diff --git a/404.html b/404.html
index f7b3290..1173f8e 100644
--- a/404.html
+++ b/404.html
@@ -8,8 +8,8 @@
 <title>Page not found (404) • GeoTox</title>
 <script src="https://github.com/NIEHS/GeoTox/deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
 <link href="https://github.com/NIEHS/GeoTox/deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
-<script src="https://github.com/NIEHS/GeoTox/deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="https://github.com/NIEHS/GeoTox/deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
-<link href="https://github.com/NIEHS/GeoTox/deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="https://github.com/NIEHS/GeoTox/deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="https://github.com/NIEHS/GeoTox/deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet">
+<link href="https://github.com/NIEHS/GeoTox/deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet">
 <script src="https://github.com/NIEHS/GeoTox/deps/headroom-0.11.0/headroom.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/search-1.0.0/fuse.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/search-1.0.0/mark.min.js"></script><script src="https://github.com/NIEHS/GeoTox/deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="https://github.com/NIEHS/GeoTox/pkgdown.js"></script><meta property="og:title" content="Page not found (404)">
 <meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg">
 </head>
@@ -21,7 +21,7 @@
 
     <a class="navbar-brand me-2" href="https://github.com/NIEHS/GeoTox/index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
diff --git a/CODE_OF_CONDUCT.html b/CODE_OF_CONDUCT.html
index 9997dcc..0785e8a 100644
--- a/CODE_OF_CONDUCT.html
+++ b/CODE_OF_CONDUCT.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Contributor Covenant Code of Conduct • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Contributor Covenant Code of Conduct"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Contributor Covenant Code of Conduct • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Contributor Covenant Code of Conduct"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="logo.svg" class="logo" alt=""><h1>Contributor Covenant Code of Conduct</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/CODE_OF_CONDUCT.md"><code>CODE_OF_CONDUCT.md</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/CODE_OF_CONDUCT.md"><code>CODE_OF_CONDUCT.md</code></a></small>
     </div>
 
 <div id="contributor-covenant-code-of-conduct" class="section level1">
diff --git a/CONTRIBUTING.html b/CONTRIBUTING.html
index 78891b6..44e683a 100644
--- a/CONTRIBUTING.html
+++ b/CONTRIBUTING.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Contributing to GeoTox • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Contributing to GeoTox"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Contributing to GeoTox • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Contributing to GeoTox"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="logo.svg" class="logo" alt=""><h1>Contributing to GeoTox</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/.github/CONTRIBUTING.md"><code>.github/CONTRIBUTING.md</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/.github/CONTRIBUTING.md"><code>.github/CONTRIBUTING.md</code></a></small>
     </div>
 
 <div id="contributing-to-geotox" class="section level1">
diff --git a/LICENSE-text.html b/LICENSE-text.html
index 5ef6363..4864bf1 100644
--- a/LICENSE-text.html
+++ b/LICENSE-text.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>License • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="License"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>License • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="License"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
diff --git a/LICENSE.html b/LICENSE.html
index 5dd01db..4290136 100644
--- a/LICENSE.html
+++ b/LICENSE.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>MIT License • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="MIT License"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>MIT License • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="MIT License"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="logo.svg" class="logo" alt=""><h1>MIT License</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/LICENSE.md"><code>LICENSE.md</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/LICENSE.md"><code>LICENSE.md</code></a></small>
     </div>
 
 <div id="mit-license" class="section level1">
diff --git a/articles/index.html b/articles/index.html
index c66201a..1624522 100644
--- a/articles/index.html
+++ b/articles/index.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
diff --git a/articles/introduction.html b/articles/introduction.html
index 197b75e..9dfbdce 100644
--- a/articles/introduction.html
+++ b/articles/introduction.html
@@ -8,8 +8,8 @@
 <title>GeoTox Introduction • GeoTox</title>
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
 <link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
-<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet">
 <script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox Introduction">
 </head>
 <body>
@@ -20,7 +20,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -58,7 +58,7 @@
       <img src="../logo.svg" class="logo" alt=""><h1>GeoTox Introduction</h1>
             
       
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/vignettes/introduction.Rmd"><code>vignettes/introduction.Rmd</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/vignettes/introduction.Rmd"><code>vignettes/introduction.Rmd</code></a></small>
       <div class="d-none name"><code>introduction.Rmd</code></div>
     </div>
 
@@ -76,8 +76,9 @@
 <blockquote>
 <p><strong>NOTE:</strong> The sample size here is the size of the
 simulated population in each region. This is different than the sample
-size in the “package_data” vignette, which is used to generate C_ss
-values for each chemical at specified age and weight combinations.</p>
+size in the “package_data” vignette, which is used to generate
+<code>C_ss</code> values for each chemical at specified age and weight
+combinations.</p>
 </blockquote>
 <div class="section level2">
 <h2 id="analysis-of-single-assay">Analysis of single assay<a class="anchor" aria-label="anchor" href="#analysis-of-single-assay"></a>
diff --git a/articles/package_data.html b/articles/package_data.html
index 196f4b6..d178406 100644
--- a/articles/package_data.html
+++ b/articles/package_data.html
@@ -8,8 +8,8 @@
 <title>GeoTox Package Data • GeoTox</title>
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
 <link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
-<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet">
 <script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox Package Data">
 </head>
 <body>
@@ -20,7 +20,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -58,7 +58,7 @@
       <img src="../logo.svg" class="logo" alt=""><h1>GeoTox Package Data</h1>
             
       
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/vignettes/package_data.Rmd"><code>vignettes/package_data.Rmd</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/vignettes/package_data.Rmd"><code>vignettes/package_data.Rmd</code></a></small>
       <div class="d-none name"><code>package_data.Rmd</code></div>
     </div>
 
@@ -358,12 +358,13 @@ <h3 id="obesity">Obesity<a class="anchor" aria-label="anchor" href="#obesity"></
 <span>  <span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span><span class="op">-</span><span class="va">OBESITY_Crude95CI</span><span class="op">)</span></span></code></pre></div>
 </div>
 <div class="section level3">
-<h3 id="steady-state-plasma-concentration-css">Steady-state plasma concentration (Css)<a class="anchor" aria-label="anchor" href="#steady-state-plasma-concentration-css"></a>
+<h3 id="steady-state-plasma-concentration-c_ss">Steady-state plasma concentration (<code>C_ss</code>)<a class="anchor" aria-label="anchor" href="#steady-state-plasma-concentration-c_ss"></a>
 </h3>
-<p>Use <code>httk</code> to generate Css values for combinations of age
-group and weight status for each chemical. The generation of these
-values is a time-intensive step, so one approach is to generate
-populations of Css values initially and then sample them later.</p>
+<p>Use <code>httk</code> to generate <code>C_ss</code> values for
+combinations of age group and weight status for each chemical. The
+generation of these values is a time-intensive step, so one approach is
+to generate populations of <code>C_ss</code> values initially and then
+sample them later.</p>
 <div class="sourceCode" id="cb8"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">2345</span><span class="op">)</span></span>
 <span><span class="va">n_samples</span> <span class="op">&lt;-</span> <span class="fl">500</span></span>
@@ -433,7 +434,7 @@ <h3 id="steady-state-plasma-concentration-css">Steady-state plasma concentration
 <span>  <span class="op">}</span></span>
 <span><span class="op">}</span></span>
 <span></span>
-<span><span class="co"># Simulate Css values</span></span>
+<span><span class="co"># Simulate `C_ss` values</span></span>
 <span><span class="va">simulated_css</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://purrr.tidyverse.org/reference/map.html" class="external-link">map</a></span><span class="op">(</span><span class="va">casn</span>, <span class="kw">function</span><span class="op">(</span><span class="va">chem.cas</span><span class="op">)</span> <span class="op">{</span></span>
 <span>  <span class="va">pop_demo</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/rowwise.html" class="external-link">rowwise</a></span><span class="op">(</span><span class="op">)</span> <span class="op">|&gt;</span></span>
@@ -450,7 +451,7 @@ <h3 id="steady-state-plasma-concentration-css">Steady-state plasma concentration
 <span><span class="op">}</span><span class="op">)</span></span>
 <span><span class="va">simulated_css</span> <span class="op">&lt;-</span> <span class="va">simulated_css</span><span class="op">[</span><span class="va">casn_keep</span><span class="op">]</span></span>
 <span></span>
-<span><span class="co"># Get median Css values for each age_group</span></span>
+<span><span class="co"># Get median `C_ss` values for each age_group</span></span>
 <span><span class="va">simulated_css</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://purrr.tidyverse.org/reference/map.html" class="external-link">map</a></span><span class="op">(</span></span>
 <span>  <span class="va">simulated_css</span>,</span>
 <span>  <span class="kw">function</span><span class="op">(</span><span class="va">cas_df</span><span class="op">)</span> <span class="op">{</span></span>
@@ -464,7 +465,7 @@ <h3 id="steady-state-plasma-concentration-css">Steady-state plasma concentration
 <span>  <span class="op">}</span></span>
 <span><span class="op">)</span></span>
 <span></span>
-<span><span class="co"># Get median Css values for each weight</span></span>
+<span><span class="co"># Get median `C_ss` values for each weight</span></span>
 <span><span class="va">simulated_css</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://purrr.tidyverse.org/reference/map.html" class="external-link">map</a></span><span class="op">(</span></span>
 <span>  <span class="va">simulated_css</span>,</span>
 <span>  <span class="kw">function</span><span class="op">(</span><span class="va">cas_df</span><span class="op">)</span> <span class="op">{</span></span>
@@ -485,8 +486,8 @@ <h3 id="steady-state-plasma-concentration-css">Steady-state plasma concentration
 <div class="section level2">
 <h2 id="prune-data">Prune data<a class="anchor" aria-label="anchor" href="#prune-data"></a>
 </h2>
-<p>Retain only those chemicals found in exposure, dose-response and Css
-datasets.</p>
+<p>Retain only those chemicals found in exposure, dose-response and
+<code>C_ss</code> datasets.</p>
 <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">casn_keep</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">geo_tox_data</span><span class="op">$</span><span class="va">simulated_css</span><span class="op">)</span></span>
 <span></span>
diff --git a/authors.html b/authors.html
index b637c65..23ed9ad 100644
--- a/authors.html
+++ b/authors.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • GeoTox</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -38,15 +38,15 @@
       <h2>Authors</h2>
 
       <ul class="list-unstyled"><li>
-          <p><strong>Skylar Marvel</strong>. Author, contributor. <a href="https://orcid.org/0000-0002-2971-9743" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
+          <p><strong>Skylar Marvel</strong>. Author. <a href="https://orcid.org/0000-0002-2971-9743" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
           </p>
         </li>
         <li>
-          <p><strong>David Reif</strong>. Author, contributor. <a href="https://orcid.org/0000-0001-7815-6767" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
+          <p><strong>David Reif</strong>. Author. <a href="https://orcid.org/0000-0001-7815-6767" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
           </p>
         </li>
         <li>
-          <p><strong>Kyle Messier</strong>. Maintainer, author, contributor. <a href="https://orcid.org/0000-0001-9508-9623" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
+          <p><strong>Kyle Messier</strong>. Maintainer, author. <a href="https://orcid.org/0000-0001-9508-9623" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
           </p>
         </li>
         <li>
@@ -57,7 +57,7 @@ <h2>Authors</h2>
 
     <div class="section level2">
       <h2 id="citation">Citation</h2>
-      <p><small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/inst/CITATION"><code>inst/CITATION</code></a></small></p>
+      <p><small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/inst/CITATION"><code>inst/CITATION</code></a></small></p>
 
