diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index 9675bc78..53b13038 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -148266,7 +148266,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -148327,7 +148326,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:16858612"
       - subsystem:
@@ -148386,7 +148384,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -148594,7 +148591,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:16858612"
       - subsystem:
@@ -148653,7 +148649,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -148711,7 +148706,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -149149,7 +149143,6 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165029"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:16858612"
       - subsystem:
@@ -150007,7 +150000,7 @@
           - MAM02900e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021488 or ENSG00000084453 or ENSG00000111700"
+      - gene_reaction_rule: "ENSG00000084453 or ENSG00000111700"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14579113"
       - subsystem:
@@ -150041,7 +150034,7 @@
           - MAM02046e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021488 or ENSG00000084453 or ENSG00000111700"
+      - gene_reaction_rule: "ENSG00000084453 or ENSG00000111700"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14579113"
       - subsystem:
@@ -150734,7 +150727,7 @@
           - MAM02039e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
+      - gene_reaction_rule: "ENSG00000100156 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12107270;PMID:12739169;PMID:12829793;PMID:17173541;PMID:17245649;PMID:18305372;PMID:18375207;PMID:8476015;PMID:8557697;PMID:9651205;PMID:9786900"
       - subsystem:
@@ -152679,7 +152672,6 @@
           - MAM02770e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -153774,7 +153766,7 @@
           - MAM02724e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103257 or ENSG00000165029"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -154297,7 +154289,6 @@
           - MAM02993e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -154496,7 +154487,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -154800,7 +154791,7 @@
           - MAM03089e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -154834,7 +154825,7 @@
           - MAM03101e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -154952,7 +154943,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155156,7 +155147,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000105281"
+      - gene_reaction_rule: "ENSG00000105281"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155377,7 +155368,7 @@
           - MAM02896e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155598,7 +155589,7 @@
           - MAM03101e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155700,7 +155691,7 @@
           - MAM02993e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155972,7 +155963,7 @@
           - MAM03089e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156156,7 +156147,6 @@
           - MAM02770e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156222,7 +156212,6 @@
           - MAM02724e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156322,7 +156311,6 @@
           - MAM03101e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156671,7 +156659,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000105281 or ENSG00000115902"
+      - gene_reaction_rule: "ENSG00000105281 or ENSG00000115902"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156721,7 +156709,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156955,7 +156942,6 @@
           - MAM02993e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157071,7 +157057,6 @@
           - MAM02770e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157088,7 +157073,6 @@
           - MAM03089e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157122,7 +157106,6 @@
           - MAM03101e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157203,7 +157186,6 @@
           - MAM02993e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157485,7 +157467,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157832,7 +157813,6 @@
           - MAM03089e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158030,7 +158010,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158063,7 +158042,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158209,7 +158187,6 @@
           - MAM02993e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158226,7 +158203,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158293,7 +158269,6 @@
           - MAM02896e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158460,7 +158435,6 @@
           - MAM02993e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158562,7 +158536,6 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158987,7 +158960,6 @@
           - MAM03089e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -161181,7 +161153,7 @@
           - MAM02403e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
+      - gene_reaction_rule: "ENSG00000100156 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12739169;PMID:18305372;PMID:11101640;PMID:23935841;PMID:31719150"
       - subsystem:
@@ -173277,7 +173249,7 @@
           - MAM02658m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000102743 or ENSG00000120329"
+      - gene_reaction_rule: "ENSG00000120329"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14598172"
       - subsystem:
@@ -174150,7 +174122,6 @@
           - MAM01756m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -174275,7 +174246,6 @@
           - MAM01753m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -174387,7 +174357,6 @@
           - MAM01645m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -179295,7 +179264,6 @@
           - MAM03114g: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000205060"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -231703,7 +231671,6 @@
           - MAM02039e: -2
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100170"
       - rxnFrom: "Recon3D"
       - eccodes: "2.4.1.92"
       - references: "PMID:11024018;PMID:11034615;PMID:12748858;PMID:2490366;PMID:8063771"
@@ -232293,7 +232260,6 @@
           - MAM02519e: 3
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165970"
       - rxnFrom: "Recon3D"
       - references: "PMID:20649585;PMID:12719981"
       - subsystem:
@@ -235282,7 +235248,6 @@
           - MAM02147e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000173638"
       - rxnFrom: "Recon3D"
       - references: "PMID:17687501"
       - subsystem:
@@ -237103,7 +237068,6 @@
           - MAM01681e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000142583"
       - rxnFrom: "Recon3D"
       - references: "PMID:23084044"
       - subsystem: