diff --git a/eng/native/configurecompiler.cmake b/eng/native/configurecompiler.cmake
index 99a8013d7cf40..685949ca33dea 100644
--- a/eng/native/configurecompiler.cmake
+++ b/eng/native/configurecompiler.cmake
@@ -393,30 +393,33 @@ if (CLR_CMAKE_HOST_UNIX)
       # replaced with a default value, and always gets expanded to an OS version.
       # https://gitlab.kitware.com/cmake/cmake/-/issues/20132
       # We need to disable the warning that -tagret replaces -mmacosx-version-min
-      add_compile_options(-Wno-overriding-t-option)
+      set(DISABLE_OVERRIDING_MIN_VERSION_ERROR -Wno-overriding-t-option)
       add_link_options(-Wno-overriding-t-option)
       if(CLR_CMAKE_HOST_ARCH_ARM64)
-        add_compile_options(-target arm64-apple-ios14.2-macabi)
+        set(MACOS_VERSION_MIN_FLAGS "-target arm64-apple-ios14.2-macabi")
         add_link_options(-target arm64-apple-ios14.2-macabi)
       elseif(CLR_CMAKE_HOST_ARCH_AMD64)
-        add_compile_options(-target x86_64-apple-ios13.5-macabi)
+        set(MACOS_VERSION_MIN_FLAGS "-target x86_64-apple-ios13.5-macabi")
         add_link_options(-target x86_64-apple-ios13.5-macabi)
       else()
         clr_unknown_arch()
       endif()
+      # These options are intentionally set using the CMAKE_XXX_FLAGS instead of
+      # add_compile_options so that they take effect on the configuration functions
+      # in various configure.cmake files.
+      set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
+      set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
+      set(CMAKE_ASM_FLAGS "${CMAKE_ASM_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
     else()
       if(CLR_CMAKE_HOST_ARCH_ARM64)
-        # 'pthread_jit_write_protect_np' is only available on macOS 11.0 or newer
-        set(MACOS_VERSION_MIN_FLAGS -mmacosx-version-min=11.0)
+        set(CMAKE_OSX_DEPLOYMENT_TARGET "11.0")
         add_compile_options(-arch arm64)
       elseif(CLR_CMAKE_HOST_ARCH_AMD64)
-        set(MACOS_VERSION_MIN_FLAGS -mmacosx-version-min=10.13)
+        set(CMAKE_OSX_DEPLOYMENT_TARGET "10.13")
         add_compile_options(-arch x86_64)
       else()
         clr_unknown_arch()
       endif()
-      add_compile_options(${MACOS_VERSION_MIN_FLAGS})
-      add_linker_flag(${MACOS_VERSION_MIN_FLAGS})
     endif(CLR_CMAKE_TARGET_MACCATALYST)
   endif(CLR_CMAKE_HOST_OSX OR CLR_CMAKE_HOST_MACCATALYST)
 
diff --git a/src/libraries/Native/Unix/CMakeLists.txt b/src/libraries/Native/Unix/CMakeLists.txt
index 24bb6264f35ae..fcd7964aacbe8 100644
--- a/src/libraries/Native/Unix/CMakeLists.txt
+++ b/src/libraries/Native/Unix/CMakeLists.txt
@@ -82,15 +82,23 @@ endif()
 if(CLR_CMAKE_TARGET_MACCATALYST)
     # -target overrides -mmacosx-version-min so suppress warning about that
     # https://gitlab.kitware.com/cmake/cmake/-/issues/20132
-    add_compile_options(-Wno-overriding-t-option)
+    set(DISABLE_OVERRIDING_MIN_VERSION_ERROR -Wno-overriding-t-option)
     add_link_options(-Wno-overriding-t-option)
     if (CLR_CMAKE_TARGET_ARCH_AMD64)
-        add_compile_options(-target x86_64-apple-ios13.5-macabi)
+        set(MACOS_VERSION_MIN_FLAGS "-target x86_64-apple-ios13.5-macabi")
         add_link_options(-target x86_64-apple-ios13.5-macabi)
     elseif (CLR_CMAKE_TARGET_ARCH_ARM64)
-        add_compile_options(-target arm64-apple-ios14.2-macabi)
+        set(MACOS_VERSION_MIN_FLAGS "-target arm64-apple-ios14.2-macabi")
         add_link_options(-target arm64-apple-ios14.2-macabi)
     endif()
+
+    # These options are intentionally set using the CMAKE_XXX_FLAGS instead of
+    # add_compile_options so that they take effect on the configuration functions
+    # in various configure.cmake files.
+    set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
+    set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
+    set(CMAKE_ASM_FLAGS "${CMAKE_ASM_FLAGS} ${MACOS_VERSION_MIN_FLAGS} ${DISABLE_OVERRIDING_MIN_VERSION_ERROR}")
+
 endif()
 
 if(CLR_CMAKE_TARGET_TVOS)
diff --git a/src/libraries/Native/Unix/System.Native/CMakeLists.txt b/src/libraries/Native/Unix/System.Native/CMakeLists.txt
index d21e27a561b0f..a28952750b3ef 100644
--- a/src/libraries/Native/Unix/System.Native/CMakeLists.txt
+++ b/src/libraries/Native/Unix/System.Native/CMakeLists.txt
@@ -4,6 +4,10 @@ if (NOT CLR_CMAKE_TARGET_MACCATALYST AND NOT CLR_CMAKE_TARGET_IOS AND NOT CLR_CM
     add_definitions(-DHAS_CONSOLE_SIGNALS)
 endif ()
 
+if (CLR_CMAKE_TARGET_OSX)
+    add_definitions(-D_DARWIN_C_SOURCE)
+endif ()
+
 include_directories("${CLR_SRC_NATIVE_DIR}/common")
 
 set(NATIVE_SOURCES
diff --git a/src/libraries/Native/build-native.sh b/src/libraries/Native/build-native.sh
index f95f1f622f0e4..ba3e88b4260be 100755
--- a/src/libraries/Native/build-native.sh
+++ b/src/libraries/Native/build-native.sh
@@ -77,7 +77,11 @@ fi
 
 if [[ "$__TargetOS" == OSX ]]; then
     # set default OSX deployment target
-    __CMakeArgs="-DCMAKE_OSX_DEPLOYMENT_TARGET=10.13 $__CMakeArgs"
+    if [[ "$__BuildArch" == x64 ]]; then
+        __CMakeArgs="-DCMAKE_OSX_DEPLOYMENT_TARGET=10.13 $__CMakeArgs"
+    else
+        __CMakeArgs="-DCMAKE_OSX_DEPLOYMENT_TARGET=11.0 $__CMakeArgs"
+    fi
 elif [[ "$__TargetOS" == Android && -z "$ROOTFS_DIR" ]]; then
     if [[ -z "$ANDROID_NDK_ROOT" ]]; then
         echo "Error: You need to set the ANDROID_NDK_ROOT environment variable pointing to the Android NDK root."