       <p>Messier, P K, Reif, M D, Marvel, W S (2024).
 “The GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk.”
diff --git a/deps/data-deps.txt b/deps/data-deps.txt
index 0e6f92e..a4ab73a 100644
--- a/deps/data-deps.txt
+++ b/deps/data-deps.txt
@@ -2,8 +2,8 @@
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" />
 <link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet" />
 <script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script>
-<link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet" />
-<link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet" />
+<link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet" />
+<link href="deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet" />
 <script src="deps/headroom-0.11.0/headroom.min.js"></script>
 <script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script>
 <script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script>
diff --git a/deps/font-awesome-6.5.2/css/all.css b/deps/font-awesome-6.5.2/css/all.css
new file mode 100644
index 0000000..151dd57
--- /dev/null
+++ b/deps/font-awesome-6.5.2/css/all.css
@@ -0,0 +1,8028 @@
+/*!
+ * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2024 Fonticons, Inc.
+ */
+.fa {
+  font-family: var(--fa-style-family, "Font Awesome 6 Free");
+  font-weight: var(--fa-style, 900); }
+
+.fa,
+.fa-classic,
+.fa-sharp,
+.fas,
+.fa-solid,
+.far,
+.fa-regular,
+.fab,
+.fa-brands {
+  -moz-osx-font-smoothing: grayscale;
+  -webkit-font-smoothing: antialiased;
+  display: var(--fa-display, inline-block);
+  font-style: normal;
+  font-variant: normal;
+  line-height: 1;
+  text-rendering: auto; }
+
+.fas,
+.fa-classic,
+.fa-solid,
+.far,
+.fa-regular {
+  font-family: 'Font Awesome 6 Free'; }
+
+.fab,
+.fa-brands {
+  font-family: 'Font Awesome 6 Brands'; }
+
+.fa-1x {
+  font-size: 1em; }
+
+.fa-2x {
+  font-size: 2em; }
+
+.fa-3x {
+  font-size: 3em; }
+
+.fa-4x {
+  font-size: 4em; }
+
+.fa-5x {
+  font-size: 5em; }
+
+.fa-6x {
+  font-size: 6em; }
+
+.fa-7x {
+  font-size: 7em; }
+
+.fa-8x {
+  font-size: 8em; }
+
+.fa-9x {
+  font-size: 9em; }
+
+.fa-10x {
+  font-size: 10em; }
+
+.fa-2xs {
+  font-size: 0.625em;
+  line-height: 0.1em;
+  vertical-align: 0.225em; }
+
+.fa-xs {
+  font-size: 0.75em;
+  line-height: 0.08333em;
+  vertical-align: 0.125em; }
+
+.fa-sm {
+  font-size: 0.875em;
+  line-height: 0.07143em;
+  vertical-align: 0.05357em; }
+
+.fa-lg {
+  font-size: 1.25em;
+  line-height: 0.05em;
+  vertical-align: -0.075em; }
+
+.fa-xl {
+  font-size: 1.5em;
+  line-height: 0.04167em;
+  vertical-align: -0.125em; }
+
+.fa-2xl {
+  font-size: 2em;
+  line-height: 0.03125em;
+  vertical-align: -0.1875em; }
+
+.fa-fw {
+  text-align: center;
+  width: 1.25em; }
+
+.fa-ul {
+  list-style-type: none;
+  margin-left: var(--fa-li-margin, 2.5em);
+  padding-left: 0; }
+  .fa-ul > li {
+    position: relative; }
+
+.fa-li {
+  left: calc(var(--fa-li-width, 2em) * -1);
+  position: absolute;
+  text-align: center;
+  width: var(--fa-li-width, 2em);
+  line-height: inherit; }
+
+.fa-border {
+  border-color: var(--fa-border-color, #eee);
+  border-radius: var(--fa-border-radius, 0.1em);
+  border-style: var(--fa-border-style, solid);
+  border-width: var(--fa-border-width, 0.08em);
+  padding: var(--fa-border-padding, 0.2em 0.25em 0.15em); }
+
+.fa-pull-left {
+  float: left;
+  margin-right: var(--fa-pull-margin, 0.3em); }
+
+.fa-pull-right {
+  float: right;
+  margin-left: var(--fa-pull-margin, 0.3em); }
+
+.fa-beat {
+  -webkit-animation-name: fa-beat;
+          animation-name: fa-beat;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-bounce {
+  -webkit-animation-name: fa-bounce;
+          animation-name: fa-bounce;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); }
+
+.fa-fade {
+  -webkit-animation-name: fa-fade;
+          animation-name: fa-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-beat-fade {
+  -webkit-animation-name: fa-beat-fade;
+          animation-name: fa-beat-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-flip {
+  -webkit-animation-name: fa-flip;
+          animation-name: fa-flip;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-shake {
+  -webkit-animation-name: fa-shake;
+          animation-name: fa-shake;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 2s);
+          animation-duration: var(--fa-animation-duration, 2s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin-reverse {
+  --fa-animation-direction: reverse; }
+
+.fa-pulse,
+.fa-spin-pulse {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, steps(8));
+          animation-timing-function: var(--fa-animation-timing, steps(8)); }
+
+@media (prefers-reduced-motion: reduce) {
+  .fa-beat,
+  .fa-bounce,
+  .fa-fade,
+  .fa-beat-fade,
+  .fa-flip,
+  .fa-pulse,
+  .fa-shake,
+  .fa-spin,
+  .fa-spin-pulse {
+    -webkit-animation-delay: -1ms;
+            animation-delay: -1ms;
+    -webkit-animation-duration: 1ms;
+            animation-duration: 1ms;
+    -webkit-animation-iteration-count: 1;
+            animation-iteration-count: 1;
+    -webkit-transition-delay: 0s;
+            transition-delay: 0s;
+    -webkit-transition-duration: 0s;
+            transition-duration: 0s; } }
+
+@-webkit-keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@-webkit-keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@-webkit-keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@-webkit-keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@-webkit-keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@-webkit-keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@-webkit-keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+@keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+.fa-rotate-90 {
+  -webkit-transform: rotate(90deg);
+          transform: rotate(90deg); }
+
+.fa-rotate-180 {
+  -webkit-transform: rotate(180deg);
+          transform: rotate(180deg); }
+
+.fa-rotate-270 {
+  -webkit-transform: rotate(270deg);
+          transform: rotate(270deg); }
+
+.fa-flip-horizontal {
+  -webkit-transform: scale(-1, 1);
+          transform: scale(-1, 1); }
+
+.fa-flip-vertical {
+  -webkit-transform: scale(1, -1);
+          transform: scale(1, -1); }
+
+.fa-flip-both,
+.fa-flip-horizontal.fa-flip-vertical {
+  -webkit-transform: scale(-1, -1);
+          transform: scale(-1, -1); }
+
+.fa-rotate-by {
+  -webkit-transform: rotate(var(--fa-rotate-angle, 0));
+          transform: rotate(var(--fa-rotate-angle, 0)); }
+
+.fa-stack {
+  display: inline-block;
+  height: 2em;
+  line-height: 2em;
+  position: relative;
+  vertical-align: middle;
+  width: 2.5em; }
+
+.fa-stack-1x,
+.fa-stack-2x {
+  left: 0;
+  position: absolute;
+  text-align: center;
+  width: 100%;
+  z-index: var(--fa-stack-z-index, auto); }
+
+.fa-stack-1x {
+  line-height: inherit; }
+
+.fa-stack-2x {
+  font-size: 2em; }
+
+.fa-inverse {
+  color: var(--fa-inverse, #fff); }
+
+/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
+readers do not read off random characters that represent icons */
+
+.fa-0::before {
+  content: "\30"; }
+
+.fa-1::before {
+  content: "\31"; }
+
+.fa-2::before {
+  content: "\32"; }
+
+.fa-3::before {
+  content: "\33"; }
+
+.fa-4::before {
+  content: "\34"; }
+
+.fa-5::before {
+  content: "\35"; }
+
+.fa-6::before {
+  content: "\36"; }
+
+.fa-7::before {
+  content: "\37"; }
+
+.fa-8::before {
+  content: "\38"; }
+
+.fa-9::before {
+  content: "\39"; }
+
+.fa-fill-drip::before {
+  content: "\f576"; }
+
+.fa-arrows-to-circle::before {
+  content: "\e4bd"; }
+
+.fa-circle-chevron-right::before {
+  content: "\f138"; }
+
+.fa-chevron-circle-right::before {
+  content: "\f138"; }
+
+.fa-at::before {
+  content: "\40"; }
+
+.fa-trash-can::before {
+  content: "\f2ed"; }
+
+.fa-trash-alt::before {
+  content: "\f2ed"; }
+
+.fa-text-height::before {
+  content: "\f034"; }
+
+.fa-user-xmark::before {
+  content: "\f235"; }
+
+.fa-user-times::before {
+  content: "\f235"; }
+
+.fa-stethoscope::before {
+  content: "\f0f1"; }
+
+.fa-message::before {
+  content: "\f27a"; }
+
+.fa-comment-alt::before {
+  content: "\f27a"; }
+
+.fa-info::before {
+  content: "\f129"; }
+
+.fa-down-left-and-up-right-to-center::before {
+  content: "\f422"; }
+
+.fa-compress-alt::before {
+  content: "\f422"; }
+
+.fa-explosion::before {
+  content: "\e4e9"; }
+
+.fa-file-lines::before {
+  content: "\f15c"; }
+
+.fa-file-alt::before {
+  content: "\f15c"; }
+
+.fa-file-text::before {
+  content: "\f15c"; }
+
+.fa-wave-square::before {
+  content: "\f83e"; }
+
+.fa-ring::before {
+  content: "\f70b"; }
+
+.fa-building-un::before {
+  content: "\e4d9"; }
+
+.fa-dice-three::before {
+  content: "\f527"; }
+
+.fa-calendar-days::before {
+  content: "\f073"; }
+
+.fa-calendar-alt::before {
+  content: "\f073"; }
+
+.fa-anchor-circle-check::before {
+  content: "\e4aa"; }
+
+.fa-building-circle-arrow-right::before {
+  content: "\e4d1"; }
+
+.fa-volleyball::before {
+  content: "\f45f"; }
+
+.fa-volleyball-ball::before {
+  content: "\f45f"; }
+
+.fa-arrows-up-to-line::before {
+  content: "\e4c2"; }
+
+.fa-sort-down::before {
+  content: "\f0dd"; }
+
+.fa-sort-desc::before {
+  content: "\f0dd"; }
+
+.fa-circle-minus::before {
+  content: "\f056"; }
+
+.fa-minus-circle::before {
+  content: "\f056"; }
+
+.fa-door-open::before {
+  content: "\f52b"; }
+
+.fa-right-from-bracket::before {
+  content: "\f2f5"; }
+
+.fa-sign-out-alt::before {
+  content: "\f2f5"; }
+
+.fa-atom::before {
+  content: "\f5d2"; }
+
+.fa-soap::before {
+  content: "\e06e"; }
+
+.fa-icons::before {
+  content: "\f86d"; }
+
+.fa-heart-music-camera-bolt::before {
+  content: "\f86d"; }
+
+.fa-microphone-lines-slash::before {
+  content: "\f539"; }
+
+.fa-microphone-alt-slash::before {
+  content: "\f539"; }
+
+.fa-bridge-circle-check::before {
+  content: "\e4c9"; }
+
+.fa-pump-medical::before {
+  content: "\e06a"; }
+
+.fa-fingerprint::before {
+  content: "\f577"; }
+
+.fa-hand-point-right::before {
+  content: "\f0a4"; }
+
+.fa-magnifying-glass-location::before {
+  content: "\f689"; }
+
+.fa-search-location::before {
+  content: "\f689"; }
+
+.fa-forward-step::before {
+  content: "\f051"; }
+
+.fa-step-forward::before {
+  content: "\f051"; }
+
+.fa-face-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-flag-checkered::before {
+  content: "\f11e"; }
+
+.fa-football::before {
+  content: "\f44e"; }
+
+.fa-football-ball::before {
+  content: "\f44e"; }
+
+.fa-school-circle-exclamation::before {
+  content: "\e56c"; }
+
+.fa-crop::before {
+  content: "\f125"; }
+
+.fa-angles-down::before {
+  content: "\f103"; }
+
+.fa-angle-double-down::before {
+  content: "\f103"; }
+
+.fa-users-rectangle::before {
+  content: "\e594"; }
+
+.fa-people-roof::before {
+  content: "\e537"; }
+
+.fa-people-line::before {
+  content: "\e534"; }
+
+.fa-beer-mug-empty::before {
+  content: "\f0fc"; }
+
+.fa-beer::before {
+  content: "\f0fc"; }
+
+.fa-diagram-predecessor::before {
+  content: "\e477"; }
+
+.fa-arrow-up-long::before {
+  content: "\f176"; }
+
+.fa-long-arrow-up::before {
+  content: "\f176"; }
+
+.fa-fire-flame-simple::before {
+  content: "\f46a"; }
+
+.fa-burn::before {
+  content: "\f46a"; }
+
+.fa-person::before {
+  content: "\f183"; }
+
+.fa-male::before {
+  content: "\f183"; }
+
+.fa-laptop::before {
+  content: "\f109"; }
+
+.fa-file-csv::before {
+  content: "\f6dd"; }
+
+.fa-menorah::before {
+  content: "\f676"; }
+
+.fa-truck-plane::before {
+  content: "\e58f"; }
+
+.fa-record-vinyl::before {
+  content: "\f8d9"; }
+
+.fa-face-grin-stars::before {
+  content: "\f587"; }
+
+.fa-grin-stars::before {
+  content: "\f587"; }
+
+.fa-bong::before {
+  content: "\f55c"; }
+
+.fa-spaghetti-monster-flying::before {
+  content: "\f67b"; }
+
+.fa-pastafarianism::before {
+  content: "\f67b"; }
+
+.fa-arrow-down-up-across-line::before {
+  content: "\e4af"; }
+
+.fa-spoon::before {
+  content: "\f2e5"; }
+
+.fa-utensil-spoon::before {
+  content: "\f2e5"; }
+
+.fa-jar-wheat::before {
+  content: "\e517"; }
+
+.fa-envelopes-bulk::before {
+  content: "\f674"; }
+
+.fa-mail-bulk::before {
+  content: "\f674"; }
+
+.fa-file-circle-exclamation::before {
+  content: "\e4eb"; }
+
+.fa-circle-h::before {
+  content: "\f47e"; }
+
+.fa-hospital-symbol::before {
+  content: "\f47e"; }
+
+.fa-pager::before {
+  content: "\f815"; }
+
+.fa-address-book::before {
+  content: "\f2b9"; }
+
+.fa-contact-book::before {
+  content: "\f2b9"; }
+
+.fa-strikethrough::before {
+  content: "\f0cc"; }
+
+.fa-k::before {
+  content: "\4b"; }
+
+.fa-landmark-flag::before {
+  content: "\e51c"; }
+
+.fa-pencil::before {
+  content: "\f303"; }
+
+.fa-pencil-alt::before {
+  content: "\f303"; }
+
+.fa-backward::before {
+  content: "\f04a"; }
+
+.fa-caret-right::before {
+  content: "\f0da"; }
+
+.fa-comments::before {
+  content: "\f086"; }
+
+.fa-paste::before {
+  content: "\f0ea"; }
+
+.fa-file-clipboard::before {
+  content: "\f0ea"; }
+
+.fa-code-pull-request::before {
+  content: "\e13c"; }
+
+.fa-clipboard-list::before {
+  content: "\f46d"; }
+
+.fa-truck-ramp-box::before {
+  content: "\f4de"; }
+
+.fa-truck-loading::before {
+  content: "\f4de"; }
+
+.fa-user-check::before {
+  content: "\f4fc"; }
+
+.fa-vial-virus::before {
+  content: "\e597"; }
+
+.fa-sheet-plastic::before {
+  content: "\e571"; }
+
+.fa-blog::before {
+  content: "\f781"; }
+
+.fa-user-ninja::before {
+  content: "\f504"; }
+
+.fa-person-arrow-up-from-line::before {
+  content: "\e539"; }
+
+.fa-scroll-torah::before {
+  content: "\f6a0"; }
+
+.fa-torah::before {
+  content: "\f6a0"; }
+
+.fa-broom-ball::before {
+  content: "\f458"; }
+
+.fa-quidditch::before {
+  content: "\f458"; }
+
+.fa-quidditch-broom-ball::before {
+  content: "\f458"; }
+
+.fa-toggle-off::before {
+  content: "\f204"; }
+
+.fa-box-archive::before {
+  content: "\f187"; }
+
+.fa-archive::before {
+  content: "\f187"; }
+
+.fa-person-drowning::before {
+  content: "\e545"; }
+
+.fa-arrow-down-9-1::before {
+  content: "\f886"; }
+
+.fa-sort-numeric-desc::before {
+  content: "\f886"; }
+
+.fa-sort-numeric-down-alt::before {
+  content: "\f886"; }
+
+.fa-face-grin-tongue-squint::before {
+  content: "\f58a"; }
+
+.fa-grin-tongue-squint::before {
+  content: "\f58a"; }
+
+.fa-spray-can::before {
+  content: "\f5bd"; }
+
+.fa-truck-monster::before {
+  content: "\f63b"; }
+
+.fa-w::before {
+  content: "\57"; }
+
+.fa-earth-africa::before {
+  content: "\f57c"; }
+
+.fa-globe-africa::before {
+  content: "\f57c"; }
+
+.fa-rainbow::before {
+  content: "\f75b"; }
+
+.fa-circle-notch::before {
+  content: "\f1ce"; }
+
+.fa-tablet-screen-button::before {
+  content: "\f3fa"; }
+
+.fa-tablet-alt::before {
+  content: "\f3fa"; }
+
+.fa-paw::before {
+  content: "\f1b0"; }
+
+.fa-cloud::before {
+  content: "\f0c2"; }
+
+.fa-trowel-bricks::before {
+  content: "\e58a"; }
+
+.fa-face-flushed::before {
+  content: "\f579"; }
+
+.fa-flushed::before {
+  content: "\f579"; }
+
+.fa-hospital-user::before {
+  content: "\f80d"; }
+
+.fa-tent-arrow-left-right::before {
+  content: "\e57f"; }
+
+.fa-gavel::before {
+  content: "\f0e3"; }
+
+.fa-legal::before {
+  content: "\f0e3"; }
+
+.fa-binoculars::before {
+  content: "\f1e5"; }
+
+.fa-microphone-slash::before {
+  content: "\f131"; }
+
+.fa-box-tissue::before {
+  content: "\e05b"; }
+
+.fa-motorcycle::before {
+  content: "\f21c"; }
+
+.fa-bell-concierge::before {
+  content: "\f562"; }
+
+.fa-concierge-bell::before {
+  content: "\f562"; }
+
+.fa-pen-ruler::before {
+  content: "\f5ae"; }
+
+.fa-pencil-ruler::before {
+  content: "\f5ae"; }
+
+.fa-people-arrows::before {
+  content: "\e068"; }
+
+.fa-people-arrows-left-right::before {
+  content: "\e068"; }
+
+.fa-mars-and-venus-burst::before {
+  content: "\e523"; }
+
+.fa-square-caret-right::before {
+  content: "\f152"; }
+
+.fa-caret-square-right::before {
+  content: "\f152"; }
+
+.fa-scissors::before {
+  content: "\f0c4"; }
+
+.fa-cut::before {
+  content: "\f0c4"; }
+
+.fa-sun-plant-wilt::before {
+  content: "\e57a"; }
+
+.fa-toilets-portable::before {
+  content: "\e584"; }
+
+.fa-hockey-puck::before {
+  content: "\f453"; }
+
+.fa-table::before {
+  content: "\f0ce"; }
+
+.fa-magnifying-glass-arrow-right::before {
+  content: "\e521"; }
+
+.fa-tachograph-digital::before {
+  content: "\f566"; }
+
+.fa-digital-tachograph::before {
+  content: "\f566"; }
+
+.fa-users-slash::before {
+  content: "\e073"; }
+
+.fa-clover::before {
+  content: "\e139"; }
+
+.fa-reply::before {
+  content: "\f3e5"; }
+
+.fa-mail-reply::before {
+  content: "\f3e5"; }
+
+.fa-star-and-crescent::before {
+  content: "\f699"; }
+
+.fa-house-fire::before {
+  content: "\e50c"; }
+
+.fa-square-minus::before {
+  content: "\f146"; }
+
+.fa-minus-square::before {
+  content: "\f146"; }
+
+.fa-helicopter::before {
+  content: "\f533"; }
+
+.fa-compass::before {
+  content: "\f14e"; }
+
+.fa-square-caret-down::before {
+  content: "\f150"; }
+
+.fa-caret-square-down::before {
+  content: "\f150"; }
+
+.fa-file-circle-question::before {
+  content: "\e4ef"; }
+
+.fa-laptop-code::before {
+  content: "\f5fc"; }
+
+.fa-swatchbook::before {
+  content: "\f5c3"; }
+
+.fa-prescription-bottle::before {
+  content: "\f485"; }
+
+.fa-bars::before {
+  content: "\f0c9"; }
+
+.fa-navicon::before {
+  content: "\f0c9"; }
+
+.fa-people-group::before {
+  content: "\e533"; }
+
+.fa-hourglass-end::before {
+  content: "\f253"; }
+
+.fa-hourglass-3::before {
+  content: "\f253"; }
+
+.fa-heart-crack::before {
+  content: "\f7a9"; }
+
+.fa-heart-broken::before {
+  content: "\f7a9"; }
+
+.fa-square-up-right::before {
+  content: "\f360"; }
+
+.fa-external-link-square-alt::before {
+  content: "\f360"; }
+
+.fa-face-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-film::before {
+  content: "\f008"; }
+
+.fa-ruler-horizontal::before {
+  content: "\f547"; }
+
+.fa-people-robbery::before {
+  content: "\e536"; }
+
+.fa-lightbulb::before {
+  content: "\f0eb"; }
+
+.fa-caret-left::before {
+  content: "\f0d9"; }
+
+.fa-circle-exclamation::before {
+  content: "\f06a"; }
+
+.fa-exclamation-circle::before {
+  content: "\f06a"; }
+
+.fa-school-circle-xmark::before {
+  content: "\e56d"; }
+
+.fa-arrow-right-from-bracket::before {
+  content: "\f08b"; }
+
+.fa-sign-out::before {
+  content: "\f08b"; }
+
+.fa-circle-chevron-down::before {
+  content: "\f13a"; }
+
+.fa-chevron-circle-down::before {
+  content: "\f13a"; }
+
+.fa-unlock-keyhole::before {
+  content: "\f13e"; }
+
+.fa-unlock-alt::before {
+  content: "\f13e"; }
+
+.fa-cloud-showers-heavy::before {
+  content: "\f740"; }
+
+.fa-headphones-simple::before {
+  content: "\f58f"; }
+
+.fa-headphones-alt::before {
+  content: "\f58f"; }
+
+.fa-sitemap::before {
+  content: "\f0e8"; }
+
+.fa-circle-dollar-to-slot::before {
+  content: "\f4b9"; }
+
+.fa-donate::before {
+  content: "\f4b9"; }
+
+.fa-memory::before {
+  content: "\f538"; }
+
+.fa-road-spikes::before {
+  content: "\e568"; }
+
+.fa-fire-burner::before {
+  content: "\e4f1"; }
+
+.fa-flag::before {
+  content: "\f024"; }
+
+.fa-hanukiah::before {
+  content: "\f6e6"; }
+
+.fa-feather::before {
+  content: "\f52d"; }
+
+.fa-volume-low::before {
+  content: "\f027"; }
+
+.fa-volume-down::before {
+  content: "\f027"; }
+
+.fa-comment-slash::before {
+  content: "\f4b3"; }
+
+.fa-cloud-sun-rain::before {
+  content: "\f743"; }
+
+.fa-compress::before {
+  content: "\f066"; }
+
+.fa-wheat-awn::before {
+  content: "\e2cd"; }
+
+.fa-wheat-alt::before {
+  content: "\e2cd"; }
+
+.fa-ankh::before {
+  content: "\f644"; }
+
+.fa-hands-holding-child::before {
+  content: "\e4fa"; }
+
+.fa-asterisk::before {
+  content: "\2a"; }
+
+.fa-square-check::before {
+  content: "\f14a"; }
+
+.fa-check-square::before {
+  content: "\f14a"; }
+
+.fa-peseta-sign::before {
+  content: "\e221"; }
+
+.fa-heading::before {
+  content: "\f1dc"; }
+
+.fa-header::before {
+  content: "\f1dc"; }
+
+.fa-ghost::before {
+  content: "\f6e2"; }
+
+.fa-list::before {
+  content: "\f03a"; }
+
+.fa-list-squares::before {
+  content: "\f03a"; }
+
+.fa-square-phone-flip::before {
+  content: "\f87b"; }
+
+.fa-phone-square-alt::before {
+  content: "\f87b"; }
+
+.fa-cart-plus::before {
+  content: "\f217"; }
+
+.fa-gamepad::before {
+  content: "\f11b"; }
+
+.fa-circle-dot::before {
+  content: "\f192"; }
+
+.fa-dot-circle::before {
+  content: "\f192"; }
+
+.fa-face-dizzy::before {
+  content: "\f567"; }
+
+.fa-dizzy::before {
+  content: "\f567"; }
+
+.fa-egg::before {
+  content: "\f7fb"; }
+
+.fa-house-medical-circle-xmark::before {
+  content: "\e513"; }
+
+.fa-campground::before {
+  content: "\f6bb"; }
+
+.fa-folder-plus::before {
+  content: "\f65e"; }
+
+.fa-futbol::before {
+  content: "\f1e3"; }
+
+.fa-futbol-ball::before {
+  content: "\f1e3"; }
+
+.fa-soccer-ball::before {
+  content: "\f1e3"; }
+
+.fa-paintbrush::before {
+  content: "\f1fc"; }
+
+.fa-paint-brush::before {
+  content: "\f1fc"; }
+
+.fa-lock::before {
+  content: "\f023"; }
+
+.fa-gas-pump::before {
+  content: "\f52f"; }
+
+.fa-hot-tub-person::before {
+  content: "\f593"; }
+
+.fa-hot-tub::before {
+  content: "\f593"; }
+
+.fa-map-location::before {
+  content: "\f59f"; }
+
+.fa-map-marked::before {
+  content: "\f59f"; }
+
+.fa-house-flood-water::before {
+  content: "\e50e"; }
+
+.fa-tree::before {
+  content: "\f1bb"; }
+
+.fa-bridge-lock::before {
+  content: "\e4cc"; }
+
+.fa-sack-dollar::before {
+  content: "\f81d"; }
+
+.fa-pen-to-square::before {
+  content: "\f044"; }
+
+.fa-edit::before {
+  content: "\f044"; }
+
+.fa-car-side::before {
+  content: "\f5e4"; }
+
+.fa-share-nodes::before {
+  content: "\f1e0"; }
+
+.fa-share-alt::before {
+  content: "\f1e0"; }
+
+.fa-heart-circle-minus::before {
+  content: "\e4ff"; }
+
+.fa-hourglass-half::before {
+  content: "\f252"; }
+
+.fa-hourglass-2::before {
+  content: "\f252"; }
+
+.fa-microscope::before {
+  content: "\f610"; }
+
+.fa-sink::before {
+  content: "\e06d"; }
+
+.fa-bag-shopping::before {
+  content: "\f290"; }
+
+.fa-shopping-bag::before {
+  content: "\f290"; }
+
+.fa-arrow-down-z-a::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-desc::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-down-alt::before {
+  content: "\f881"; }
+
+.fa-mitten::before {
+  content: "\f7b5"; }
+
+.fa-person-rays::before {
+  content: "\e54d"; }
+
+.fa-users::before {
+  content: "\f0c0"; }
+
+.fa-eye-slash::before {
+  content: "\f070"; }
+
+.fa-flask-vial::before {
+  content: "\e4f3"; }
+
+.fa-hand::before {
+  content: "\f256"; }
+
+.fa-hand-paper::before {
+  content: "\f256"; }
+
+.fa-om::before {
+  content: "\f679"; }
+
+.fa-worm::before {
+  content: "\e599"; }
+
+.fa-house-circle-xmark::before {
+  content: "\e50b"; }
+
+.fa-plug::before {
+  content: "\f1e6"; }
+
+.fa-chevron-up::before {
+  content: "\f077"; }
+
+.fa-hand-spock::before {
+  content: "\f259"; }
+
+.fa-stopwatch::before {
+  content: "\f2f2"; }
+
+.fa-face-kiss::before {
+  content: "\f596"; }
+
+.fa-kiss::before {
+  content: "\f596"; }
+
+.fa-bridge-circle-xmark::before {
+  content: "\e4cb"; }
+
+.fa-face-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-chess-bishop::before {
+  content: "\f43a"; }
+
+.fa-face-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-ear-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deafness::before {
+  content: "\f2a4"; }
+
+.fa-hard-of-hearing::before {
+  content: "\f2a4"; }
+
+.fa-road-circle-check::before {
+  content: "\e564"; }
+
+.fa-dice-five::before {
+  content: "\f523"; }
+
+.fa-square-rss::before {
+  content: "\f143"; }
+
+.fa-rss-square::before {
+  content: "\f143"; }
+
+.fa-land-mine-on::before {
+  content: "\e51b"; }
+
+.fa-i-cursor::before {
+  content: "\f246"; }
+
+.fa-stamp::before {
+  content: "\f5bf"; }
+
+.fa-stairs::before {
+  content: "\e289"; }
+
+.fa-i::before {
+  content: "\49"; }
+
+.fa-hryvnia-sign::before {
+  content: "\f6f2"; }
+
+.fa-hryvnia::before {
+  content: "\f6f2"; }
+
+.fa-pills::before {
+  content: "\f484"; }
+
+.fa-face-grin-wide::before {
+  content: "\f581"; }
+
+.fa-grin-alt::before {
+  content: "\f581"; }
+
+.fa-tooth::before {
+  content: "\f5c9"; }
+
+.fa-v::before {
+  content: "\56"; }
+
+.fa-bangladeshi-taka-sign::before {
+  content: "\e2e6"; }
+
+.fa-bicycle::before {
+  content: "\f206"; }
+
+.fa-staff-snake::before {
+  content: "\e579"; }
+
+.fa-rod-asclepius::before {
+  content: "\e579"; }
+
+.fa-rod-snake::before {
+  content: "\e579"; }
+
+.fa-staff-aesculapius::before {
+  content: "\e579"; }
+
+.fa-head-side-cough-slash::before {
+  content: "\e062"; }
+
+.fa-truck-medical::before {
+  content: "\f0f9"; }
+
+.fa-ambulance::before {
+  content: "\f0f9"; }
+
+.fa-wheat-awn-circle-exclamation::before {
+  content: "\e598"; }
+
+.fa-snowman::before {
+  content: "\f7d0"; }
+
+.fa-mortar-pestle::before {
+  content: "\f5a7"; }
+
+.fa-road-barrier::before {
+  content: "\e562"; }
+
+.fa-school::before {
+  content: "\f549"; }
+
+.fa-igloo::before {
+  content: "\f7ae"; }
+
+.fa-joint::before {
+  content: "\f595"; }
+
+.fa-angle-right::before {
+  content: "\f105"; }
+
+.fa-horse::before {
+  content: "\f6f0"; }
+
+.fa-q::before {
+  content: "\51"; }
+
+.fa-g::before {
+  content: "\47"; }
+
+.fa-notes-medical::before {
+  content: "\f481"; }
+
+.fa-temperature-half::before {
+  content: "\f2c9"; }
+
+.fa-temperature-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-half::before {
+  content: "\f2c9"; }
+
+.fa-dong-sign::before {
+  content: "\e169"; }
+
+.fa-capsules::before {
+  content: "\f46b"; }
+
+.fa-poo-storm::before {
+  content: "\f75a"; }
+
+.fa-poo-bolt::before {
+  content: "\f75a"; }
+
+.fa-face-frown-open::before {
+  content: "\f57a"; }
+
+.fa-frown-open::before {
+  content: "\f57a"; }
+
+.fa-hand-point-up::before {
+  content: "\f0a6"; }
+
+.fa-money-bill::before {
+  content: "\f0d6"; }
+
+.fa-bookmark::before {
+  content: "\f02e"; }
+
+.fa-align-justify::before {
+  content: "\f039"; }
+
+.fa-umbrella-beach::before {
+  content: "\f5ca"; }
+
+.fa-helmet-un::before {
+  content: "\e503"; }
+
+.fa-bullseye::before {
+  content: "\f140"; }
+
+.fa-bacon::before {
+  content: "\f7e5"; }
+
+.fa-hand-point-down::before {
+  content: "\f0a7"; }
+
+.fa-arrow-up-from-bracket::before {
+  content: "\e09a"; }
+
+.fa-folder::before {
+  content: "\f07b"; }
+
+.fa-folder-blank::before {
+  content: "\f07b"; }
+
+.fa-file-waveform::before {
+  content: "\f478"; }
+
+.fa-file-medical-alt::before {
+  content: "\f478"; }
+
+.fa-radiation::before {
+  content: "\f7b9"; }
+
+.fa-chart-simple::before {
+  content: "\e473"; }
+
+.fa-mars-stroke::before {
+  content: "\f229"; }
+
+.fa-vial::before {
+  content: "\f492"; }
+
+.fa-gauge::before {
+  content: "\f624"; }
+
+.fa-dashboard::before {
+  content: "\f624"; }
+
+.fa-gauge-med::before {
+  content: "\f624"; }
+
+.fa-tachometer-alt-average::before {
+  content: "\f624"; }
+
+.fa-wand-magic-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-magic-wand-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-e::before {
+  content: "\45"; }
+
+.fa-pen-clip::before {
+  content: "\f305"; }
+
+.fa-pen-alt::before {
+  content: "\f305"; }
+
+.fa-bridge-circle-exclamation::before {
+  content: "\e4ca"; }
+
+.fa-user::before {
+  content: "\f007"; }
+
+.fa-school-circle-check::before {
+  content: "\e56b"; }
+
+.fa-dumpster::before {
+  content: "\f793"; }
+
+.fa-van-shuttle::before {
+  content: "\f5b6"; }
+
+.fa-shuttle-van::before {
+  content: "\f5b6"; }
+
+.fa-building-user::before {
+  content: "\e4da"; }
+
+.fa-square-caret-left::before {
+  content: "\f191"; }
+
+.fa-caret-square-left::before {
+  content: "\f191"; }
+
+.fa-highlighter::before {
+  content: "\f591"; }
+
+.fa-key::before {
+  content: "\f084"; }
+
+.fa-bullhorn::before {
+  content: "\f0a1"; }
+
+.fa-globe::before {
+  content: "\f0ac"; }
+
+.fa-synagogue::before {
+  content: "\f69b"; }
+
+.fa-person-half-dress::before {
+  content: "\e548"; }
+
+.fa-road-bridge::before {
+  content: "\e563"; }
+
+.fa-location-arrow::before {
+  content: "\f124"; }
+
+.fa-c::before {
+  content: "\43"; }
+
+.fa-tablet-button::before {
+  content: "\f10a"; }
+
+.fa-building-lock::before {
+  content: "\e4d6"; }
+
+.fa-pizza-slice::before {
+  content: "\f818"; }
+
+.fa-money-bill-wave::before {
+  content: "\f53a"; }
+
+.fa-chart-area::before {
+  content: "\f1fe"; }
+
+.fa-area-chart::before {
+  content: "\f1fe"; }
+
+.fa-house-flag::before {
+  content: "\e50d"; }
+
+.fa-person-circle-minus::before {
+  content: "\e540"; }
+
+.fa-ban::before {
+  content: "\f05e"; }
+
+.fa-cancel::before {
+  content: "\f05e"; }
+
+.fa-camera-rotate::before {
+  content: "\e0d8"; }
+
+.fa-spray-can-sparkles::before {
+  content: "\f5d0"; }
+
+.fa-air-freshener::before {
+  content: "\f5d0"; }
+
+.fa-star::before {
+  content: "\f005"; }
+
+.fa-repeat::before {
+  content: "\f363"; }
+
+.fa-cross::before {
+  content: "\f654"; }
+
+.fa-box::before {
+  content: "\f466"; }
+
+.fa-venus-mars::before {
+  content: "\f228"; }
+
+.fa-arrow-pointer::before {
+  content: "\f245"; }
+
+.fa-mouse-pointer::before {
+  content: "\f245"; }
+
+.fa-maximize::before {
+  content: "\f31e"; }
+
+.fa-expand-arrows-alt::before {
+  content: "\f31e"; }
+
+.fa-charging-station::before {
+  content: "\f5e7"; }
+
+.fa-shapes::before {
+  content: "\f61f"; }
+
+.fa-triangle-circle-square::before {
+  content: "\f61f"; }
+
+.fa-shuffle::before {
+  content: "\f074"; }
+
+.fa-random::before {
+  content: "\f074"; }
+
+.fa-person-running::before {
+  content: "\f70c"; }
+
+.fa-running::before {
+  content: "\f70c"; }
+
+.fa-mobile-retro::before {
+  content: "\e527"; }
+
+.fa-grip-lines-vertical::before {
+  content: "\f7a5"; }
+
+.fa-spider::before {
+  content: "\f717"; }
+
+.fa-hands-bound::before {
+  content: "\e4f9"; }
+
+.fa-file-invoice-dollar::before {
+  content: "\f571"; }
+
+.fa-plane-circle-exclamation::before {
+  content: "\e556"; }
+
+.fa-x-ray::before {
+  content: "\f497"; }
+
+.fa-spell-check::before {
+  content: "\f891"; }
+
+.fa-slash::before {
+  content: "\f715"; }
+
+.fa-computer-mouse::before {
+  content: "\f8cc"; }
+
+.fa-mouse::before {
+  content: "\f8cc"; }
+
+.fa-arrow-right-to-bracket::before {
+  content: "\f090"; }
+
+.fa-sign-in::before {
+  content: "\f090"; }
+
+.fa-shop-slash::before {
+  content: "\e070"; }
+
+.fa-store-alt-slash::before {
+  content: "\e070"; }
+
+.fa-server::before {
+  content: "\f233"; }
+
+.fa-virus-covid-slash::before {
+  content: "\e4a9"; }
+
+.fa-shop-lock::before {
+  content: "\e4a5"; }
+
+.fa-hourglass-start::before {
+  content: "\f251"; }
+
+.fa-hourglass-1::before {
+  content: "\f251"; }
+
+.fa-blender-phone::before {
+  content: "\f6b6"; }
+
+.fa-building-wheat::before {
+  content: "\e4db"; }
+
+.fa-person-breastfeeding::before {
+  content: "\e53a"; }
+
+.fa-right-to-bracket::before {
+  content: "\f2f6"; }
+
+.fa-sign-in-alt::before {
+  content: "\f2f6"; }
+
+.fa-venus::before {
+  content: "\f221"; }
+
+.fa-passport::before {
+  content: "\f5ab"; }
+
+.fa-heart-pulse::before {
+  content: "\f21e"; }
+
+.fa-heartbeat::before {
+  content: "\f21e"; }
+
+.fa-people-carry-box::before {
+  content: "\f4ce"; }
+
+.fa-people-carry::before {
+  content: "\f4ce"; }
+
+.fa-temperature-high::before {
+  content: "\f769"; }
+
+.fa-microchip::before {
+  content: "\f2db"; }
+
+.fa-crown::before {
+  content: "\f521"; }
+
+.fa-weight-hanging::before {
+  content: "\f5cd"; }
+
+.fa-xmarks-lines::before {
+  content: "\e59a"; }
+
+.fa-file-prescription::before {
+  content: "\f572"; }
+
+.fa-weight-scale::before {
+  content: "\f496"; }
+
+.fa-weight::before {
+  content: "\f496"; }
+
+.fa-user-group::before {
+  content: "\f500"; }
+
+.fa-user-friends::before {
+  content: "\f500"; }
+
+.fa-arrow-up-a-z::before {
+  content: "\f15e"; }
+
+.fa-sort-alpha-up::before {
+  content: "\f15e"; }
+
+.fa-chess-knight::before {
+  content: "\f441"; }
+
+.fa-face-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-wheelchair::before {
+  content: "\f193"; }
+
+.fa-circle-arrow-up::before {
+  content: "\f0aa"; }
+
+.fa-arrow-circle-up::before {
+  content: "\f0aa"; }
+
+.fa-toggle-on::before {
+  content: "\f205"; }
+
+.fa-person-walking::before {
+  content: "\f554"; }
+
+.fa-walking::before {
+  content: "\f554"; }
+
+.fa-l::before {
+  content: "\4c"; }
+
+.fa-fire::before {
+  content: "\f06d"; }
+
+.fa-bed-pulse::before {
+  content: "\f487"; }
+
+.fa-procedures::before {
+  content: "\f487"; }
+
+.fa-shuttle-space::before {
+  content: "\f197"; }
+
+.fa-space-shuttle::before {
+  content: "\f197"; }
+
+.fa-face-laugh::before {
+  content: "\f599"; }
+
+.fa-laugh::before {
+  content: "\f599"; }
+
+.fa-folder-open::before {
+  content: "\f07c"; }
+
+.fa-heart-circle-plus::before {
+  content: "\e500"; }
+
+.fa-code-fork::before {
+  content: "\e13b"; }
+
+.fa-city::before {
+  content: "\f64f"; }
+
+.fa-microphone-lines::before {
+  content: "\f3c9"; }
+
+.fa-microphone-alt::before {
+  content: "\f3c9"; }
+
+.fa-pepper-hot::before {
+  content: "\f816"; }
+
+.fa-unlock::before {
+  content: "\f09c"; }
+
+.fa-colon-sign::before {
+  content: "\e140"; }
+
+.fa-headset::before {
+  content: "\f590"; }
+
+.fa-store-slash::before {
+  content: "\e071"; }
+
+.fa-road-circle-xmark::before {
+  content: "\e566"; }
+
+.fa-user-minus::before {
+  content: "\f503"; }
+
+.fa-mars-stroke-up::before {
+  content: "\f22a"; }
+
+.fa-mars-stroke-v::before {
+  content: "\f22a"; }
+
+.fa-champagne-glasses::before {
+  content: "\f79f"; }
+
+.fa-glass-cheers::before {
+  content: "\f79f"; }
+
+.fa-clipboard::before {
+  content: "\f328"; }
+
+.fa-house-circle-exclamation::before {
+  content: "\e50a"; }
+
+.fa-file-arrow-up::before {
+  content: "\f574"; }
+
+.fa-file-upload::before {
+  content: "\f574"; }
+
+.fa-wifi::before {
+  content: "\f1eb"; }
+
+.fa-wifi-3::before {
+  content: "\f1eb"; }
+
+.fa-wifi-strong::before {
+  content: "\f1eb"; }
+
+.fa-bath::before {
+  content: "\f2cd"; }
+
+.fa-bathtub::before {
+  content: "\f2cd"; }
+
+.fa-underline::before {
+  content: "\f0cd"; }
+
+.fa-user-pen::before {
+  content: "\f4ff"; }
+
+.fa-user-edit::before {
+  content: "\f4ff"; }
+
+.fa-signature::before {
+  content: "\f5b7"; }
+
+.fa-stroopwafel::before {
+  content: "\f551"; }
+
+.fa-bold::before {
+  content: "\f032"; }
+
+.fa-anchor-lock::before {
+  content: "\e4ad"; }
+
+.fa-building-ngo::before {
+  content: "\e4d7"; }
+
+.fa-manat-sign::before {
+  content: "\e1d5"; }
+
+.fa-not-equal::before {
+  content: "\f53e"; }
+
+.fa-border-top-left::before {
+  content: "\f853"; }
+
+.fa-border-style::before {
+  content: "\f853"; }
+
+.fa-map-location-dot::before {
+  content: "\f5a0"; }
+
+.fa-map-marked-alt::before {
+  content: "\f5a0"; }
+
+.fa-jedi::before {
+  content: "\f669"; }
+
+.fa-square-poll-vertical::before {
+  content: "\f681"; }
+
+.fa-poll::before {
+  content: "\f681"; }
+
+.fa-mug-hot::before {
+  content: "\f7b6"; }
+
+.fa-car-battery::before {
+  content: "\f5df"; }
+
+.fa-battery-car::before {
+  content: "\f5df"; }
+
+.fa-gift::before {
+  content: "\f06b"; }
+
+.fa-dice-two::before {
+  content: "\f528"; }
+
+.fa-chess-queen::before {
+  content: "\f445"; }
+
+.fa-glasses::before {
+  content: "\f530"; }
+
+.fa-chess-board::before {
+  content: "\f43c"; }
+
+.fa-building-circle-check::before {
+  content: "\e4d2"; }
+
+.fa-person-chalkboard::before {
+  content: "\e53d"; }
+
+.fa-mars-stroke-right::before {
+  content: "\f22b"; }
+
+.fa-mars-stroke-h::before {
+  content: "\f22b"; }
+
+.fa-hand-back-fist::before {
+  content: "\f255"; }
+
+.fa-hand-rock::before {
+  content: "\f255"; }
+
+.fa-square-caret-up::before {
+  content: "\f151"; }
+
+.fa-caret-square-up::before {
+  content: "\f151"; }
+
+.fa-cloud-showers-water::before {
+  content: "\e4e4"; }
+
+.fa-chart-bar::before {
+  content: "\f080"; }
+
+.fa-bar-chart::before {
+  content: "\f080"; }
+
+.fa-hands-bubbles::before {
+  content: "\e05e"; }
+
+.fa-hands-wash::before {
+  content: "\e05e"; }
+
+.fa-less-than-equal::before {
+  content: "\f537"; }
+
+.fa-train::before {
+  content: "\f238"; }
+
+.fa-eye-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-crow::before {
+  content: "\f520"; }
+
+.fa-sailboat::before {
+  content: "\e445"; }
+
+.fa-window-restore::before {
+  content: "\f2d2"; }
+
+.fa-square-plus::before {
+  content: "\f0fe"; }
+
+.fa-plus-square::before {
+  content: "\f0fe"; }
+
+.fa-torii-gate::before {
+  content: "\f6a1"; }
+
+.fa-frog::before {
+  content: "\f52e"; }
+
+.fa-bucket::before {
+  content: "\e4cf"; }
+
+.fa-image::before {
+  content: "\f03e"; }
+
+.fa-microphone::before {
+  content: "\f130"; }
+
+.fa-cow::before {
+  content: "\f6c8"; }
+
+.fa-caret-up::before {
+  content: "\f0d8"; }
+
+.fa-screwdriver::before {
+  content: "\f54a"; }
+
+.fa-folder-closed::before {
+  content: "\e185"; }
+
+.fa-house-tsunami::before {
+  content: "\e515"; }
+
+.fa-square-nfi::before {
+  content: "\e576"; }
+
+.fa-arrow-up-from-ground-water::before {
+  content: "\e4b5"; }
+
+.fa-martini-glass::before {
+  content: "\f57b"; }
+
+.fa-glass-martini-alt::before {
+  content: "\f57b"; }
+
+.fa-rotate-left::before {
+  content: "\f2ea"; }
+
+.fa-rotate-back::before {
+  content: "\f2ea"; }
+
+.fa-rotate-backward::before {
+  content: "\f2ea"; }
+
+.fa-undo-alt::before {
+  content: "\f2ea"; }
+
+.fa-table-columns::before {
+  content: "\f0db"; }
+
+.fa-columns::before {
+  content: "\f0db"; }
+
+.fa-lemon::before {
+  content: "\f094"; }
+
+.fa-head-side-mask::before {
+  content: "\e063"; }
+
+.fa-handshake::before {
+  content: "\f2b5"; }
+
+.fa-gem::before {
+  content: "\f3a5"; }
+
+.fa-dolly::before {
+  content: "\f472"; }
+
+.fa-dolly-box::before {
+  content: "\f472"; }
+
+.fa-smoking::before {
+  content: "\f48d"; }
+
+.fa-minimize::before {
+  content: "\f78c"; }
+
+.fa-compress-arrows-alt::before {
+  content: "\f78c"; }
+
+.fa-monument::before {
+  content: "\f5a6"; }
+
+.fa-snowplow::before {
+  content: "\f7d2"; }
+
+.fa-angles-right::before {
+  content: "\f101"; }
+
+.fa-angle-double-right::before {
+  content: "\f101"; }
+
+.fa-cannabis::before {
+  content: "\f55f"; }
+
+.fa-circle-play::before {
+  content: "\f144"; }
+
+.fa-play-circle::before {
+  content: "\f144"; }
+
+.fa-tablets::before {
+  content: "\f490"; }
+
+.fa-ethernet::before {
+  content: "\f796"; }
+
+.fa-euro-sign::before {
+  content: "\f153"; }
+
+.fa-eur::before {
+  content: "\f153"; }
+
+.fa-euro::before {
+  content: "\f153"; }
+
+.fa-chair::before {
+  content: "\f6c0"; }
+
+.fa-circle-check::before {
+  content: "\f058"; }
+
+.fa-check-circle::before {
+  content: "\f058"; }
+
+.fa-circle-stop::before {
+  content: "\f28d"; }
+
+.fa-stop-circle::before {
+  content: "\f28d"; }
+
+.fa-compass-drafting::before {
+  content: "\f568"; }
+
+.fa-drafting-compass::before {
+  content: "\f568"; }
+
+.fa-plate-wheat::before {
+  content: "\e55a"; }
+
+.fa-icicles::before {
+  content: "\f7ad"; }
+
+.fa-person-shelter::before {
+  content: "\e54f"; }
+
+.fa-neuter::before {
+  content: "\f22c"; }
+
+.fa-id-badge::before {
+  content: "\f2c1"; }
+
+.fa-marker::before {
+  content: "\f5a1"; }
+
+.fa-face-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-helicopter-symbol::before {
+  content: "\e502"; }
+
+.fa-universal-access::before {
+  content: "\f29a"; }
+
+.fa-circle-chevron-up::before {
+  content: "\f139"; }
+
+.fa-chevron-circle-up::before {
+  content: "\f139"; }
+
+.fa-lari-sign::before {
+  content: "\e1c8"; }
+
+.fa-volcano::before {
+  content: "\f770"; }
+
+.fa-person-walking-dashed-line-arrow-right::before {
+  content: "\e553"; }
+
+.fa-sterling-sign::before {
+  content: "\f154"; }
+
+.fa-gbp::before {
+  content: "\f154"; }
+
+.fa-pound-sign::before {
+  content: "\f154"; }
+
+.fa-viruses::before {
+  content: "\e076"; }
+
+.fa-square-person-confined::before {
+  content: "\e577"; }
+
+.fa-user-tie::before {
+  content: "\f508"; }
+
+.fa-arrow-down-long::before {
+  content: "\f175"; }
+
+.fa-long-arrow-down::before {
+  content: "\f175"; }
+
+.fa-tent-arrow-down-to-line::before {
+  content: "\e57e"; }
+
+.fa-certificate::before {
+  content: "\f0a3"; }
+
+.fa-reply-all::before {
+  content: "\f122"; }
+
+.fa-mail-reply-all::before {
+  content: "\f122"; }
+
+.fa-suitcase::before {
+  content: "\f0f2"; }
+
+.fa-person-skating::before {
+  content: "\f7c5"; }
+
+.fa-skating::before {
+  content: "\f7c5"; }
+
+.fa-filter-circle-dollar::before {
+  content: "\f662"; }
+
+.fa-funnel-dollar::before {
+  content: "\f662"; }
+
+.fa-camera-retro::before {
+  content: "\f083"; }
+
+.fa-circle-arrow-down::before {
+  content: "\f0ab"; }
+
+.fa-arrow-circle-down::before {
+  content: "\f0ab"; }
+
+.fa-file-import::before {
+  content: "\f56f"; }
+
+.fa-arrow-right-to-file::before {
+  content: "\f56f"; }
+
+.fa-square-arrow-up-right::before {
+  content: "\f14c"; }
+
+.fa-external-link-square::before {
+  content: "\f14c"; }
+
+.fa-box-open::before {
+  content: "\f49e"; }
+
+.fa-scroll::before {
+  content: "\f70e"; }
+
+.fa-spa::before {
+  content: "\f5bb"; }
+
+.fa-location-pin-lock::before {
+  content: "\e51f"; }
+
+.fa-pause::before {
+  content: "\f04c"; }
+
+.fa-hill-avalanche::before {
+  content: "\e507"; }
+
+.fa-temperature-empty::before {
+  content: "\f2cb"; }
+
+.fa-temperature-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-empty::before {
+  content: "\f2cb"; }
+
+.fa-bomb::before {
+  content: "\f1e2"; }
+
+.fa-registered::before {
+  content: "\f25d"; }
+
+.fa-address-card::before {
+  content: "\f2bb"; }
+
+.fa-contact-card::before {
+  content: "\f2bb"; }
+
+.fa-vcard::before {
+  content: "\f2bb"; }
+
+.fa-scale-unbalanced-flip::before {
+  content: "\f516"; }
+
+.fa-balance-scale-right::before {
+  content: "\f516"; }
+
+.fa-subscript::before {
+  content: "\f12c"; }
+
+.fa-diamond-turn-right::before {
+  content: "\f5eb"; }
+
+.fa-directions::before {
+  content: "\f5eb"; }
+
+.fa-burst::before {
+  content: "\e4dc"; }
+
+.fa-house-laptop::before {
+  content: "\e066"; }
+
+.fa-laptop-house::before {
+  content: "\e066"; }
+
+.fa-face-tired::before {
+  content: "\f5c8"; }
+
+.fa-tired::before {
+  content: "\f5c8"; }
+
+.fa-money-bills::before {
+  content: "\e1f3"; }
+
+.fa-smog::before {
+  content: "\f75f"; }
+
+.fa-crutch::before {
+  content: "\f7f7"; }
+
+.fa-cloud-arrow-up::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload-alt::before {
+  content: "\f0ee"; }
+
+.fa-palette::before {
+  content: "\f53f"; }
+
+.fa-arrows-turn-right::before {
+  content: "\e4c0"; }
+
+.fa-vest::before {
+  content: "\e085"; }
+
+.fa-ferry::before {
+  content: "\e4ea"; }
+
+.fa-arrows-down-to-people::before {
+  content: "\e4b9"; }
+
+.fa-seedling::before {
+  content: "\f4d8"; }
+
+.fa-sprout::before {
+  content: "\f4d8"; }
+
+.fa-left-right::before {
+  content: "\f337"; }
+
+.fa-arrows-alt-h::before {
+  content: "\f337"; }
+
+.fa-boxes-packing::before {
+  content: "\e4c7"; }
+
+.fa-circle-arrow-left::before {
+  content: "\f0a8"; }
+
+.fa-arrow-circle-left::before {
+  content: "\f0a8"; }
+
+.fa-group-arrows-rotate::before {
+  content: "\e4f6"; }
+
+.fa-bowl-food::before {
+  content: "\e4c6"; }
+
+.fa-candy-cane::before {
+  content: "\f786"; }
+
+.fa-arrow-down-wide-short::before {
+  content: "\f160"; }
+
+.fa-sort-amount-asc::before {
+  content: "\f160"; }
+
+.fa-sort-amount-down::before {
+  content: "\f160"; }
+
+.fa-cloud-bolt::before {
+  content: "\f76c"; }
+
+.fa-thunderstorm::before {
+  content: "\f76c"; }
+
+.fa-text-slash::before {
+  content: "\f87d"; }
+
+.fa-remove-format::before {
+  content: "\f87d"; }
+
+.fa-face-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-file-word::before {
+  content: "\f1c2"; }
+
+.fa-file-powerpoint::before {
+  content: "\f1c4"; }
+
+.fa-arrows-left-right::before {
+  content: "\f07e"; }
+
+.fa-arrows-h::before {
+  content: "\f07e"; }
+
+.fa-house-lock::before {
+  content: "\e510"; }
+
+.fa-cloud-arrow-down::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download-alt::before {
+  content: "\f0ed"; }
+
+.fa-children::before {
+  content: "\e4e1"; }
+
+.fa-chalkboard::before {
+  content: "\f51b"; }
+
+.fa-blackboard::before {
+  content: "\f51b"; }
+
+.fa-user-large-slash::before {
+  content: "\f4fa"; }
+
+.fa-user-alt-slash::before {
+  content: "\f4fa"; }
+
+.fa-envelope-open::before {
+  content: "\f2b6"; }
+
+.fa-handshake-simple-slash::before {
+  content: "\e05f"; }
+
+.fa-handshake-alt-slash::before {
+  content: "\e05f"; }
+
+.fa-mattress-pillow::before {
+  content: "\e525"; }
+
+.fa-guarani-sign::before {
+  content: "\e19a"; }
+
+.fa-arrows-rotate::before {
+  content: "\f021"; }
+
+.fa-refresh::before {
+  content: "\f021"; }
+
+.fa-sync::before {
+  content: "\f021"; }
+
+.fa-fire-extinguisher::before {
+  content: "\f134"; }
+
+.fa-cruzeiro-sign::before {
+  content: "\e152"; }
+
+.fa-greater-than-equal::before {
+  content: "\f532"; }
+
+.fa-shield-halved::before {
+  content: "\f3ed"; }
+
+.fa-shield-alt::before {
+  content: "\f3ed"; }
+
+.fa-book-atlas::before {
+  content: "\f558"; }
+
+.fa-atlas::before {
+  content: "\f558"; }
+
+.fa-virus::before {
+  content: "\e074"; }
+
+.fa-envelope-circle-check::before {
+  content: "\e4e8"; }
+
+.fa-layer-group::before {
+  content: "\f5fd"; }
+
+.fa-arrows-to-dot::before {
+  content: "\e4be"; }
+
+.fa-archway::before {
+  content: "\f557"; }
+
+.fa-heart-circle-check::before {
+  content: "\e4fd"; }
+
+.fa-house-chimney-crack::before {
+  content: "\f6f1"; }
+
+.fa-house-damage::before {
+  content: "\f6f1"; }
+
+.fa-file-zipper::before {
+  content: "\f1c6"; }
+
+.fa-file-archive::before {
+  content: "\f1c6"; }
+
+.fa-square::before {
+  content: "\f0c8"; }
+
+.fa-martini-glass-empty::before {
+  content: "\f000"; }
+
+.fa-glass-martini::before {
+  content: "\f000"; }
+
+.fa-couch::before {
+  content: "\f4b8"; }
+
+.fa-cedi-sign::before {
+  content: "\e0df"; }
+
+.fa-italic::before {
+  content: "\f033"; }
+
+.fa-table-cells-column-lock::before {
+  content: "\e678"; }
+
+.fa-church::before {
+  content: "\f51d"; }
+
+.fa-comments-dollar::before {
+  content: "\f653"; }
+
+.fa-democrat::before {
+  content: "\f747"; }
+
+.fa-z::before {
+  content: "\5a"; }
+
+.fa-person-skiing::before {
+  content: "\f7c9"; }
+
+.fa-skiing::before {
+  content: "\f7c9"; }
+
+.fa-road-lock::before {
+  content: "\e567"; }
+
+.fa-a::before {
+  content: "\41"; }
+
+.fa-temperature-arrow-down::before {
+  content: "\e03f"; }
+
+.fa-temperature-down::before {
+  content: "\e03f"; }
+
+.fa-feather-pointed::before {
+  content: "\f56b"; }
+
+.fa-feather-alt::before {
+  content: "\f56b"; }
+
+.fa-p::before {
+  content: "\50"; }
+
+.fa-snowflake::before {
+  content: "\f2dc"; }
+
+.fa-newspaper::before {
+  content: "\f1ea"; }
+
+.fa-rectangle-ad::before {
+  content: "\f641"; }
+
+.fa-ad::before {
+  content: "\f641"; }
+
+.fa-circle-arrow-right::before {
+  content: "\f0a9"; }
+
+.fa-arrow-circle-right::before {
+  content: "\f0a9"; }
+
+.fa-filter-circle-xmark::before {
+  content: "\e17b"; }
+
+.fa-locust::before {
+  content: "\e520"; }
+
+.fa-sort::before {
+  content: "\f0dc"; }
+
+.fa-unsorted::before {
+  content: "\f0dc"; }
+
+.fa-list-ol::before {
+  content: "\f0cb"; }
+
+.fa-list-1-2::before {
+  content: "\f0cb"; }
+
+.fa-list-numeric::before {
+  content: "\f0cb"; }
+
+.fa-person-dress-burst::before {
+  content: "\e544"; }
+
+.fa-money-check-dollar::before {
+  content: "\f53d"; }
+
+.fa-money-check-alt::before {
+  content: "\f53d"; }
+
+.fa-vector-square::before {
+  content: "\f5cb"; }
+
+.fa-bread-slice::before {
+  content: "\f7ec"; }
+
+.fa-language::before {
+  content: "\f1ab"; }
+
+.fa-face-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-filter::before {
+  content: "\f0b0"; }
+
+.fa-question::before {
+  content: "\3f"; }
+
+.fa-file-signature::before {
+  content: "\f573"; }
+
+.fa-up-down-left-right::before {
+  content: "\f0b2"; }
+
+.fa-arrows-alt::before {
+  content: "\f0b2"; }
+
+.fa-house-chimney-user::before {
+  content: "\e065"; }
+
+.fa-hand-holding-heart::before {
+  content: "\f4be"; }
+
+.fa-puzzle-piece::before {
+  content: "\f12e"; }
+
+.fa-money-check::before {
+  content: "\f53c"; }
+
+.fa-star-half-stroke::before {
+  content: "\f5c0"; }
+
+.fa-star-half-alt::before {
+  content: "\f5c0"; }
+
+.fa-code::before {
+  content: "\f121"; }
+
+.fa-whiskey-glass::before {
+  content: "\f7a0"; }
+
+.fa-glass-whiskey::before {
+  content: "\f7a0"; }
+
+.fa-building-circle-exclamation::before {
+  content: "\e4d3"; }
+
+.fa-magnifying-glass-chart::before {
+  content: "\e522"; }
+
+.fa-arrow-up-right-from-square::before {
+  content: "\f08e"; }
+
+.fa-external-link::before {
+  content: "\f08e"; }
+
+.fa-cubes-stacked::before {
+  content: "\e4e6"; }
+
+.fa-won-sign::before {
+  content: "\f159"; }
+
+.fa-krw::before {
+  content: "\f159"; }
+
+.fa-won::before {
+  content: "\f159"; }
+
+.fa-virus-covid::before {
+  content: "\e4a8"; }
+
+.fa-austral-sign::before {
+  content: "\e0a9"; }
+
+.fa-f::before {
+  content: "\46"; }
+
+.fa-leaf::before {
+  content: "\f06c"; }
+
+.fa-road::before {
+  content: "\f018"; }
+
+.fa-taxi::before {
+  content: "\f1ba"; }
+
+.fa-cab::before {
+  content: "\f1ba"; }
+
+.fa-person-circle-plus::before {
+  content: "\e541"; }
+
+.fa-chart-pie::before {
+  content: "\f200"; }
+
+.fa-pie-chart::before {
+  content: "\f200"; }
+
+.fa-bolt-lightning::before {
+  content: "\e0b7"; }
+
+.fa-sack-xmark::before {
+  content: "\e56a"; }
+
+.fa-file-excel::before {
+  content: "\f1c3"; }
+
+.fa-file-contract::before {
+  content: "\f56c"; }
+
+.fa-fish-fins::before {
+  content: "\e4f2"; }
+
+.fa-building-flag::before {
+  content: "\e4d5"; }
+
+.fa-face-grin-beam::before {
+  content: "\f582"; }
+
+.fa-grin-beam::before {
+  content: "\f582"; }
+
+.fa-object-ungroup::before {
+  content: "\f248"; }
+
+.fa-poop::before {
+  content: "\f619"; }
+
+.fa-location-pin::before {
+  content: "\f041"; }
+
+.fa-map-marker::before {
+  content: "\f041"; }
+
+.fa-kaaba::before {
+  content: "\f66b"; }
+
+.fa-toilet-paper::before {
+  content: "\f71e"; }
+
+.fa-helmet-safety::before {
+  content: "\f807"; }
+
+.fa-hard-hat::before {
+  content: "\f807"; }
+
+.fa-hat-hard::before {
+  content: "\f807"; }
+
+.fa-eject::before {
+  content: "\f052"; }
+
+.fa-circle-right::before {
+  content: "\f35a"; }
+
+.fa-arrow-alt-circle-right::before {
+  content: "\f35a"; }
+
+.fa-plane-circle-check::before {
+  content: "\e555"; }
+
+.fa-face-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-meh-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-object-group::before {
+  content: "\f247"; }
+
+.fa-chart-line::before {
+  content: "\f201"; }
+
+.fa-line-chart::before {
+  content: "\f201"; }
+
+.fa-mask-ventilator::before {
+  content: "\e524"; }
+
+.fa-arrow-right::before {
+  content: "\f061"; }
+
+.fa-signs-post::before {
+  content: "\f277"; }
+
+.fa-map-signs::before {
+  content: "\f277"; }
+
+.fa-cash-register::before {
+  content: "\f788"; }
+
+.fa-person-circle-question::before {
+  content: "\e542"; }
+
+.fa-h::before {
+  content: "\48"; }
+
+.fa-tarp::before {
+  content: "\e57b"; }
+
+.fa-screwdriver-wrench::before {
+  content: "\f7d9"; }
+
+.fa-tools::before {
+  content: "\f7d9"; }
+
+.fa-arrows-to-eye::before {
+  content: "\e4bf"; }
+
+.fa-plug-circle-bolt::before {
+  content: "\e55b"; }
+
+.fa-heart::before {
+  content: "\f004"; }
+
+.fa-mars-and-venus::before {
+  content: "\f224"; }
+
+.fa-house-user::before {
+  content: "\e1b0"; }
+
+.fa-home-user::before {
+  content: "\e1b0"; }
+
+.fa-dumpster-fire::before {
+  content: "\f794"; }
+
+.fa-house-crack::before {
+  content: "\e3b1"; }
+
+.fa-martini-glass-citrus::before {
+  content: "\f561"; }
+
+.fa-cocktail::before {
+  content: "\f561"; }
+
+.fa-face-surprise::before {
+  content: "\f5c2"; }
+
+.fa-surprise::before {
+  content: "\f5c2"; }
+
+.fa-bottle-water::before {
+  content: "\e4c5"; }
+
+.fa-circle-pause::before {
+  content: "\f28b"; }
+
+.fa-pause-circle::before {
+  content: "\f28b"; }
+
+.fa-toilet-paper-slash::before {
+  content: "\e072"; }
+
+.fa-apple-whole::before {
+  content: "\f5d1"; }
+
+.fa-apple-alt::before {
+  content: "\f5d1"; }
+
+.fa-kitchen-set::before {
+  content: "\e51a"; }
+
+.fa-r::before {
+  content: "\52"; }
+
+.fa-temperature-quarter::before {
+  content: "\f2ca"; }
+
+.fa-temperature-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-quarter::before {
+  content: "\f2ca"; }
+
+.fa-cube::before {
+  content: "\f1b2"; }
+
+.fa-bitcoin-sign::before {
+  content: "\e0b4"; }
+
+.fa-shield-dog::before {
+  content: "\e573"; }
+
+.fa-solar-panel::before {
+  content: "\f5ba"; }
+
+.fa-lock-open::before {
+  content: "\f3c1"; }
+
+.fa-elevator::before {
+  content: "\e16d"; }
+
+.fa-money-bill-transfer::before {
+  content: "\e528"; }
+
+.fa-money-bill-trend-up::before {
+  content: "\e529"; }
+
+.fa-house-flood-water-circle-arrow-right::before {
+  content: "\e50f"; }
+
+.fa-square-poll-horizontal::before {
+  content: "\f682"; }
+
+.fa-poll-h::before {
+  content: "\f682"; }
+
+.fa-circle::before {
+  content: "\f111"; }
+
+.fa-backward-fast::before {
+  content: "\f049"; }
+
+.fa-fast-backward::before {
+  content: "\f049"; }
+
+.fa-recycle::before {
+  content: "\f1b8"; }
+
+.fa-user-astronaut::before {
+  content: "\f4fb"; }
+
+.fa-plane-slash::before {
+  content: "\e069"; }
+
+.fa-trademark::before {
+  content: "\f25c"; }
+
+.fa-basketball::before {
+  content: "\f434"; }
+
+.fa-basketball-ball::before {
+  content: "\f434"; }
+
+.fa-satellite-dish::before {
+  content: "\f7c0"; }
+
+.fa-circle-up::before {
+  content: "\f35b"; }
+
+.fa-arrow-alt-circle-up::before {
+  content: "\f35b"; }
+
+.fa-mobile-screen-button::before {
+  content: "\f3cd"; }
+
+.fa-mobile-alt::before {
+  content: "\f3cd"; }
+
+.fa-volume-high::before {
+  content: "\f028"; }
+
+.fa-volume-up::before {
+  content: "\f028"; }
+
+.fa-users-rays::before {
+  content: "\e593"; }
+
+.fa-wallet::before {
+  content: "\f555"; }
+
+.fa-clipboard-check::before {
+  content: "\f46c"; }
+
+.fa-file-audio::before {
+  content: "\f1c7"; }
+
+.fa-burger::before {
+  content: "\f805"; }
+
+.fa-hamburger::before {
+  content: "\f805"; }
+
+.fa-wrench::before {
+  content: "\f0ad"; }
+
+.fa-bugs::before {
+  content: "\e4d0"; }
+
+.fa-rupee-sign::before {
+  content: "\f156"; }
+
+.fa-rupee::before {
+  content: "\f156"; }
+
+.fa-file-image::before {
+  content: "\f1c5"; }
+
+.fa-circle-question::before {
+  content: "\f059"; }
+
+.fa-question-circle::before {
+  content: "\f059"; }
+
+.fa-plane-departure::before {
+  content: "\f5b0"; }
+
+.fa-handshake-slash::before {
+  content: "\e060"; }
+
+.fa-book-bookmark::before {
+  content: "\e0bb"; }
+
+.fa-code-branch::before {
+  content: "\f126"; }
+
+.fa-hat-cowboy::before {
+  content: "\f8c0"; }
+
+.fa-bridge::before {
+  content: "\e4c8"; }
+
+.fa-phone-flip::before {
+  content: "\f879"; }
+
+.fa-phone-alt::before {
+  content: "\f879"; }
+
+.fa-truck-front::before {
+  content: "\e2b7"; }
+
+.fa-cat::before {
+  content: "\f6be"; }
+
+.fa-anchor-circle-exclamation::before {
+  content: "\e4ab"; }
+
+.fa-truck-field::before {
+  content: "\e58d"; }
+
+.fa-route::before {
+  content: "\f4d7"; }
+
+.fa-clipboard-question::before {
+  content: "\e4e3"; }
+
+.fa-panorama::before {
+  content: "\e209"; }
+
+.fa-comment-medical::before {
+  content: "\f7f5"; }
+
+.fa-teeth-open::before {
+  content: "\f62f"; }
+
+.fa-file-circle-minus::before {
+  content: "\e4ed"; }
+
+.fa-tags::before {
+  content: "\f02c"; }
+
+.fa-wine-glass::before {
+  content: "\f4e3"; }
+
+.fa-forward-fast::before {
+  content: "\f050"; }
+
+.fa-fast-forward::before {
+  content: "\f050"; }
+
+.fa-face-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-square-parking::before {
+  content: "\f540"; }
+
+.fa-parking::before {
+  content: "\f540"; }
+
+.fa-house-signal::before {
+  content: "\e012"; }
+
+.fa-bars-progress::before {
+  content: "\f828"; }
+
+.fa-tasks-alt::before {
+  content: "\f828"; }
+
+.fa-faucet-drip::before {
+  content: "\e006"; }
+
+.fa-cart-flatbed::before {
+  content: "\f474"; }
+
+.fa-dolly-flatbed::before {
+  content: "\f474"; }
+
+.fa-ban-smoking::before {
+  content: "\f54d"; }
+
+.fa-smoking-ban::before {
+  content: "\f54d"; }
+
+.fa-terminal::before {
+  content: "\f120"; }
+
+.fa-mobile-button::before {
+  content: "\f10b"; }
+
+.fa-house-medical-flag::before {
+  content: "\e514"; }
+
+.fa-basket-shopping::before {
+  content: "\f291"; }
+
+.fa-shopping-basket::before {
+  content: "\f291"; }
+
+.fa-tape::before {
+  content: "\f4db"; }
+
+.fa-bus-simple::before {
+  content: "\f55e"; }
+
+.fa-bus-alt::before {
+  content: "\f55e"; }
+
+.fa-eye::before {
+  content: "\f06e"; }
+
+.fa-face-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-audio-description::before {
+  content: "\f29e"; }
+
+.fa-person-military-to-person::before {
+  content: "\e54c"; }
+
+.fa-file-shield::before {
+  content: "\e4f0"; }
+
+.fa-user-slash::before {
+  content: "\f506"; }
+
+.fa-pen::before {
+  content: "\f304"; }
+
+.fa-tower-observation::before {
+  content: "\e586"; }
+
+.fa-file-code::before {
+  content: "\f1c9"; }
+
+.fa-signal::before {
+  content: "\f012"; }
+
+.fa-signal-5::before {
+  content: "\f012"; }
+
+.fa-signal-perfect::before {
+  content: "\f012"; }
+
+.fa-bus::before {
+  content: "\f207"; }
+
+.fa-heart-circle-xmark::before {
+  content: "\e501"; }
+
+.fa-house-chimney::before {
+  content: "\e3af"; }
+
+.fa-home-lg::before {
+  content: "\e3af"; }
+
+.fa-window-maximize::before {
+  content: "\f2d0"; }
+
+.fa-face-frown::before {
+  content: "\f119"; }
+
+.fa-frown::before {
+  content: "\f119"; }
+
+.fa-prescription::before {
+  content: "\f5b1"; }
+
+.fa-shop::before {
+  content: "\f54f"; }
+
+.fa-store-alt::before {
+  content: "\f54f"; }
+
+.fa-floppy-disk::before {
+  content: "\f0c7"; }
+
+.fa-save::before {
+  content: "\f0c7"; }
+
+.fa-vihara::before {
+  content: "\f6a7"; }
+
+.fa-scale-unbalanced::before {
+  content: "\f515"; }
+
+.fa-balance-scale-left::before {
+  content: "\f515"; }
+
+.fa-sort-up::before {
+  content: "\f0de"; }
+
+.fa-sort-asc::before {
+  content: "\f0de"; }
+
+.fa-comment-dots::before {
+  content: "\f4ad"; }
+
+.fa-commenting::before {
+  content: "\f4ad"; }
+
+.fa-plant-wilt::before {
+  content: "\e5aa"; }
+
+.fa-diamond::before {
+  content: "\f219"; }
+
+.fa-face-grin-squint::before {
+  content: "\f585"; }
+
+.fa-grin-squint::before {
+  content: "\f585"; }
+
+.fa-hand-holding-dollar::before {
+  content: "\f4c0"; }
+
+.fa-hand-holding-usd::before {
+  content: "\f4c0"; }
+
+.fa-bacterium::before {
+  content: "\e05a"; }
+
+.fa-hand-pointer::before {
+  content: "\f25a"; }
+
+.fa-drum-steelpan::before {
+  content: "\f56a"; }
+
+.fa-hand-scissors::before {
+  content: "\f257"; }
+
+.fa-hands-praying::before {
+  content: "\f684"; }
+
+.fa-praying-hands::before {
+  content: "\f684"; }
+
+.fa-arrow-rotate-right::before {
+  content: "\f01e"; }
+
+.fa-arrow-right-rotate::before {
+  content: "\f01e"; }
+
+.fa-arrow-rotate-forward::before {
+  content: "\f01e"; }
+
+.fa-redo::before {
+  content: "\f01e"; }
+
+.fa-biohazard::before {
+  content: "\f780"; }
+
+.fa-location-crosshairs::before {
+  content: "\f601"; }
+
+.fa-location::before {
+  content: "\f601"; }
+
+.fa-mars-double::before {
+  content: "\f227"; }
+
+.fa-child-dress::before {
+  content: "\e59c"; }
+
+.fa-users-between-lines::before {
+  content: "\e591"; }
+
+.fa-lungs-virus::before {
+  content: "\e067"; }
+
+.fa-face-grin-tears::before {
+  content: "\f588"; }
+
+.fa-grin-tears::before {
+  content: "\f588"; }
+
+.fa-phone::before {
+  content: "\f095"; }
+
+.fa-calendar-xmark::before {
+  content: "\f273"; }
+
+.fa-calendar-times::before {
+  content: "\f273"; }
+
+.fa-child-reaching::before {
+  content: "\e59d"; }
+
+.fa-head-side-virus::before {
+  content: "\e064"; }
+
+.fa-user-gear::before {
+  content: "\f4fe"; }
+
+.fa-user-cog::before {
+  content: "\f4fe"; }
+
+.fa-arrow-up-1-9::before {
+  content: "\f163"; }
+
+.fa-sort-numeric-up::before {
+  content: "\f163"; }
+
+.fa-door-closed::before {
+  content: "\f52a"; }
+
+.fa-shield-virus::before {
+  content: "\e06c"; }
+
+.fa-dice-six::before {
+  content: "\f526"; }
+
+.fa-mosquito-net::before {
+  content: "\e52c"; }
+
+.fa-bridge-water::before {
+  content: "\e4ce"; }
+
+.fa-person-booth::before {
+  content: "\f756"; }
+
+.fa-text-width::before {
+  content: "\f035"; }
+
+.fa-hat-wizard::before {
+  content: "\f6e8"; }
+
+.fa-pen-fancy::before {
+  content: "\f5ac"; }
+
+.fa-person-digging::before {
+  content: "\f85e"; }
+
+.fa-digging::before {
+  content: "\f85e"; }
+
+.fa-trash::before {
+  content: "\f1f8"; }
+
+.fa-gauge-simple::before {
+  content: "\f629"; }
+
+.fa-gauge-simple-med::before {
+  content: "\f629"; }
+
+.fa-tachometer-average::before {
+  content: "\f629"; }
+
+.fa-book-medical::before {
+  content: "\f7e6"; }
+
+.fa-poo::before {
+  content: "\f2fe"; }
+
+.fa-quote-right::before {
+  content: "\f10e"; }
+
+.fa-quote-right-alt::before {
+  content: "\f10e"; }
+
+.fa-shirt::before {
+  content: "\f553"; }
+
+.fa-t-shirt::before {
+  content: "\f553"; }
+
+.fa-tshirt::before {
+  content: "\f553"; }
+
+.fa-cubes::before {
+  content: "\f1b3"; }
+
+.fa-divide::before {
+  content: "\f529"; }
+
+.fa-tenge-sign::before {
+  content: "\f7d7"; }
+
+.fa-tenge::before {
+  content: "\f7d7"; }
+
+.fa-headphones::before {
+  content: "\f025"; }
+
+.fa-hands-holding::before {
+  content: "\f4c2"; }
+
+.fa-hands-clapping::before {
+  content: "\e1a8"; }
+
+.fa-republican::before {
+  content: "\f75e"; }
+
+.fa-arrow-left::before {
+  content: "\f060"; }
+
+.fa-person-circle-xmark::before {
+  content: "\e543"; }
+
+.fa-ruler::before {
+  content: "\f545"; }
+
+.fa-align-left::before {
+  content: "\f036"; }
+
+.fa-dice-d6::before {
+  content: "\f6d1"; }
+
+.fa-restroom::before {
+  content: "\f7bd"; }
+
+.fa-j::before {
+  content: "\4a"; }
+
+.fa-users-viewfinder::before {
+  content: "\e595"; }
+
+.fa-file-video::before {
+  content: "\f1c8"; }
+
+.fa-up-right-from-square::before {
+  content: "\f35d"; }
+
+.fa-external-link-alt::before {
+  content: "\f35d"; }
+
+.fa-table-cells::before {
+  content: "\f00a"; }
+
+.fa-th::before {
+  content: "\f00a"; }
+
+.fa-file-pdf::before {
+  content: "\f1c1"; }
+
+.fa-book-bible::before {
+  content: "\f647"; }
+
+.fa-bible::before {
+  content: "\f647"; }
+
+.fa-o::before {
+  content: "\4f"; }
+
+.fa-suitcase-medical::before {
+  content: "\f0fa"; }
+
+.fa-medkit::before {
+  content: "\f0fa"; }
+
+.fa-user-secret::before {
+  content: "\f21b"; }
+
+.fa-otter::before {
+  content: "\f700"; }
+
+.fa-person-dress::before {
+  content: "\f182"; }
+
+.fa-female::before {
+  content: "\f182"; }
+
+.fa-comment-dollar::before {
+  content: "\f651"; }
+
+.fa-business-time::before {
+  content: "\f64a"; }
+
+.fa-briefcase-clock::before {
+  content: "\f64a"; }
+
+.fa-table-cells-large::before {
+  content: "\f009"; }
+
+.fa-th-large::before {
+  content: "\f009"; }
+
+.fa-book-tanakh::before {
+  content: "\f827"; }
+
+.fa-tanakh::before {
+  content: "\f827"; }
+
+.fa-phone-volume::before {
+  content: "\f2a0"; }
+
+.fa-volume-control-phone::before {
+  content: "\f2a0"; }
+
+.fa-hat-cowboy-side::before {
+  content: "\f8c1"; }
+
+.fa-clipboard-user::before {
+  content: "\f7f3"; }
+
+.fa-child::before {
+  content: "\f1ae"; }
+
+.fa-lira-sign::before {
+  content: "\f195"; }
+
+.fa-satellite::before {
+  content: "\f7bf"; }
+
+.fa-plane-lock::before {
+  content: "\e558"; }
+
+.fa-tag::before {
+  content: "\f02b"; }
+
+.fa-comment::before {
+  content: "\f075"; }
+
+.fa-cake-candles::before {
+  content: "\f1fd"; }
+
+.fa-birthday-cake::before {
+  content: "\f1fd"; }
+
+.fa-cake::before {
+  content: "\f1fd"; }
+
+.fa-envelope::before {
+  content: "\f0e0"; }
+
+.fa-angles-up::before {
+  content: "\f102"; }
+
+.fa-angle-double-up::before {
+  content: "\f102"; }
+
+.fa-paperclip::before {
+  content: "\f0c6"; }
+
+.fa-arrow-right-to-city::before {
+  content: "\e4b3"; }
+
+.fa-ribbon::before {
+  content: "\f4d6"; }
+
+.fa-lungs::before {
+  content: "\f604"; }
+
+.fa-arrow-up-9-1::before {
+  content: "\f887"; }
+
+.fa-sort-numeric-up-alt::before {
+  content: "\f887"; }
+
+.fa-litecoin-sign::before {
+  content: "\e1d3"; }
+
+.fa-border-none::before {
+  content: "\f850"; }
+
+.fa-circle-nodes::before {
+  content: "\e4e2"; }
+
+.fa-parachute-box::before {
+  content: "\f4cd"; }
+
+.fa-indent::before {
+  content: "\f03c"; }
+
+.fa-truck-field-un::before {
+  content: "\e58e"; }
+
+.fa-hourglass::before {
+  content: "\f254"; }
+
+.fa-hourglass-empty::before {
+  content: "\f254"; }
+
+.fa-mountain::before {
+  content: "\f6fc"; }
+
+.fa-user-doctor::before {
+  content: "\f0f0"; }
+
+.fa-user-md::before {
+  content: "\f0f0"; }
+
+.fa-circle-info::before {
+  content: "\f05a"; }
+
+.fa-info-circle::before {
+  content: "\f05a"; }
+
+.fa-cloud-meatball::before {
+  content: "\f73b"; }
+
+.fa-camera::before {
+  content: "\f030"; }
+
+.fa-camera-alt::before {
+  content: "\f030"; }
+
+.fa-square-virus::before {
+  content: "\e578"; }
+
+.fa-meteor::before {
+  content: "\f753"; }
+
+.fa-car-on::before {
+  content: "\e4dd"; }
+
+.fa-sleigh::before {
+  content: "\f7cc"; }
+
+.fa-arrow-down-1-9::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-asc::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-down::before {
+  content: "\f162"; }
+
+.fa-hand-holding-droplet::before {
+  content: "\f4c1"; }
+
+.fa-hand-holding-water::before {
+  content: "\f4c1"; }
+
+.fa-water::before {
+  content: "\f773"; }
+
+.fa-calendar-check::before {
+  content: "\f274"; }
+
+.fa-braille::before {
+  content: "\f2a1"; }
+
+.fa-prescription-bottle-medical::before {
+  content: "\f486"; }
+
+.fa-prescription-bottle-alt::before {
+  content: "\f486"; }
+
+.fa-landmark::before {
+  content: "\f66f"; }
+
+.fa-truck::before {
+  content: "\f0d1"; }
+
+.fa-crosshairs::before {
+  content: "\f05b"; }
+
+.fa-person-cane::before {
+  content: "\e53c"; }
+
+.fa-tent::before {
+  content: "\e57d"; }
+
+.fa-vest-patches::before {
+  content: "\e086"; }
+
+.fa-check-double::before {
+  content: "\f560"; }
+
+.fa-arrow-down-a-z::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-asc::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-down::before {
+  content: "\f15d"; }
+
+.fa-money-bill-wheat::before {
+  content: "\e52a"; }
+
+.fa-cookie::before {
+  content: "\f563"; }
+
+.fa-arrow-rotate-left::before {
+  content: "\f0e2"; }
+
+.fa-arrow-left-rotate::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-back::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-backward::before {
+  content: "\f0e2"; }
+
+.fa-undo::before {
+  content: "\f0e2"; }
+
+.fa-hard-drive::before {
+  content: "\f0a0"; }
+
+.fa-hdd::before {
+  content: "\f0a0"; }
+
+.fa-face-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-dumbbell::before {
+  content: "\f44b"; }
+
+.fa-rectangle-list::before {
+  content: "\f022"; }
+
+.fa-list-alt::before {
+  content: "\f022"; }
+
+.fa-tarp-droplet::before {
+  content: "\e57c"; }
+
+.fa-house-medical-circle-check::before {
+  content: "\e511"; }
+
+.fa-person-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-calendar-plus::before {
+  content: "\f271"; }
+
+.fa-plane-arrival::before {
+  content: "\f5af"; }
+
+.fa-circle-left::before {
+  content: "\f359"; }
+
+.fa-arrow-alt-circle-left::before {
+  content: "\f359"; }
+
+.fa-train-subway::before {
+  content: "\f239"; }
+
+.fa-subway::before {
+  content: "\f239"; }
+
+.fa-chart-gantt::before {
+  content: "\e0e4"; }
+
+.fa-indian-rupee-sign::before {
+  content: "\e1bc"; }
+
+.fa-indian-rupee::before {
+  content: "\e1bc"; }
+
+.fa-inr::before {
+  content: "\e1bc"; }
+
+.fa-crop-simple::before {
+  content: "\f565"; }
+
+.fa-crop-alt::before {
+  content: "\f565"; }
+
+.fa-money-bill-1::before {
+  content: "\f3d1"; }
+
+.fa-money-bill-alt::before {
+  content: "\f3d1"; }
+
+.fa-left-long::before {
+  content: "\f30a"; }
+
+.fa-long-arrow-alt-left::before {
+  content: "\f30a"; }
+
+.fa-dna::before {
+  content: "\f471"; }
+
+.fa-virus-slash::before {
+  content: "\e075"; }
+
+.fa-minus::before {
+  content: "\f068"; }
+
+.fa-subtract::before {
+  content: "\f068"; }
+
+.fa-chess::before {
+  content: "\f439"; }
+
+.fa-arrow-left-long::before {
+  content: "\f177"; }
+
+.fa-long-arrow-left::before {
+  content: "\f177"; }
+
+.fa-plug-circle-check::before {
+  content: "\e55c"; }
+
+.fa-street-view::before {
+  content: "\f21d"; }
+
+.fa-franc-sign::before {
+  content: "\e18f"; }
+
+.fa-volume-off::before {
+  content: "\f026"; }
+
+.fa-hands-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-hands-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-gear::before {
+  content: "\f013"; }
+
+.fa-cog::before {
+  content: "\f013"; }
+
+.fa-droplet-slash::before {
+  content: "\f5c7"; }
+
+.fa-tint-slash::before {
+  content: "\f5c7"; }
+
+.fa-mosque::before {
+  content: "\f678"; }
+
+.fa-mosquito::before {
+  content: "\e52b"; }
+
+.fa-star-of-david::before {
+  content: "\f69a"; }
+
+.fa-person-military-rifle::before {
+  content: "\e54b"; }
+
+.fa-cart-shopping::before {
+  content: "\f07a"; }
+
+.fa-shopping-cart::before {
+  content: "\f07a"; }
+
+.fa-vials::before {
+  content: "\f493"; }
+
+.fa-plug-circle-plus::before {
+  content: "\e55f"; }
+
+.fa-place-of-worship::before {
+  content: "\f67f"; }
+
+.fa-grip-vertical::before {
+  content: "\f58e"; }
+
+.fa-arrow-turn-up::before {
+  content: "\f148"; }
+
+.fa-level-up::before {
+  content: "\f148"; }
+
+.fa-u::before {
+  content: "\55"; }
+
+.fa-square-root-variable::before {
+  content: "\f698"; }
+
+.fa-square-root-alt::before {
+  content: "\f698"; }
+
+.fa-clock::before {
+  content: "\f017"; }
+
+.fa-clock-four::before {
+  content: "\f017"; }
+
+.fa-backward-step::before {
+  content: "\f048"; }
+
+.fa-step-backward::before {
+  content: "\f048"; }
+
+.fa-pallet::before {
+  content: "\f482"; }
+
+.fa-faucet::before {
+  content: "\e005"; }
+
+.fa-baseball-bat-ball::before {
+  content: "\f432"; }
+
+.fa-s::before {
+  content: "\53"; }
+
+.fa-timeline::before {
+  content: "\e29c"; }
+
+.fa-keyboard::before {
+  content: "\f11c"; }
+
+.fa-caret-down::before {
+  content: "\f0d7"; }
+
+.fa-house-chimney-medical::before {
+  content: "\f7f2"; }
+
+.fa-clinic-medical::before {
+  content: "\f7f2"; }
+
+.fa-temperature-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-temperature-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-mobile-screen::before {
+  content: "\f3cf"; }
+
+.fa-mobile-android-alt::before {
+  content: "\f3cf"; }
+
+.fa-plane-up::before {
+  content: "\e22d"; }
+
+.fa-piggy-bank::before {
+  content: "\f4d3"; }
+
+.fa-battery-half::before {
+  content: "\f242"; }
+
+.fa-battery-3::before {
+  content: "\f242"; }
+
+.fa-mountain-city::before {
+  content: "\e52e"; }
+
+.fa-coins::before {
+  content: "\f51e"; }
+
+.fa-khanda::before {
+  content: "\f66d"; }
+
+.fa-sliders::before {
+  content: "\f1de"; }
+
+.fa-sliders-h::before {
+  content: "\f1de"; }
+
+.fa-folder-tree::before {
+  content: "\f802"; }
+
+.fa-network-wired::before {
+  content: "\f6ff"; }
+
+.fa-map-pin::before {
+  content: "\f276"; }
+
+.fa-hamsa::before {
+  content: "\f665"; }
+
+.fa-cent-sign::before {
+  content: "\e3f5"; }
+
+.fa-flask::before {
+  content: "\f0c3"; }
+
+.fa-person-pregnant::before {
+  content: "\e31e"; }
+
+.fa-wand-sparkles::before {
+  content: "\f72b"; }
+
+.fa-ellipsis-vertical::before {
+  content: "\f142"; }
+
+.fa-ellipsis-v::before {
+  content: "\f142"; }
+
+.fa-ticket::before {
+  content: "\f145"; }
+
+.fa-power-off::before {
+  content: "\f011"; }
+
+.fa-right-long::before {
+  content: "\f30b"; }
+
+.fa-long-arrow-alt-right::before {
