUFFIX@">0</token>
     <token name="@TARGET_INPUT_COMMAND_LINE@"><![CDATA[
         #if $source.ref_source=="history":