diff --git a/src/lib/spinel/CMakeLists.txt b/src/lib/spinel/CMakeLists.txt
index 8d552cf08cd..47de4d44175 100644
--- a/src/lib/spinel/CMakeLists.txt
+++ b/src/lib/spinel/CMakeLists.txt
@@ -65,8 +65,8 @@ set(COMMON_SOURCES
 set(OT_SPINEL_VENDOR_HOOK_SOURCE "" CACHE STRING "set vendor hook source file for Spinel")
 set(OT_SPINEL_VENDOR_HOOK_HEADER "" CACHE STRING "set vendor hook header file for Spinel")
 if(OT_SPINEL_VENDOR_HOOK_SOURCE)
-    target_compile_definitions(openthread-spinel-rcp PUBLIC "OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK=1")
-    target_compile_definitions(openthread-spinel-ncp PUBLIC "OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK=1")
+    target_compile_definitions(openthread-spinel-rcp PUBLIC "OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE=1")
+    target_compile_definitions(openthread-spinel-ncp PUBLIC "OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE=1")
     target_compile_definitions(openthread-spinel-rcp PUBLIC "OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_HEADER=\"${OT_SPINEL_VENDOR_HOOK_HEADER}\"")
     target_compile_definitions(openthread-spinel-ncp PUBLIC "OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_HEADER=\"${OT_SPINEL_VENDOR_HOOK_HEADER}\"")
     list(APPEND COMMON_SOURCES ${OT_SPINEL_VENDOR_HOOK_SOURCE_DIR}${OT_SPINEL_VENDOR_HOOK_SOURCE})
diff --git a/src/lib/spinel/example_vendor_hook.cpp b/src/lib/spinel/example_vendor_hook.cpp
index 3c0a73a159a..c43961b7986 100644
--- a/src/lib/spinel/example_vendor_hook.cpp
+++ b/src/lib/spinel/example_vendor_hook.cpp
@@ -30,7 +30,7 @@
  *   This file shows how to implement the Radio Spinel vendor hook.
  */
 
-#if OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
 
 #include OPENTRHEAD_SPINEL_CONFIG_VENDOR_HOOK_HEADER
 #include "common/log.hpp"
@@ -64,4 +64,4 @@ otError RadioSpinel::VendorHandleValueIs(spinel_prop_key_t aPropKey)
 
 extern ot::Spinel::RadioSpinel &GetRadioSpinel(void);
 
-#endif // OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#endif // OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
diff --git a/src/lib/spinel/example_vendor_hook.hpp b/src/lib/spinel/example_vendor_hook.hpp
index f9dedb6269f..df35e8bc3a3 100644
--- a/src/lib/spinel/example_vendor_hook.hpp
+++ b/src/lib/spinel/example_vendor_hook.hpp
@@ -33,7 +33,7 @@
 #ifndef SPINEL_EXTENSION_H
 #define SPINEL_EXTENSION_H
 
-#if OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
 
 #include <openthread/thread_ftd.h>
 #include "lib/spinel/radio_spinel.hpp"
@@ -55,5 +55,5 @@ class VendorRadioSpinel : public ot::Spinel::RadioSpinel
 } // namespace Spinel
 } // namespace ot
 
-#endif // OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#endif // OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
 #endif // SPINEL_EXTENSION_H
diff --git a/src/lib/spinel/openthread-spinel-config.h b/src/lib/spinel/openthread-spinel-config.h
index ef6d5abd249..75dd496ceae 100644
--- a/src/lib/spinel/openthread-spinel-config.h
+++ b/src/lib/spinel/openthread-spinel-config.h
@@ -90,13 +90,13 @@
 #endif
 
 /**
- * @def OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+ * @def OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
  *
  * Enables compilation of vendor specific code for Spinel
  *
  */
-#ifndef OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
-#define OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK 0
+#ifndef OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
+#define OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE 0
 #endif
 
 /**
diff --git a/src/lib/spinel/radio_spinel.cpp b/src/lib/spinel/radio_spinel.cpp
index 7da561ae2cc..495a9bb1ce3 100644
--- a/src/lib/spinel/radio_spinel.cpp
+++ b/src/lib/spinel/radio_spinel.cpp
@@ -747,7 +747,7 @@ void RadioSpinel::HandleValueIs(spinel_prop_key_t aKey, const uint8_t *aBuffer,
             break;
         }
     }
-#if OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
     else if (aKey >= SPINEL_PROP_VENDOR__BEGIN && aKey < SPINEL_PROP_VENDOR__END)
     {
         error = VendorHandleValueIs(aKey);
diff --git a/src/lib/spinel/radio_spinel.hpp b/src/lib/spinel/radio_spinel.hpp
index dcac23e9e9f..594ce9126c2 100644
--- a/src/lib/spinel/radio_spinel.hpp
+++ b/src/lib/spinel/radio_spinel.hpp
@@ -1065,7 +1065,7 @@ class RadioSpinel
      */
     void RestoreProperties(void);
 #endif
-#if OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
     /**
      * Defines a vendor "set property handler" hook to process vendor spinel properties.
      *
diff --git a/src/posix/platform/radio.hpp b/src/posix/platform/radio.hpp
index 00c958c2ff1..49cdfdf3d67 100644
--- a/src/posix/platform/radio.hpp
+++ b/src/posix/platform/radio.hpp
@@ -35,7 +35,7 @@
 #include "posix/platform/radio_url.hpp"
 #include "posix/platform/spi_interface.hpp"
 #include "posix/platform/vendor_interface.hpp"
-#if OPENTHREAD_SPINEL_CONFIG_ENABLE_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
 #ifdef OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_HEADER
 #include OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_HEADER
 #endif
@@ -110,7 +110,7 @@ class Radio
 #endif
 
     RadioUrl mRadioUrl;
-#if OPENTHREAD_ENABLE_SPINEL_VENDOR_HOOK
+#if OPENTHREAD_SPINEL_CONFIG_VENDOR_HOOK_ENABLE
     Spinel::VendorRadioSpinel mRadioSpinel;
 #else
     Spinel::RadioSpinel     mRadioSpinel;