+  content: "\f30b"; }
+
+.fa-flag-usa::before {
+  content: "\f74d"; }
+
+.fa-laptop-file::before {
+  content: "\e51d"; }
+
+.fa-tty::before {
+  content: "\f1e4"; }
+
+.fa-teletype::before {
+  content: "\f1e4"; }
+
+.fa-diagram-next::before {
+  content: "\e476"; }
+
+.fa-person-rifle::before {
+  content: "\e54e"; }
+
+.fa-house-medical-circle-exclamation::before {
+  content: "\e512"; }
+
+.fa-closed-captioning::before {
+  content: "\f20a"; }
+
+.fa-person-hiking::before {
+  content: "\f6ec"; }
+
+.fa-hiking::before {
+  content: "\f6ec"; }
+
+.fa-venus-double::before {
+  content: "\f226"; }
+
+.fa-images::before {
+  content: "\f302"; }
+
+.fa-calculator::before {
+  content: "\f1ec"; }
+
+.fa-people-pulling::before {
+  content: "\e535"; }
+
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+  content: "\4e"; }
+
+.fa-cable-car::before {
+  content: "\f7da"; }
+
+.fa-tram::before {
+  content: "\f7da"; }
+
+.fa-cloud-rain::before {
+  content: "\f73d"; }
+
+.fa-building-circle-xmark::before {
+  content: "\e4d4"; }
+
+.fa-ship::before {
+  content: "\f21a"; }
+
+.fa-arrows-down-to-line::before {
+  content: "\e4b8"; }
+
+.fa-download::before {
+  content: "\f019"; }
+
+.fa-face-grin::before {
+  content: "\f580"; }
+
+.fa-grin::before {
+  content: "\f580"; }
+
+.fa-delete-left::before {
+  content: "\f55a"; }
+
+.fa-backspace::before {
+  content: "\f55a"; }
+
+.fa-eye-dropper::before {
+  content: "\f1fb"; }
+
+.fa-eye-dropper-empty::before {
+  content: "\f1fb"; }
+
+.fa-eyedropper::before {
+  content: "\f1fb"; }
+
+.fa-file-circle-check::before {
+  content: "\e5a0"; }
+
+.fa-forward::before {
+  content: "\f04e"; }
+
+.fa-mobile::before {
+  content: "\f3ce"; }
+
+.fa-mobile-android::before {
+  content: "\f3ce"; }
+
+.fa-mobile-phone::before {
+  content: "\f3ce"; }
+
+.fa-face-meh::before {
+  content: "\f11a"; }
+
+.fa-meh::before {
+  content: "\f11a"; }
+
+.fa-align-center::before {
+  content: "\f037"; }
+
+.fa-book-skull::before {
+  content: "\f6b7"; }
+
+.fa-book-dead::before {
+  content: "\f6b7"; }
+
+.fa-id-card::before {
+  content: "\f2c2"; }
+
+.fa-drivers-license::before {
+  content: "\f2c2"; }
+
+.fa-outdent::before {
+  content: "\f03b"; }
+
+.fa-dedent::before {
+  content: "\f03b"; }
+
+.fa-heart-circle-exclamation::before {
+  content: "\e4fe"; }
+
+.fa-house::before {
+  content: "\f015"; }
+
+.fa-home::before {
+  content: "\f015"; }
+
+.fa-home-alt::before {
+  content: "\f015"; }
+
+.fa-home-lg-alt::before {
+  content: "\f015"; }
+
+.fa-calendar-week::before {
+  content: "\f784"; }
+
+.fa-laptop-medical::before {
+  content: "\f812"; }
+
+.fa-b::before {
+  content: "\42"; }
+
+.fa-file-medical::before {
+  content: "\f477"; }
+
+.fa-dice-one::before {
+  content: "\f525"; }
+
+.fa-kiwi-bird::before {
+  content: "\f535"; }
+
+.fa-arrow-right-arrow-left::before {
+  content: "\f0ec"; }
+
+.fa-exchange::before {
+  content: "\f0ec"; }
+
+.fa-rotate-right::before {
+  content: "\f2f9"; }
+
+.fa-redo-alt::before {
+  content: "\f2f9"; }
+
+.fa-rotate-forward::before {
+  content: "\f2f9"; }
+
+.fa-utensils::before {
+  content: "\f2e7"; }
+
+.fa-cutlery::before {
+  content: "\f2e7"; }
+
+.fa-arrow-up-wide-short::before {
+  content: "\f161"; }
+
+.fa-sort-amount-up::before {
+  content: "\f161"; }
+
+.fa-mill-sign::before {
+  content: "\e1ed"; }
+
+.fa-bowl-rice::before {
+  content: "\e2eb"; }
+
+.fa-skull::before {
+  content: "\f54c"; }
+
+.fa-tower-broadcast::before {
+  content: "\f519"; }
+
+.fa-broadcast-tower::before {
+  content: "\f519"; }
+
+.fa-truck-pickup::before {
+  content: "\f63c"; }
+
+.fa-up-long::before {
+  content: "\f30c"; }
+
+.fa-long-arrow-alt-up::before {
+  content: "\f30c"; }
+
+.fa-stop::before {
+  content: "\f04d"; }
+
+.fa-code-merge::before {
+  content: "\f387"; }
+
+.fa-upload::before {
+  content: "\f093"; }
+
+.fa-hurricane::before {
+  content: "\f751"; }
+
+.fa-mound::before {
+  content: "\e52d"; }
+
+.fa-toilet-portable::before {
+  content: "\e583"; }
+
+.fa-compact-disc::before {
+  content: "\f51f"; }
+
+.fa-file-arrow-down::before {
+  content: "\f56d"; }
+
+.fa-file-download::before {
+  content: "\f56d"; }
+
+.fa-caravan::before {
+  content: "\f8ff"; }
+
+.fa-shield-cat::before {
+  content: "\e572"; }
+
+.fa-bolt::before {
+  content: "\f0e7"; }
+
+.fa-zap::before {
+  content: "\f0e7"; }
+
+.fa-glass-water::before {
+  content: "\e4f4"; }
+
+.fa-oil-well::before {
+  content: "\e532"; }
+
+.fa-vault::before {
+  content: "\e2c5"; }
+
+.fa-mars::before {
+  content: "\f222"; }
+
+.fa-toilet::before {
+  content: "\f7d8"; }
+
+.fa-plane-circle-xmark::before {
+  content: "\e557"; }
+
+.fa-yen-sign::before {
+  content: "\f157"; }
+
+.fa-cny::before {
+  content: "\f157"; }
+
+.fa-jpy::before {
+  content: "\f157"; }
+
+.fa-rmb::before {
+  content: "\f157"; }
+
+.fa-yen::before {
+  content: "\f157"; }
+
+.fa-ruble-sign::before {
+  content: "\f158"; }
+
+.fa-rouble::before {
+  content: "\f158"; }
+
+.fa-rub::before {
+  content: "\f158"; }
+
+.fa-ruble::before {
+  content: "\f158"; }
+
+.fa-sun::before {
+  content: "\f185"; }
+
+.fa-guitar::before {
+  content: "\f7a6"; }
+
+.fa-face-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-horse-head::before {
+  content: "\f7ab"; }
+
+.fa-bore-hole::before {
+  content: "\e4c3"; }
+
+.fa-industry::before {
+  content: "\f275"; }
+
+.fa-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrow-alt-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrows-turn-to-dots::before {
+  content: "\e4c1"; }
+
+.fa-florin-sign::before {
+  content: "\e184"; }
+
+.fa-arrow-down-short-wide::before {
+  content: "\f884"; }
+
+.fa-sort-amount-desc::before {
+  content: "\f884"; }
+
+.fa-sort-amount-down-alt::before {
+  content: "\f884"; }
+
+.fa-less-than::before {
+  content: "\3c"; }
+
+.fa-angle-down::before {
+  content: "\f107"; }
+
+.fa-car-tunnel::before {
+  content: "\e4de"; }
+
+.fa-head-side-cough::before {
+  content: "\e061"; }
+
+.fa-grip-lines::before {
+  content: "\f7a4"; }
+
+.fa-thumbs-down::before {
+  content: "\f165"; }
+
+.fa-user-lock::before {
+  content: "\f502"; }
+
+.fa-arrow-right-long::before {
+  content: "\f178"; }
+
+.fa-long-arrow-right::before {
+  content: "\f178"; }
+
+.fa-anchor-circle-xmark::before {
+  content: "\e4ac"; }
+
+.fa-ellipsis::before {
+  content: "\f141"; }
+
+.fa-ellipsis-h::before {
+  content: "\f141"; }
+
+.fa-chess-pawn::before {
+  content: "\f443"; }
+
+.fa-kit-medical::before {
+  content: "\f479"; }
+
+.fa-first-aid::before {
+  content: "\f479"; }
+
+.fa-person-through-window::before {
+  content: "\e5a9"; }
+
+.fa-toolbox::before {
+  content: "\f552"; }
+
+.fa-hands-holding-circle::before {
+  content: "\e4fb"; }
+
+.fa-bug::before {
+  content: "\f188"; }
+
+.fa-credit-card::before {
+  content: "\f09d"; }
+
+.fa-credit-card-alt::before {
+  content: "\f09d"; }
+
+.fa-car::before {
+  content: "\f1b9"; }
+
+.fa-automobile::before {
+  content: "\f1b9"; }
+
+.fa-hand-holding-hand::before {
+  content: "\e4f7"; }
+
+.fa-book-open-reader::before {
+  content: "\f5da"; }
+
+.fa-book-reader::before {
+  content: "\f5da"; }
+
+.fa-mountain-sun::before {
+  content: "\e52f"; }
+
+.fa-arrows-left-right-to-line::before {
+  content: "\e4ba"; }
+
+.fa-dice-d20::before {
+  content: "\f6cf"; }
+
+.fa-truck-droplet::before {
+  content: "\e58c"; }
+
+.fa-file-circle-xmark::before {
+  content: "\e5a1"; }
+
+.fa-temperature-arrow-up::before {
+  content: "\e040"; }
+
+.fa-temperature-up::before {
+  content: "\e040"; }
+
+.fa-medal::before {
+  content: "\f5a2"; }
+
+.fa-bed::before {
+  content: "\f236"; }
+
+.fa-square-h::before {
+  content: "\f0fd"; }
+
+.fa-h-square::before {
+  content: "\f0fd"; }
+
+.fa-podcast::before {
+  content: "\f2ce"; }
+
+.fa-temperature-full::before {
+  content: "\f2c7"; }
+
+.fa-temperature-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-full::before {
+  content: "\f2c7"; }
+
+.fa-bell::before {
+  content: "\f0f3"; }
+
+.fa-superscript::before {
+  content: "\f12b"; }
+
+.fa-plug-circle-xmark::before {
+  content: "\e560"; }
+
+.fa-star-of-life::before {
+  content: "\f621"; }
+
+.fa-phone-slash::before {
+  content: "\f3dd"; }
+
+.fa-paint-roller::before {
+  content: "\f5aa"; }
+
+.fa-handshake-angle::before {
+  content: "\f4c4"; }
+
+.fa-hands-helping::before {
+  content: "\f4c4"; }
+
+.fa-location-dot::before {
+  content: "\f3c5"; }
+
+.fa-map-marker-alt::before {
+  content: "\f3c5"; }
+
+.fa-file::before {
+  content: "\f15b"; }
+
+.fa-greater-than::before {
+  content: "\3e"; }
+
+.fa-person-swimming::before {
+  content: "\f5c4"; }
+
+.fa-swimmer::before {
+  content: "\f5c4"; }
+
+.fa-arrow-down::before {
+  content: "\f063"; }
+
+.fa-droplet::before {
+  content: "\f043"; }
+
+.fa-tint::before {
+  content: "\f043"; }
+
+.fa-eraser::before {
+  content: "\f12d"; }
+
+.fa-earth-americas::before {
+  content: "\f57d"; }
+
+.fa-earth::before {
+  content: "\f57d"; }
+
+.fa-earth-america::before {
+  content: "\f57d"; }
+
+.fa-globe-americas::before {
+  content: "\f57d"; }
+
+.fa-person-burst::before {
+  content: "\e53b"; }
+
+.fa-dove::before {
+  content: "\f4ba"; }
+
+.fa-battery-empty::before {
+  content: "\f244"; }
+
+.fa-battery-0::before {
+  content: "\f244"; }
+
+.fa-socks::before {
+  content: "\f696"; }
+
+.fa-inbox::before {
+  content: "\f01c"; }
+
+.fa-section::before {
+  content: "\e447"; }
+
+.fa-gauge-high::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt-fast::before {
+  content: "\f625"; }
+
+.fa-envelope-open-text::before {
+  content: "\f658"; }
+
+.fa-hospital::before {
+  content: "\f0f8"; }
+
+.fa-hospital-alt::before {
+  content: "\f0f8"; }
+
+.fa-hospital-wide::before {
+  content: "\f0f8"; }
+
+.fa-wine-bottle::before {
+  content: "\f72f"; }
+
+.fa-chess-rook::before {
+  content: "\f447"; }
+
+.fa-bars-staggered::before {
+  content: "\f550"; }
+
+.fa-reorder::before {
+  content: "\f550"; }
+
+.fa-stream::before {
+  content: "\f550"; }
+
+.fa-dharmachakra::before {
+  content: "\f655"; }
+
+.fa-hotdog::before {
+  content: "\f80f"; }
+
+.fa-person-walking-with-cane::before {
+  content: "\f29d"; }
+
+.fa-blind::before {
+  content: "\f29d"; }
+
+.fa-drum::before {
+  content: "\f569"; }
+
+.fa-ice-cream::before {
+  content: "\f810"; }
+
+.fa-heart-circle-bolt::before {
+  content: "\e4fc"; }
+
+.fa-fax::before {
+  content: "\f1ac"; }
+
+.fa-paragraph::before {
+  content: "\f1dd"; }
+
+.fa-check-to-slot::before {
+  content: "\f772"; }
+
+.fa-vote-yea::before {
+  content: "\f772"; }
+
+.fa-star-half::before {
+  content: "\f089"; }
+
+.fa-boxes-stacked::before {
+  content: "\f468"; }
+
+.fa-boxes::before {
+  content: "\f468"; }
+
+.fa-boxes-alt::before {
+  content: "\f468"; }
+
+.fa-link::before {
+  content: "\f0c1"; }
+
+.fa-chain::before {
+  content: "\f0c1"; }
+
+.fa-ear-listen::before {
+  content: "\f2a2"; }
+
+.fa-assistive-listening-systems::before {
+  content: "\f2a2"; }
+
+.fa-tree-city::before {
+  content: "\e587"; }
+
+.fa-play::before {
+  content: "\f04b"; }
+
+.fa-font::before {
+  content: "\f031"; }
+
+.fa-table-cells-row-lock::before {
+  content: "\e67a"; }
+
+.fa-rupiah-sign::before {
+  content: "\e23d"; }
+
+.fa-magnifying-glass::before {
+  content: "\f002"; }
+
+.fa-search::before {
+  content: "\f002"; }
+
+.fa-table-tennis-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-ping-pong-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-table-tennis::before {
+  content: "\f45d"; }
+
+.fa-person-dots-from-line::before {
+  content: "\f470"; }
+
+.fa-diagnoses::before {
+  content: "\f470"; }
+
+.fa-trash-can-arrow-up::before {
+  content: "\f82a"; }
+
+.fa-trash-restore-alt::before {
+  content: "\f82a"; }
+
+.fa-naira-sign::before {
+  content: "\e1f6"; }
+
+.fa-cart-arrow-down::before {
+  content: "\f218"; }
+
+.fa-walkie-talkie::before {
+  content: "\f8ef"; }
+
+.fa-file-pen::before {
+  content: "\f31c"; }
+
+.fa-file-edit::before {
+  content: "\f31c"; }
+
+.fa-receipt::before {
+  content: "\f543"; }
+
+.fa-square-pen::before {
+  content: "\f14b"; }
+
+.fa-pen-square::before {
+  content: "\f14b"; }
+
+.fa-pencil-square::before {
+  content: "\f14b"; }
+
+.fa-suitcase-rolling::before {
+  content: "\f5c1"; }
+
+.fa-person-circle-exclamation::before {
+  content: "\e53f"; }
+
+.fa-chevron-down::before {
+  content: "\f078"; }
+
+.fa-battery-full::before {
+  content: "\f240"; }
+
+.fa-battery::before {
+  content: "\f240"; }
+
+.fa-battery-5::before {
+  content: "\f240"; }
+
+.fa-skull-crossbones::before {
+  content: "\f714"; }
+
+.fa-code-compare::before {
+  content: "\e13a"; }
+
+.fa-list-ul::before {
+  content: "\f0ca"; }
+
+.fa-list-dots::before {
+  content: "\f0ca"; }
+
+.fa-school-lock::before {
+  content: "\e56f"; }
+
+.fa-tower-cell::before {
+  content: "\e585"; }
+
+.fa-down-long::before {
+  content: "\f309"; }
+
+.fa-long-arrow-alt-down::before {
+  content: "\f309"; }
+
+.fa-ranking-star::before {
+  content: "\e561"; }
+
+.fa-chess-king::before {
+  content: "\f43f"; }
+
+.fa-person-harassing::before {
+  content: "\e549"; }
+
+.fa-brazilian-real-sign::before {
+  content: "\e46c"; }
+
+.fa-landmark-dome::before {
+  content: "\f752"; }
+
+.fa-landmark-alt::before {
+  content: "\f752"; }
+
+.fa-arrow-up::before {
+  content: "\f062"; }
+
+.fa-tv::before {
+  content: "\f26c"; }
+
+.fa-television::before {
+  content: "\f26c"; }
+
+.fa-tv-alt::before {
+  content: "\f26c"; }
+
+.fa-shrimp::before {
+  content: "\e448"; }
+
+.fa-list-check::before {
+  content: "\f0ae"; }
+
+.fa-tasks::before {
+  content: "\f0ae"; }
+
+.fa-jug-detergent::before {
+  content: "\e519"; }
+
+.fa-circle-user::before {
+  content: "\f2bd"; }
+
+.fa-user-circle::before {
+  content: "\f2bd"; }
+
+.fa-user-shield::before {
+  content: "\f505"; }
+
+.fa-wind::before {
+  content: "\f72e"; }
+
+.fa-car-burst::before {
+  content: "\f5e1"; }
+
+.fa-car-crash::before {
+  content: "\f5e1"; }
+
+.fa-y::before {
+  content: "\59"; }
+
+.fa-person-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-truck-fast::before {
+  content: "\f48b"; }
+
+.fa-shipping-fast::before {
+  content: "\f48b"; }
+
+.fa-fish::before {
+  content: "\f578"; }
+
+.fa-user-graduate::before {
+  content: "\f501"; }
+
+.fa-circle-half-stroke::before {
+  content: "\f042"; }
+
+.fa-adjust::before {
+  content: "\f042"; }
+
+.fa-clapperboard::before {
+  content: "\e131"; }
+
+.fa-circle-radiation::before {
+  content: "\f7ba"; }
+
+.fa-radiation-alt::before {
+  content: "\f7ba"; }
+
+.fa-baseball::before {
+  content: "\f433"; }
+
+.fa-baseball-ball::before {
+  content: "\f433"; }
+
+.fa-jet-fighter-up::before {
+  content: "\e518"; }
+
+.fa-diagram-project::before {
+  content: "\f542"; }
+
+.fa-project-diagram::before {
+  content: "\f542"; }
+
+.fa-copy::before {
+  content: "\f0c5"; }
+
+.fa-volume-xmark::before {
+  content: "\f6a9"; }
+
+.fa-volume-mute::before {
+  content: "\f6a9"; }
+
+.fa-volume-times::before {
+  content: "\f6a9"; }
+
+.fa-hand-sparkles::before {
+  content: "\e05d"; }
+
+.fa-grip::before {
+  content: "\f58d"; }
+
+.fa-grip-horizontal::before {
+  content: "\f58d"; }
+
+.fa-share-from-square::before {
+  content: "\f14d"; }
+
+.fa-share-square::before {
+  content: "\f14d"; }
+
+.fa-child-combatant::before {
+  content: "\e4e0"; }
+
+.fa-child-rifle::before {
+  content: "\e4e0"; }
+
+.fa-gun::before {
+  content: "\e19b"; }
+
+.fa-square-phone::before {
+  content: "\f098"; }
+
+.fa-phone-square::before {
+  content: "\f098"; }
+
+.fa-plus::before {
+  content: "\2b"; }
+
+.fa-add::before {
+  content: "\2b"; }
+
+.fa-expand::before {
+  content: "\f065"; }
+
+.fa-computer::before {
+  content: "\e4e5"; }
+
+.fa-xmark::before {
+  content: "\f00d"; }
+
+.fa-close::before {
+  content: "\f00d"; }
+
+.fa-multiply::before {
+  content: "\f00d"; }
+
+.fa-remove::before {
+  content: "\f00d"; }
+
+.fa-times::before {
+  content: "\f00d"; }
+
+.fa-arrows-up-down-left-right::before {
+  content: "\f047"; }
+
+.fa-arrows::before {
+  content: "\f047"; }
+
+.fa-chalkboard-user::before {
+  content: "\f51c"; }
+
+.fa-chalkboard-teacher::before {
+  content: "\f51c"; }
+
+.fa-peso-sign::before {
+  content: "\e222"; }
+
+.fa-building-shield::before {
+  content: "\e4d8"; }
+
+.fa-baby::before {
+  content: "\f77c"; }
+
+.fa-users-line::before {
+  content: "\e592"; }
+
+.fa-quote-left::before {
+  content: "\f10d"; }
+
+.fa-quote-left-alt::before {
+  content: "\f10d"; }
+
+.fa-tractor::before {
+  content: "\f722"; }
+
+.fa-trash-arrow-up::before {
+  content: "\f829"; }
+
+.fa-trash-restore::before {
+  content: "\f829"; }
+
+.fa-arrow-down-up-lock::before {
+  content: "\e4b0"; }
+
+.fa-lines-leaning::before {
+  content: "\e51e"; }
+
+.fa-ruler-combined::before {
+  content: "\f546"; }
+
+.fa-copyright::before {
+  content: "\f1f9"; }
+
+.fa-equals::before {
+  content: "\3d"; }
+
+.fa-blender::before {
+  content: "\f517"; }
+
+.fa-teeth::before {
+  content: "\f62e"; }
+
+.fa-shekel-sign::before {
+  content: "\f20b"; }
+
+.fa-ils::before {
+  content: "\f20b"; }
+
+.fa-shekel::before {
+  content: "\f20b"; }
+
+.fa-sheqel::before {
+  content: "\f20b"; }
+
+.fa-sheqel-sign::before {
+  content: "\f20b"; }
+
+.fa-map::before {
+  content: "\f279"; }
+
+.fa-rocket::before {
+  content: "\f135"; }
+
+.fa-photo-film::before {
+  content: "\f87c"; }
+
+.fa-photo-video::before {
+  content: "\f87c"; }
+
+.fa-folder-minus::before {
+  content: "\f65d"; }
+
+.fa-store::before {
+  content: "\f54e"; }
+
+.fa-arrow-trend-up::before {
+  content: "\e098"; }
+
+.fa-plug-circle-minus::before {
+  content: "\e55e"; }
+
+.fa-sign-hanging::before {
+  content: "\f4d9"; }
+
+.fa-sign::before {
+  content: "\f4d9"; }
+
+.fa-bezier-curve::before {
+  content: "\f55b"; }
+
+.fa-bell-slash::before {
+  content: "\f1f6"; }
+
+.fa-tablet::before {
+  content: "\f3fb"; }
+
+.fa-tablet-android::before {
+  content: "\f3fb"; }
+
+.fa-school-flag::before {
+  content: "\e56e"; }
+
+.fa-fill::before {
+  content: "\f575"; }
+
+.fa-angle-up::before {
+  content: "\f106"; }
+
+.fa-drumstick-bite::before {
+  content: "\f6d7"; }
+
+.fa-holly-berry::before {
+  content: "\f7aa"; }
+
+.fa-chevron-left::before {
+  content: "\f053"; }
+
+.fa-bacteria::before {
+  content: "\e059"; }
+
+.fa-hand-lizard::before {
+  content: "\f258"; }
+
+.fa-notdef::before {
+  content: "\e1fe"; }
+
+.fa-disease::before {
+  content: "\f7fa"; }
+
+.fa-briefcase-medical::before {
+  content: "\f469"; }
+
+.fa-genderless::before {
+  content: "\f22d"; }
+
+.fa-chevron-right::before {
+  content: "\f054"; }
+
+.fa-retweet::before {
+  content: "\f079"; }
+
+.fa-car-rear::before {
+  content: "\f5de"; }
+
+.fa-car-alt::before {
+  content: "\f5de"; }
+
+.fa-pump-soap::before {
+  content: "\e06b"; }
+
+.fa-video-slash::before {
+  content: "\f4e2"; }
+
+.fa-battery-quarter::before {
+  content: "\f243"; }
+
+.fa-battery-2::before {
+  content: "\f243"; }
+
+.fa-radio::before {
+  content: "\f8d7"; }
+
+.fa-baby-carriage::before {
+  content: "\f77d"; }
+
+.fa-carriage-baby::before {
+  content: "\f77d"; }
+
+.fa-traffic-light::before {
+  content: "\f637"; }
+
+.fa-thermometer::before {
+  content: "\f491"; }
+
+.fa-vr-cardboard::before {
+  content: "\f729"; }
+
+.fa-hand-middle-finger::before {
+  content: "\f806"; }
+
+.fa-percent::before {
+  content: "\25"; }
+
+.fa-percentage::before {
+  content: "\25"; }
+
+.fa-truck-moving::before {
+  content: "\f4df"; }
+
+.fa-glass-water-droplet::before {
+  content: "\e4f5"; }
+
+.fa-display::before {
+  content: "\e163"; }
+
+.fa-face-smile::before {
+  content: "\f118"; }
+
+.fa-smile::before {
+  content: "\f118"; }
+
+.fa-thumbtack::before {
+  content: "\f08d"; }
+
+.fa-thumb-tack::before {
+  content: "\f08d"; }
+
+.fa-trophy::before {
+  content: "\f091"; }
+
+.fa-person-praying::before {
+  content: "\f683"; }
+
+.fa-pray::before {
+  content: "\f683"; }
+
+.fa-hammer::before {
+  content: "\f6e3"; }
+
+.fa-hand-peace::before {
+  content: "\f25b"; }
+
+.fa-rotate::before {
+  content: "\f2f1"; }
+
+.fa-sync-alt::before {
+  content: "\f2f1"; }
+
+.fa-spinner::before {
+  content: "\f110"; }
+
+.fa-robot::before {
+  content: "\f544"; }
+
+.fa-peace::before {
+  content: "\f67c"; }
+
+.fa-gears::before {
+  content: "\f085"; }
+
+.fa-cogs::before {
+  content: "\f085"; }
+
+.fa-warehouse::before {
+  content: "\f494"; }
+
+.fa-arrow-up-right-dots::before {
+  content: "\e4b7"; }
+
+.fa-splotch::before {
+  content: "\f5bc"; }
+
+.fa-face-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-dice-four::before {
+  content: "\f524"; }
+
+.fa-sim-card::before {
+  content: "\f7c4"; }
+
+.fa-transgender::before {
+  content: "\f225"; }
+
+.fa-transgender-alt::before {
+  content: "\f225"; }
+
+.fa-mercury::before {
+  content: "\f223"; }
+
+.fa-arrow-turn-down::before {
+  content: "\f149"; }
+
+.fa-level-down::before {
+  content: "\f149"; }
+
+.fa-person-falling-burst::before {
+  content: "\e547"; }
+
+.fa-award::before {
+  content: "\f559"; }
+
+.fa-ticket-simple::before {
+  content: "\f3ff"; }
+
+.fa-ticket-alt::before {
+  content: "\f3ff"; }
+
+.fa-building::before {
+  content: "\f1ad"; }
+
+.fa-angles-left::before {
+  content: "\f100"; }
+
+.fa-angle-double-left::before {
+  content: "\f100"; }
+
+.fa-qrcode::before {
+  content: "\f029"; }
+
+.fa-clock-rotate-left::before {
+  content: "\f1da"; }
+
+.fa-history::before {
+  content: "\f1da"; }
+
+.fa-face-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-file-export::before {
+  content: "\f56e"; }
+
+.fa-arrow-right-from-file::before {
+  content: "\f56e"; }
+
+.fa-shield::before {
+  content: "\f132"; }
+
+.fa-shield-blank::before {
+  content: "\f132"; }
+
+.fa-arrow-up-short-wide::before {
+  content: "\f885"; }
+
+.fa-sort-amount-up-alt::before {
+  content: "\f885"; }
+
+.fa-house-medical::before {
+  content: "\e3b2"; }
+
+.fa-golf-ball-tee::before {
+  content: "\f450"; }
+
+.fa-golf-ball::before {
+  content: "\f450"; }
+
+.fa-circle-chevron-left::before {
+  content: "\f137"; }
+
+.fa-chevron-circle-left::before {
+  content: "\f137"; }
+
+.fa-house-chimney-window::before {
+  content: "\e00d"; }
+
+.fa-pen-nib::before {
+  content: "\f5ad"; }
+
+.fa-tent-arrow-turn-left::before {
+  content: "\e580"; }
+
+.fa-tents::before {
+  content: "\e582"; }
+
+.fa-wand-magic::before {
+  content: "\f0d0"; }
+
+.fa-magic::before {
+  content: "\f0d0"; }
+
+.fa-dog::before {
+  content: "\f6d3"; }
+
+.fa-carrot::before {
+  content: "\f787"; }
+
+.fa-moon::before {
+  content: "\f186"; }
+
+.fa-wine-glass-empty::before {
+  content: "\f5ce"; }
+
+.fa-wine-glass-alt::before {
+  content: "\f5ce"; }
+
+.fa-cheese::before {
+  content: "\f7ef"; }
+
+.fa-yin-yang::before {
+  content: "\f6ad"; }
+
+.fa-music::before {
+  content: "\f001"; }
+
+.fa-code-commit::before {
+  content: "\f386"; }
+
+.fa-temperature-low::before {
+  content: "\f76b"; }
+
+.fa-person-biking::before {
+  content: "\f84a"; }
+
+.fa-biking::before {
+  content: "\f84a"; }
+
+.fa-broom::before {
+  content: "\f51a"; }
+
+.fa-shield-heart::before {
+  content: "\e574"; }
+
+.fa-gopuram::before {
+  content: "\f664"; }
+
+.fa-earth-oceania::before {
+  content: "\e47b"; }
+
+.fa-globe-oceania::before {
+  content: "\e47b"; }
+
+.fa-square-xmark::before {
+  content: "\f2d3"; }
+
+.fa-times-square::before {
+  content: "\f2d3"; }
+
+.fa-xmark-square::before {
+  content: "\f2d3"; }
+
+.fa-hashtag::before {
+  content: "\23"; }
+
+.fa-up-right-and-down-left-from-center::before {
+  content: "\f424"; }
+
+.fa-expand-alt::before {
+  content: "\f424"; }
+
+.fa-oil-can::before {
+  content: "\f613"; }
+
+.fa-t::before {
+  content: "\54"; }
+
+.fa-hippo::before {
+  content: "\f6ed"; }
+
+.fa-chart-column::before {
+  content: "\e0e3"; }
+
+.fa-infinity::before {
+  content: "\f534"; }
+
+.fa-vial-circle-check::before {
+  content: "\e596"; }
+
+.fa-person-arrow-down-to-line::before {
+  content: "\e538"; }
+
+.fa-voicemail::before {
+  content: "\f897"; }
+
+.fa-fan::before {
+  content: "\f863"; }
+
+.fa-person-walking-luggage::before {
+  content: "\e554"; }
+
+.fa-up-down::before {
+  content: "\f338"; }
+
+.fa-arrows-alt-v::before {
+  content: "\f338"; }
+
+.fa-cloud-moon-rain::before {
+  content: "\f73c"; }
+
+.fa-calendar::before {
+  content: "\f133"; }
+
+.fa-trailer::before {
+  content: "\e041"; }
+
+.fa-bahai::before {
+  content: "\f666"; }
+
+.fa-haykal::before {
+  content: "\f666"; }
+
+.fa-sd-card::before {
+  content: "\f7c2"; }
+
+.fa-dragon::before {
+  content: "\f6d5"; }
+
+.fa-shoe-prints::before {
+  content: "\f54b"; }
+
+.fa-circle-plus::before {
+  content: "\f055"; }
+
+.fa-plus-circle::before {
+  content: "\f055"; }
+
+.fa-face-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-hand-holding::before {
+  content: "\f4bd"; }
+
+.fa-plug-circle-exclamation::before {
+  content: "\e55d"; }
+
+.fa-link-slash::before {
+  content: "\f127"; }
+
+.fa-chain-broken::before {
+  content: "\f127"; }
+
+.fa-chain-slash::before {
+  content: "\f127"; }
+
+.fa-unlink::before {
+  content: "\f127"; }
+
+.fa-clone::before {
+  content: "\f24d"; }
+
+.fa-person-walking-arrow-loop-left::before {
+  content: "\e551"; }
+
+.fa-arrow-up-z-a::before {
+  content: "\f882"; }
+
+.fa-sort-alpha-up-alt::before {
+  content: "\f882"; }
+
+.fa-fire-flame-curved::before {
+  content: "\f7e4"; }
+
+.fa-fire-alt::before {
+  content: "\f7e4"; }
+
+.fa-tornado::before {
+  content: "\f76f"; }
+
+.fa-file-circle-plus::before {
+  content: "\e494"; }
+
+.fa-book-quran::before {
+  content: "\f687"; }
+
+.fa-quran::before {
+  content: "\f687"; }
+
+.fa-anchor::before {
+  content: "\f13d"; }
+
+.fa-border-all::before {
+  content: "\f84c"; }
+
+.fa-face-angry::before {
+  content: "\f556"; }
+
+.fa-angry::before {
+  content: "\f556"; }
+
+.fa-cookie-bite::before {
+  content: "\f564"; }
+
+.fa-arrow-trend-down::before {
+  content: "\e097"; }
+
+.fa-rss::before {
+  content: "\f09e"; }
+
+.fa-feed::before {
+  content: "\f09e"; }
+
+.fa-draw-polygon::before {
+  content: "\f5ee"; }
+
+.fa-scale-balanced::before {
+  content: "\f24e"; }
+
+.fa-balance-scale::before {
+  content: "\f24e"; }
+
+.fa-gauge-simple-high::before {
+  content: "\f62a"; }
+
+.fa-tachometer::before {
+  content: "\f62a"; }
+
+.fa-tachometer-fast::before {
+  content: "\f62a"; }
+
+.fa-shower::before {
+  content: "\f2cc"; }
+
+.fa-desktop::before {
+  content: "\f390"; }
+
+.fa-desktop-alt::before {
+  content: "\f390"; }
+
+.fa-m::before {
+  content: "\4d"; }
+
+.fa-table-list::before {
+  content: "\f00b"; }
+
+.fa-th-list::before {
+  content: "\f00b"; }
+
+.fa-comment-sms::before {
+  content: "\f7cd"; }
+
+.fa-sms::before {
+  content: "\f7cd"; }
+
+.fa-book::before {
+  content: "\f02d"; }
+
+.fa-user-plus::before {
+  content: "\f234"; }
+
+.fa-check::before {
+  content: "\f00c"; }
+
+.fa-battery-three-quarters::before {
+  content: "\f241"; }
+
+.fa-battery-4::before {
+  content: "\f241"; }
+
+.fa-house-circle-check::before {
+  content: "\e509"; }
+
+.fa-angle-left::before {
+  content: "\f104"; }
+
+.fa-diagram-successor::before {
+  content: "\e47a"; }
+
+.fa-truck-arrow-right::before {
+  content: "\e58b"; }
+
+.fa-arrows-split-up-and-left::before {
+  content: "\e4bc"; }
+
+.fa-hand-fist::before {
+  content: "\f6de"; }
+
+.fa-fist-raised::before {
+  content: "\f6de"; }
+
+.fa-cloud-moon::before {
+  content: "\f6c3"; }
+
+.fa-briefcase::before {
+  content: "\f0b1"; }
+
+.fa-person-falling::before {
+  content: "\e546"; }
+
+.fa-image-portrait::before {
+  content: "\f3e0"; }
+
+.fa-portrait::before {
+  content: "\f3e0"; }
+
+.fa-user-tag::before {
+  content: "\f507"; }
+
+.fa-rug::before {
+  content: "\e569"; }
+
+.fa-earth-europe::before {
+  content: "\f7a2"; }
+
+.fa-globe-europe::before {
+  content: "\f7a2"; }
+
+.fa-cart-flatbed-suitcase::before {
+  content: "\f59d"; }
+
+.fa-luggage-cart::before {
+  content: "\f59d"; }
+
+.fa-rectangle-xmark::before {
+  content: "\f410"; }
+
+.fa-rectangle-times::before {
+  content: "\f410"; }
+
+.fa-times-rectangle::before {
+  content: "\f410"; }
+
+.fa-window-close::before {
+  content: "\f410"; }
+
+.fa-baht-sign::before {
+  content: "\e0ac"; }
+
+.fa-book-open::before {
+  content: "\f518"; }
+
+.fa-book-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-handcuffs::before {
+  content: "\e4f8"; }
+
+.fa-triangle-exclamation::before {
+  content: "\f071"; }
+
+.fa-exclamation-triangle::before {
+  content: "\f071"; }
+
+.fa-warning::before {
+  content: "\f071"; }
+
+.fa-database::before {
+  content: "\f1c0"; }
+
+.fa-share::before {
+  content: "\f064"; }
+
+.fa-mail-forward::before {
+  content: "\f064"; }
+
+.fa-bottle-droplet::before {
+  content: "\e4c4"; }
+
+.fa-mask-face::before {
+  content: "\e1d7"; }
+
+.fa-hill-rockslide::before {
+  content: "\e508"; }
+
+.fa-right-left::before {
+  content: "\f362"; }
+
+.fa-exchange-alt::before {
+  content: "\f362"; }
+
+.fa-paper-plane::before {
+  content: "\f1d8"; }
+
+.fa-road-circle-exclamation::before {
+  content: "\e565"; }
+
+.fa-dungeon::before {
+  content: "\f6d9"; }
+
+.fa-align-right::before {
+  content: "\f038"; }
+
+.fa-money-bill-1-wave::before {
+  content: "\f53b"; }
+
+.fa-money-bill-wave-alt::before {
+  content: "\f53b"; }
+
+.fa-life-ring::before {
+  content: "\f1cd"; }
+
+.fa-hands::before {
+  content: "\f2a7"; }
+
+.fa-sign-language::before {
+  content: "\f2a7"; }
+
+.fa-signing::before {
+  content: "\f2a7"; }
+
+.fa-calendar-day::before {
+  content: "\f783"; }
+
+.fa-water-ladder::before {
+  content: "\f5c5"; }
+
+.fa-ladder-water::before {
+  content: "\f5c5"; }
+
+.fa-swimming-pool::before {
+  content: "\f5c5"; }
+
+.fa-arrows-up-down::before {
+  content: "\f07d"; }
+
+.fa-arrows-v::before {
+  content: "\f07d"; }
+
+.fa-face-grimace::before {
+  content: "\f57f"; }
+
+.fa-grimace::before {
+  content: "\f57f"; }
+
+.fa-wheelchair-move::before {
+  content: "\e2ce"; }
+
+.fa-wheelchair-alt::before {
+  content: "\e2ce"; }
+
+.fa-turn-down::before {
+  content: "\f3be"; }
+
+.fa-level-down-alt::before {
+  content: "\f3be"; }
+
+.fa-person-walking-arrow-right::before {
+  content: "\e552"; }
+
+.fa-square-envelope::before {
+  content: "\f199"; }
+
+.fa-envelope-square::before {
+  content: "\f199"; }
+
+.fa-dice::before {
+  content: "\f522"; }
+
+.fa-bowling-ball::before {
+  content: "\f436"; }
+
+.fa-brain::before {
+  content: "\f5dc"; }
+
+.fa-bandage::before {
+  content: "\f462"; }
+
+.fa-band-aid::before {
+  content: "\f462"; }
+
+.fa-calendar-minus::before {
+  content: "\f272"; }
+
+.fa-circle-xmark::before {
+  content: "\f057"; }
+
+.fa-times-circle::before {
+  content: "\f057"; }
+
+.fa-xmark-circle::before {
+  content: "\f057"; }
+
+.fa-gifts::before {
+  content: "\f79c"; }
+
+.fa-hotel::before {
+  content: "\f594"; }
+
+.fa-earth-asia::before {
+  content: "\f57e"; }
+
+.fa-globe-asia::before {
+  content: "\f57e"; }
+
+.fa-id-card-clip::before {
+  content: "\f47f"; }
+
+.fa-id-card-alt::before {
+  content: "\f47f"; }
+
+.fa-magnifying-glass-plus::before {
+  content: "\f00e"; }
+
+.fa-search-plus::before {
+  content: "\f00e"; }
+
+.fa-thumbs-up::before {
+  content: "\f164"; }
+
+.fa-user-clock::before {
+  content: "\f4fd"; }
+
+.fa-hand-dots::before {
+  content: "\f461"; }
+
+.fa-allergies::before {
+  content: "\f461"; }
+
+.fa-file-invoice::before {
+  content: "\f570"; }
+
+.fa-window-minimize::before {
+  content: "\f2d1"; }
+
+.fa-mug-saucer::before {
+  content: "\f0f4"; }
+
+.fa-coffee::before {
+  content: "\f0f4"; }
+
+.fa-brush::before {
+  content: "\f55d"; }
+
+.fa-mask::before {
+  content: "\f6fa"; }
+
+.fa-magnifying-glass-minus::before {
+  content: "\f010"; }
+
+.fa-search-minus::before {
+  content: "\f010"; }
+
+.fa-ruler-vertical::before {
+  content: "\f548"; }
+
+.fa-user-large::before {
+  content: "\f406"; }
+
+.fa-user-alt::before {
+  content: "\f406"; }
+
+.fa-train-tram::before {
+  content: "\e5b4"; }
+
+.fa-user-nurse::before {
+  content: "\f82f"; }
+
+.fa-syringe::before {
+  content: "\f48e"; }
+
+.fa-cloud-sun::before {
+  content: "\f6c4"; }
+
+.fa-stopwatch-20::before {
+  content: "\e06f"; }
+
+.fa-square-full::before {
+  content: "\f45c"; }
+
+.fa-magnet::before {
+  content: "\f076"; }
+
+.fa-jar::before {
+  content: "\e516"; }
+
+.fa-note-sticky::before {
+  content: "\f249"; }
+
+.fa-sticky-note::before {
+  content: "\f249"; }
+
+.fa-bug-slash::before {
+  content: "\e490"; }
+
+.fa-arrow-up-from-water-pump::before {
+  content: "\e4b6"; }
+
+.fa-bone::before {
+  content: "\f5d7"; }
+
+.fa-user-injured::before {
+  content: "\f728"; }
+
+.fa-face-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-plane::before {
+  content: "\f072"; }
+
+.fa-tent-arrows-down::before {
+  content: "\e581"; }
+
+.fa-exclamation::before {
+  content: "\21"; }
+
+.fa-arrows-spin::before {
+  content: "\e4bb"; }
+
+.fa-print::before {
+  content: "\f02f"; }
+
+.fa-turkish-lira-sign::before {
+  content: "\e2bb"; }
+
+.fa-try::before {
+  content: "\e2bb"; }
+
+.fa-turkish-lira::before {
+  content: "\e2bb"; }
+
+.fa-dollar-sign::before {
+  content: "\24"; }
+
+.fa-dollar::before {
+  content: "\24"; }
+
+.fa-usd::before {
+  content: "\24"; }
+
+.fa-x::before {
+  content: "\58"; }
+
+.fa-magnifying-glass-dollar::before {
+  content: "\f688"; }
+
+.fa-search-dollar::before {
+  content: "\f688"; }
+
+.fa-users-gear::before {
+  content: "\f509"; }
+
+.fa-users-cog::before {
+  content: "\f509"; }
+
+.fa-person-military-pointing::before {
+  content: "\e54a"; }
+
+.fa-building-columns::before {
+  content: "\f19c"; }
+
+.fa-bank::before {
+  content: "\f19c"; }
+
+.fa-institution::before {
+  content: "\f19c"; }
+
+.fa-museum::before {
+  content: "\f19c"; }
+
+.fa-university::before {
+  content: "\f19c"; }
+
+.fa-umbrella::before {
+  content: "\f0e9"; }
+
+.fa-trowel::before {
+  content: "\e589"; }
+
+.fa-d::before {
+  content: "\44"; }
+
+.fa-stapler::before {
+  content: "\e5af"; }
+
+.fa-masks-theater::before {
+  content: "\f630"; }
+
+.fa-theater-masks::before {
+  content: "\f630"; }
+
+.fa-kip-sign::before {
+  content: "\e1c4"; }
+
+.fa-hand-point-left::before {
+  content: "\f0a5"; }
+
+.fa-handshake-simple::before {
+  content: "\f4c6"; }
+
+.fa-handshake-alt::before {
+  content: "\f4c6"; }
+
+.fa-jet-fighter::before {
+  content: "\f0fb"; }
+
+.fa-fighter-jet::before {
+  content: "\f0fb"; }
+
+.fa-square-share-nodes::before {
+  content: "\f1e1"; }
+
+.fa-share-alt-square::before {
+  content: "\f1e1"; }
+
+.fa-barcode::before {
+  content: "\f02a"; }
+
+.fa-plus-minus::before {
+  content: "\e43c"; }
+
+.fa-video::before {
+  content: "\f03d"; }
+
+.fa-video-camera::before {
+  content: "\f03d"; }
+
+.fa-graduation-cap::before {
+  content: "\f19d"; }
+
+.fa-mortar-board::before {
+  content: "\f19d"; }
+
+.fa-hand-holding-medical::before {
+  content: "\e05c"; }
+
+.fa-person-circle-check::before {
+  content: "\e53e"; }
+
+.fa-turn-up::before {
+  content: "\f3bf"; }
+
+.fa-level-up-alt::before {
+  content: "\f3bf"; }
+
+.sr-only,
+.fa-sr-only {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+
+.sr-only-focusable:not(:focus),
+.fa-sr-only-focusable:not(:focus) {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+:root, :host {
+  --fa-style-family-brands: 'Font Awesome 6 Brands';
+  --fa-font-brands: normal 400 1em/1 'Font Awesome 6 Brands'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Brands';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+.fab,
+.fa-brands {
+  font-weight: 400; }
+
+.fa-monero:before {
+  content: "\f3d0"; }
+
+.fa-hooli:before {
+  content: "\f427"; }
+
+.fa-yelp:before {
+  content: "\f1e9"; }
+
+.fa-cc-visa:before {
+  content: "\f1f0"; }
+
+.fa-lastfm:before {
+  content: "\f202"; }
+
+.fa-shopware:before {
+  content: "\f5b5"; }
+
+.fa-creative-commons-nc:before {
+  content: "\f4e8"; }
+
+.fa-aws:before {
+  content: "\f375"; }
+
+.fa-redhat:before {
+  content: "\f7bc"; }
+
+.fa-yoast:before {
+  content: "\f2b1"; }
+
+.fa-cloudflare:before {
+  content: "\e07d"; }
+
+.fa-ups:before {
+  content: "\f7e0"; }
+
+.fa-pixiv:before {
+  content: "\e640"; }
+
+.fa-wpexplorer:before {
+  content: "\f2de"; }
+
+.fa-dyalog:before {
+  content: "\f399"; }
+
+.fa-bity:before {
+  content: "\f37a"; }
+
+.fa-stackpath:before {
+  content: "\f842"; }
+
+.fa-buysellads:before {
+  content: "\f20d"; }
+
+.fa-first-order:before {
+  content: "\f2b0"; }
+
+.fa-modx:before {
+  content: "\f285"; }
+
+.fa-guilded:before {
+  content: "\e07e"; }
+
+.fa-vnv:before {
+  content: "\f40b"; }
+
+.fa-square-js:before {
+  content: "\f3b9"; }
+
+.fa-js-square:before {
+  content: "\f3b9"; }
+
+.fa-microsoft:before {
+  content: "\f3ca"; }
+
+.fa-qq:before {
+  content: "\f1d6"; }
+
+.fa-orcid:before {
+  content: "\f8d2"; }
+
+.fa-java:before {
+  content: "\f4e4"; }
+
+.fa-invision:before {
+  content: "\f7b0"; }
+
+.fa-creative-commons-pd-alt:before {
+  content: "\f4ed"; }
+
+.fa-centercode:before {
+  content: "\f380"; }
+
+.fa-glide-g:before {
+  content: "\f2a6"; }
+
+.fa-drupal:before {
+  content: "\f1a9"; }
+
+.fa-jxl:before {
+  content: "\e67b"; }
+
+.fa-hire-a-helper:before {
+  content: "\f3b0"; }
+
+.fa-creative-commons-by:before {
+  content: "\f4e7"; }
+
+.fa-unity:before {
+  content: "\e049"; }
+
+.fa-whmcs:before {
+  content: "\f40d"; }
+
+.fa-rocketchat:before {
+  content: "\f3e8"; }
+
+.fa-vk:before {
+  content: "\f189"; }
+
+.fa-untappd:before {
+  content: "\f405"; }
+
+.fa-mailchimp:before {
+  content: "\f59e"; }
+
+.fa-css3-alt:before {
+  content: "\f38b"; }
+
+.fa-square-reddit:before {
+  content: "\f1a2"; }
+
+.fa-reddit-square:before {
+  content: "\f1a2"; }
+
+.fa-vimeo-v:before {
+  content: "\f27d"; }
+
+.fa-contao:before {
+  content: "\f26d"; }
+
+.fa-square-font-awesome:before {
+  content: "\e5ad"; }
+
+.fa-deskpro:before {
+  content: "\f38f"; }
+
+.fa-brave:before {
+  content: "\e63c"; }
+
+.fa-sistrix:before {
+  content: "\f3ee"; }
+
+.fa-square-instagram:before {
+  content: "\e055"; }
+
+.fa-instagram-square:before {
+  content: "\e055"; }
+
+.fa-battle-net:before {
+  content: "\f835"; }
+
+.fa-the-red-yeti:before {
+  content: "\f69d"; }
+
+.fa-square-hacker-news:before {
+  content: "\f3af"; }
+
+.fa-hacker-news-square:before {
+  content: "\f3af"; }
+
+.fa-edge:before {
+  content: "\f282"; }
+
+.fa-threads:before {
+  content: "\e618"; }
+
+.fa-napster:before {
+  content: "\f3d2"; }
+
+.fa-square-snapchat:before {
+  content: "\f2ad"; }
+
+.fa-snapchat-square:before {
+  content: "\f2ad"; }
+
+.fa-google-plus-g:before {
+  content: "\f0d5"; }
+
+.fa-artstation:before {
+  content: "\f77a"; }
+
+.fa-markdown:before {
+  content: "\f60f"; }
+
+.fa-sourcetree:before {
+  content: "\f7d3"; }
+
+.fa-google-plus:before {
+  content: "\f2b3"; }
+
+.fa-diaspora:before {
+  content: "\f791"; }
+
+.fa-foursquare:before {
+  content: "\f180"; }
+
+.fa-stack-overflow:before {
+  content: "\f16c"; }
+
+.fa-github-alt:before {
+  content: "\f113"; }
+
+.fa-phoenix-squadron:before {
+  content: "\f511"; }
+
+.fa-pagelines:before {
+  content: "\f18c"; }
+
+.fa-algolia:before {
+  content: "\f36c"; }
+
+.fa-red-river:before {
+  content: "\f3e3"; }
+
+.fa-creative-commons-sa:before {
+  content: "\f4ef"; }
+
+.fa-safari:before {
+  content: "\f267"; }
+
+.fa-google:before {
+  content: "\f1a0"; }
+
+.fa-square-font-awesome-stroke:before {
+  content: "\f35c"; }
+
+.fa-font-awesome-alt:before {
+  content: "\f35c"; }
+
+.fa-atlassian:before {
+  content: "\f77b"; }
+
+.fa-linkedin-in:before {
+  content: "\f0e1"; }
+
+.fa-digital-ocean:before {
+  content: "\f391"; }
+
+.fa-nimblr:before {
+  content: "\f5a8"; }
+
+.fa-chromecast:before {
+  content: "\f838"; }
+
+.fa-evernote:before {
+  content: "\f839"; }
+
+.fa-hacker-news:before {
+  content: "\f1d4"; }
+
+.fa-creative-commons-sampling:before {
+  content: "\f4f0"; }
+
+.fa-adversal:before {
+  content: "\f36a"; }
+
+.fa-creative-commons:before {
+  content: "\f25e"; }
+
+.fa-watchman-monitoring:before {
+  content: "\e087"; }
+
+.fa-fonticons:before {
+  content: "\f280"; }
+
+.fa-weixin:before {
+  content: "\f1d7"; }
+
+.fa-shirtsinbulk:before {
+  content: "\f214"; }
+
+.fa-codepen:before {
+  content: "\f1cb"; }
+
+.fa-git-alt:before {
+  content: "\f841"; }
+
+.fa-lyft:before {
+  content: "\f3c3"; }
+
+.fa-rev:before {
+  content: "\f5b2"; }
+
+.fa-windows:before {
+  content: "\f17a"; }
+
+.fa-wizards-of-the-coast:before {
+  content: "\f730"; }
+
+.fa-square-viadeo:before {
+  content: "\f2aa"; }
+
+.fa-viadeo-square:before {
+  content: "\f2aa"; }
+
+.fa-meetup:before {
+  content: "\f2e0"; }
+
+.fa-centos:before {
+  content: "\f789"; }
+
+.fa-adn:before {
+  content: "\f170"; }
+
+.fa-cloudsmith:before {
+  content: "\f384"; }
+
+.fa-opensuse:before {
+  content: "\e62b"; }
+
+.fa-pied-piper-alt:before {
+  content: "\f1a8"; }
+
+.fa-square-dribbble:before {
+  content: "\f397"; }
+
+.fa-dribbble-square:before {
+  content: "\f397"; }
+
+.fa-codiepie:before {
+  content: "\f284"; }
+
+.fa-node:before {
+  content: "\f419"; }
+
+.fa-mix:before {
+  content: "\f3cb"; }
+
+.fa-steam:before {
+  content: "\f1b6"; }
+
+.fa-cc-apple-pay:before {
+  content: "\f416"; }
+
+.fa-scribd:before {
+  content: "\f28a"; }
+
+.fa-debian:before {
+  content: "\e60b"; }
+
+.fa-openid:before {
+  content: "\f19b"; }
+
+.fa-instalod:before {
+  content: "\e081"; }
+
+.fa-expeditedssl:before {
+  content: "\f23e"; }
+
+.fa-sellcast:before {
+  content: "\f2da"; }
+
+.fa-square-twitter:before {
+  content: "\f081"; }
+
+.fa-twitter-square:before {
+  content: "\f081"; }
+
+.fa-r-project:before {
+  content: "\f4f7"; }
+
+.fa-delicious:before {
+  content: "\f1a5"; }
+
+.fa-freebsd:before {
+  content: "\f3a4"; }
+
+.fa-vuejs:before {
+  content: "\f41f"; }
+
+.fa-accusoft:before {
+  content: "\f369"; }
+
+.fa-ioxhost:before {
+  content: "\f208"; }
+
+.fa-fonticons-fi:before {
+  content: "\f3a2"; }
+
+.fa-app-store:before {
+  content: "\f36f"; }
+
+.fa-cc-mastercard:before {
+  content: "\f1f1"; }
+
+.fa-itunes-note:before {
+  content: "\f3b5"; }
+
+.fa-golang:before {
+  content: "\e40f"; }
+
+.fa-kickstarter:before {
+  content: "\f3bb"; }
+
+.fa-square-kickstarter:before {
+  content: "\f3bb"; }
+
+.fa-grav:before {
+  content: "\f2d6"; }
+
+.fa-weibo:before {
+  content: "\f18a"; }
+
+.fa-uncharted:before {
+  content: "\e084"; }
+
+.fa-firstdraft:before {
+  content: "\f3a1"; }
+
+.fa-square-youtube:before {
+  content: "\f431"; }
+
+.fa-youtube-square:before {
+  content: "\f431"; }
+
+.fa-wikipedia-w:before {
+  content: "\f266"; }
+
+.fa-wpressr:before {
+  content: "\f3e4"; }
+
+.fa-rendact:before {
+  content: "\f3e4"; }
+
+.fa-angellist:before {
+  content: "\f209"; }
+
+.fa-galactic-republic:before {
+  content: "\f50c"; }
+
+.fa-nfc-directional:before {
+  content: "\e530"; }
+
+.fa-skype:before {
+  content: "\f17e"; }
+
+.fa-joget:before {
+  content: "\f3b7"; }
+
+.fa-fedora:before {
+  content: "\f798"; }
+
+.fa-stripe-s:before {
+  content: "\f42a"; }
+
+.fa-meta:before {
+  content: "\e49b"; }
+
+.fa-laravel:before {
+  content: "\f3bd"; }
+
+.fa-hotjar:before {
+  content: "\f3b1"; }
+
+.fa-bluetooth-b:before {
+  content: "\f294"; }
+
+.fa-square-letterboxd:before {
+  content: "\e62e"; }
+
+.fa-sticker-mule:before {
+  content: "\f3f7"; }
+
+.fa-creative-commons-zero:before {
+  content: "\f4f3"; }
+
+.fa-hips:before {
+  content: "\f452"; }
+
+.fa-behance:before {
+  content: "\f1b4"; }
+
+.fa-reddit:before {
+  content: "\f1a1"; }
+
+.fa-discord:before {
+  content: "\f392"; }
+
+.fa-chrome:before {
+  content: "\f268"; }
+
+.fa-app-store-ios:before {
+  content: "\f370"; }
+
+.fa-cc-discover:before {
+  content: "\f1f2"; }
+
+.fa-wpbeginner:before {
+  content: "\f297"; }
+
+.fa-confluence:before {
+  content: "\f78d"; }
+
+.fa-shoelace:before {
+  content: "\e60c"; }
+
+.fa-mdb:before {
+  content: "\f8ca"; }
+
+.fa-dochub:before {
+  content: "\f394"; }
+
+.fa-accessible-icon:before {
+  content: "\f368"; }
+
+.fa-ebay:before {
+  content: "\f4f4"; }
+
+.fa-amazon:before {
+  content: "\f270"; }
+
+.fa-unsplash:before {
+  content: "\e07c"; }
+
+.fa-yarn:before {
+  content: "\f7e3"; }
+
+.fa-square-steam:before {
+  content: "\f1b7"; }
+
+.fa-steam-square:before {
+  content: "\f1b7"; }
+
+.fa-500px:before {
+  content: "\f26e"; }
+
+.fa-square-vimeo:before {
+  content: "\f194"; }
+
+.fa-vimeo-square:before {
+  content: "\f194"; }
+
+.fa-asymmetrik:before {
+  content: "\f372"; }
+
+.fa-font-awesome:before {
+  content: "\f2b4"; }
+
+.fa-font-awesome-flag:before {
+  content: "\f2b4"; }
+
+.fa-font-awesome-logo-full:before {
+  content: "\f2b4"; }
+
+.fa-gratipay:before {
+  content: "\f184"; }
+
+.fa-apple:before {
+  content: "\f179"; }
+
+.fa-hive:before {
+  content: "\e07f"; }
+
+.fa-gitkraken:before {
+  content: "\f3a6"; }
+
+.fa-keybase:before {
+  content: "\f4f5"; }
+
+.fa-apple-pay:before {
+  content: "\f415"; }
+
+.fa-padlet:before {
+  content: "\e4a0"; }
+
+.fa-amazon-pay:before {
+  content: "\f42c"; }
+
+.fa-square-github:before {
+  content: "\f092"; }
+
+.fa-github-square:before {
+  content: "\f092"; }
+
+.fa-stumbleupon:before {
+  content: "\f1a4"; }
+
+.fa-fedex:before {
+  content: "\f797"; }
+
+.fa-phoenix-framework:before {
+  content: "\f3dc"; }
+
+.fa-shopify:before {
+  content: "\e057"; }
+
+.fa-neos:before {
+  content: "\f612"; }
+
+.fa-square-threads:before {
+  content: "\e619"; }
+
+.fa-hackerrank:before {
+  content: "\f5f7"; }
+
+.fa-researchgate:before {
+  content: "\f4f8"; }
+
+.fa-swift:before {
+  content: "\f8e1"; }
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+.fa-angular:before {
+  content: "\f420"; }
+
+.fa-speakap:before {
+  content: "\f3f3"; }
+
+.fa-angrycreative:before {
+  content: "\f36e"; }
+
+.fa-y-combinator:before {
+  content: "\f23b"; }
+
+.fa-empire:before {
+  content: "\f1d1"; }
+
+.fa-envira:before {
+  content: "\f299"; }
+
+.fa-google-scholar:before {
+  content: "\e63b"; }
+
+.fa-square-gitlab:before {
+  content: "\e5ae"; }
+
+.fa-gitlab-square:before {
+  content: "\e5ae"; }
+
+.fa-studiovinari:before {
+  content: "\f3f8"; }
+
+.fa-pied-piper:before {
+  content: "\f2ae"; }
+
+.fa-wordpress:before {
+  content: "\f19a"; }
+
+.fa-product-hunt:before {
+  content: "\f288"; }
+
+.fa-firefox:before {
+  content: "\f269"; }
+
+.fa-linode:before {
+  content: "\f2b8"; }
+
+.fa-goodreads:before {
+  content: "\f3a8"; }
+
+.fa-square-odnoklassniki:before {
+  content: "\f264"; }
+
+.fa-odnoklassniki-square:before {
+  content: "\f264"; }
+
+.fa-jsfiddle:before {
+  content: "\f1cc"; }
+
+.fa-sith:before {
+  content: "\f512"; }
+
+.fa-themeisle:before {
+  content: "\f2b2"; }
+
+.fa-page4:before {
+  content: "\f3d7"; }
+
+.fa-hashnode:before {
+  content: "\e499"; }
+
+.fa-react:before {
+  content: "\f41b"; }
+
+.fa-cc-paypal:before {
+  content: "\f1f4"; }
+
+.fa-squarespace:before {
+  content: "\f5be"; }
+
+.fa-cc-stripe:before {
+  content: "\f1f5"; }
+
+.fa-creative-commons-share:before {
+  content: "\f4f2"; }
+
+.fa-bitcoin:before {
+  content: "\f379"; }
+
+.fa-keycdn:before {
+  content: "\f3ba"; }
+
+.fa-opera:before {
+  content: "\f26a"; }
+
+.fa-itch-io:before {
+  content: "\f83a"; }
+
+.fa-umbraco:before {
+  content: "\f8e8"; }
+
+.fa-galactic-senate:before {
+  content: "\f50d"; }
+
+.fa-ubuntu:before {
+  content: "\f7df"; }
+
+.fa-draft2digital:before {
+  content: "\f396"; }
+
+.fa-stripe:before {
+  content: "\f429"; }
+
+.fa-houzz:before {
+  content: "\f27c"; }
+
+.fa-gg:before {
+  content: "\f260"; }
+
+.fa-dhl:before {
+  content: "\f790"; }
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+  content: "\f412"; }
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+  content: "\f3eb"; }
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+  content: "\e07b"; }
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+  content: "\f082"; }
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+  content: "\f17c"; }
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+  content: "\f2a5"; }
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+  content: "\f3b2"; }
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+  content: "\e056"; }
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+  content: "\f203"; }
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+.fa-lastfm-square:before {
+  content: "\f203"; }
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+.fa-vimeo:before {
+  content: "\f40a"; }
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+  content: "\f7b3"; }
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+  content: "\f404"; }
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+.fa-figma:before {
+  content: "\f799"; }
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+  content: "\f4ee"; }
+
+.fa-cc-amazon-pay:before {
+  content: "\f42d"; }
+
+.fa-dropbox:before {
+  content: "\f16b"; }
+
+.fa-instagram:before {
+  content: "\f16d"; }
+
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+  content: "\e360"; }
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+  content: "\e641"; }
+
+.fa-facebook:before {
+  content: "\f09a"; }
+
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+  content: "\f3ac"; }
+
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+  content: "\f50e"; }
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+  content: "\f403"; }
+
+.fa-fort-awesome-alt:before {
+  content: "\f3a3"; }
+
+.fa-phabricator:before {
+  content: "\f3db"; }
+
+.fa-ussunnah:before {
+  content: "\f407"; }
+
+.fa-earlybirds:before {
+  content: "\f39a"; }
+
+.fa-trade-federation:before {
+  content: "\f513"; }
+
+.fa-autoprefixer:before {
+  content: "\f41c"; }
+
+.fa-whatsapp:before {
+  content: "\f232"; }
+
+.fa-square-upwork:before {
+  content: "\e67c"; }
+
+.fa-slideshare:before {
+  content: "\f1e7"; }
+
+.fa-google-play:before {
+  content: "\f3ab"; }
+
+.fa-viadeo:before {
+  content: "\f2a9"; }
+
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+  content: "\f3c0"; }
+
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+  content: "\f3aa"; }
+
+.fa-servicestack:before {
+  content: "\f3ec"; }
+
+.fa-simplybuilt:before {
+  content: "\f215"; }
+
+.fa-bitbucket:before {
+  content: "\f171"; }
+
+.fa-imdb:before {
+  content: "\f2d8"; }
+
+.fa-deezer:before {
+  content: "\e077"; }
+
+.fa-raspberry-pi:before {
+  content: "\f7bb"; }
+
+.fa-jira:before {
+  content: "\f7b1"; }
+
+.fa-docker:before {
+  content: "\f395"; }
+
+.fa-screenpal:before {
+  content: "\e570"; }
+
+.fa-bluetooth:before {
+  content: "\f293"; }
+
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+  content: "\f426"; }
+
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+  content: "\f38d"; }
+
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+  content: "\e01a"; }
+
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+  content: "\f24c"; }
+
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+  content: "\f261"; }
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+  content: "\f4e5"; }
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+  content: "\f3bc"; }
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+  content: "\f413"; }
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+  content: "\f4d5"; }
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+  content: "\f13b"; }
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+  content: "\f213"; }
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+  content: "\e683"; }
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+  content: "\f41e"; }
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+  content: "\e2d0"; }
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+  content: "\e2d0"; }
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+  content: "\f37f"; }
+
+.fa-salesforce:before {
+  content: "\f83b"; }
+
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+  content: "\e082"; }
+
+.fa-medapps:before {
+  content: "\f3c6"; }
+
+.fa-ns8:before {
+  content: "\f3d5"; }
+
+.fa-pinterest-p:before {
+  content: "\f231"; }
+
+.fa-apper:before {
+  content: "\f371"; }
+
+.fa-fort-awesome:before {
+  content: "\f286"; }
+
+.fa-waze:before {
+  content: "\f83f"; }
+
+.fa-bluesky:before {
+  content: "\e671"; }
+
+.fa-cc-jcb:before {
+  content: "\f24b"; }
+
+.fa-snapchat:before {
+  content: "\f2ab"; }
+
+.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa-fantasy-flight-games:before {
+  content: "\f6dc"; }
+
+.fa-rust:before {
+  content: "\e07a"; }
+
+.fa-wix:before {
+  content: "\f5cf"; }
+
+.fa-square-behance:before {
+  content: "\f1b5"; }
+
+.fa-behance-square:before {
+  content: "\f1b5"; }
+
+.fa-supple:before {
+  content: "\f3f9"; }
+
+.fa-webflow:before {
+  content: "\e65c"; }
+
+.fa-rebel:before {
+  content: "\f1d0"; }
+
+.fa-css3:before {
+  content: "\f13c"; }
+
+.fa-staylinked:before {
+  content: "\f3f5"; }
+
+.fa-kaggle:before {
+  content: "\f5fa"; }
+
+.fa-space-awesome:before {
+  content: "\e5ac"; }
+
+.fa-deviantart:before {
+  content: "\f1bd"; }
+
+.fa-cpanel:before {
+  content: "\f388"; }
+
+.fa-goodreads-g:before {
+  content: "\f3a9"; }
+
+.fa-square-git:before {
+  content: "\f1d2"; }
+
+.fa-git-square:before {
+  content: "\f1d2"; }
+
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+  content: "\f174"; }
+
+.fa-tumblr-square:before {
+  content: "\f174"; }
+
+.fa-trello:before {
+  content: "\f181"; }
+
+.fa-creative-commons-nc-jp:before {
+  content: "\f4ea"; }
+
+.fa-get-pocket:before {
+  content: "\f265"; }
+
+.fa-perbyte:before {
+  content: "\e083"; }
+
+.fa-grunt:before {
+  content: "\f3ad"; }
+
+.fa-weebly:before {
+  content: "\f5cc"; }
+
+.fa-connectdevelop:before {
+  content: "\f20e"; }
+
+.fa-leanpub:before {
+  content: "\f212"; }
+
+.fa-black-tie:before {
+  content: "\f27e"; }
+
+.fa-themeco:before {
+  content: "\f5c6"; }
+
+.fa-python:before {
+  content: "\f3e2"; }
+
+.fa-android:before {
+  content: "\f17b"; }
+
+.fa-bots:before {
+  content: "\e340"; }
+
+.fa-free-code-camp:before {
+  content: "\f2c5"; }
+
+.fa-hornbill:before {
+  content: "\f592"; }
+
+.fa-js:before {
+  content: "\f3b8"; }
+
+.fa-ideal:before {
+  content: "\e013"; }
+
+.fa-git:before {
+  content: "\f1d3"; }
+
+.fa-dev:before {
+  content: "\f6cc"; }
+
+.fa-sketch:before {
+  content: "\f7c6"; }
+
+.fa-yandex-international:before {
+  content: "\f414"; }
+
+.fa-cc-amex:before {
+  content: "\f1f3"; }
+
+.fa-uber:before {
+  content: "\f402"; }
+
+.fa-github:before {
+  content: "\f09b"; }
+
+.fa-php:before {
+  content: "\f457"; }
+
+.fa-alipay:before {
+  content: "\f642"; }
+
+.fa-youtube:before {
+  content: "\f167"; }
+
+.fa-skyatlas:before {
+  content: "\f216"; }
+
+.fa-firefox-browser:before {
+  content: "\e007"; }
+
+.fa-replyd:before {
+  content: "\f3e6"; }
+
+.fa-suse:before {
+  content: "\f7d6"; }
+
+.fa-jenkins:before {
+  content: "\f3b6"; }
+
+.fa-twitter:before {
+  content: "\f099"; }
+
+.fa-rockrms:before {
+  content: "\f3e9"; }
+
+.fa-pinterest:before {
+  content: "\f0d2"; }
+
+.fa-buffer:before {
+  content: "\f837"; }
+
+.fa-npm:before {
+  content: "\f3d4"; }
+
+.fa-yammer:before {
+  content: "\f840"; }
+
+.fa-btc:before {
+  content: "\f15a"; }
+
+.fa-dribbble:before {
+  content: "\f17d"; }
+
+.fa-stumbleupon-circle:before {
+  content: "\f1a3"; }
+
+.fa-internet-explorer:before {
+  content: "\f26b"; }
+
+.fa-stubber:before {
+  content: "\e5c7"; }
+
+.fa-telegram:before {
+  content: "\f2c6"; }
+
+.fa-telegram-plane:before {
+  content: "\f2c6"; }
+
+.fa-old-republic:before {
+  content: "\f510"; }
+
+.fa-odysee:before {
+  content: "\e5c6"; }
+
+.fa-square-whatsapp:before {
+  content: "\f40c"; }
+
+.fa-whatsapp-square:before {
+  content: "\f40c"; }
+
+.fa-node-js:before {
+  content: "\f3d3"; }
+
+.fa-edge-legacy:before {
+  content: "\e078"; }
+
+.fa-slack:before {
+  content: "\f198"; }
+
+.fa-slack-hash:before {
+  content: "\f198"; }
+
+.fa-medrt:before {
+  content: "\f3c8"; }
+
+.fa-usb:before {
+  content: "\f287"; }
+
+.fa-tumblr:before {
+  content: "\f173"; }
+
+.fa-vaadin:before {
+  content: "\f408"; }
+
+.fa-quora:before {
+  content: "\f2c4"; }
+
+.fa-square-x-twitter:before {
+  content: "\e61a"; }
+
+.fa-reacteurope:before {
+  content: "\f75d"; }
+
+.fa-medium:before {
+  content: "\f23a"; }
+
+.fa-medium-m:before {
+  content: "\f23a"; }
+
+.fa-amilia:before {
+  content: "\f36d"; }
+
+.fa-mixcloud:before {
+  content: "\f289"; }
+
+.fa-flipboard:before {
+  content: "\f44d"; }
+
+.fa-viacoin:before {
+  content: "\f237"; }
+
+.fa-critical-role:before {
+  content: "\f6c9"; }
+
+.fa-sitrox:before {
+  content: "\e44a"; }
+
+.fa-discourse:before {
+  content: "\f393"; }
+
+.fa-joomla:before {
+  content: "\f1aa"; }
+
+.fa-mastodon:before {
+  content: "\f4f6"; }
+
+.fa-airbnb:before {
+  content: "\f834"; }
+
+.fa-wolf-pack-battalion:before {
+  content: "\f514"; }
+
+.fa-buy-n-large:before {
+  content: "\f8a6"; }
+
+.fa-gulp:before {
+  content: "\f3ae"; }
+
+.fa-creative-commons-sampling-plus:before {
+  content: "\f4f1"; }
+
+.fa-strava:before {
+  content: "\f428"; }
+
+.fa-ember:before {
+  content: "\f423"; }
+
+.fa-canadian-maple-leaf:before {
+  content: "\f785"; }
+
+.fa-teamspeak:before {
+  content: "\f4f9"; }
+
+.fa-pushed:before {
+  content: "\f3e1"; }
+
+.fa-wordpress-simple:before {
+  content: "\f411"; }
+
+.fa-nutritionix:before {
+  content: "\f3d6"; }
+
+.fa-wodu:before {
+  content: "\e088"; }
+
+.fa-google-pay:before {
+  content: "\e079"; }
+
+.fa-intercom:before {
+  content: "\f7af"; }
+
+.fa-zhihu:before {
+  content: "\f63f"; }
+
+.fa-korvue:before {
+  content: "\f42f"; }
+
+.fa-pix:before {
+  content: "\e43a"; }
+
+.fa-steam-symbol:before {
+  content: "\f3f6"; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-regular: normal 400 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+.far,
+.fa-regular {
+  font-weight: 400; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-solid: normal 900 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 900;
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+.fas,
+.fa-solid {
+  font-weight: 900; }
+@font-face {
+  font-family: 'Font Awesome 5 Brands';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 900;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-v4compatibility.woff2") format("woff2"), url("../webfonts/fa-v4compatibility.ttf") format("truetype"); }
diff --git a/deps/font-awesome-6.5.2/css/all.min.css b/deps/font-awesome-6.5.2/css/all.min.css
new file mode 100644
index 0000000..269bcee
--- /dev/null
+++ b/deps/font-awesome-6.5.2/css/all.min.css
@@ -0,0 +1,9 @@
+/*!
+ * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2024 Fonticons, Inc.
+ */
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diff --git a/deps/font-awesome-6.5.2/css/v4-shims.css b/deps/font-awesome-6.5.2/css/v4-shims.css
new file mode 100644
index 0000000..ea60ea4
--- /dev/null
+++ b/deps/font-awesome-6.5.2/css/v4-shims.css
@@ -0,0 +1,2194 @@
+/*!
+ * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2024 Fonticons, Inc.
+ */
+.fa.fa-glass:before {
+  content: "\f000"; }
+
+.fa.fa-envelope-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-o:before {
+  content: "\f0e0"; }
+
+.fa.fa-star-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-o:before {
+  content: "\f005"; }
+
+.fa.fa-remove:before {
+  content: "\f00d"; }
+
+.fa.fa-close:before {
+  content: "\f00d"; }
+
+.fa.fa-gear:before {
+  content: "\f013"; }
+
+.fa.fa-trash-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-trash-o:before {
+  content: "\f2ed"; }
+
+.fa.fa-home:before {
+  content: "\f015"; }
+
+.fa.fa-file-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-file-o:before {
+  content: "\f15b"; }
+
+.fa.fa-clock-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-clock-o:before {
+  content: "\f017"; }
+
+.fa.fa-arrow-circle-o-down {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-arrow-circle-o-down:before {
+  content: "\f358"; }
+
+.fa.fa-arrow-circle-o-up {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-arrow-circle-o-up:before {
+  content: "\f35b"; }
+
+.fa.fa-play-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-play-circle-o:before {
+  content: "\f144"; }
+
+.fa.fa-repeat:before {
+  content: "\f01e"; }
+
+.fa.fa-rotate-right:before {
+  content: "\f01e"; }
+
+.fa.fa-refresh:before {
+  content: "\f021"; }
+
+.fa.fa-list-alt {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-list-alt:before {
+  content: "\f022"; }
+
+.fa.fa-dedent:before {
+  content: "\f03b"; }
+
+.fa.fa-video-camera:before {
+  content: "\f03d"; }
+
+.fa.fa-picture-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-picture-o:before {
+  content: "\f03e"; }
+
+.fa.fa-photo {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-photo:before {
+  content: "\f03e"; }
+
+.fa.fa-image {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-image:before {
+  content: "\f03e"; }
+
+.fa.fa-map-marker:before {
+  content: "\f3c5"; }
+
+.fa.fa-pencil-square-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-pencil-square-o:before {
+  content: "\f044"; }
+
+.fa.fa-edit {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-edit:before {
+  content: "\f044"; }
+
+.fa.fa-share-square-o:before {
+  content: "\f14d"; }
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+.fa.fa-check-square-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-check-square-o:before {
+  content: "\f14a"; }
+
+.fa.fa-arrows:before {
+  content: "\f0b2"; }
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+.fa.fa-times-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-times-circle-o:before {
+  content: "\f057"; }
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+.fa.fa-check-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-check-circle-o:before {
+  content: "\f058"; }
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+.fa.fa-mail-forward:before {
+  content: "\f064"; }
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+.fa.fa-expand:before {
+  content: "\f424"; }
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+.fa.fa-modx {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fort-awesome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-usb {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-product-hunt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-mixcloud {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-scribd {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-pause-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-pause-circle-o:before {
+  content: "\f28b"; }
+
+.fa.fa-stop-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-stop-circle-o:before {
+  content: "\f28d"; }
+
+.fa.fa-bluetooth {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-bluetooth-b {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-gitlab {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpbeginner {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpforms {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-envira {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt:before {
+  content: "\f368"; }
+
+.fa.fa-question-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-question-circle-o:before {
+  content: "\f059"; }
+
+.fa.fa-volume-control-phone:before {
+  content: "\f2a0"; }
+
+.fa.fa-asl-interpreting:before {
+  content: "\f2a3"; }
+
+.fa.fa-deafness:before {
+  content: "\f2a4"; }
+
+.fa.fa-hard-of-hearing:before {
+  content: "\f2a4"; }
+
+.fa.fa-glide {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-glide-g {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-signing:before {
+  content: "\f2a7"; }
+
+.fa.fa-viadeo {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square:before {
+  content: "\f2aa"; }
+
+.fa.fa-snapchat {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa.fa-snapchat-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-square:before {
+  content: "\f2ad"; }
+
+.fa.fa-pied-piper {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-first-order {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-yoast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-themeisle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official:before {
+  content: "\f2b3"; }
+
+.fa.fa-google-plus-circle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-circle:before {
+  content: "\f2b3"; }
+
+.fa.fa-font-awesome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa:before {
+  content: "\f2b4"; }
+
+.fa.fa-handshake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-handshake-o:before {
+  content: "\f2b5"; }
+
+.fa.fa-envelope-open-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-open-o:before {
+  content: "\f2b6"; }
+
+.fa.fa-linode {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-address-book-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-book-o:before {
+  content: "\f2b9"; }
+
+.fa.fa-vcard:before {
+  content: "\f2bb"; }
+
+.fa.fa-address-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-card-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-vcard-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-vcard-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-user-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-circle-o:before {
+  content: "\f2bd"; }
+
+.fa.fa-user-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-o:before {
+  content: "\f007"; }
+
+.fa.fa-id-badge {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license:before {
+  content: "\f2c2"; }
+
+.fa.fa-id-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-id-card-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-drivers-license-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-quora {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-free-code-camp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-telegram {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-thermometer-4:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer-3:before {
+  content: "\f2c8"; }
+
+.fa.fa-thermometer-2:before {
+  content: "\f2c9"; }
+
+.fa.fa-thermometer-1:before {
+  content: "\f2ca"; }
+
+.fa.fa-thermometer-0:before {
+  content: "\f2cb"; }
+
+.fa.fa-bathtub:before {
+  content: "\f2cd"; }
+
+.fa.fa-s15:before {
+  content: "\f2cd"; }
+
+.fa.fa-window-maximize {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-restore {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle:before {
+  content: "\f410"; }
+
+.fa.fa-window-close-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-close-o:before {
+  content: "\f410"; }
+
+.fa.fa-times-rectangle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle-o:before {
+  content: "\f410"; }
+
+.fa.fa-bandcamp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-grav {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-etsy {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-imdb {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-ravelry {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast:before {
+  content: "\f2da"; }
+
+.fa.fa-snowflake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-snowflake-o:before {
+  content: "\f2dc"; }
+
+.fa.fa-superpowers {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpexplorer {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-meetup {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
diff --git a/deps/font-awesome-6.5.2/css/v4-shims.min.css b/deps/font-awesome-6.5.2/css/v4-shims.min.css
new file mode 100644
index 0000000..09baf5f
--- /dev/null
+++ b/deps/font-awesome-6.5.2/css/v4-shims.min.css
@@ -0,0 +1,6 @@
+/*!
+ * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2024 Fonticons, Inc.
+ */
+.fa.fa-glass:before{content:"\f000"}.fa.fa-envelope-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-envelope-o:before{content:"\f0e0"}.fa.fa-star-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-star-o:before{content:"\f005"}.fa.fa-close:before,.fa.fa-remove:before{content:"\f00d"}.fa.fa-gear:before{content:"\f013"}.fa.fa-trash-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-trash-o:before{content:"\f2ed"}.fa.fa-home:before{content:"\f015"}.fa.fa-file-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-file-o:before{content:"\f15b"}.fa.fa-clock-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-clock-o:before{content:"\f017"}.fa.fa-arrow-circle-o-down{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-arrow-circle-o-down:before{content:"\f358"}.fa.fa-arrow-circle-o-up{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-arrow-circle-o-up:before{content:"\f35b"}.fa.fa-play-circle-o{font-family:"Font Awesome 6 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Awesome 6 Free";font-weight:400}.fa.fa-check-square-o:before{content:"\f14a"}.fa.fa-arrows:before{content:"\f0b2"}.fa.fa-times-circle-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-times-circle-o:before{content:"\f057"}.fa.fa-check-circle-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-check-circle-o:before{content:"\f058"}.fa.fa-mail-forward:before{content:"\f064"}.fa.fa-expand:before{content:"\f424"}.fa.fa-compress:before{content:"\f422"}.fa.fa-eye,.fa.fa-eye-slash{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-warning:before{content:"\f071"}.fa.fa-calendar:before{content:"\f073"}.fa.fa-arrows-v:before{content:"\f338"}.fa.fa-arrows-h:before{content:"\f337"}.fa.fa-bar-chart-o:before,.fa.fa-bar-chart:before{content:"\e0e3"}.fa.fa-twitter-square{font-family:"Font Awesome 6 Brands";font-weight:400}.fa.fa-twitter-square:before{content:"\f081"}.fa.fa-facebook-square{font-family:"Font Awesome 6 Brands";font-weight:400}.fa.fa-facebook-square:before{content:"\f082"}.fa.fa-gears:before{content:"\f085"}.fa.fa-thumbs-o-up{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-thumbs-o-up:before{content:"\f164"}.fa.fa-thumbs-o-down{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-thumbs-o-down:before{content:"\f165"}.fa.fa-heart-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-heart-o:before{content:"\f004"}.fa.fa-sign-out:before{content:"\f2f5"}.fa.fa-linkedin-square{font-family:"Font Awesome 6 Brands";font-weight:400}.fa.fa-linkedin-square:before{content:"\f08c"}.fa.fa-thumb-tack:before{content:"\f08d"}.fa.fa-external-link:before{content:"\f35d"}.fa.fa-sign-in:before{content:"\f2f6"}.fa.fa-github-square{font-family:"Font Awesome 6 Brands";font-weight:400}.fa.fa-github-square:before{content:"\f092"}.fa.fa-lemon-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-lemon-o:before{content:"\f094"}.fa.fa-square-o{font-family:"Font Awesome 6 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 <title>Spatiotemporal Mixture Risk Assessment • GeoTox</title>
 <script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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-<script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
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+<script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet">
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 <script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><script src="deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Spatiotemporal Mixture Risk Assessment">
 <meta name="description" content="Connecting spatiotemporal exposure to individual and population-level risk via source-to-outcome continuum modeling. The package, methods, and case-studies are described in Messier, Reif, and Marvel (2024) &lt;doi:10.1101/2024.09.23.24314096&gt; and Eccles et al. (2023) &lt;doi:10.1016/j.scitotenv.2022.158905&gt;.">
 <meta property="og:description" content="Connecting spatiotemporal exposure to individual and population-level risk via source-to-outcome continuum modeling. The package, methods, and case-studies are described in Messier, Reif, and Marvel (2024) &lt;doi:10.1101/2024.09.23.24314096&gt; and Eccles et al. (2023) &lt;doi:10.1016/j.scitotenv.2022.158905&gt;.">
@@ -23,7 +23,7 @@
 
