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Drug quantity convention example #708

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MaximMoinat opened this issue Aug 26, 2024 · 3 comments
Open

Drug quantity convention example #708

MaximMoinat opened this issue Aug 26, 2024 · 3 comments

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@MaximMoinat
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The description for drug quantity says:
image

However, in calculation examples I can find it is suggested that total dose is normally calculated as quantity * numerator_value for divisible products. For example:

See also OHDSI/Themis#137.

@MaximMoinat MaximMoinat changed the title Drug Quantity convention example - is this correct? Drug quantity convention example Aug 26, 2024
@MaximMoinat
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MaximMoinat commented Aug 27, 2024

To clarify: for a liquid/suspension/solution drug product, I expect the quantity to refer to the number of milliliters given, not the total dose in milligram. The dose can then be calculated from quantity and numerator_value in drug_strength table.

It would also help if there was an example in the drug dose page specifically for a solution clinical drug and a number of ml administered.

e.g.

  1. Clinical Drug formulated as a concentration
    Example: The Clinical Drug is Acetaminophen 200 MG/ML Oral Suspension. 5 ml is administered (quantity 5).
    DRUG_STRENGTH The denominator_unit is mL. The denominator_value might be different from 1.
    DRUG_EXPOSURE The quantity refers to the amount administered, in the denominator_value.
    In the example: 5
    Ingredient dose= quantity x numerator_value [numerator_unit_concept_id]
    Acetaminophen dose = 5 x 200mg = 1000mg
    Daily dose = Acetaminophen dose/drug duration

@MelaniePhilofsky
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We also need the denominator value as per my example in this post. I have a question to the Vocab team about this field.

@MaximMoinat
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For awareness, there is now a thread on the Forums with new proposal for the CDM and conventions.
Drug Dose: Fixes required to allow a standardized calculation - Call for input

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