diff --git a/tools/phyloseq/macros.xml b/tools/phyloseq/macros.xml
index ebe365840ac..04bf9c50a3f 100644
--- a/tools/phyloseq/macros.xml
+++ b/tools/phyloseq/macros.xml
@@ -1,5 +1,5 @@
 <macros>
-    <token name="@TOOL_VERSION@">1.46.0</token>
+    <token name="@TOOL_VERSION@">1.50.0</token>
     <token name="@VERSION_SUFFIX@">0</token>
     <token name="@PROFILE@">21.01</token>
     <xml name="bio_tools">
@@ -10,7 +10,7 @@
     <xml name="requirements">
         <requirements>
             <requirement type="package" version="@TOOL_VERSION@">bioconductor-phyloseq</requirement>
-            <requirement type="package" version="1.7.3">r-optparse</requirement>
+            <requirement type="package" version="1.7.5">r-optparse</requirement>
             <requirement type="package" version="2.0.0">r-tidyverse</requirement>
         </requirements>
     </xml>