     <a class="navbar-brand me-2" href="index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -67,25 +67,21 @@
 <div class="section level2">
 <h2 id="installation">Installation<a class="anchor" aria-label="anchor" href="#installation"></a>
 </h2>
-<p>The package will be on CRAN in the near future - please stay tuned.</p>
-<!--
-``` r
-install.packages("GeoTox")
-```
--->
+<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/install.packages.html" class="external-link">install.packages</a></span><span class="op">(</span><span class="st">"GeoTox"</span><span class="op">)</span></span></code></pre></div>
 </div>
 <div class="section level2">
 <h2 id="development-version">Development Version<a class="anchor" aria-label="anchor" href="#development-version"></a>
 </h2>
-<p>The development version can be installed from <a href="https://github.com/NIEHS/GeoTox">GitHub</a> with:</p>
-<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r">
+<p>The development version can be installed from GitHub.</p>
+<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="co">#install.packages("pak")</span></span>
 <span><span class="fu">pak</span><span class="fu">::</span><span class="fu"><a href="https://pak.r-lib.org/reference/pak.html" class="external-link">pak</a></span><span class="op">(</span><span class="st">"NIEHS/GeoTox"</span><span class="op">)</span></span></code></pre></div>
 </div>
 <div class="section level2">
 <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"></a>
 </h2>
-<p>Figure 1 below shows the steps in the source-to-outcome-continuum or GeoTox modelling framework that is capable in the <code>GeoTox</code> package. <span style="color: blue;">blue text</span> nodes represent an object and <span style="color: green;">green text</span>, rounded nodes represent a methodology or function required to go from one to the next. The <code>GeoTox</code> package uses R S3 object-oriented programming to create the <strong>GeoTox</strong> object. The <strong>GeoTox</strong> object is a list that contains all of the information required to run the analysis including tracking exposure, assays, dose-response, and geospatial referencing.</p>
+<p>Figure 1 below shows the steps in the source-to-outcome-continuum or GeoTox modeling framework that is capable in the <code>GeoTox</code> package. <span style="color: blue;">blue text</span> nodes represent an object and <span style="color: green;">green text</span>, rounded nodes represent a methodology or function required to go from one to the next. The <code>GeoTox</code> package uses R S3 object-oriented programming to create the <strong>GeoTox</strong> object. The <strong>GeoTox</strong> object is a list that contains all of the information required to run the analysis including tracking exposure, assays, dose-response, and geospatial referencing.</p>
 <p align="center">
 <img src="reference/figures/GeoTox-Workflow.png" alt="GeoTox-Workflow"><br><em>Figure 1: Overview of the steps in the GeoTox framework</em>
 </p>
@@ -112,6 +108,7 @@ <h2 data-toc-skip>Links</h2>
 <ul class="list-unstyled">
 <li><a href="https://cloud.r-project.org/package=GeoTox" class="external-link">View on CRAN</a></li>
 <li><a href="https://github.com/NIEHS/GeoTox/">Browse source code</a></li>
+<li><a href="https://github.com/NIEHS/GeoTox/issues">Report a bug</a></li>
 </ul>
 </div>
 
@@ -141,9 +138,9 @@ <h2 data-toc-skip>Citation</h2>
 <div class="developers">
 <h2 data-toc-skip>Developers</h2>
 <ul class="list-unstyled">
-<li>Skylar Marvel <br><small class="roles"> Author, contributor </small> <a href="https://orcid.org/0000-0002-2971-9743" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
-<li>David Reif <br><small class="roles"> Author, contributor </small> <a href="https://orcid.org/0000-0001-7815-6767" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
-<li>Kyle Messier <br><small class="roles"> Maintainer, author, contributor </small> <a href="https://orcid.org/0000-0001-9508-9623" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
+<li>Skylar Marvel <br><small class="roles"> Author </small> <a href="https://orcid.org/0000-0002-2971-9743" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
+<li>David Reif <br><small class="roles"> Author </small> <a href="https://orcid.org/0000-0001-7815-6767" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
+<li>Kyle Messier <br><small class="roles"> Maintainer, author </small> <a href="https://orcid.org/0000-0001-9508-9623" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li>
 <li><a href="authors.html">More about authors...</a></li>
 </ul>
 </div>
diff --git a/news/index.html b/news/index.html
index 1439faa..fe75fd6 100644
--- a/news/index.html
+++ b/news/index.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Changelog • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Changelog • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,22 +32,14 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Changelog</h1>
-      <small>Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/NEWS.md"><code>NEWS.md</code></a></small>
+      <small>Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/NEWS.md"><code>NEWS.md</code></a></small>
     </div>
 
     <div class="section level2">
-<h2 class="pkg-version" data-toc-text="0.1.4" id="geotox-014">GeoTox 0.1.4<a class="anchor" aria-label="anchor" href="#geotox-014"></a></h2>
-<ul><li>Updated unit test coverage and function examples</li>
+<h2 class="pkg-version" data-toc-text="0.2.0" id="geotox-020">GeoTox 0.2.0<a class="anchor" aria-label="anchor" href="#geotox-020"></a></h2><p class="text-muted">CRAN release: 2024-11-15</p>
+<ul><li>Initial CRAN submission.</li>
 </ul></div>
-    <div class="section level2">
-<h2 class="pkg-version" data-toc-text="0.0.1" id="geotox-001">GeoTox 0.0.1<a class="anchor" aria-label="anchor" href="#geotox-001"></a></h2>
-<ul><li>Adding supporting documents to the <code>GeoTox</code> repository such as this news.md, issue templates, and contributor’s guide</li>
-<li>NC areal level analysis vignette is complete</li>
-<li>Key developments on the object oriented approach: simulate and sensitivity wrappers</li>
-<li>oo-s3.Rmd is updated to include object oriented improvements including more plotting options</li>
-</ul></div>
-  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
-    </nav></aside></div>
+  </main></div>
 
 
     <footer><div class="pkgdown-footer-left">
diff --git a/pkgdown.yml b/pkgdown.yml
index 1867b8a..3ff8c17 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -4,7 +4,7 @@ pkgdown_sha: ~
 articles:
   introduction: introduction.html
   package_data: package_data.html
-last_built: 2024-11-15T15:48Z
+last_built: 2024-11-19T16:20Z
 urls:
   reference: https://github.com/NIEHS/GeoTox/reference
   article: https://github.com/NIEHS/GeoTox/articles
diff --git a/reference/GeoTox-package.html b/reference/GeoTox-package.html
index 6f9b8b0..af47ce8 100644
--- a/reference/GeoTox-package.html
+++ b/reference/GeoTox-package.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package"><meta name="description" content="
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package"><meta name="description" content="
 Connecting spatiotemporal exposure to individual and population-level risk via source-to-outcome continuum modeling. The package, methods, and case-studies are described in Messier, Reif, and Marvel (2024) doi:10.1101/2024.09.23.24314096
  and Eccles et al. (2023) doi:10.1016/j.scitotenv.2022.158905
 ."><meta property="og:description" content="
@@ -13,7 +13,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -38,7 +38,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>GeoTox: Spatiotemporal Mixture Risk Assessment</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/GeoTox-package.R"><code>R/GeoTox-package.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/GeoTox-package.R"><code>R/GeoTox-package.R</code></a></small>
       <div class="d-none name"><code>GeoTox-package.Rd</code></div>
     </div>
 
@@ -54,13 +54,14 @@
     <h2 id="see-also">See also<a class="anchor" aria-label="anchor" href="#see-also"></a></h2>
     <div class="dont-index"><p>Useful links:</p><ul><li><p><a href="https://niehs.github.io/GeoTox/" class="external-link">https://niehs.github.io/GeoTox/</a></p></li>
 <li><p><a href="https://github.com/NIEHS/GeoTox">https://github.com/NIEHS/GeoTox</a></p></li>
+<li><p>Report bugs at <a href="https://github.com/NIEHS/GeoTox/issues">https://github.com/NIEHS/GeoTox/issues</a></p></li>
 </ul></div>
     </div>
     <div class="section level2">
     <h2 id="author">Author<a class="anchor" aria-label="anchor" href="#author"></a></h2>
-    <p><strong>Maintainer</strong>: Kyle Messier <a href="mailto:kyle.messier@nih.gov">kyle.messier@nih.gov</a> (<a href="https://orcid.org/0000-0001-9508-9623" class="external-link">ORCID</a>) [contributor]</p>
-<p>Authors:</p><ul><li><p>Skylar Marvel <a href="mailto:skylar.marvel@nih.gov">skylar.marvel@nih.gov</a> (<a href="https://orcid.org/0000-0002-2971-9743" class="external-link">ORCID</a>) [contributor]</p></li>
-<li><p>David Reif <a href="mailto:david.reif@nih.gov">david.reif@nih.gov</a> (<a href="https://orcid.org/0000-0001-7815-6767" class="external-link">ORCID</a>) [contributor]</p></li>
+    <p><strong>Maintainer</strong>: Kyle Messier <a href="mailto:kyle.messier@nih.gov">kyle.messier@nih.gov</a> (<a href="https://orcid.org/0000-0001-9508-9623" class="external-link">ORCID</a>)</p>
+<p>Authors:</p><ul><li><p>Skylar Marvel <a href="mailto:skylar.marvel@nih.gov">skylar.marvel@nih.gov</a> (<a href="https://orcid.org/0000-0002-2971-9743" class="external-link">ORCID</a>)</p></li>
+<li><p>David Reif <a href="mailto:david.reif@nih.gov">david.reif@nih.gov</a> (<a href="https://orcid.org/0000-0001-7815-6767" class="external-link">ORCID</a>)</p></li>
 </ul><p>Other contributors:</p><ul><li><p>Spatiotemporal Exposures and Toxicology Group [copyright holder]</p></li>
 </ul></div>
 
diff --git a/reference/GeoTox.html b/reference/GeoTox.html
index b9f8fec..6888906 100644
--- a/reference/GeoTox.html
+++ b/reference/GeoTox.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox S3 object — GeoTox • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox S3 object — GeoTox"><meta name="description" content="An S3 object that can be used to help organize the data and results of a
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox S3 object — GeoTox • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox S3 object — GeoTox"><meta name="description" content="An S3 object that can be used to help organize the data and results of a
 GeoTox analysis."><meta property="og:description" content="An S3 object that can be used to help organize the data and results of a
 GeoTox analysis."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
@@ -9,7 +9,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -34,7 +34,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>GeoTox S3 object</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/GeoTox.R"><code>R/GeoTox.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/GeoTox.R"><code>R/GeoTox.R</code></a></small>
       <div class="d-none name"><code>GeoTox.Rd</code></div>
     </div>
 
@@ -67,6 +67,10 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 <dd><p>arguments passed to subsequent methods.</p></dd>
 
 </dl></div>
+    <div class="section level2">
+    <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
+    <p>a GeoTox S3 object</p>
+    </div>
     <div class="section level2">
     <h2 id="see-also">See also<a class="anchor" aria-label="anchor" href="#see-also"></a></h2>
     <div class="dont-index"><p><a href="plot_resp.html">plot_resp</a>, <a href="plot_hill.html">plot_hill</a>, <a href="plot_exposure.html">plot_exposure</a>, <a href="plot_sensitivity.html">plot_sensitivity</a></p></div>
diff --git a/reference/calc_concentration_response.html b/reference/calc_concentration_response.html
index 4901ed6..46f1b3e 100644
--- a/reference/calc_concentration_response.html
+++ b/reference/calc_concentration_response.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response"><meta name="description" content="Calculate the combined response of multiple chemicals. It calculates the
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response"><meta name="description" content="Calculate the combined response of multiple chemicals. It calculates the
 generalized concentration addition response, the independent action
 response, and a hazard quotient"><meta property="og:description" content="Calculate the combined response of multiple chemicals. It calculates the
 generalized concentration addition response, the independent action
@@ -11,7 +11,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -36,7 +36,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/calc_concentration_response.R"><code>R/calc_concentration_response.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/calc_concentration_response.R"><code>R/calc_concentration_response.R</code></a></small>
       <div class="d-none name"><code>calc_concentration_response.Rd</code></div>
     </div>
 
diff --git a/reference/calc_independent_action.html b/reference/calc_independent_action.html
index 697a819..2d64d7b 100644
--- a/reference/calc_independent_action.html
+++ b/reference/calc_independent_action.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Independent Action — calc_independent_action • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Independent Action — calc_independent_action"><meta name="description" content="Calculate independent action response for a set of chemicals with Hill
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Independent Action — calc_independent_action • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Independent Action — calc_independent_action"><meta name="description" content="Calculate independent action response for a set of chemicals with Hill
 concentration-response curves."><meta property="og:description" content="Calculate independent action response for a set of chemicals with Hill
 concentration-response curves."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
@@ -9,7 +9,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -34,7 +34,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Independent Action</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/calc_independent_action.R"><code>R/calc_independent_action.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/calc_independent_action.R"><code>R/calc_independent_action.R</code></a></small>
       <div class="d-none name"><code>calc_independent_action.Rd</code></div>
     </div>
 
@@ -57,7 +57,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dt id="arg-max">max<a class="anchor" aria-label="anchor" href="#arg-max"></a></dt>
-<dd><p>maximal (asymtotic) responses</p></dd>
+<dd><p>maximal (asymptotic) responses</p></dd>
 
 
 <dt id="arg-ac-">AC50<a class="anchor" aria-label="anchor" href="#arg-ac-"></a></dt>
diff --git a/reference/calc_internal_dose.html b/reference/calc_internal_dose.html
index ee768c7..5ba860d 100644
--- a/reference/calc_internal_dose.html
+++ b/reference/calc_internal_dose.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate internal chemical dose — calc_internal_dose • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate internal chemical dose — calc_internal_dose"><meta name="description" content="Estimate the internal dose from inhalation of a chemical given inhalation
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate internal chemical dose — calc_internal_dose • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate internal chemical dose — calc_internal_dose"><meta name="description" content="Estimate the internal dose from inhalation of a chemical given inhalation
 rate, time, and body weight"><meta property="og:description" content="Estimate the internal dose from inhalation of a chemical given inhalation
 rate, time, and body weight"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
@@ -9,7 +9,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -34,7 +34,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Calculate internal chemical dose</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/calc_internal_dose.R"><code>R/calc_internal_dose.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/calc_internal_dose.R"><code>R/calc_internal_dose.R</code></a></small>
       <div class="d-none name"><code>calc_internal_dose.Rd</code></div>
     </div>
 
diff --git a/reference/calc_invitro_concentration.html b/reference/calc_invitro_concentration.html
index ef2a264..80ace8d 100644
--- a/reference/calc_invitro_concentration.html
+++ b/reference/calc_invitro_concentration.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate in vitro concentration — calc_invitro_concentration • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate in vitro concentration — calc_invitro_concentration"><meta name="description" content="Estimate the in vitro equivalent plasma concentration given internal
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate in vitro concentration — calc_invitro_concentration • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate in vitro concentration — calc_invitro_concentration"><meta name="description" content="Estimate the in vitro equivalent plasma concentration given internal
 chemical dose and steady-state plasma concentration."><meta property="og:description" content="Estimate the in vitro equivalent plasma concentration given internal
 chemical dose and steady-state plasma concentration."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
@@ -9,7 +9,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -34,7 +34,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Calculate <em>in vitro</em> concentration</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/calc_invitro_concentration.R"><code>R/calc_invitro_concentration.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/calc_invitro_concentration.R"><code>R/calc_invitro_concentration.R</code></a></small>
       <div class="d-none name"><code>calc_invitro_concentration.Rd</code></div>
     </div>
 
diff --git a/reference/calculate_response.html b/reference/calculate_response.html
index 7426dde..9c9c720 100644
--- a/reference/calculate_response.html
+++ b/reference/calculate_response.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate response — calculate_response • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate response — calculate_response"><meta name="description" content="Calculate mixture response for GeoTox population data"><meta property="og:description" content="Calculate mixture response for GeoTox population data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Calculate response — calculate_response • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate response — calculate_response"><meta name="description" content="Calculate mixture response for GeoTox population data"><meta property="og:description" content="Calculate mixture response for GeoTox population data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Calculate response</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/calculate_response.R"><code>R/calculate_response.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/calculate_response.R"><code>R/calculate_response.R</code></a></small>
       <div class="d-none name"><code>calculate_response.Rd</code></div>
     </div>
 
diff --git a/reference/compute_sensitivity.html b/reference/compute_sensitivity.html
index 766ae8b..c862151 100644
--- a/reference/compute_sensitivity.html
+++ b/reference/compute_sensitivity.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Compute response sensitivity to parameter variation. — compute_sensitivity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Compute response sensitivity to parameter variation. — compute_sensitivity"><meta name="description" content="Compute response sensitivity to parameter variation."><meta property="og:description" content="Compute response sensitivity to parameter variation."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Compute response sensitivity to parameter variation. — compute_sensitivity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Compute response sensitivity to parameter variation. — compute_sensitivity"><meta name="description" content="Compute response sensitivity to parameter variation."><meta property="og:description" content="Compute response sensitivity to parameter variation."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Compute response sensitivity to parameter variation.</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/compute_sensitivity.R"><code>R/compute_sensitivity.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/compute_sensitivity.R"><code>R/compute_sensitivity.R</code></a></small>
       <div class="d-none name"><code>compute_sensitivity.Rd</code></div>
     </div>
 
diff --git a/reference/fit_hill.html b/reference/fit_hill.html
index 199d6c7..635da87 100644
--- a/reference/fit_hill.html
+++ b/reference/fit_hill.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Fit 2- or 3-parameter Hill model — fit_hill • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Fit 2- or 3-parameter Hill model — fit_hill"><meta name="description" content="Fit 2- or 3-parameter Hill model"><meta property="og:description" content="Fit 2- or 3-parameter Hill model"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Fit 2- or 3-parameter Hill model — fit_hill • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Fit 2- or 3-parameter Hill model — fit_hill"><meta name="description" content="Fit 2- or 3-parameter Hill model"><meta property="og:description" content="Fit 2- or 3-parameter Hill model"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Fit 2- or 3-parameter Hill model</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/fit_hill.R"><code>R/fit_hill.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/fit_hill.R"><code>R/fit_hill.R</code></a></small>
       <div class="d-none name"><code>fit_hill.Rd</code></div>
     </div>
 
diff --git a/reference/geo_tox_data.html b/reference/geo_tox_data.html
index 8a93742..33e70c6 100644
--- a/reference/geo_tox_data.html
+++ b/reference/geo_tox_data.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox Data — geo_tox_data • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox Data — geo_tox_data"><meta name="description" content='Sample data for use in vignettes and function examples. See the Package
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>GeoTox Data — geo_tox_data • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="GeoTox Data — geo_tox_data"><meta name="description" content='Sample data for use in vignettes and function examples. See the Package
 Data vignette, vignette("package_data", package = "GeoTox"), for
 details on how this data was gathered.'><meta property="og:description" content='Sample data for use in vignettes and function examples. See the Package
 Data vignette, vignette("package_data", package = "GeoTox"), for
@@ -11,7 +11,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -36,7 +36,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>GeoTox Data</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/data.R"><code>R/data.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/data.R"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>geo_tox_data.Rd</code></div>
     </div>
 
diff --git a/reference/get_fixed_age.html b/reference/get_fixed_age.html
index d8bf926..997e681 100644
--- a/reference/get_fixed_age.html
+++ b/reference/get_fixed_age.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed Age — get_fixed_age • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed Age — get_fixed_age"><meta name="description" content="Get C_ss Data for Fixed Age"><meta property="og:description" content="Get C_ss Data for Fixed Age"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed Age — get_fixed_age • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed Age — get_fixed_age"><meta name="description" content="Get C_ss Data for Fixed Age"><meta property="og:description" content="Get C_ss Data for Fixed Age"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Get C_ss Data for Fixed Age</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/get_fixed_age.R"><code>R/get_fixed_age.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Get <code>C_ss</code> Data for Fixed Age</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/get_fixed_age.R"><code>R/get_fixed_age.R</code></a></small>
       <div class="d-none name"><code>get_fixed_age.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Get C_ss Data for Fixed Age</p>
+    <p>Get <code>C_ss</code> Data for Fixed Age</p>
     </div>
 
     <div class="section level2">
@@ -50,7 +50,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-simulated-css">simulated_css<a class="anchor" aria-label="anchor" href="#arg-simulated-css"></a></dt>
-<dd><p>list of pre-generated C_ss data, for details see:
+<dd><p>list of pre-generated <code>C_ss</code> data, for details see:
 <code><a href="../articles/package_data.html">vignette("package_data", package = "GeoTox")</a></code>.</p></dd>
 
 
@@ -60,7 +60,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of matrices containing median C_ss values.</p>
+    <p>list of matrices containing median <code>C_ss</code> values.</p>
     </div>
 
     <div class="section level2">
diff --git a/reference/get_fixed_css.html b/reference/get_fixed_css.html
index 87af834..5e5f905 100644
--- a/reference/get_fixed_css.html
+++ b/reference/get_fixed_css.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get Fixed C_ss Data — get_fixed_css • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get Fixed C_ss Data — get_fixed_css"><meta name="description" content="Get C_ss values for use in sensitivity_analysis and compute_sensitivity."><meta property="og:description" content="Get C_ss values for use in sensitivity_analysis and compute_sensitivity."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get Fixed C_ss Data — get_fixed_css • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get Fixed C_ss Data — get_fixed_css"><meta name="description" content="Get C_ss values for use in sensitivity_analysis and compute_sensitivity."><meta property="og:description" content="Get C_ss values for use in sensitivity_analysis and compute_sensitivity."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Get Fixed C_ss Data</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/get_fixed_css.R"><code>R/get_fixed_css.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Get Fixed <code>C_ss</code> Data</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/get_fixed_css.R"><code>R/get_fixed_css.R</code></a></small>
       <div class="d-none name"><code>get_fixed_css.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Get C_ss values for use in <a href="sensitivity_analysis.html">sensitivity_analysis</a> and <a href="compute_sensitivity.html">compute_sensitivity</a>.</p>
+    <p>Get <code>C_ss</code> values for use in <a href="sensitivity_analysis.html">sensitivity_analysis</a> and <a href="compute_sensitivity.html">compute_sensitivity</a>.</p>
     </div>
 
     <div class="section level2">
@@ -50,7 +50,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-simulated-css">simulated_css<a class="anchor" aria-label="anchor" href="#arg-simulated-css"></a></dt>
-<dd><p>list of pre-generated C_ss data, for details see:
+<dd><p>list of pre-generated <code>C_ss</code> data, for details see:
 <code><a href="../articles/package_data.html">vignette("package_data", package = "GeoTox")</a></code>.</p></dd>
 
 
@@ -63,12 +63,12 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dt id="arg-c-ss">C_ss<a class="anchor" aria-label="anchor" href="#arg-c-ss"></a></dt>
-<dd><p>list of matrices containing C_ss values.</p></dd>
+<dd><p>list of matrices containing <code>C_ss</code> values.</p></dd>
 
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of matrices or atomic vectors containing C_ss values.</p>
+    <p>list of matrices or atomic vectors containing <code>C_ss</code> values.</p>
     </div>
 
     <div class="section level2">
diff --git a/reference/get_fixed_obesity.html b/reference/get_fixed_obesity.html
index eb9f3f5..5972f8e 100644
--- a/reference/get_fixed_obesity.html
+++ b/reference/get_fixed_obesity.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed Obesity Status — get_fixed_obesity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed Obesity Status — get_fixed_obesity"><meta name="description" content="Get C_ss Data for Fixed Obesity Status"><meta property="og:description" content="Get C_ss Data for Fixed Obesity Status"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed Obesity Status — get_fixed_obesity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed Obesity Status — get_fixed_obesity"><meta name="description" content="Get C_ss Data for Fixed Obesity Status"><meta property="og:description" content="Get C_ss Data for Fixed Obesity Status"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Get C_ss Data for Fixed Obesity Status</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/get_fixed_obesity.R"><code>R/get_fixed_obesity.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Get <code>C_ss</code> Data for Fixed Obesity Status</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/get_fixed_obesity.R"><code>R/get_fixed_obesity.R</code></a></small>
       <div class="d-none name"><code>get_fixed_obesity.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Get C_ss Data for Fixed Obesity Status</p>
+    <p>Get <code>C_ss</code> Data for Fixed Obesity Status</p>
     </div>
 
     <div class="section level2">
@@ -50,7 +50,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-simulated-css">simulated_css<a class="anchor" aria-label="anchor" href="#arg-simulated-css"></a></dt>
-<dd><p>list of pre-generated C_ss data, for details see:
+<dd><p>list of pre-generated <code>C_ss</code> data, for details see:
 <code><a href="../articles/package_data.html">vignette("package_data", package = "GeoTox")</a></code>.</p></dd>
 
 
@@ -60,7 +60,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of matrices containing median C_ss values.</p>
+    <p>list of matrices containing median <code>C_ss</code> values.</p>
     </div>
 
     <div class="section level2">
diff --git a/reference/get_fixed_other.html b/reference/get_fixed_other.html
index ab22113..5dae8c6 100644
--- a/reference/get_fixed_other.html
+++ b/reference/get_fixed_other.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get median C_ss Values — get_fixed_other • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get median C_ss Values — get_fixed_other"><meta name="description" content="Get median C_ss Values"><meta property="og:description" content="Get median C_ss Values"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get median C_ss Values — get_fixed_other • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get median C_ss Values — get_fixed_other"><meta name="description" content="Get median C_ss Values"><meta property="og:description" content="Get median C_ss Values"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Get median C_ss Values</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/get_fixed_other.R"><code>R/get_fixed_other.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Get median <code>C_ss</code> Values</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/get_fixed_other.R"><code>R/get_fixed_other.R</code></a></small>
       <div class="d-none name"><code>get_fixed_other.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Get median C_ss Values</p>
+    <p>Get median <code>C_ss</code> Values</p>
     </div>
 
     <div class="section level2">
@@ -50,12 +50,12 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-c-ss">C_ss<a class="anchor" aria-label="anchor" href="#arg-c-ss"></a></dt>
-<dd><p>list of matrices containing C_ss data</p></dd>
+<dd><p>list of matrices containing <code>C_ss</code> data</p></dd>
 
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of atomic vectors containing median C_ss values.</p>
+    <p>list of atomic vectors containing median <code>C_ss</code> values.</p>
     </div>
 
     <div class="section level2">
diff --git a/reference/get_fixed_params.html b/reference/get_fixed_params.html
index 13cb3d8..cf94b30 100644
--- a/reference/get_fixed_params.html
+++ b/reference/get_fixed_params.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params"><meta name="description" content="Get C_ss Data for Fixed C_ss Generation Parameters"><meta property="og:description" content="Get C_ss Data for Fixed C_ss Generation Parameters"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params"><meta name="description" content="Get C_ss Data for Fixed C_ss Generation Parameters"><meta property="og:description" content="Get C_ss Data for Fixed C_ss Generation Parameters"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Get C_ss Data for Fixed C_ss Generation Parameters</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/get_fixed_params.R"><code>R/get_fixed_params.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Get <code>C_ss</code> Data for Fixed <code>C_ss</code> Generation Parameters</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/get_fixed_params.R"><code>R/get_fixed_params.R</code></a></small>
       <div class="d-none name"><code>get_fixed_params.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Get C_ss Data for Fixed C_ss Generation Parameters</p>
+    <p>Get <code>C_ss</code> Data for Fixed <code>C_ss</code> Generation Parameters</p>
     </div>
 
     <div class="section level2">
@@ -50,7 +50,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-simulated-css">simulated_css<a class="anchor" aria-label="anchor" href="#arg-simulated-css"></a></dt>
-<dd><p>list of pre-generated C_ss data, for details see:
+<dd><p>list of pre-generated <code>C_ss</code> data, for details see:
 <code><a href="../articles/package_data.html">vignette("package_data", package = "GeoTox")</a></code>.</p></dd>
 
 
@@ -60,7 +60,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of matrices containing C_ss values.</p>
+    <p>list of matrices containing <code>C_ss</code> values.</p>
     </div>
 
     <div class="section level2">
diff --git a/reference/hill_conc.html b/reference/hill_conc.html
index 9bf2645..7dab6c7 100644
--- a/reference/hill_conc.html
+++ b/reference/hill_conc.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Hill model concentration — hill_conc • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Hill model concentration — hill_conc"><meta name="description" content="Calculate the concentration in regular space for a given response value."><meta property="og:description" content="Calculate the concentration in regular space for a given response value."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Hill model concentration — hill_conc • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Hill model concentration — hill_conc"><meta name="description" content="Calculate the concentration in regular space for a given response value."><meta property="og:description" content="Calculate the concentration in regular space for a given response value."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Hill model concentration</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/hill_conc.R"><code>R/hill_conc.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/hill_conc.R"><code>R/hill_conc.R</code></a></small>
       <div class="d-none name"><code>hill_conc.Rd</code></div>
     </div>
 
@@ -54,7 +54,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dt id="arg-max">max<a class="anchor" aria-label="anchor" href="#arg-max"></a></dt>
-<dd><p>maximal (asymtotic) response</p></dd>
+<dd><p>maximal (asymptotic) response</p></dd>
 
 
 <dt id="arg-ac-">AC50<a class="anchor" aria-label="anchor" href="#arg-ac-"></a></dt>
diff --git a/reference/hill_val.html b/reference/hill_val.html
index 12b20d3..be3791c 100644
--- a/reference/hill_val.html
+++ b/reference/hill_val.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Hill model response — hill_val • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Hill model response — hill_val"><meta name="description" content="Calculate the response for a given concentration in regular space."><meta property="og:description" content="Calculate the response for a given concentration in regular space."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Hill model response — hill_val • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Hill model response — hill_val"><meta name="description" content="Calculate the response for a given concentration in regular space."><meta property="og:description" content="Calculate the response for a given concentration in regular space."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Hill model response</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/hill_val.R"><code>R/hill_val.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/hill_val.R"><code>R/hill_val.R</code></a></small>
       <div class="d-none name"><code>hill_val.Rd</code></div>
     </div>
 
@@ -54,7 +54,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dt id="arg-max">max<a class="anchor" aria-label="anchor" href="#arg-max"></a></dt>
-<dd><p>maximal (asymtotic) response</p></dd>
+<dd><p>maximal (asymptotic) response</p></dd>
 
 
 <dt id="arg-ac-">AC50<a class="anchor" aria-label="anchor" href="#arg-ac-"></a></dt>
diff --git a/reference/index.html b/reference/index.html
index 4c41f97..8257c8e 100644
--- a/reference/index.html
+++ b/reference/index.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Package index • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Package index"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Package index • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Package index"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -109,7 +109,7 @@ <h3 id="simulate">Simulate<a class="anchor" aria-label="anchor" href="#simulate"
           <code><a href="sample_Css.html">sample_Css()</a></code>
 
         </dt>
-        <dd>Sample from pre-generated C_ss data</dd>
+        <dd>Sample from pre-generated <code>C_ss</code> data</dd>
       </dl><dl><dt>
 
           <code><a href="simulate_age.html">simulate_age()</a></code>
@@ -238,31 +238,31 @@ <h3 id="auxiliary">Auxiliary<a class="anchor" aria-label="anchor" href="#auxilia
           <code><a href="get_fixed_age.html">get_fixed_age()</a></code>
 
         </dt>
-        <dd>Get C_ss Data for Fixed Age</dd>
+        <dd>Get <code>C_ss</code> Data for Fixed Age</dd>
       </dl><dl><dt>
 
           <code><a href="get_fixed_css.html">get_fixed_css()</a></code>
 
         </dt>
-        <dd>Get Fixed C_ss Data</dd>
+        <dd>Get Fixed <code>C_ss</code> Data</dd>
       </dl><dl><dt>
 
           <code><a href="get_fixed_obesity.html">get_fixed_obesity()</a></code>
 
         </dt>
-        <dd>Get C_ss Data for Fixed Obesity Status</dd>
+        <dd>Get <code>C_ss</code> Data for Fixed Obesity Status</dd>
       </dl><dl><dt>
 
           <code><a href="get_fixed_other.html">get_fixed_other()</a></code>
 
         </dt>
-        <dd>Get median C_ss Values</dd>
+        <dd>Get median <code>C_ss</code> Values</dd>
       </dl><dl><dt>
 
           <code><a href="get_fixed_params.html">get_fixed_params()</a></code>
 
         </dt>
-        <dd>Get C_ss Data for Fixed C_ss Generation Parameters</dd>
+        <dd>Get <code>C_ss</code> Data for Fixed <code>C_ss</code> Generation Parameters</dd>
       </dl></div><div class="section level2">
 
       <h3 id="datasets">Datasets<a class="anchor" aria-label="anchor" href="#datasets"></a></h3>
diff --git a/reference/plot_exposure.html b/reference/plot_exposure.html
index 5b5371d..a88ccbb 100644
--- a/reference/plot_exposure.html
+++ b/reference/plot_exposure.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot exposure data. — plot_exposure • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot exposure data. — plot_exposure"><meta name="description" content="Plot exposure data."><meta property="og:description" content="Plot exposure data."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot exposure data. — plot_exposure • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot exposure data. — plot_exposure"><meta name="description" content="Plot exposure data."><meta property="og:description" content="Plot exposure data."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Plot exposure data.</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/plot_exposure.R"><code>R/plot_exposure.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/plot_exposure.R"><code>R/plot_exposure.R</code></a></small>
       <div class="d-none name"><code>plot_exposure.Rd</code></div>
     </div>
 
diff --git a/reference/plot_hill.html b/reference/plot_hill.html
index a0df314..9e3b338 100644
--- a/reference/plot_hill.html
+++ b/reference/plot_hill.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot Hill equation fits. — plot_hill • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot Hill equation fits. — plot_hill"><meta name="description" content="Plot Hill equation fits."><meta property="og:description" content="Plot Hill equation fits."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot Hill equation fits. — plot_hill • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot Hill equation fits. — plot_hill"><meta name="description" content="Plot Hill equation fits."><meta property="og:description" content="Plot Hill equation fits."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Plot Hill equation fits.</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/plot_hill.R"><code>R/plot_hill.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/plot_hill.R"><code>R/plot_hill.R</code></a></small>
       <div class="d-none name"><code>plot_hill.Rd</code></div>
     </div>
 
diff --git a/reference/plot_resp.html b/reference/plot_resp.html
index 45aecec..a067156 100644
--- a/reference/plot_resp.html
+++ b/reference/plot_resp.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot response data — plot_resp • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot response data — plot_resp"><meta name="description" content="Plot response data"><meta property="og:description" content="Plot response data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot response data — plot_resp • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot response data — plot_resp"><meta name="description" content="Plot response data"><meta property="og:description" content="Plot response data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Plot response data</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/plot_resp.R"><code>R/plot_resp.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/plot_resp.R"><code>R/plot_resp.R</code></a></small>
       <div class="d-none name"><code>plot_resp.Rd</code></div>
     </div>
 
diff --git a/reference/plot_sensitivity.html b/reference/plot_sensitivity.html
index d701681..249b568 100644
--- a/reference/plot_sensitivity.html
+++ b/reference/plot_sensitivity.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot results of sensitivity analysis. — plot_sensitivity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot results of sensitivity analysis. — plot_sensitivity"><meta name="description" content="Plot results of sensitivity analysis."><meta property="og:description" content="Plot results of sensitivity analysis."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot results of sensitivity analysis. — plot_sensitivity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot results of sensitivity analysis. — plot_sensitivity"><meta name="description" content="Plot results of sensitivity analysis."><meta property="og:description" content="Plot results of sensitivity analysis."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Plot results of sensitivity analysis.</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/plot_sensitivity.R"><code>R/plot_sensitivity.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/plot_sensitivity.R"><code>R/plot_sensitivity.R</code></a></small>
       <div class="d-none name"><code>plot_sensitivity.Rd</code></div>
     </div>
 
diff --git a/reference/resp_quantiles.html b/reference/resp_quantiles.html
index 15b82b6..6220fc6 100644
--- a/reference/resp_quantiles.html
+++ b/reference/resp_quantiles.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get response quantiles — resp_quantiles • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get response quantiles — resp_quantiles"><meta name="description" content="Get response quantiles"><meta property="og:description" content="Get response quantiles"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Get response quantiles — resp_quantiles • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Get response quantiles — resp_quantiles"><meta name="description" content="Get response quantiles"><meta property="og:description" content="Get response quantiles"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Get response quantiles</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/resp_quantiles.R"><code>R/resp_quantiles.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/resp_quantiles.R"><code>R/resp_quantiles.R</code></a></small>
       <div class="d-none name"><code>resp_quantiles.Rd</code></div>
     </div>
 
diff --git a/reference/sample_Css.html b/reference/sample_Css.html
index 9cdbbd7..857be74 100644
--- a/reference/sample_Css.html
+++ b/reference/sample_Css.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Sample from pre-generated C_ss data — sample_Css • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Sample from pre-generated C_ss data — sample_Css"><meta name="description" content="Sample from pre-generated C_ss data"><meta property="og:description" content="Sample from pre-generated C_ss data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Sample from pre-generated C_ss data — sample_Css • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Sample from pre-generated C_ss data — sample_Css"><meta name="description" content="Sample from pre-generated C_ss data"><meta property="og:description" content="Sample from pre-generated C_ss data"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,13 +31,13 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.svg" class="logo" alt=""><h1>Sample from pre-generated C_ss data</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/sample_Css.R"><code>R/sample_Css.R</code></a></small>
+      <img src="../logo.svg" class="logo" alt=""><h1>Sample from pre-generated <code>C_ss</code> data</h1>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/sample_Css.R"><code>R/sample_Css.R</code></a></small>
       <div class="d-none name"><code>sample_Css.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Sample from pre-generated C_ss data</p>
+    <p>Sample from pre-generated <code>C_ss</code> data</p>
     </div>
 
     <div class="section level2">
@@ -50,7 +50,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
 <dl><dt id="arg-simulated-css">simulated_css<a class="anchor" aria-label="anchor" href="#arg-simulated-css"></a></dt>
-<dd><p>list of pre-generated C_ss data, for details see:
+<dd><p>list of pre-generated <code>C_ss</code> data, for details see:
 <code><a href="../articles/package_data.html">vignette("package_data", package = "GeoTox")</a></code>.</p></dd>
 
 
@@ -64,7 +64,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    <p>list of matrices containing C_ss values. Columns are sorted to have
+    <p>list of matrices containing <code>C_ss</code> values. Columns are sorted to have
 consistent order across functions.</p>
     </div>
 
diff --git a/reference/sensitivity_analysis.html b/reference/sensitivity_analysis.html
index 82f66f4..be8a94e 100644
--- a/reference/sensitivity_analysis.html
+++ b/reference/sensitivity_analysis.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Perform sensitivity analysis — sensitivity_analysis • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Perform sensitivity analysis — sensitivity_analysis"><meta name="description" content="Perform sensitivity analysis"><meta property="og:description" content="Perform sensitivity analysis"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Perform sensitivity analysis — sensitivity_analysis • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Perform sensitivity analysis — sensitivity_analysis"><meta name="description" content="Perform sensitivity analysis"><meta property="og:description" content="Perform sensitivity analysis"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Perform sensitivity analysis</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/sensitivity_analysis.R"><code>R/sensitivity_analysis.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/sensitivity_analysis.R"><code>R/sensitivity_analysis.R</code></a></small>
       <div class="d-none name"><code>sensitivity_analysis.Rd</code></div>
     </div>
 
diff --git a/reference/set_boundaries.html b/reference/set_boundaries.html
index aa3ff3b..a59371b 100644
--- a/reference/set_boundaries.html
+++ b/reference/set_boundaries.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Set GeoTox boundaries — set_boundaries • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Set GeoTox boundaries — set_boundaries"><meta name="description" content="Set GeoTox boundaries"><meta property="og:description" content="Set GeoTox boundaries"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Set GeoTox boundaries — set_boundaries • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Set GeoTox boundaries — set_boundaries"><meta name="description" content="Set GeoTox boundaries"><meta property="og:description" content="Set GeoTox boundaries"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Set GeoTox boundaries</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/set_boundaries.R"><code>R/set_boundaries.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/set_boundaries.R"><code>R/set_boundaries.R</code></a></small>
       <div class="d-none name"><code>set_boundaries.Rd</code></div>
     </div>
 
diff --git a/reference/set_hill_params.html b/reference/set_hill_params.html
index 195fcbc..ecdf510 100644
--- a/reference/set_hill_params.html
+++ b/reference/set_hill_params.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Set Hill parameters for a GeoTox object. — set_hill_params • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Set Hill parameters for a GeoTox object. — set_hill_params"><meta name="description" content="Set Hill parameters for a GeoTox object."><meta property="og:description" content="Set Hill parameters for a GeoTox object."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Set Hill parameters for a GeoTox object. — set_hill_params • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Set Hill parameters for a GeoTox object. — set_hill_params"><meta name="description" content="Set Hill parameters for a GeoTox object."><meta property="og:description" content="Set Hill parameters for a GeoTox object."><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Set Hill parameters for a GeoTox object.</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/set_hill_params.R"><code>R/set_hill_params.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/set_hill_params.R"><code>R/set_hill_params.R</code></a></small>
       <div class="d-none name"><code>set_hill_params.Rd</code></div>
     </div>
 
diff --git a/reference/simulate_age.html b/reference/simulate_age.html
index 9daeade..81c95b2 100644
--- a/reference/simulate_age.html
+++ b/reference/simulate_age.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate ages — simulate_age • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate ages — simulate_age"><meta name="description" content="Simulate ages"><meta property="og:description" content="Simulate ages"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate ages — simulate_age • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate ages — simulate_age"><meta name="description" content="Simulate ages"><meta property="og:description" content="Simulate ages"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Simulate ages</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/simulate_age.R"><code>R/simulate_age.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/simulate_age.R"><code>R/simulate_age.R</code></a></small>
       <div class="d-none name"><code>simulate_age.Rd</code></div>
     </div>
 
diff --git a/reference/simulate_exposure.html b/reference/simulate_exposure.html
index 4fa7c5e..40a1ff0 100644
--- a/reference/simulate_exposure.html
+++ b/reference/simulate_exposure.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate external exposure — simulate_exposure • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate external exposure — simulate_exposure"><meta name="description" content="Simulate external exposure"><meta property="og:description" content="Simulate external exposure"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate external exposure — simulate_exposure • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate external exposure — simulate_exposure"><meta name="description" content="Simulate external exposure"><meta property="og:description" content="Simulate external exposure"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Simulate external exposure</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/simulate_exposure.R"><code>R/simulate_exposure.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/simulate_exposure.R"><code>R/simulate_exposure.R</code></a></small>
       <div class="d-none name"><code>simulate_exposure.Rd</code></div>
     </div>
 
diff --git a/reference/simulate_inhalation_rate.html b/reference/simulate_inhalation_rate.html
index a3d70e9..2b28a6f 100644
--- a/reference/simulate_inhalation_rate.html
+++ b/reference/simulate_inhalation_rate.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate inhalation rates — simulate_inhalation_rate • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate inhalation rates — simulate_inhalation_rate"><meta name="description" content="Simulate inhalation rates"><meta property="og:description" content="Simulate inhalation rates"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate inhalation rates — simulate_inhalation_rate • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate inhalation rates — simulate_inhalation_rate"><meta name="description" content="Simulate inhalation rates"><meta property="og:description" content="Simulate inhalation rates"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Simulate inhalation rates</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/simulate_inhalation_rate.R"><code>R/simulate_inhalation_rate.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/simulate_inhalation_rate.R"><code>R/simulate_inhalation_rate.R</code></a></small>
       <div class="d-none name"><code>simulate_inhalation_rate.Rd</code></div>
     </div>
 
diff --git a/reference/simulate_obesity.html b/reference/simulate_obesity.html
index 881cd9f..dacbb35 100644
--- a/reference/simulate_obesity.html
+++ b/reference/simulate_obesity.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate obesity status — simulate_obesity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate obesity status — simulate_obesity"><meta name="description" content="Simulate obesity status"><meta property="og:description" content="Simulate obesity status"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate obesity status — simulate_obesity • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate obesity status — simulate_obesity"><meta name="description" content="Simulate obesity status"><meta property="og:description" content="Simulate obesity status"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Simulate obesity status</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/simulate_obesity.R"><code>R/simulate_obesity.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/simulate_obesity.R"><code>R/simulate_obesity.R</code></a></small>
       <div class="d-none name"><code>simulate_obesity.Rd</code></div>
     </div>
 
diff --git a/reference/simulate_population.html b/reference/simulate_population.html
index 509cdc7..c6edccf 100644
--- a/reference/simulate_population.html
+++ b/reference/simulate_population.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate population data — simulate_population • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate population data — simulate_population"><meta name="description" content="Simulate population data for given input fields"><meta property="og:description" content="Simulate population data for given input fields"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Simulate population data — simulate_population • GeoTox</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.5.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.5.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><script src="../deps/MathJax-3.2.2/tex-chtml.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Simulate population data — simulate_population"><meta name="description" content="Simulate population data for given input fields"><meta property="og:description" content="Simulate population data for given input fields"><meta property="og:image" content="https://github.com/NIEHS/GeoTox/logo.svg"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
 
 
@@ -7,7 +7,7 @@
 
     <a class="navbar-brand me-2" href="../index.html">GeoTox</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.4</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.2.0</small>
 
 
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -32,7 +32,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.svg" class="logo" alt=""><h1>Simulate population data</h1>
-      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/main/R/simulate_population.R"><code>R/simulate_population.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/NIEHS/GeoTox/blob/v0.2.0/R/simulate_population.R"><code>R/simulate_population.R</code></a></small>
       <div class="d-none name"><code>simulate_population.Rd</code></div>
     </div>
 
diff --git a/search.json b/search.json
index 09ba06b..8a71f2f 100644
--- a/search.json
+++ b/search.json
@@ -1 +1 @@
-[{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"members, contributors, leaders pledge make participation community harassment-free experience everyone, regardless age, body size, visible invisible disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, caste, color, religion, sexual identity orientation. pledge act interact ways contribute open, welcoming, diverse, inclusive, healthy community.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes positive environment community include: Demonstrating empathy kindness toward people respectful differing opinions, viewpoints, experiences Giving gracefully accepting constructive feedback Accepting responsibility apologizing affected mistakes, learning experience Focusing best just us individuals, overall community Examples unacceptable behavior include: use sexualized language imagery, sexual attention advances kind Trolling, insulting derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical email address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement-responsibilities","dir":"","previous_headings":"","what":"Enforcement Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Community leaders responsible clarifying enforcing standards acceptable behavior take appropriate fair corrective action response behavior deem inappropriate, threatening, offensive, harmful. Community leaders right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, communicate reasons moderation decisions appropriate.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within community spaces, also applies individual officially representing community public spaces. Examples representing community include using official e-mail address, posting via official social media account, acting appointed representative online offline event.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported community leaders responsible enforcement kyle.messier@nih.gov. complaints reviewed investigated promptly fairly. community leaders obligated respect privacy security reporter incident.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement-guidelines","dir":"","previous_headings":"","what":"Enforcement Guidelines","title":"Contributor Covenant Code of Conduct","text":"Community leaders follow Community Impact Guidelines determining consequences action deem violation Code Conduct:","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_1-correction","dir":"","previous_headings":"Enforcement Guidelines","what":"1. Correction","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Use inappropriate language behavior deemed unprofessional unwelcome community. Consequence: private, written warning community leaders, providing clarity around nature violation explanation behavior inappropriate. public apology may requested.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_2-warning","dir":"","previous_headings":"Enforcement Guidelines","what":"2. Warning","title":"Contributor Covenant Code of Conduct","text":"Community Impact: violation single incident series actions. Consequence: warning consequences continued behavior. interaction people involved, including unsolicited interaction enforcing Code Conduct, specified period time. includes avoiding interactions community spaces well external channels like social media. Violating terms may lead temporary permanent ban.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_3-temporary-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"3. Temporary Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: serious violation community standards, including sustained inappropriate behavior. Consequence: temporary ban sort interaction public communication community specified period time. public private interaction people involved, including unsolicited interaction enforcing Code Conduct, allowed period. Violating terms may lead permanent ban.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_4-permanent-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"4. Permanent Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Demonstrating pattern violation community standards, including sustained inappropriate behavior, harassment individual, aggression toward disparagement classes individuals. Consequence: permanent ban sort public interaction within community.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 2.1, available https://www.contributor-covenant.org/version/2/1/code_of_conduct.html. Community Impact Guidelines inspired [Mozilla’s code conduct enforcement ladder][https://github.com/mozilla/inclusion]. answers common questions code conduct, see FAQ https://www.contributor-covenant.org/faq. Translations available https://www.contributor-covenant.org/translations.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to GeoTox","title":"Contributing to GeoTox","text":"outlines (1) propose change GeoTox (2) serves log potential enhancements GeoTox.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"best-practices","dir":"","previous_headings":"","what":"Best Practices","title":"Contributing to GeoTox","text":"’ve found bug, please file issue illustrates bug minimal reprex (also help write unit test, needed). See tidyverse team’s guide create great issue advice. adding new function package, always add working examples new function roxygen2 documentation #' @examples.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"pull-request-process","dir":"","previous_headings":"Best Practices","what":"Pull request process","title":"Contributing to GeoTox","text":"Fork package clone onto computer. haven’t done , recommend using usethis::create_from_github(\"NIEHS/GeoTox\", fork = TRUE). Install development dependencies devtools::install_dev_deps(), make sure package passes R CMD check running devtools::check(). R CMD check doesn’t pass cleanly, ’s good idea ask help continuing. Create Git branch pull request (PR). recommend using usethis::pr_init(\"brief-description--change\"). Make changes, commit git, create PR running usethis::pr_push(), following prompts browser. title PR briefly describe change. body PR contain Fixes #issue-number. user-facing changes, add bullet top NEWS.md (.e. just first header).","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"code-style","dir":"","previous_headings":"Best Practices","what":"Code style","title":"Contributing to GeoTox","text":"Please abide 80-character line rules (default settings lintr) use roxygen2, Markdown syntax, documentation. use testthat unit tests. Contributions test cases included easier accept.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"fixing-typos","dir":"","previous_headings":"","what":"Fixing typos","title":"Contributing to GeoTox","text":"can fix typos, spelling mistakes, grammatical errors documentation directly using GitHub web interface, long changes made source file. generally means ’ll need edit roxygen2 comments .R, .Rd file. can find .R file generates .Rd reading comment first line.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"geotox-open-issues-and-enhancements","dir":"","previous_headings":"","what":"GeoTox Open Issues and Enhancements","title":"Contributing to GeoTox","text":"section serves log potential enhancements GeoTox. Community members welcomed encouraged use contributing guide address open issues enhancements package. Additionally, new enhancements can proposed using enhancements template request. want address open enchancement suggest new one, ’s good idea first file issue make sure someone team agrees ’s needed.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"scientific","dir":"","previous_headings":"GeoTox Open Issues and Enhancements","what":"Scientific","title":"Contributing to GeoTox","text":"Non-steady state toxicokinetics. likely require additional usage httk package. Complete integration multiple end-point analysis GeoTox objects Integration Reflected Generalized Concentration Addition (RGCA), allow 3+ parameter hill models used additive mixture predictions. Benchmark Dose modeling (BMD) metric risk assessment. Suggested ingetrations include BMDexpress2.0 transcryptR - note transcryptR also currently ","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"computational","dir":"","previous_headings":"GeoTox Open Issues and Enhancements","what":"Computational","title":"Contributing to GeoTox","text":"targets pipeline template. provide make-like targets pipeline, new users reproducible template run analysis ease.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Contributing to GeoTox","text":"Please note chopin project released Contributor Code Conduct. contributing project agree abide terms.","code":""},{"path":"https://github.com/NIEHS/GeoTox/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"MIT License","title":"MIT License","text":"Copyright (c) 2024 GeoTox authors Permission hereby granted, free charge, person obtaining copy software associated documentation files (“Software”), deal Software without restriction, including without limitation rights use, copy, modify, merge, publish, distribute, sublicense, /sell copies Software, permit persons Software furnished , subject following conditions: copyright notice permission notice shall included copies substantial portions Software. SOFTWARE PROVIDED “”, WITHOUT WARRANTY KIND, EXPRESS IMPLIED, INCLUDING LIMITED WARRANTIES MERCHANTABILITY, FITNESS PARTICULAR PURPOSE NONINFRINGEMENT. EVENT SHALL AUTHORS COPYRIGHT HOLDERS LIABLE CLAIM, DAMAGES LIABILITY, WHETHER ACTION CONTRACT, TORT OTHERWISE, ARISING , CONNECTION SOFTWARE USE DEALINGS SOFTWARE.","code":""},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"analysis-of-single-assay","dir":"Articles","previous_headings":"","what":"Analysis of single assay","title":"GeoTox Introduction","text":"Create GeoTox object, run simulations computations Plot outputs","code":"set.seed(2357) geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS),                       obesity       = geo_tox_data$obesity,                       exposure      = split(geo_tox_data$exposure, ~FIPS),                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") |>                     fit_hill(chem = \"casn\") |>                      filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  geoTox #> GeoTox object #> Assays: 1 #> Chemicals: 5 #> Regions: 100 #> Population: 250 #> Data Fields: #>      Name            Class               Dim #>       age    list(integer)       100 x (250) #>        IR    list(numeric)       100 x (250) #>   obesity  list(character)       100 x (250) #>     C_ext     list(matrix)  100 x (250 x 21) #>      C_ss     list(matrix)  100 x (250 x 21) #> Computed Fields: #>          Name             Class               Dim #>         D_int      list(matrix)  100 x (250 x 21) #>     C_invitro      list(matrix)  100 x (250 x 21) #>          resp  list(data.frame)   100 x (250 x 5) #>   sensitivity        list(list)         5 x (100) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params plot(geoTox) plot(geoTox, type = \"hill\") plot(geoTox, type = \"sensitivity\") #> Picking joint bandwidth of 0.139"},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"analysis-of-multiple-assay","dir":"Articles","previous_headings":"","what":"Analysis of multiple assay","title":"GeoTox Introduction","text":"Create GeoTox object, run simulations computations Plot outputs","code":"set.seed(2357) geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS),                       obesity       = geo_tox_data$obesity,                       exposure      = split(geo_tox_data$exposure, ~FIPS),                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                      filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  geoTox #> GeoTox object #> Assays: 13 #> Chemicals: 20 #> Regions: 100 #> Population: 250 #> Data Fields: #>      Name            Class               Dim #>       age    list(integer)       100 x (250) #>        IR    list(numeric)       100 x (250) #>   obesity  list(character)       100 x (250) #>     C_ext     list(matrix)  100 x (250 x 21) #>      C_ss     list(matrix)  100 x (250 x 21) #> Computed Fields: #>          Name             Class               Dim #>         D_int      list(matrix)  100 x (250 x 21) #>     C_invitro      list(matrix)  100 x (250 x 21) #>          resp  list(data.frame)  100 x (3250 x 6) #>   sensitivity        list(list)         5 x (100) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params plot(geoTox) #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' plot(geoTox, assays = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") plot(geoTox, type = \"hill\") plot(geoTox, type = \"sensitivity\") #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' #> Warning: Removed 93000 NA values #> Picking joint bandwidth of 0.133 plot(geoTox, type = \"sensitivity\", assay = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") #> Picking joint bandwidth of 0.139"},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"exposure-map","dir":"Articles","previous_headings":"","what":"Exposure Map","title":"GeoTox Introduction","text":"exposure map single multiple assay analyses. map shows distribution chemical exposure across regions chemicals, just used particular analysis.  facet labels present can specified using chem_label argument.","code":"plot(geoTox, type = \"exposure\", ncol = 5) plot(geoTox, type = \"exposure\", chem_label = \"chnm\", ncol = 5)"},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"exposure-data","dir":"Articles","previous_headings":"Chemical data","what":"Exposure data","title":"GeoTox Package Data","text":"Download modeled exposure data AirToxScreen. Results AirToxScreen 2019 subset chemicals North Carolina counties included package data geo_tox_data$exposure. NOTE: 2020 release currently provide single file exposure national concentration summaries. 2019 data can found following “Previous air toxics assessments” link.","code":"filename <- \"2019_Toxics_Exposure_Concentrations.xlsx\" tmp <- tempfile(filename) download.file(   paste0(\"https://www.epa.gov/system/files/documents/2022-12/\", filename),   tmp ) exposure <- read_xlsx(tmp)  # Normalization function min_max_norm = function(x) {   min_x <- min(x, na.rm = TRUE)   max_x <- max(x, na.rm = TRUE)   if (min_x == max_x) {     rep(0, length(x))   } else {     (x - min_x) / (max_x - min_x)   } }  geo_tox_data$exposure <- exposure |>    # North Carolina counties   filter(State == \"NC\", !grepl(\"0$\", FIPS)) |>    # Aggregate chemicals by county   summarize(across(-c(State:Tract), c(mean, sd)), .by = FIPS) |>    pivot_longer(-FIPS, names_to = \"chemical\") |>    mutate(stat = if_else(grepl(\"_1$\", chemical), \"mean\", \"sd\"),          chemical = gsub('.{2}$', '', chemical)) |>    pivot_wider(names_from = stat) |>    # Normalize concentrations   mutate(norm = min_max_norm(mean), .by = chemical)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"get-casrn-and-preferred_name-from-comptox-dashboard","dir":"Articles","previous_headings":"Chemical data > Exposure data","what":"Get CASRN and PREFERRED_NAME from CompTox Dashboard","title":"GeoTox Package Data","text":"","code":"# Copy/paste the chemical names into the batch search field # https://comptox.epa.gov/dashboard/batch-search cat(geo_tox_data$exposure |> distinct(chemical) |> pull(), sep = \"\\n\") # Export results with \"CAS-RN\" identifiers as a csv file, then process in R  exposure_casrn <- read_csv(\"CCD-Batch-Search.csv\",                            show_col_types = FALSE) |>    filter(DTXSID != \"N/A\") |>    # Prioritize results based on FOUND_BY status   arrange(INPUT,           grepl(\"Approved Name\", FOUND_BY),           grepl(\"^Synonym\", FOUND_BY)) |>    # Keep one result per INPUT   group_by(INPUT) |>    slice(1) |>    ungroup()  # Update exposure data with CompTox Dashboard data geo_tox_data$exposure <- geo_tox_data$exposure |>    inner_join(exposure_casrn, by = join_by(chemical == INPUT)) |>    select(FIPS, casn = CASRN, chnm = PREFERRED_NAME, mean, sd, norm)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"ice-chts-data","dir":"Articles","previous_headings":"Chemical data","what":"ICE cHTS data","title":"GeoTox Package Data","text":"Use ICE cHTS data identify active chemicals given set assays.","code":"get_cHTS_hits <- function(assays = NULL, chemids = NULL) {      if (is.null(assays) & is.null(chemids)) {     stop(\"Must provide at least one of 'assays' or 'chemids'\")   }      # Format query parameters   req_params <- list()      if (!is.null(assays)) {     if (!is.list(assays)) assays <- as.list(assays)     req_params$assays <- assays   }      if (!is.null(chemids)) {     if (!is.list(chemids)) chemids <- as.list(chemids)     req_params$chemids <- chemids   }      # Query ICE API   resp <- request(\"https://ice.ntp.niehs.nih.gov/api/v1/search\") |>      req_body_json(req_params) |>      req_perform()      if (resp$status_code != 200) {     stop(\"Failed to retrieve data from ICE API\")   }      # Return active chemicals   result <- resp |> resp_body_json() |> pluck(\"endPoints\")      fields <- c(\"assay\", \"casrn\", \"dtxsid\", \"substanceName\",               \"endpoint\", \"value\")      map(fields, \\(x) map_chr(result, x)) |>      set_names(fields) |>     bind_cols() |>      filter(endpoint == \"Call\", value == \"Active\") |>      select(-c(endpoint, value)) |>      distinct() }  assays <- c(\"APR_HepG2_p53Act_1h_dn\",             \"APR_HepG2_p53Act_1h_up\",             \"APR_HepG2_p53Act_24h_dn\",             \"APR_HepG2_p53Act_24h_up\",             \"APR_HepG2_p53Act_72h_dn\",             \"APR_HepG2_p53Act_72h_up\",             \"ATG_p53_CIS_up\",             \"TOX21_DT40\",             \"TOX21_DT40_100\",             \"TOX21_DT40_657\",             \"TOX21_ELG1_LUC_Agonist\",             \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",             \"TOX21_p53_BLA_p1_ratio\",             \"TOX21_p53_BLA_p2_ratio\",             \"TOX21_p53_BLA_p3_ratio\",             \"TOX21_p53_BLA_p4_ratio\",             \"TOX21_p53_BLA_p5_ratio\")  chemids <- unique(geo_tox_data$exposure$casn)    cHTS_hits_API <- get_cHTS_hits(assays = assays, chemids = chemids)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"dose-response-data","dir":"Articles","previous_headings":"Chemical data","what":"Dose-response data","title":"GeoTox Package Data","text":"Use ICE API retrieve dose-response data selected assays chemicals.","code":"get_ICE_dose_resp <- function(assays = NULL, chemids = NULL) {      if (is.null(assays) & is.null(chemids)) {     stop(\"Must provide at least one of 'assays' or 'chemids'\")   }      # Format query parameters   req_params <- list()      if (!is.null(assays)) {     if (!is.list(assays)) assays <- as.list(assays)     req_params$assays <- assays   }      if (!is.null(chemids)) {     if (!is.list(chemids)) chemids <- as.list(chemids)     req_params$chemids <- chemids   }      # Query ICE API   resp <- request(\"https://ice.ntp.niehs.nih.gov/api/v1/curves\") |>      req_body_json(req_params) |>      req_perform()      if (resp$status_code != 200) {     stop(\"Failed to retrieve data from ICE API\")   }      # Return dose-response data   result <- resp |> resp_body_json() |> pluck(\"curves\")      map(result, function(x) {     tibble(       endp = x[[\"assay\"]],       casn = x[[\"casrn\"]],       call = x[[\"dsstoxsid\"]],       chnm = x[[\"substance\"]],       call = x[[\"call\"]],       logc = map_dbl(x[[\"concentrationResponses\"]], \"concentration\") |> log10(),       resp = map_dbl(x[[\"concentrationResponses\"]], \"response\")     )   }) |>      bind_rows() }  assays <- unique(cHTS_hits_API$assay)  chemids <- intersect(cHTS_hits_API$casrn, geo_tox_data$exposure$casn)  dose_response <- get_ICE_dose_resp(assays = assays, chemids = chemids)  # Only keep active calls for assay/chemical combinations geo_tox_data$dose_response <- dose_response |>    filter(call == \"Active\") |>    select(-call)  # Update dose-response data with CompTox Dashboard data geo_tox_data$dose_response <- geo_tox_data$dose_response |>   inner_join(exposure_casrn, by = join_by(casn == CASRN)) |>   select(endp, casn, chnm = PREFERRED_NAME, logc, resp)"},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"age","dir":"Articles","previous_headings":"Population data","what":"Age","title":"GeoTox Package Data","text":"Download age data U.S. Census Bureau searching “County Population Characteristics”. subset data North Carolina 2019 included package data geo_tox_data$age.","code":"# Data for North Carolina url <- paste0(\"https://www2.census.gov/programs-surveys/popest/datasets/\",               \"2010-2019/counties/asrh/cc-est2019-alldata-37.csv\") age <- read_csv(url, show_col_types = FALSE)  geo_tox_data$age <- age |>   # 7/1/2019 population estimate   filter(YEAR == 12) |>   # Create FIPS   mutate(FIPS = str_c(STATE, COUNTY)) |>   # Keep selected columns   select(FIPS, AGEGRP, TOT_POP)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"obesity","dir":"Articles","previous_headings":"Population data","what":"Obesity","title":"GeoTox Package Data","text":"Follow “Data Portal” link CDC PLACES search “places county data”. Go desired dataset webpage, example 2020 county data, download data selecting Actions → API → Download file. subset data North Carolina included package data geo_tox_data$obesity.","code":"places <- read_csv(\"PLACES__County_Data__GIS_Friendly_Format___2020_release.csv\",                    show_col_types = FALSE)  # Convert confidence interval to standard deviation extract_SD <- function(x) {   range <- as.numeric(str_split_1(str_sub(x, 2, -2), \",\"))   diff(range) / 3.92 }  geo_tox_data$obesity <- places |>   # North Carolina Counties   filter(StateAbbr == \"NC\") |>   # Select obesity data   select(FIPS = CountyFIPS, OBESITY_CrudePrev, OBESITY_Crude95CI) |>   # Change confidence interval to standard deviation   rowwise() |>   mutate(OBESITY_SD = extract_SD(OBESITY_Crude95CI)) |>   ungroup() |>   select(-OBESITY_Crude95CI)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"steady-state-plasma-concentration-css","dir":"Articles","previous_headings":"Population data","what":"Steady-state plasma concentration (Css)","title":"GeoTox Package Data","text":"Use httk generate Css values combinations age group weight status chemical. generation values time-intensive step, one approach generate populations Css values initially sample later.","code":"set.seed(2345) n_samples <- 500  # Get CASN for which httk simulation is possible. Try using load_dawson2021, # load_sipes2017, or load_pradeep2020 to increase availability. load_sipes2017() casn <- intersect(unique(geo_tox_data$dose_response$casn),                   get_cheminfo(suppress.messages = TRUE))  # Define population demographics for httk simulation pop_demo <- cross_join(   tibble(age_group = list(c(0, 2), c(3, 5), c(6, 10), c(11, 15),                           c(16, 20), c(21, 30), c(31, 40), c(41, 50),                           c(51, 60), c(61, 70), c(71, 100))),   tibble(weight = c(\"Normal\", \"Obese\"))) |>   # Create column of lower age_group values   rowwise() |>   mutate(age_min = age_group[1]) |>   ungroup()  # Create wrapper function around httk steps simulate_css <- function(chem.cas, agelim_years, weight_category,                          samples, verbose = TRUE) {      if (verbose) {     cat(chem.cas,         paste0(\"(\", paste(agelim_years, collapse = \", \"), \")\"),         weight_category,         \"\\n\")   }      httkpop <- list(method = \"vi\",                   gendernum = NULL,                   agelim_years = agelim_years,                   agelim_months = NULL,                   weight_category = weight_category,                   reths = c(                     \"Mexican American\",                     \"Other Hispanic\",                     \"Non-Hispanic White\",                     \"Non-Hispanic Black\",                     \"Other\"                   ))      css <- try(     suppressWarnings({       mcs <- create_mc_samples(chem.cas = chem.cas,                                samples = samples,                                httkpop.generate.arg.list = httkpop,                                suppress.messages = TRUE)              calc_analytic_css(chem.cas = chem.cas,                         parameters = mcs,                         model = \"3compartmentss\",                         suppress.messages = TRUE)     }),     silent = TRUE   )      # Return   if (is(css, \"try-error\")) {     warning(paste0(\"simulate_css failed to generate data for CASN \", chem.cas))     list(NA)   } else {     list(css)   } }  # Simulate Css values simulated_css <- map(casn, function(chem.cas) {   pop_demo |>     rowwise() |>     mutate(       css = simulate_css(.env$chem.cas, age_group, weight, .env$n_samples)     ) |>     ungroup() }) simulated_css <- setNames(simulated_css, casn)  # Remove CASN that failed simulate_css casn_keep <- map_lgl(simulated_css, function(df) {   !(length(df$css[[1]]) == 1 && is.na(df$css[[1]])) }) simulated_css <- simulated_css[casn_keep]  # Get median Css values for each age_group simulated_css <- map(   simulated_css,   function(cas_df) {     cas_df |>       nest(.by = age_group) |>       mutate(         age_median_css = map_dbl(data, function(df) median(unlist(df$css),                                                            na.rm = TRUE))       ) |>       unnest(data)   } )  # Get median Css values for each weight simulated_css <- map(   simulated_css,   function(cas_df) {     cas_df |>       nest(.by = weight) |>       mutate(         weight_median_css = map_dbl(data, function(df) median(unlist(df$css),                                                               na.rm = TRUE))       ) |>       unnest(data) |>       arrange(age_min, weight)   } )  geo_tox_data$simulated_css <- simulated_css"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"prune-data","dir":"Articles","previous_headings":"","what":"Prune data","title":"GeoTox Package Data","text":"Retain chemicals found exposure, dose-response Css datasets.","code":"casn_keep <- names(geo_tox_data$simulated_css)  geo_tox_data$exposure <- geo_tox_data$exposure |>    filter(casn %in% casn_keep)  geo_tox_data$dose_response <- geo_tox_data$dose_response |>    filter(casn %in% casn_keep)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"countystate-boundaries","dir":"Articles","previous_headings":"","what":"County/State boundaries","title":"GeoTox Package Data","text":"Download cartographic boundary files counties states U.S. Census Bureau. geometry data North Carolina counties state included package data geo_tox_data$boundaries.","code":"county <- st_read(\"cb_2019_us_county_5m/cb_2019_us_county_5m.shp\") state <- st_read(\"cb_2019_us_state_5m/cb_2019_us_state_5m.shp\")  geo_tox_data$boundaries <- list(   county = county |>     filter(STATEFP == 37) |>     select(FIPS = GEOID, geometry),   state = state |>     filter(STATEFP == 37) |>     select(geometry) )"},{"path":"https://github.com/NIEHS/GeoTox/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Skylar Marvel. Author, contributor. David Reif. Author, contributor. Kyle Messier. Maintainer, author, contributor. Spatiotemporal Exposures Toxicology Group. Copyright holder.","code":""},{"path":"https://github.com/NIEHS/GeoTox/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Messier, P K, Reif, M D, Marvel, W S (2024). “GeoTox Package: Open-source software connecting spatiotemporal exposure individual population-level risk.” medRxiv. doi:10.1101/2024.09.23.24314096, https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1.full.pdf, https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1. Eccles, M K, Karmaus, L , Kleinstreuer, C N, Parham, Fred, Rider, V C, Wambaugh, F J, Messier, P K (2023). “geospatial modeling approach quantifying risk exposure environmental chemical mixtures via common molecular target.” Science Total Environment, 855, 158905.","code":"@Article{,   author = {{Messier} and Kyle P and {Reif} and David M and {Marvel} and Skylar W},   title = {The GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk},   journal = {medRxiv},   year = {2024},   doi = {10.1101/2024.09.23.24314096},   elocationid = {2024.09.23.24314096},   url = {https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1},   eprint = {https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1.full.pdf}, } @Article{,   author = {{Eccles} and Kristin M and {Karmaus} and Agnes L and {Kleinstreuer} and Nicole C and {Parham} and {Fred} and {Rider} and Cynthia V and {Wambaugh} and John F and {Messier} and Kyle P},   title = {A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target},   journal = {Science of The Total Environment},   volume = {855},   pages = {158905},   year = {2023},   publisher = {Elsevier}, }"},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"geotox-","dir":"","previous_headings":"","what":"Spatiotemporal Mixture Risk Assessment","title":"Spatiotemporal Mixture Risk Assessment","text":"GeoTox open-source R software package characterizing risk perturbing molecular targets involved adverse human health outcomes based exposure spatially-referenced stressor mixtures via GeoTox framework - otherwise known source--outcome-continuum modeling. package, methods, case-studies described Messier, Reif, Marvel, 2024, medRxiv-Preprint. GeoTox framework first described Eccles et al. geospatial modeling approach quantifying risk exposure environmental chemical mixtures via common molecular target. Sci Total Environ. 2023 Jan 10;855:158905.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Spatiotemporal Mixture Risk Assessment","text":"package CRAN near future - please stay tuned.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"development-version","dir":"","previous_headings":"","what":"Development Version","title":"Spatiotemporal Mixture Risk Assessment","text":"development version can installed GitHub :","code":"#install.packages(\"pak\") pak::pak(\"NIEHS/GeoTox\")"},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Spatiotemporal Mixture Risk Assessment","text":"Figure 1 shows steps source--outcome-continuum GeoTox modelling framework capable GeoTox package. blue text nodes represent object green text, rounded nodes represent methodology function required go one next. GeoTox package uses R S3 object-oriented programming create GeoTox object. GeoTox object list contains information required run analysis including tracking exposure, assays, dose-response, geospatial referencing. Figure 1: Overview steps GeoTox framework","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"getting-started","dir":"","previous_headings":"","what":"Getting Started","title":"Spatiotemporal Mixture Risk Assessment","text":"Please refer introduction vignette detailed description use GeoTox.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Spatiotemporal Mixture Risk Assessment","text":"citation information, please refer CITATION file.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"issues-and-contributions","dir":"","previous_headings":"","what":"Issues and Contributions","title":"Spatiotemporal Mixture Risk Assessment","text":"add edit functionality, open pull request main branch detailed description proposed changes. Pull requests must pass status checks, approved rejected GeoTox maintainers. Utilize GitHub issues notify authors bugs, questions, recommendations. Identify issue appropriate label help ensure timely response.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox-package.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","title":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","text":"Connecting spatiotemporal exposure individual population-level risk via source--outcome continuum modeling. package, methods, case-studies described Messier, Reif, Marvel (2024) doi:10.1101/2024.09.23.24314096  Eccles et al. (2023) doi:10.1016/j.scitotenv.2022.158905 .","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","text":"Maintainer: Kyle Messier kyle.messier@nih.gov (ORCID) [contributor] Authors: Skylar Marvel skylar.marvel@nih.gov (ORCID) [contributor] David Reif david.reif@nih.gov (ORCID) [contributor] contributors: Spatiotemporal Exposures Toxicology Group [copyright holder]","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox S3 object — GeoTox","title":"GeoTox S3 object — GeoTox","text":"S3 object can used help organize data results GeoTox analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"GeoTox S3 object — GeoTox","text":"","code":"GeoTox()  # S3 method for class 'GeoTox' plot(x, type = c(\"resp\", \"hill\", \"exposure\", \"sensitivity\"), ...)"},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"GeoTox S3 object — GeoTox","text":"x GeoTox object. type type plot. ... arguments passed subsequent methods.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"GeoTox S3 object — GeoTox","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS)[idx],                       obesity       = geo_tox_data$obesity[idx, ],                       exposure      = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                      dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  # Print GeoTox object geoTox #> GeoTox object #> Assays: 13 #> Chemicals: 20 #> Regions: 5 #> Population: 10 #> Data Fields: #>      Name            Class            Dim #>       age    list(integer)       5 x (10) #>        IR    list(numeric)       5 x (10) #>   obesity  list(character)       5 x (10) #>     C_ext     list(matrix)  5 x (10 x 21) #>      C_ss     list(matrix)  5 x (10 x 21) #> Computed Fields: #>          Name             Class            Dim #>         D_int      list(matrix)  5 x (10 x 21) #>     C_invitro      list(matrix)  5 x (10 x 21) #>          resp  list(data.frame)  5 x (130 x 6) #>   sensitivity        list(list)        5 x (5) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params  # Plot hill fits plot(geoTox, type = \"hill\")  # Plot exposure data plot(geoTox, type = \"exposure\", ncol = 5)  # Plot response data plot(geoTox) #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up'  plot(geoTox, assays = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\")  # Plot sensitivity data plot(geoTox, type = \"sensitivity\") #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' #> Warning: Removed 240 NA values #> Picking joint bandwidth of 0.204  plot(geoTox, type = \"sensitivity\", assay = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") #> Picking joint bandwidth of 0.489"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"Calculate combined response multiple chemicals. calculates generalized concentration addition response, independent action response, hazard quotient","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"","code":"calc_concentration_response(   C_invitro,   hill_params,   max_mult = 1.5,   fixed = FALSE )"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"C_invitro vitro concentrations hill_params output fit_hill() max_mult upper bound multiplier max response fixed TRUE, sd = 0","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"list data frames","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"","code":"C_invitro <- list(   matrix(1:8 / 1e3, ncol = 2, dimnames = list(NULL, c(\"c1\", \"c2\"))),   matrix(9:16 / 1e3, ncol = 2, dimnames = list(NULL, c(\"c1\", \"c2\"))) ) hill_params <- fit_hill(   data.frame(chem = rep(c(\"c1\", \"c2\"), each = 3),              logc = c(-1, 0, 1, 0, 1, 2),              resp = c(10, 5, 0, 4, 2, 0) / 10),   chem = \"chem\" )  calc_concentration_response(C_invitro, hill_params) #> [[1]] #>   sample      GCA.Eff       IA.Eff  GCA.HQ.10   IA.HQ.10 #> 1      1 0.0076864671 0.0077364934 0.55601871 0.55600659 #> 2      2 0.0006767173 0.0006770262 0.01534725 0.01534744 #> 3      3 0.0722956637 0.0741979092 1.45744108 1.45745710 #> 4      4 0.0273376842 0.0274220130 0.39699362 0.39699367 #>  #> [[2]] #>   sample    GCA.Eff     IA.Eff GCA.HQ.10  IA.HQ.10 #> 1      1 0.18688743 0.18693404 3.7723954 3.7724269 #> 2      2 0.01226720 0.01227572 0.3474801 0.3474778 #> 3      3 0.01883785 0.01894890 1.7068482 1.7068523 #> 4      4 0.12791787 0.12799417 2.2230433 2.2230437 #>  calc_concentration_response(C_invitro, hill_params, fixed = TRUE) #> [[1]] #>   sample   GCA.Eff    IA.Eff GCA.HQ.10 IA.HQ.10 #> 1      1 0.2393398 0.2742427  13.49985     13.5 #> 2      2 0.3102525 0.3493325  23.39997     23.4 #> 3      3 0.3479706 0.3866123  33.29939     33.3 #> 4      4 0.3713827 0.4087487  43.19904     43.2 #>  #> [[2]] #>   sample   GCA.Eff    IA.Eff GCA.HQ.10 IA.HQ.10 #> 1      1 0.4200784 0.4517192  92.70122     92.7 #> 2      2 0.4246337 0.4554551 102.60133    102.6 #> 3      3 0.4284513 0.4585306 112.50143    112.5 #> 4      4 0.4316926 0.4611019 122.40154    122.4 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":null,"dir":"Reference","previous_headings":"","what":"Independent Action — calc_independent_action","title":"Independent Action — calc_independent_action","text":"Calculate independent action response set chemicals Hill concentration-response curves.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Independent Action — calc_independent_action","text":"","code":"calc_independent_action(conc, max, AC50, Emax, n = 1)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Independent Action — calc_independent_action","text":"conc concentrations regular space max maximal (asymtotic) responses AC50 concentrations half-maximal response Emax maximum mixture response n Hill coefficients (slopes)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Independent Action — calc_independent_action","text":"response value","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Independent Action — calc_independent_action","text":"concentration computed : $$   IA = E_{max} \\times   \\left(     1 - \\prod\\limits_{} \\left(1 - \\frac{x_i}{E_{max}}\\right)   \\right), $$ \\(x_i = hill\\_val(conc_i, max_i, AC50_i, n_i)\\) Hill model response function chemical.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Independent Action — calc_independent_action","text":"","code":"n_chem <- 5 conc <- 10^sample(-1:4, n_chem, replace = TRUE) max <- 80 * runif(n_chem) AC50 <- 10^(5 * runif(n_chem) - 1) Emax <- 100  calc_independent_action(conc, max, AC50, Emax) #> [1] 79.86892"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate internal chemical dose — calc_internal_dose","title":"Calculate internal chemical dose — calc_internal_dose","text":"Estimate internal dose inhalation chemical given inhalation rate, time, body weight","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate internal chemical dose — calc_internal_dose","text":"","code":"calc_internal_dose(C_ext, IR, time = 1, BW = 1, scaling = 1)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate internal chemical dose — calc_internal_dose","text":"C_ext ambient chemical concentration \\(\\frac{mg}{m^3}\\) IR inhalation rate \\(\\frac{m^3}{day}\\) time total time \\(days\\) BW body weight \\(kg\\) scaling scaling factor encompassing required unit adjustments","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate internal chemical dose — calc_internal_dose","text":"list matrices containing internal chemical doses \\(\\frac{mg}{kg}\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate internal chemical dose — calc_internal_dose","text":"Input C_ext must matrix list matrices. Input IR must atomic vector list atomic vectors. time, BW scaling arguments scalars. internal dose calculated : $$D_{int} = \\frac{C_{ext} \\times IR \\times time}{BW} \\times scaling$$","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate internal chemical dose — calc_internal_dose","text":"","code":"# Single population C_ext <- matrix(1:15, ncol = 3) IR <- 1:5 calc_internal_dose(C_ext, IR) #> [[1]] #>      [,1] [,2] [,3] #> [1,]    1    6   11 #> [2,]    4   14   24 #> [3,]    9   24   39 #> [4,]   16   36   56 #> [5,]   25   50   75 #>   # Multiple populations C_ext <- list(   \"a\" = matrix(1:15 / 10, ncol = 3),   \"b\" = matrix(1:8, ncol = 2) ) IR <- list(1:5, 1:4 / 2) calc_internal_dose(C_ext, IR) #> $a #>      [,1] [,2] [,3] #> [1,]  0.1  0.6  1.1 #> [2,]  0.4  1.4  2.4 #> [3,]  0.9  2.4  3.9 #> [4,]  1.6  3.6  5.6 #> [5,]  2.5  5.0  7.5 #>  #> $b #>      [,1] [,2] #> [1,]  0.5  2.5 #> [2,]  2.0  6.0 #> [3,]  4.5 10.5 #> [4,]  8.0 16.0 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate in vitro concentration — calc_invitro_concentration","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"Estimate vitro equivalent plasma concentration given internal chemical dose steady-state plasma concentration.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"","code":"calc_invitro_concentration(D_int, C_ss = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"D_int internal chemical dose \\(\\frac{mg}{kg}\\) C_ss steady-state plasma concentration \\(\\frac{\\mu M}{mg / kg}\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"list matrices containing concentrations \\(\\mu M\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"Input D_int must matrix list matrices. Input C_ss must numeric atomic vector matrix, list types. vitro equivalent plasma concentration calculated : $$C_{plasma} = C_{ss} \\times D_{int}$$","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"","code":"# Single population D_int <- matrix(1:15, ncol = 3) C_ss <- 1:5 calc_invitro_concentration(D_int, C_ss) #> [[1]] #>      [,1] [,2] [,3] #> [1,]    1    6   11 #> [2,]    4   14   24 #> [3,]    9   24   39 #> [4,]   16   36   56 #> [5,]   25   50   75 #>   # Multiple populations D_int <- list(   \"a\" = matrix(1:15 / 10, ncol = 3),   \"b\" = matrix(1:8, ncol = 2) ) C_ss <- list(1:5, 1:4 / 2) calc_invitro_concentration(D_int, C_ss) #> $a #>      [,1] [,2] [,3] #> [1,]  0.1  0.6  1.1 #> [2,]  0.4  1.4  2.4 #> [3,]  0.9  2.4  3.9 #> [4,]  1.6  3.6  5.6 #> [5,]  2.5  5.0  7.5 #>  #> $b #>      [,1] [,2] #> [1,]  0.5  2.5 #> [2,]  2.0  6.0 #> [3,]  4.5 10.5 #> [4,]  8.0 16.0 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate response — calculate_response","title":"Calculate response — calculate_response","text":"Calculate mixture response GeoTox population data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate response — calculate_response","text":"","code":"calculate_response(x, ...)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate response — calculate_response","text":"x GeoTox object ... additional arguments passed functions. See details.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate response — calculate_response","text":"object additional fields added updated","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate response — calculate_response","text":"Additional parameters include time, BW, scaling calc_internal_dose, max_mult calc_concentration_response.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate response — calculate_response","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Response computations can now be done geoTox <- geoTox |> calculate_response()"},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute response sensitivity to parameter variation. — compute_sensitivity","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"Compute response sensitivity parameter variation.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"","code":"compute_sensitivity(   x,   vary = c(\"age\", \"obesity\", \"css_params\", \"fit_params\", \"C_ext\"),   max_mult = NULL )"},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"x GeoTox object. vary parameter vary. max_mult input calc_concentration_response step.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"output calc_concentration_response","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Sensitivity computations can now be done age_resp <- geoTox |> compute_sensitivity() obesity_resp <- geoTox |> compute_sensitivity(vary = \"obesity\")"},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":null,"dir":"Reference","previous_headings":"","what":"Fit 2- or 3-parameter Hill model — fit_hill","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"Fit 2- 3-parameter Hill model","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"","code":"fit_hill(   x,   conc = \"logc\",   resp = \"resp\",   fixed_slope = TRUE,   chem = NULL,   assay = NULL )"},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"x data frame dose response data. conc column name base-10 log scaled concentration. resp column name response. fixed_slope TRUE, slope fixed 1. chem (optional) column name chemical identifiers. assay (optional) column name assay identifiers.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"data frame fit parameters.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"Optional chem assay identifiers can used fit multiple chemicals /assays. Returned columns tp top asymptote logAC50 50% response concentration. computation standard deviations two parameters fails, standard deviation set equal parameter estimate indicated respective imputed flag TRUE.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"","code":"# Multiple assays, multiple chemicals df <- geo_tox_data$dose_response fit_hill(df, assay = \"endp\", chem = \"casn\") #> # A tibble: 89 × 15 #>    assay  chem     tp  tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max #>    <chr>  <chr> <dbl>  <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl> #>  1 APR_H… 510-…  4.44  5.86     2.06      0.448     1        0   -0.398     2.30 #>  2 APR_H… 92-8…  2.14  0.945    2.05      0.271     1        0   -0.398     2.30 #>  3 APR_H… 95-9…  1.46  0.556    1.67      0.246     1        0   -0.699     2    #>  4 APR_H… 510-…  2.33  0.542    1.79      0.192     1        0   -0.398     2.30 #>  5 APR_H… 72-4…  1.93  1.93     1.95      1.95      1        0   -0.398     2.30 #>  6 APR_H… 92-8…  2.43  1.50     2.22      0.317     1        0   -0.398     2.30 #>  7 ATG_p… 87-8…  2.15  0.877    1.57      0.321     1        0   -1.30      2    #>  8 TOX21… 100-… 71.4  27.2      1.54      0.294     1        0   -3         2    #>  9 TOX21… 101-… 80.1  80.1      2.31      2.31      1        0   -3         1.95 #> 10 TOX21… 101-…  0     0        2.45      0.101     1        0   -3         1.95 #> # ℹ 79 more rows #> # ℹ 5 more variables: resp_min <dbl>, resp_max <dbl>, AIC <dbl>, #> #   tp.sd.imputed <lgl>, logAC50.sd.imputed <lgl>  # Single assay, multiple chemicals df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") fit_hill(df, chem = \"casn\") #> # A tibble: 7 × 14 #>   chem        tp  tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max #>   <chr>    <dbl>  <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl> #> 1 106-50-3  29.9  14.7     1.88     0.363      1        0    -3        1.90 #> 2 119-90-4  65.6  65.6     2.09     2.09       1        0    -2.70     2.30 #> 3 120-80-9 126.    8.29    1.54     0.0796     1        0    -2.70     2.30 #> 4 123-31-9 108.  108.      2.39     2.39       1        0    -2.70     2.30 #> 5 510-15-6  48.5   7.47    2.24     0.123      1        0    -2.70     2.30 #> 6 88-06-2   58.7  37.0     2.80     0.310      1        0    -2.70     2.30 #> 7 92-87-5   73.7   7.22    2.06     0.0863     1        0    -2.70     2.30 #> # ℹ 5 more variables: resp_min <dbl>, resp_max <dbl>, AIC <dbl>, #> #   tp.sd.imputed <lgl>, logAC50.sd.imputed <lgl>  # Single assay, single chemical df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",                 casn == \"510-15-6\") fit_hill(df) #> # A tibble: 1 × 13 #>      tp tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max resp_min #>   <dbl> <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl>    <dbl> #> 1  48.5  7.47    2.24      0.123     1        0    -2.70     2.30    -2.38 #> # ℹ 4 more variables: resp_max <dbl>, AIC <dbl>, tp.sd.imputed <lgl>, #> #   logAC50.sd.imputed <lgl> # 3-parameter Hill model fit_hill(df, fixed_slope = FALSE) #> # A tibble: 1 × 13 #>      tp tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max resp_min #>   <dbl> <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl>    <dbl> #> 1  31.2  1.29    1.83     0.0173  4.02    0.864    -2.70     2.30    -2.38 #> # ℹ 4 more variables: resp_max <dbl>, AIC <dbl>, tp.sd.imputed <lgl>, #> #   logAC50.sd.imputed <lgl>"},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox Data — geo_tox_data","title":"GeoTox Data — geo_tox_data","text":"Sample data use vignettes function examples. See Package Data vignette, vignette(\"package_data\", package = \"GeoTox\"), details data gathered.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"GeoTox Data — geo_tox_data","text":"","code":"geo_tox_data"},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"GeoTox Data — geo_tox_data","text":"list items: exposure 2019 AirToxScreen exposure concentrations subset chemicals North Carolina counties. dose_response Subset chemicals curated ICE cHTS active within set assays. age County population estimates 7/1/2019 North Carolina. obesity CDC PLACES obesity data North Carolina counties 2020. simulated_css Simulated steady-state plasma concentrations various age groups obesity status combinations. boundaries County state boundaries North Carolina 2019.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed Age — get_fixed_age","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"Get C_ss Data Fixed Age","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"","code":"get_fixed_age(simulated_css, age)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"list matrices containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"","code":"get_fixed_age(simulated_css = geo_tox_data$simulated_css,               age = list(c(25, 35, 55), c(15, 60))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  5.6245   6.656   2.3210  0.20555 0.10435  0.11010  0.35850  0.1832 #> [2,]  6.7320   8.194   3.0145  0.26055 0.13450  0.14015  0.48860  0.2070 #> [3,]  9.7745  10.615   3.7720  0.34805 0.18920  0.21190  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.2445   1.4985  0.84285   6.7105  0.30055  2.2450  3.4785  3.3765 #> [2,]  1.6280   1.9545  1.17400   7.3715  0.39220  2.7920  3.8750  4.4375 #> [3,]  2.2435   2.5475  1.44250   8.6155  0.53005  3.6225  4.6450  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  1.0200   1.3740   3.187  4.7235  2.6265 #> [2,]  1.2380   1.6265   3.648  5.8290  3.2970 #> [3,]  1.5575   2.1620   4.755  7.8175  4.3650 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4  63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.3915  4.7355   1.7015  0.16175 0.073885 0.089035  0.27315  0.1245 #> [2,]  9.7745 10.6150   3.7720  0.34805 0.189200 0.211900  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,] 0.97755   1.1135  0.68195   5.3505  0.20900  1.6395   2.781  2.6675 #> [2,] 2.24350   2.5475  1.44250   8.6155  0.53005  3.6225   4.645  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7936    1.023   2.194  3.9780  1.9685 #> [2,]  1.5575    2.162   4.755  7.8175  4.3650 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":null,"dir":"Reference","previous_headings":"","what":"Get Fixed C_ss Data — get_fixed_css","title":"Get Fixed C_ss Data — get_fixed_css","text":"Get C_ss values use sensitivity_analysis compute_sensitivity.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get Fixed C_ss Data — get_fixed_css","text":"","code":"get_fixed_css(simulated_css, age, obesity, C_ss)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get Fixed C_ss Data — get_fixed_css","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages. obesity list atomic vectors containing obesity status. C_ss list matrices containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get Fixed C_ss Data — get_fixed_css","text":"list matrices atomic vectors containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get Fixed C_ss Data — get_fixed_css","text":"","code":"# Define inputs age <- list(c(25, 35, 55),             c(15, 60)) obesity <- list(c(\"Obese\", \"Normal\", \"Obese\"),                 c(\"Normal\", \"Normal\")) C_ss <- sample_Css(simulated_css = geo_tox_data$simulated_css,                    age = age,                    obesity = obesity)  # Get fixed C_ss data get_fixed_css(simulated_css = geo_tox_data$simulated_css,               age = age,               obesity = obesity,               C_ss = C_ss) #> $age #> $age[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  5.6245   6.656   2.3210  0.20555 0.10435  0.11010  0.35850  0.1832 #> [2,]  6.7320   8.194   3.0145  0.26055 0.13450  0.14015  0.48860  0.2070 #> [3,]  9.7745  10.615   3.7720  0.34805 0.18920  0.21190  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.2445   1.4985  0.84285   6.7105  0.30055  2.2450  3.4785  3.3765 #> [2,]  1.6280   1.9545  1.17400   7.3715  0.39220  2.7920  3.8750  4.4375 #> [3,]  2.2435   2.5475  1.44250   8.6155  0.53005  3.6225  4.6450  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  1.0200   1.3740   3.187  4.7235  2.6265 #> [2,]  1.2380   1.6265   3.648  5.8290  3.2970 #> [3,]  1.5575   2.1620   4.755  7.8175  4.3650 #>  #> $age[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4  63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.3915  4.7355   1.7015  0.16175 0.073885 0.089035  0.27315  0.1245 #> [2,]  9.7745 10.6150   3.7720  0.34805 0.189200 0.211900  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,] 0.97755   1.1135  0.68195   5.3505  0.20900  1.6395   2.781  2.6675 #> [2,] 2.24350   2.5475  1.44250   8.6155  0.53005  3.6225   4.645  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7936    1.023   2.194  3.9780  1.9685 #> [2,]  1.5575    2.162   4.755  7.8175  4.3650 #>  #>  #> $params #> $params[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   3.720 25.9000    4.800  0.07592 0.29870  0.23420   0.7295 0.14230 #> [2,]   2.488  0.8094   22.560  0.23280 0.05003  0.02254   0.2919 0.07566 #> [3,]   4.384  1.6220    1.325  0.12190 0.08474  0.06052   1.0870 0.11880 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.680    1.089   4.5530   21.360   0.3849  1.5030   2.979  20.780 #> [2,]   1.974    1.475   1.1020    1.717   0.3452  0.5761   2.150   1.355 #> [3,]   1.212    1.341   0.9264   11.510   0.2517  7.2560   2.450   2.109 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7866   0.3238   2.186  0.9258  0.8813 #> [2,]  1.3160   1.0380   3.410  3.8810  1.5600 #> [3,]  1.0760   1.9520   4.217  5.9390  3.1460 #>  #> $params[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   2.276   2.578   0.4497   0.4456 0.07661   0.1058   0.2782  0.1107 #> [2,]  16.200   7.308   2.9800   0.5936 1.45200   0.1064   0.6615  0.1498 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.4790   0.5304   0.2464    5.750  0.08054   1.703  23.150   14.06 #> [2,]  0.5934   2.4130   0.6624    3.265  0.12990   4.181   1.659   14.13 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]   1.743   0.8955   1.574   8.728   2.302 #> [2,]   2.014   1.0190  10.580   3.001   1.525 #>  #>  #> $obesity #> $obesity[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #> [2,]  4.4205  4.9300    1.849  0.16290  0.0820 0.088135   0.3035 0.12915 #> [3,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387  1.7780   2.953   2.757 #> [3,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 1.31000    1.758  3.8180  6.3620  3.6535 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [3,] 1.31000    1.758  3.8180  6.3620  3.6535 #>  #> $obesity[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #> [2,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #>  #>  #> $other #> $other[[1]] #> [1] 2.588 2.588 2.588 #>  #> $other[[2]] #> [1] 1.381 1.381 #>  #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"Get C_ss Data Fixed Obesity Status","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"","code":"get_fixed_obesity(simulated_css, obesity)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). obesity list atomic vectors containing obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"list matrices containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"","code":"get_fixed_obesity(simulated_css = geo_tox_data$simulated_css,                   obesity = list(c(\"Obese\", \"Normal\", \"Obese\"),                                  c(\"Normal\", \"Normal\"))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #> [2,]  4.4205  4.9300    1.849  0.16290  0.0820 0.088135   0.3035 0.12915 #> [3,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387  1.7780   2.953   2.757 #> [3,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 1.31000    1.758  3.8180  6.3620  3.6535 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [3,] 1.31000    1.758  3.8180  6.3620  3.6535 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #> [2,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":null,"dir":"Reference","previous_headings":"","what":"Get median C_ss Values — get_fixed_other","title":"Get median C_ss Values — get_fixed_other","text":"Get median C_ss Values","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get median C_ss Values — get_fixed_other","text":"","code":"get_fixed_other(C_ss)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get median C_ss Values — get_fixed_other","text":"C_ss list matrices containing C_ss data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get median C_ss Values — get_fixed_other","text":"list atomic vectors containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get median C_ss Values — get_fixed_other","text":"","code":"# Generate input C_ss data age <- list(c(25, 35, 55),             c(15, 60)) obesity <- list(c(\"Obese\", \"Normal\", \"Obese\"),                 c(\"Normal\", \"Normal\")) C_ss <- sample_Css(simulated_css = geo_tox_data$simulated_css,                    age = age,                    obesity = obesity)  # Get median C_ss values get_fixed_other(C_ss) #> [[1]] #> [1] 2.45 2.45 2.45 #>  #> [[2]] #> [1] 1.6895 1.6895 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"Get C_ss Data Fixed C_ss Generation Parameters","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"","code":"get_fixed_params(simulated_css, age)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"list matrices containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"","code":"get_fixed_params(simulated_css = geo_tox_data$simulated_css,                  age = list(c(25, 35, 55), c(15, 60))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   2.595  0.5459    1.782   0.2642 0.18630  0.03007   1.4080 0.09582 #> [2,]   3.543  1.0850    5.692   0.1298 0.03938  0.10010  13.7300 0.40390 #> [3,]   3.250  1.7390    9.401   0.2014 0.06880  0.02218   0.3102 0.17550 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  3.1200   0.3398   0.3828    6.138   0.6469  0.4783   6.558   3.050 #> [2,]  0.4771   1.6840   9.7810    3.915   0.6829 14.8500   4.514   3.637 #> [3,]  1.0180   5.4550   0.6603   11.830   0.2534  2.0280   3.349   3.140 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.5220    0.733   5.581   7.804  6.7490 #> [2,]  0.5415    3.464   3.815   7.185  1.9910 #> [3,]  0.2630    4.582   8.341   1.561  0.5831 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   1.794   15.08   0.4329   0.9152 0.04971  0.04314   0.7964 0.08704 #> [2,]  25.920    6.18   1.9380   0.1242 0.61000  0.10650   4.6570 0.05691 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  0.3507    2.951   1.8480    8.269   0.8545   0.858   5.395  2.5680 #> [2,]  0.8936    1.769   0.8127    2.375   0.1742   2.632  43.790  0.8412 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  3.0890   0.7562  0.9738   5.518  0.7429 #> [2,]  0.2205   2.3210  5.7920   3.051  2.9160 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":null,"dir":"Reference","previous_headings":"","what":"Hill model concentration — hill_conc","title":"Hill model concentration — hill_conc","text":"Calculate concentration regular space given response value.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Hill model concentration — hill_conc","text":"","code":"hill_conc(resp, max, AC50, n)"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Hill model concentration — hill_conc","text":"resp response value max maximal (asymtotic) response AC50 concentration half-maximal response n Hill coefficient (slope)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Hill model concentration — hill_conc","text":"concentration regular space","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Hill model concentration — hill_conc","text":"regular space version tcpl::tcplHillConc(). concentration computed : $$conc = AC50 * (\\frac{max}{resp} - 1)^{-1 / n}$$","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Hill model concentration — hill_conc","text":"","code":"hill_conc(c(0.2, 0.5, 0.75), 1, 0.01, 1) #> [1] 0.0025 0.0100 0.0300 hill_conc(c(0.2, 0.5, 0.9), 1, c(0.1, 0.01, 0.001), 2) #> [1] 0.050 0.010 0.003"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":null,"dir":"Reference","previous_headings":"","what":"Hill model response — hill_val","title":"Hill model response — hill_val","text":"Calculate response given concentration regular space.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Hill model response — hill_val","text":"","code":"hill_val(conc, max, AC50, n)"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Hill model response — hill_val","text":"conc concentration regular space max maximal (asymtotic) response AC50 concentration half-maximal response n Hill coefficient (slope)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Hill model response — hill_val","text":"response value","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Hill model response — hill_val","text":"regular space version tcpl::tcplHillVal(). Hill model defined : $$resp = \\frac{max}{1 + (\\frac{AC50}{conc})^{n}}$$","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Hill model response — hill_val","text":"","code":"hill_val(c(0.0025, 0.01, 0.03), 1, 0.01, 1) #> [1] 0.20 0.50 0.75 hill_val(c(0.05, 0.01, 0.003), 1, c(0.1, 0.01, 0.001), 2) #> [1] 0.2 0.5 0.9"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot exposure data. — plot_exposure","title":"Plot exposure data. — plot_exposure","text":"Plot exposure data.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot exposure data. — plot_exposure","text":"","code":"plot_exposure(   exposure,   region_boundary,   group_boundary = NULL,   chem_label = \"chnm\",   ncol = 2 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot exposure data. — plot_exposure","text":"exposure list exposure data named region label. region_boundary \"sf\" data.frame mapping features \"geometry\" column. Used color regions. group_boundary (optional) \"sf\" data.frame containing \"geometry\" column. Used draw outlines. chem_label label facet_wrap. ncol number columns wrap.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot exposure data. — plot_exposure","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot exposure data. — plot_exposure","text":"","code":"# Load package data exposure <- split(geo_tox_data$exposure, ~FIPS) region_boundary <- geo_tox_data$boundaries$county group_boundary <- geo_tox_data$boundaries$state  # Plot county exposure data # Use CASN as label to avoid long chemical names plot_exposure(exposure,               region_boundary,               chem_label = \"casn\",               ncol = 5)   # Add state boundaries plot_exposure(exposure,               region_boundary,               group_boundary = group_boundary,               chem_label = \"casn\",               ncol = 5)"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot Hill equation fits. — plot_hill","title":"Plot Hill equation fits. — plot_hill","text":"Plot Hill equation fits.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot Hill equation fits. — plot_hill","text":"","code":"plot_hill(hill_params, xlim = c(-1, 4))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot Hill equation fits. — plot_hill","text":"hill_params output fit_hill. xlim log-10 scaled concentration limits.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot Hill equation fits. — plot_hill","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot Hill equation fits. — plot_hill","text":"","code":"# Multiple assays, multiple chemicals df <- geo_tox_data$dose_response plot_hill(fit_hill(df, assay = \"endp\", chem = \"casn\"))   # Single assay, multiple chemicals df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") fig <- plot_hill(fit_hill(df, chem = \"casn\")) fig  # Modify plot fig + ggplot2::guides(color = ggplot2::guide_legend(title = \"Chemical\\nCASN\"))   # Single assay, single chemical df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",                 casn == \"510-15-6\") plot_hill(fit_hill(df))  # 3-parameter Hill model plot_hill(fit_hill(df, fixed_slope = FALSE))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot response data — plot_resp","title":"Plot response data — plot_resp","text":"Plot response data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot response data — plot_resp","text":"","code":"plot_resp(   df,   region_boundary,   group_boundary = NULL,   assay_quantiles = c(Median = 0.5),   summary_quantiles = c(`10th percentile` = 0.1) )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot response data — plot_resp","text":"df output resp_quantiles. region_boundary \"sf\" data.frame mapping features \"geometry\" column. Used color map regions. group_boundary \"sf\" data.frame containing \"geometry\" column. Used draw outlines around groups regions. assay_quantiles named numeric vector assay quantile labels. summary_quantiles named numeric vector summary quantile labels.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot response data — plot_resp","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot response data — plot_resp","text":"","code":"# Use example boundary data from package region_boundary <- geo_tox_data$boundaries$county group_boundary <- geo_tox_data$boundaries$state n <- nrow(region_boundary)  # Single assay quantile df <- data.frame(id = region_boundary$FIPS,                  metric = \"GCA.Eff\",                  assay_quantile = 0.5,                  value = runif(n)^3) # Default plot plot_resp(df, region_boundary)  # Add group boundary, a state border in this case plot_resp(df, region_boundary, group_boundary)  # Change quantile label plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"Q50\" = 0.5))   # Multiple assay quantiles df <- data.frame(id = rep(region_boundary$FIPS, 2),                  metric = \"GCA.Eff\",                  assay_quantile = rep(c(0.25, 0.75), each = n),                  value = c(runif(n)^3, runif(n)^3 + 0.15)) plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"Q25\" = 0.25, \"Q75\" = 0.75))   # Summary quantiles df <- data.frame(id = rep(region_boundary$FIPS, 4),                  assay_quantile = rep(rep(c(0.25, 0.75), each = n), 2),                  summary_quantile = rep(c(0.05, 0.95), each = n * 2),                  metric = \"GCA.Eff\",                  value = c(runif(n)^3, runif(n)^3 + 0.15,                            runif(n)^3 + 0.7, runif(n)^3 + 0.85)) plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"A_Q25\" = 0.25, \"A_Q75\" = 0.75),           summary_quantiles = c(\"S_Q05\" = 0.05, \"S_Q95\" = 0.95))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot results of sensitivity analysis. — plot_sensitivity","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"Plot results sensitivity analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"","code":"plot_sensitivity(   x,   metric = \"GCA.Eff\",   assay = NULL,   y = \"\",   xlab = metric,   ylab = \"\" )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"x GeoTox object. metric metric plot. Valid choices \"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\", \"IA.HQ.10\". assay assay plot, multiple exist. y y value text bottom ridge plot. xlab x-axis label. ylab y-axis label.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"","code":"# Required GeoTox fields are generated by first running [calculate_response] # and [sensitivity_analysis] on a GeoTox object. This will create the fields # `resp` and `sensitivity`. For this example, dummy data will be used. make_data <- function(n = 5, metric = \"GCA.Eff\") {   list(stats::setNames(data.frame(1:n, runif(n)),                        c(\"sample\", metric))) }  geoTox <- GeoTox() geoTox$resp <- make_data() geoTox$sensitivity <- list(age = make_data(),                            obesity = make_data(),                            css_params = make_data(),                            fit_params = make_data(),                            C_ext = make_data())  plot_sensitivity(geoTox) #> Picking joint bandwidth of 0.11"},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":null,"dir":"Reference","previous_headings":"","what":"Get response quantiles — resp_quantiles","title":"Get response quantiles — resp_quantiles","text":"Get response quantiles","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get response quantiles — resp_quantiles","text":"","code":"resp_quantiles(   resp,   metric = c(\"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\", \"IA.HQ.10\"),   assays = NULL,   assay_summary = FALSE,   assay_quantiles = c(Median = 0.5),   summary_quantiles = c(`10th percentile` = 0.1) )"},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get response quantiles — resp_quantiles","text":"resp calculated mixture response output calc_concentration_response. metric response metric, one \"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\" \"IA.HQ.10\". assays assays summarize. NULL multiple assays exist, first assay used. assay_summary boolean indicating whether summarize across assays. assay_quantiles numeric vector assay quantiles. summary_quantiles numeric vector quantiles compute across assay quantiles.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get response quantiles — resp_quantiles","text":"data frame computed response quantiles.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Get response quantiles — resp_quantiles","text":"columns returned data frame vary based inputs. assays specified assay_summary FALSE, resulting data frame assay column. assay_summary TRUE, data frame summary_quantile column.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get response quantiles — resp_quantiles","text":"","code":"# Dummy response data resp <- list(   \"r1\" = data.frame(assay = c(\"a1\", \"a1\", \"a2\", \"a2\"),                     sample = c(1, 2, 1, 2),                     GCA.Eff = c(1, 2, 3, 4),                     IA.Eff = c(5, 6, 7, 8),                     \"GCA.HQ.10\" = c(9, 10, 11, 12),                     \"IA.HQ.10\" = c(13, 14, 15, 16)))  # Summarize single assay resp_quantiles(resp) #> Warning: Multiple assays found, using first assay 'a1' #> # A tibble: 1 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff            0.5   1.5 # Specify assay resp_quantiles(resp, assays = \"a1\") #> # A tibble: 1 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff            0.5   1.5 # Specify quantiles resp_quantiles(resp, assays = \"a1\", assay_quantiles = c(0.25, 0.75)) #> # A tibble: 2 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff           0.25  1.25 #> 2 r1    a1    GCA.Eff           0.75  1.75 # Specify metric resp_quantiles(resp, assays = \"a1\", metric = \"IA.HQ.10\") #> # A tibble: 1 × 5 #>   id    assay metric   assay_quantile value #>   <chr> <chr> <chr>             <dbl> <dbl> #> 1 r1    a1    IA.HQ.10            0.5  13.5  # Summarize across assays resp_quantiles(resp, assay_summary = TRUE) #> Warning: There are only 2 assays. #> Consider using a larger number of assays for a more robust analysis. #> # A tibble: 1 × 5 #>   id    assay_quantile metric  summary_quantile value #>   <chr>          <dbl> <chr>              <dbl> <dbl> #> 1 r1               0.5 GCA.Eff              0.1   1.7 # Specify quantiles suppressWarnings(   resp_quantiles(resp,                  assay_summary = TRUE,                  assay_quantiles = c(0.25, 0.75),                  summary_quantiles = c(0.1, 0.9)) ) #> # A tibble: 4 × 5 #>   id    assay_quantile metric  summary_quantile value #>   <chr>          <dbl> <chr>              <dbl> <dbl> #> 1 r1              0.25 GCA.Eff              0.1  1.45 #> 2 r1              0.25 GCA.Eff              0.9  3.05 #> 3 r1              0.75 GCA.Eff              0.1  1.95 #> 4 r1              0.75 GCA.Eff              0.9  3.55"},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":null,"dir":"Reference","previous_headings":"","what":"Sample from pre-generated C_ss data — sample_Css","title":"Sample from pre-generated C_ss data — sample_Css","text":"Sample pre-generated C_ss data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Sample from pre-generated C_ss data — sample_Css","text":"","code":"sample_Css(simulated_css, age, obesity)"},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Sample from pre-generated C_ss data — sample_Css","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vector ages. obesity list atomic vector obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Sample from pre-generated C_ss data — sample_Css","text":"list matrices containing C_ss values. Columns sorted consistent order across functions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Sample from pre-generated C_ss data — sample_Css","text":"","code":"# Vector inputs sample_Css(geo_tox_data$simulated_css,            c(15, 25, 35),            c(\"Normal\", \"Obese\", \"Normal\")) #> [[1]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   0.4032  0.06119   0.4044  0.04516    3.125    1.505  0.08384   4.1070 #> [2,]   0.8511  0.40070   1.5170  0.20540    8.311    1.713  0.30070   0.8906 #> [3,]   0.6539  0.39460   0.3364  0.68070    1.555    3.633  0.42150   1.9910 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]  0.08366  0.6665   2.187   2.193 0.03733   3.545   2.067   5.036  0.7018 #> [2,]  0.07002  6.3640   1.945   4.409 0.21210   4.614   1.967   7.638 12.9700 #> [3,]  0.19310  3.7220   1.539   1.727 0.06266   4.898   0.985   9.054  1.5870 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,] 0.06077  0.3466   2.231  11.650 #> [2,] 0.19230  0.8108   1.401  17.550 #> [3,] 0.22590  2.6400   2.103   1.502 #>   # List inputs sample_Css(geo_tox_data$simulated_css,            list(c(34, 29), 55),            list(c(\"Obese\", \"Normal\"), \"Normal\")) #> [[1]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   2.1290   0.3820    3.652   0.2247    6.800   0.8395   0.6320    2.746 #> [2,]   0.6427   0.1391    2.175   0.2645    3.766   3.4160   0.4531    1.364 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]   0.4971   5.819   5.986   3.001 0.06565    4.73  1.1280   1.239   5.524 #> [2,]   0.1654   1.163   1.315   2.156 0.03879  265.30  0.9735   3.735   9.349 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,]  1.3720  1.2370   3.461   9.255 #> [2,]  0.0863  0.3199   4.240   5.488 #>  #> [[2]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   0.4114   0.2184    1.091   0.4477    3.899   0.7356   0.8564    11.01 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]  0.09589   4.414   3.463   3.304 0.09706   3.237   1.294   2.108   1.301 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,]  0.1822   2.242   1.932   1.595 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":null,"dir":"Reference","previous_headings":"","what":"Perform sensitivity analysis — sensitivity_analysis","title":"Perform sensitivity analysis — sensitivity_analysis","text":"Perform sensitivity analysis","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Perform sensitivity analysis — sensitivity_analysis","text":"","code":"sensitivity_analysis(x, max_mult = list(NULL, NULL, NULL, 1.2, NULL))"},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Perform sensitivity analysis — sensitivity_analysis","text":"x GeoTox object. max_mult numeric list length 5 step sensitivity analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Perform sensitivity analysis — sensitivity_analysis","text":"GeoTox object added sensitivity field.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Perform sensitivity analysis — sensitivity_analysis","text":"wrapper function sequentially call compute_sensitivity function inputs age, obesity, css_params, fit_params, C_ext. results returned named list stored sensitivity field input GeoTox object. Values NULL max_mult input use default value stored GeoTox object (x$par$resp$max_mult). GeoTox object created initialized 1.5, can changed via calculate_response function directly object.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Perform sensitivity analysis — sensitivity_analysis","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Sensitivity analysis can now be done geoTox <- geoTox |> sensitivity_analysis()"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":null,"dir":"Reference","previous_headings":"","what":"Set GeoTox boundaries — set_boundaries","title":"Set GeoTox boundaries — set_boundaries","text":"Set GeoTox boundaries","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Set GeoTox boundaries — set_boundaries","text":"","code":"set_boundaries(x, region = NULL, group = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Set GeoTox boundaries — set_boundaries","text":"x GeoTox object. region \"sf\" data.frame mapping features \"geometry\" column. Used coloring map regions. group \"sf\" data.frame containing \"geometry\" column. Used draw outlines around groups regions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Set GeoTox boundaries — set_boundaries","text":"GeoTox object boundaries set.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Set GeoTox boundaries — set_boundaries","text":"","code":"geoTox <- GeoTox() |>    set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":null,"dir":"Reference","previous_headings":"","what":"Set Hill parameters for a GeoTox object. — set_hill_params","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"Set Hill parameters GeoTox object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"","code":"set_hill_params(x, hill_params)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"x GeoTox object. hill_params output fit_hill.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"GeoTox object Hill parameters set.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"","code":"hill_params <- geo_tox_data$dose_response |>   fit_hill(chem = \"casn\", assay = \"endp\") |>   dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed)  geoTox <- GeoTox() |>    set_hill_params(hill_params)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate ages — simulate_age","title":"Simulate ages — simulate_age","text":"Simulate ages","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate ages — simulate_age","text":"","code":"simulate_age(x, n = 1000)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate ages — simulate_age","text":"x data frame list data frames containing population data age groups. data frame must contain columns \"AGEGRP\" \"TOT_POP\". n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate ages — simulate_age","text":"List arrays containing simulated ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate ages — simulate_age","text":"data frame must contain 19 rows. first row represents total population age groups next 18 rows represent age groups 0 89 increments 5 years.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate ages — simulate_age","text":"","code":"# Single data frame x <- data.frame(AGEGRP = 0:18, TOT_POP = 0) # populate only age range 40-44, set population total of all ages x$TOT_POP[c(1, 10)] <- 100 simulate_age(x, 5) #> [[1]] #> [1] 41 40 40 40 44 #>   # List of 2 data frames y <- data.frame(AGEGRP = 0:18, TOT_POP = 0) # populate age ranges 5-9 and 50-54 y$TOT_POP[c(3, 12)] <- 10 # set population total for all age groups y$TOT_POP[1] <- sum(y$TOT_POP) simulate_age(list(x = x, y = y), 15) #> $x #>  [1] 44 41 41 44 44 40 42 41 44 41 42 42 41 44 43 #>  #> $y #>  [1]  8  9 53 53 52 51  7  7 50  6  5 51 54 51  7 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate external exposure — simulate_exposure","title":"Simulate external exposure — simulate_exposure","text":"Simulate external exposure","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate external exposure — simulate_exposure","text":"","code":"simulate_exposure(   x,   expos_mean = \"mean\",   expos_sd = \"sd\",   expos_label = \"casn\",   n = 1000 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate external exposure — simulate_exposure","text":"x data frame list data frames containing exposure data. expos_mean column name mean values. expos_sd column name standard deviations. expos_label column name labeling term, required x one row. n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate external exposure — simulate_exposure","text":"list matrices containing inhalation rates. Matrix columns named using values expos_label column one data frame row. Columns sorted consistent order across functions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate external exposure — simulate_exposure","text":"","code":"# Single data frame x <- data.frame(mean = 1:3, sd = (1:3) / 10, casn = letters[1:3]) simulate_exposure(x, n = 5) #> [[1]] #>              a        b        c #> [1,] 0.9589639 1.942589 2.451133 #> [2,] 0.8855310 2.023900 2.695203 #> [3,] 1.1057684 2.063064 2.496449 #> [4,] 1.2500731 2.162863 3.524906 #> [5,] 0.8554196 2.259877 3.247982 #>   # List of 2 data frames y <- data.frame(mean = 4:6, sd = 0.1, casn = letters[1:3]) simulate_exposure(list(loc1 = x, loc2 = y), n = 5) #> $loc1 #>              a        b        c #> [1,] 0.9985420 2.418962 2.889693 #> [2,] 1.0071619 1.904265 2.958021 #> [3,] 0.9372769 1.914698 3.174726 #> [4,] 0.9754153 2.018951 3.189433 #> [5,] 1.1182927 1.871831 2.871555 #>  #> $loc2 #>             a        b        c #> [1,] 3.949621 5.048086 6.059213 #> [2,] 3.949047 5.009067 5.847476 #> [3,] 3.938871 4.883739 5.957730 #> [4,] 4.050804 5.091922 5.960801 #> [5,] 4.057940 5.047837 6.006035 #>   # Input has custom column names z <- data.frame(ave = 1:3, stdev = (1:3) / 10, chnm = letters[1:3]) simulate_exposure(z,                   expos_mean = \"ave\",                   expos_sd = \"stdev\",                   expos_label = \"chnm\",                   n = 5) #> [[1]] #>              a        b        c #> [1,] 1.0068706 2.246875 2.465981 #> [2,] 1.1088794 2.286902 2.671737 #> [3,] 0.9603815 2.013617 3.227719 #> [4,] 0.9356854 2.088608 2.733121 #> [5,] 1.0065421 2.397329 2.783188 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate inhalation rates — simulate_inhalation_rate","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"Simulate inhalation rates","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"","code":"simulate_inhalation_rate(x, IR_params = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"x atomic vector list atomic vectors containing ages. IR_params (optional) data frame columns \"age\", \"mean\" \"sd\". See details information.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"List atomic vectors containing inhalation rates.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"age column optional IR_params data frame ascending order represent lower value age groups corresponding mean sd values. provided, default values come Table 6.7 EPA's 2011 Exposure Factors Handbook using mean male female values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"","code":"# Single atomic vector ages <- sample(1:100, 6, replace = TRUE) simulate_inhalation_rate(ages) #> [[1]] #> [1] 0.1625213 0.2281144 0.1786136 0.2349537 0.2106563 0.2596359 #>   # List of atomic vectors ages <- list(   sample(1:100, 5, replace = TRUE),   sample(1:100, 3, replace = TRUE) ) simulate_inhalation_rate(ages) #> [[1]] #> [1] 0.1971633 0.3031290 0.2993870 0.2280779 0.2170229 #>  #> [[2]] #> [1] 0.3514907 0.2375111 0.2301368 #>   # Custom IR_params IR_params <- data.frame(\"age\" = c(0, 20, 50),                         \"mean\" = c(0.5, 0.3, 0.2),                         \"sd\" = c(0.1, 0.06, 0.03)) simulate_inhalation_rate(c(15, 30, 65), IR_params) #> [[1]] #> [1] 0.3858133 0.2594459 0.1721599 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate obesity status — simulate_obesity","title":"Simulate obesity status — simulate_obesity","text":"Simulate obesity status","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate obesity status — simulate_obesity","text":"","code":"simulate_obesity(   x,   obes_prev = \"OBESITY_CrudePrev\",   obes_sd = \"OBESITY_SD\",   obes_label = \"FIPS\",   n = 1000 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate obesity status — simulate_obesity","text":"x data frame containing obesity data percentage 0 100. obes_prev column name prevalence. obes_sd column name standard deviation. obes_label column name labeling term, required x one row. n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate obesity status — simulate_obesity","text":"List arrays containing simulated obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate obesity status — simulate_obesity","text":"","code":"# Input has default column names df <- data.frame(OBESITY_CrudePrev = c(20, 50, 80),                  OBESITY_SD = c(5, 5, 5),                  FIPS = letters[1:3]) simulate_obesity(df, n = 5) #> $a #> [1] \"Normal\" \"Normal\" \"Normal\" \"Normal\" \"Normal\" #>  #> $b #> [1] \"Normal\" \"Obese\"  \"Normal\" \"Normal\" \"Normal\" #>  #> $c #> [1] \"Obese\" \"Obese\" \"Obese\" \"Obese\" \"Obese\" #>   # Input has custom column names df <- data.frame(prev = c(20, 50, 80),                  sd = c(5, 5, 5),                  label = letters[1:3]) simulate_obesity(df,                  obes_prev = \"prev\",                  obes_sd = \"sd\",                  obes_label = \"label\",                  n = 5) #> $a #> [1] \"Normal\" \"Obese\"  \"Normal\" \"Normal\" \"Normal\" #>  #> $b #> [1] \"Normal\" \"Obese\"  \"Obese\"  \"Normal\" \"Obese\"  #>  #> $c #> [1] \"Obese\" \"Obese\" \"Obese\" \"Obese\" \"Obese\" #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate population data — simulate_population","title":"Simulate population data — simulate_population","text":"Simulate population data given input fields","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate population data — simulate_population","text":"","code":"simulate_population(   x,   age = NULL,   obesity = NULL,   exposure = NULL,   simulated_css = NULL,   ... )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate population data — simulate_population","text":"x GeoTox object. age input x function simulate_age. simulating ages, inhalation rate subsequently calculated using simulate_inhalation_rate. obesity input x function simulate_obesity. exposure input x function simulate_exposure. simulated_css input simulated_css functions sample_Css get_fixed_css. ... additional arguments passed functions. See details.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate population data — simulate_population","text":"object simulated fields added.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate population data — simulate_population","text":"Additional parameters include n sample size, IR_params simulate_inhalation_rate, obes_prev, obes_sd, obes_label simulate_obesity, expos_mean, expos_sd, expos_label simulate_exposure.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate population data — simulate_population","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n)"},{"path":"https://github.com/NIEHS/GeoTox/news/index.html","id":"geotox-014","dir":"Changelog","previous_headings":"","what":"GeoTox 0.1.4","title":"GeoTox 0.1.4","text":"Updated unit test coverage function examples","code":""},{"path":"https://github.com/NIEHS/GeoTox/news/index.html","id":"geotox-001","dir":"Changelog","previous_headings":"","what":"GeoTox 0.0.1","title":"GeoTox 0.0.1","text":"Adding supporting documents GeoTox repository news.md, issue templates, contributor’s guide NC areal level analysis vignette complete Key developments object oriented approach: simulate sensitivity wrappers oo-s3.Rmd updated include object oriented improvements including plotting options","code":""}]
+[{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"members, contributors, leaders pledge make participation community harassment-free experience everyone, regardless age, body size, visible invisible disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, caste, color, religion, sexual identity orientation. pledge act interact ways contribute open, welcoming, diverse, inclusive, healthy community.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes positive environment community include: Demonstrating empathy kindness toward people respectful differing opinions, viewpoints, experiences Giving gracefully accepting constructive feedback Accepting responsibility apologizing affected mistakes, learning experience Focusing best just us individuals, overall community Examples unacceptable behavior include: use sexualized language imagery, sexual attention advances kind Trolling, insulting derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical email address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement-responsibilities","dir":"","previous_headings":"","what":"Enforcement Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Community leaders responsible clarifying enforcing standards acceptable behavior take appropriate fair corrective action response behavior deem inappropriate, threatening, offensive, harmful. Community leaders right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, communicate reasons moderation decisions appropriate.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within community spaces, also applies individual officially representing community public spaces. Examples representing community include using official e-mail address, posting via official social media account, acting appointed representative online offline event.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported community leaders responsible enforcement kyle.messier@nih.gov. complaints reviewed investigated promptly fairly. community leaders obligated respect privacy security reporter incident.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"enforcement-guidelines","dir":"","previous_headings":"","what":"Enforcement Guidelines","title":"Contributor Covenant Code of Conduct","text":"Community leaders follow Community Impact Guidelines determining consequences action deem violation Code Conduct:","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_1-correction","dir":"","previous_headings":"Enforcement Guidelines","what":"1. Correction","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Use inappropriate language behavior deemed unprofessional unwelcome community. Consequence: private, written warning community leaders, providing clarity around nature violation explanation behavior inappropriate. public apology may requested.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_2-warning","dir":"","previous_headings":"Enforcement Guidelines","what":"2. Warning","title":"Contributor Covenant Code of Conduct","text":"Community Impact: violation single incident series actions. Consequence: warning consequences continued behavior. interaction people involved, including unsolicited interaction enforcing Code Conduct, specified period time. includes avoiding interactions community spaces well external channels like social media. Violating terms may lead temporary permanent ban.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_3-temporary-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"3. Temporary Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: serious violation community standards, including sustained inappropriate behavior. Consequence: temporary ban sort interaction public communication community specified period time. public private interaction people involved, including unsolicited interaction enforcing Code Conduct, allowed period. Violating terms may lead permanent ban.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"id_4-permanent-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"4. Permanent Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Demonstrating pattern violation community standards, including sustained inappropriate behavior, harassment individual, aggression toward disparagement classes individuals. Consequence: permanent ban sort public interaction within community.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 2.1, available https://www.contributor-covenant.org/version/2/1/code_of_conduct.html. Community Impact Guidelines inspired [Mozilla’s code conduct enforcement ladder][https://github.com/mozilla/inclusion]. answers common questions code conduct, see FAQ https://www.contributor-covenant.org/faq. Translations available https://www.contributor-covenant.org/translations.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to GeoTox","title":"Contributing to GeoTox","text":"outlines (1) propose change GeoTox (2) serves log potential enhancements GeoTox.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"best-practices","dir":"","previous_headings":"","what":"Best Practices","title":"Contributing to GeoTox","text":"’ve found bug, please file issue illustrates bug minimal reprex (also help write unit test, needed). See tidyverse team’s guide create great issue advice. adding new function package, always add working examples new function roxygen2 documentation #' @examples.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"pull-request-process","dir":"","previous_headings":"Best Practices","what":"Pull request process","title":"Contributing to GeoTox","text":"Fork package clone onto computer. haven’t done , recommend using usethis::create_from_github(\"NIEHS/GeoTox\", fork = TRUE). Install development dependencies devtools::install_dev_deps(), make sure package passes R CMD check running devtools::check(). R CMD check doesn’t pass cleanly, ’s good idea ask help continuing. Create Git branch pull request (PR). recommend using usethis::pr_init(\"brief-description--change\"). Make changes, commit git, create PR running usethis::pr_push(), following prompts browser. title PR briefly describe change. body PR contain Fixes #issue-number. user-facing changes, add bullet top NEWS.md (.e. just first header).","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"code-style","dir":"","previous_headings":"Best Practices","what":"Code style","title":"Contributing to GeoTox","text":"Please abide 80-character line rules (default settings lintr) use roxygen2, Markdown syntax, documentation. use testthat unit tests. Contributions test cases included easier accept.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"fixing-typos","dir":"","previous_headings":"","what":"Fixing typos","title":"Contributing to GeoTox","text":"can fix typos, spelling mistakes, grammatical errors documentation directly using GitHub web interface, long changes made source file. generally means ’ll need edit roxygen2 comments .R, .Rd file. can find .R file generates .Rd reading comment first line.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"geotox-open-issues-and-enhancements","dir":"","previous_headings":"","what":"GeoTox Open Issues and Enhancements","title":"Contributing to GeoTox","text":"section serves log potential enhancements GeoTox. Community members welcomed encouraged use contributing guide address open issues enhancements package. Additionally, new enhancements can proposed using enhancements template request. want address open enchancement suggest new one, ’s good idea first file issue make sure someone team agrees ’s needed.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"scientific","dir":"","previous_headings":"GeoTox Open Issues and Enhancements","what":"Scientific","title":"Contributing to GeoTox","text":"Non-steady state toxicokinetics. likely require additional usage httk package. Complete integration multiple end-point analysis GeoTox objects Integration Reflected Generalized Concentration Addition (RGCA), allow 3+ parameter hill models used additive mixture predictions. Benchmark Dose modeling (BMD) metric risk assessment. Suggested ingetrations include BMDexpress2.0 transcryptR - note transcryptR also currently ","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"computational","dir":"","previous_headings":"GeoTox Open Issues and Enhancements","what":"Computational","title":"Contributing to GeoTox","text":"targets pipeline template. provide make-like targets pipeline, new users reproducible template run analysis ease.","code":""},{"path":"https://github.com/NIEHS/GeoTox/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Contributing to GeoTox","text":"Please note chopin project released Contributor Code Conduct. contributing project agree abide terms.","code":""},{"path":"https://github.com/NIEHS/GeoTox/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"MIT License","title":"MIT License","text":"Copyright (c) 2024 GeoTox authors Permission hereby granted, free charge, person obtaining copy software associated documentation files (“Software”), deal Software without restriction, including without limitation rights use, copy, modify, merge, publish, distribute, sublicense, /sell copies Software, permit persons Software furnished , subject following conditions: copyright notice permission notice shall included copies substantial portions Software. SOFTWARE PROVIDED “”, WITHOUT WARRANTY KIND, EXPRESS IMPLIED, INCLUDING LIMITED WARRANTIES MERCHANTABILITY, FITNESS PARTICULAR PURPOSE NONINFRINGEMENT. EVENT SHALL AUTHORS COPYRIGHT HOLDERS LIABLE CLAIM, DAMAGES LIABILITY, WHETHER ACTION CONTRACT, TORT OTHERWISE, ARISING , CONNECTION SOFTWARE USE DEALINGS SOFTWARE.","code":""},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"analysis-of-single-assay","dir":"Articles","previous_headings":"","what":"Analysis of single assay","title":"GeoTox Introduction","text":"Create GeoTox object, run simulations computations Plot outputs","code":"set.seed(2357) geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS),                       obesity       = geo_tox_data$obesity,                       exposure      = split(geo_tox_data$exposure, ~FIPS),                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") |>                     fit_hill(chem = \"casn\") |>                      filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  geoTox #> GeoTox object #> Assays: 1 #> Chemicals: 5 #> Regions: 100 #> Population: 250 #> Data Fields: #>      Name            Class               Dim #>       age    list(integer)       100 x (250) #>        IR    list(numeric)       100 x (250) #>   obesity  list(character)       100 x (250) #>     C_ext     list(matrix)  100 x (250 x 21) #>      C_ss     list(matrix)  100 x (250 x 21) #> Computed Fields: #>          Name             Class               Dim #>         D_int      list(matrix)  100 x (250 x 21) #>     C_invitro      list(matrix)  100 x (250 x 21) #>          resp  list(data.frame)   100 x (250 x 5) #>   sensitivity        list(list)         5 x (100) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params plot(geoTox) plot(geoTox, type = \"hill\") plot(geoTox, type = \"sensitivity\") #> Picking joint bandwidth of 0.139"},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"analysis-of-multiple-assay","dir":"Articles","previous_headings":"","what":"Analysis of multiple assay","title":"GeoTox Introduction","text":"Create GeoTox object, run simulations computations Plot outputs","code":"set.seed(2357) geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS),                       obesity       = geo_tox_data$obesity,                       exposure      = split(geo_tox_data$exposure, ~FIPS),                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                      filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  geoTox #> GeoTox object #> Assays: 13 #> Chemicals: 20 #> Regions: 100 #> Population: 250 #> Data Fields: #>      Name            Class               Dim #>       age    list(integer)       100 x (250) #>        IR    list(numeric)       100 x (250) #>   obesity  list(character)       100 x (250) #>     C_ext     list(matrix)  100 x (250 x 21) #>      C_ss     list(matrix)  100 x (250 x 21) #> Computed Fields: #>          Name             Class               Dim #>         D_int      list(matrix)  100 x (250 x 21) #>     C_invitro      list(matrix)  100 x (250 x 21) #>          resp  list(data.frame)  100 x (3250 x 6) #>   sensitivity        list(list)         5 x (100) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params plot(geoTox) #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' plot(geoTox, assays = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") plot(geoTox, type = \"hill\") plot(geoTox, type = \"sensitivity\") #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' #> Warning: Removed 93000 NA values #> Picking joint bandwidth of 0.133 plot(geoTox, type = \"sensitivity\", assay = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") #> Picking joint bandwidth of 0.139"},{"path":"https://github.com/NIEHS/GeoTox/articles/introduction.html","id":"exposure-map","dir":"Articles","previous_headings":"","what":"Exposure Map","title":"GeoTox Introduction","text":"exposure map single multiple assay analyses. map shows distribution chemical exposure across regions chemicals, just used particular analysis.  facet labels present can specified using chem_label argument.","code":"plot(geoTox, type = \"exposure\", ncol = 5) plot(geoTox, type = \"exposure\", chem_label = \"chnm\", ncol = 5)"},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"exposure-data","dir":"Articles","previous_headings":"Chemical data","what":"Exposure data","title":"GeoTox Package Data","text":"Download modeled exposure data AirToxScreen. Results AirToxScreen 2019 subset chemicals North Carolina counties included package data geo_tox_data$exposure. NOTE: 2020 release currently provide single file exposure national concentration summaries. 2019 data can found following “Previous air toxics assessments” link.","code":"filename <- \"2019_Toxics_Exposure_Concentrations.xlsx\" tmp <- tempfile(filename) download.file(   paste0(\"https://www.epa.gov/system/files/documents/2022-12/\", filename),   tmp ) exposure <- read_xlsx(tmp)  # Normalization function min_max_norm = function(x) {   min_x <- min(x, na.rm = TRUE)   max_x <- max(x, na.rm = TRUE)   if (min_x == max_x) {     rep(0, length(x))   } else {     (x - min_x) / (max_x - min_x)   } }  geo_tox_data$exposure <- exposure |>    # North Carolina counties   filter(State == \"NC\", !grepl(\"0$\", FIPS)) |>    # Aggregate chemicals by county   summarize(across(-c(State:Tract), c(mean, sd)), .by = FIPS) |>    pivot_longer(-FIPS, names_to = \"chemical\") |>    mutate(stat = if_else(grepl(\"_1$\", chemical), \"mean\", \"sd\"),          chemical = gsub('.{2}$', '', chemical)) |>    pivot_wider(names_from = stat) |>    # Normalize concentrations   mutate(norm = min_max_norm(mean), .by = chemical)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"get-casrn-and-preferred_name-from-comptox-dashboard","dir":"Articles","previous_headings":"Chemical data > Exposure data","what":"Get CASRN and PREFERRED_NAME from CompTox Dashboard","title":"GeoTox Package Data","text":"","code":"# Copy/paste the chemical names into the batch search field # https://comptox.epa.gov/dashboard/batch-search cat(geo_tox_data$exposure |> distinct(chemical) |> pull(), sep = \"\\n\") # Export results with \"CAS-RN\" identifiers as a csv file, then process in R  exposure_casrn <- read_csv(\"CCD-Batch-Search.csv\",                            show_col_types = FALSE) |>    filter(DTXSID != \"N/A\") |>    # Prioritize results based on FOUND_BY status   arrange(INPUT,           grepl(\"Approved Name\", FOUND_BY),           grepl(\"^Synonym\", FOUND_BY)) |>    # Keep one result per INPUT   group_by(INPUT) |>    slice(1) |>    ungroup()  # Update exposure data with CompTox Dashboard data geo_tox_data$exposure <- geo_tox_data$exposure |>    inner_join(exposure_casrn, by = join_by(chemical == INPUT)) |>    select(FIPS, casn = CASRN, chnm = PREFERRED_NAME, mean, sd, norm)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"ice-chts-data","dir":"Articles","previous_headings":"Chemical data","what":"ICE cHTS data","title":"GeoTox Package Data","text":"Use ICE cHTS data identify active chemicals given set assays.","code":"get_cHTS_hits <- function(assays = NULL, chemids = NULL) {      if (is.null(assays) & is.null(chemids)) {     stop(\"Must provide at least one of 'assays' or 'chemids'\")   }      # Format query parameters   req_params <- list()      if (!is.null(assays)) {     if (!is.list(assays)) assays <- as.list(assays)     req_params$assays <- assays   }      if (!is.null(chemids)) {     if (!is.list(chemids)) chemids <- as.list(chemids)     req_params$chemids <- chemids   }      # Query ICE API   resp <- request(\"https://ice.ntp.niehs.nih.gov/api/v1/search\") |>      req_body_json(req_params) |>      req_perform()      if (resp$status_code != 200) {     stop(\"Failed to retrieve data from ICE API\")   }      # Return active chemicals   result <- resp |> resp_body_json() |> pluck(\"endPoints\")      fields <- c(\"assay\", \"casrn\", \"dtxsid\", \"substanceName\",               \"endpoint\", \"value\")      map(fields, \\(x) map_chr(result, x)) |>      set_names(fields) |>     bind_cols() |>      filter(endpoint == \"Call\", value == \"Active\") |>      select(-c(endpoint, value)) |>      distinct() }  assays <- c(\"APR_HepG2_p53Act_1h_dn\",             \"APR_HepG2_p53Act_1h_up\",             \"APR_HepG2_p53Act_24h_dn\",             \"APR_HepG2_p53Act_24h_up\",             \"APR_HepG2_p53Act_72h_dn\",             \"APR_HepG2_p53Act_72h_up\",             \"ATG_p53_CIS_up\",             \"TOX21_DT40\",             \"TOX21_DT40_100\",             \"TOX21_DT40_657\",             \"TOX21_ELG1_LUC_Agonist\",             \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",             \"TOX21_p53_BLA_p1_ratio\",             \"TOX21_p53_BLA_p2_ratio\",             \"TOX21_p53_BLA_p3_ratio\",             \"TOX21_p53_BLA_p4_ratio\",             \"TOX21_p53_BLA_p5_ratio\")  chemids <- unique(geo_tox_data$exposure$casn)    cHTS_hits_API <- get_cHTS_hits(assays = assays, chemids = chemids)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"dose-response-data","dir":"Articles","previous_headings":"Chemical data","what":"Dose-response data","title":"GeoTox Package Data","text":"Use ICE API retrieve dose-response data selected assays chemicals.","code":"get_ICE_dose_resp <- function(assays = NULL, chemids = NULL) {      if (is.null(assays) & is.null(chemids)) {     stop(\"Must provide at least one of 'assays' or 'chemids'\")   }      # Format query parameters   req_params <- list()      if (!is.null(assays)) {     if (!is.list(assays)) assays <- as.list(assays)     req_params$assays <- assays   }      if (!is.null(chemids)) {     if (!is.list(chemids)) chemids <- as.list(chemids)     req_params$chemids <- chemids   }      # Query ICE API   resp <- request(\"https://ice.ntp.niehs.nih.gov/api/v1/curves\") |>      req_body_json(req_params) |>      req_perform()      if (resp$status_code != 200) {     stop(\"Failed to retrieve data from ICE API\")   }      # Return dose-response data   result <- resp |> resp_body_json() |> pluck(\"curves\")      map(result, function(x) {     tibble(       endp = x[[\"assay\"]],       casn = x[[\"casrn\"]],       call = x[[\"dsstoxsid\"]],       chnm = x[[\"substance\"]],       call = x[[\"call\"]],       logc = map_dbl(x[[\"concentrationResponses\"]], \"concentration\") |> log10(),       resp = map_dbl(x[[\"concentrationResponses\"]], \"response\")     )   }) |>      bind_rows() }  assays <- unique(cHTS_hits_API$assay)  chemids <- intersect(cHTS_hits_API$casrn, geo_tox_data$exposure$casn)  dose_response <- get_ICE_dose_resp(assays = assays, chemids = chemids)  # Only keep active calls for assay/chemical combinations geo_tox_data$dose_response <- dose_response |>    filter(call == \"Active\") |>    select(-call)  # Update dose-response data with CompTox Dashboard data geo_tox_data$dose_response <- geo_tox_data$dose_response |>   inner_join(exposure_casrn, by = join_by(casn == CASRN)) |>   select(endp, casn, chnm = PREFERRED_NAME, logc, resp)"},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"age","dir":"Articles","previous_headings":"Population data","what":"Age","title":"GeoTox Package Data","text":"Download age data U.S. Census Bureau searching “County Population Characteristics”. subset data North Carolina 2019 included package data geo_tox_data$age.","code":"# Data for North Carolina url <- paste0(\"https://www2.census.gov/programs-surveys/popest/datasets/\",               \"2010-2019/counties/asrh/cc-est2019-alldata-37.csv\") age <- read_csv(url, show_col_types = FALSE)  geo_tox_data$age <- age |>   # 7/1/2019 population estimate   filter(YEAR == 12) |>   # Create FIPS   mutate(FIPS = str_c(STATE, COUNTY)) |>   # Keep selected columns   select(FIPS, AGEGRP, TOT_POP)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"obesity","dir":"Articles","previous_headings":"Population data","what":"Obesity","title":"GeoTox Package Data","text":"Follow “Data Portal” link CDC PLACES search “places county data”. Go desired dataset webpage, example 2020 county data, download data selecting Actions → API → Download file. subset data North Carolina included package data geo_tox_data$obesity.","code":"places <- read_csv(\"PLACES__County_Data__GIS_Friendly_Format___2020_release.csv\",                    show_col_types = FALSE)  # Convert confidence interval to standard deviation extract_SD <- function(x) {   range <- as.numeric(str_split_1(str_sub(x, 2, -2), \",\"))   diff(range) / 3.92 }  geo_tox_data$obesity <- places |>   # North Carolina Counties   filter(StateAbbr == \"NC\") |>   # Select obesity data   select(FIPS = CountyFIPS, OBESITY_CrudePrev, OBESITY_Crude95CI) |>   # Change confidence interval to standard deviation   rowwise() |>   mutate(OBESITY_SD = extract_SD(OBESITY_Crude95CI)) |>   ungroup() |>   select(-OBESITY_Crude95CI)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"steady-state-plasma-concentration-c_ss","dir":"Articles","previous_headings":"Population data","what":"Steady-state plasma concentration (C_ss)","title":"GeoTox Package Data","text":"Use httk generate C_ss values combinations age group weight status chemical. generation values time-intensive step, one approach generate populations C_ss values initially sample later.","code":"set.seed(2345) n_samples <- 500  # Get CASN for which httk simulation is possible. Try using load_dawson2021, # load_sipes2017, or load_pradeep2020 to increase availability. load_sipes2017() casn <- intersect(unique(geo_tox_data$dose_response$casn),                   get_cheminfo(suppress.messages = TRUE))  # Define population demographics for httk simulation pop_demo <- cross_join(   tibble(age_group = list(c(0, 2), c(3, 5), c(6, 10), c(11, 15),                           c(16, 20), c(21, 30), c(31, 40), c(41, 50),                           c(51, 60), c(61, 70), c(71, 100))),   tibble(weight = c(\"Normal\", \"Obese\"))) |>   # Create column of lower age_group values   rowwise() |>   mutate(age_min = age_group[1]) |>   ungroup()  # Create wrapper function around httk steps simulate_css <- function(chem.cas, agelim_years, weight_category,                          samples, verbose = TRUE) {      if (verbose) {     cat(chem.cas,         paste0(\"(\", paste(agelim_years, collapse = \", \"), \")\"),         weight_category,         \"\\n\")   }      httkpop <- list(method = \"vi\",                   gendernum = NULL,                   agelim_years = agelim_years,                   agelim_months = NULL,                   weight_category = weight_category,                   reths = c(                     \"Mexican American\",                     \"Other Hispanic\",                     \"Non-Hispanic White\",                     \"Non-Hispanic Black\",                     \"Other\"                   ))      css <- try(     suppressWarnings({       mcs <- create_mc_samples(chem.cas = chem.cas,                                samples = samples,                                httkpop.generate.arg.list = httkpop,                                suppress.messages = TRUE)              calc_analytic_css(chem.cas = chem.cas,                         parameters = mcs,                         model = \"3compartmentss\",                         suppress.messages = TRUE)     }),     silent = TRUE   )      # Return   if (is(css, \"try-error\")) {     warning(paste0(\"simulate_css failed to generate data for CASN \", chem.cas))     list(NA)   } else {     list(css)   } }  # Simulate `C_ss` values simulated_css <- map(casn, function(chem.cas) {   pop_demo |>     rowwise() |>     mutate(       css = simulate_css(.env$chem.cas, age_group, weight, .env$n_samples)     ) |>     ungroup() }) simulated_css <- setNames(simulated_css, casn)  # Remove CASN that failed simulate_css casn_keep <- map_lgl(simulated_css, function(df) {   !(length(df$css[[1]]) == 1 && is.na(df$css[[1]])) }) simulated_css <- simulated_css[casn_keep]  # Get median `C_ss` values for each age_group simulated_css <- map(   simulated_css,   function(cas_df) {     cas_df |>       nest(.by = age_group) |>       mutate(         age_median_css = map_dbl(data, function(df) median(unlist(df$css),                                                            na.rm = TRUE))       ) |>       unnest(data)   } )  # Get median `C_ss` values for each weight simulated_css <- map(   simulated_css,   function(cas_df) {     cas_df |>       nest(.by = weight) |>       mutate(         weight_median_css = map_dbl(data, function(df) median(unlist(df$css),                                                               na.rm = TRUE))       ) |>       unnest(data) |>       arrange(age_min, weight)   } )  geo_tox_data$simulated_css <- simulated_css"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"prune-data","dir":"Articles","previous_headings":"","what":"Prune data","title":"GeoTox Package Data","text":"Retain chemicals found exposure, dose-response C_ss datasets.","code":"casn_keep <- names(geo_tox_data$simulated_css)  geo_tox_data$exposure <- geo_tox_data$exposure |>    filter(casn %in% casn_keep)  geo_tox_data$dose_response <- geo_tox_data$dose_response |>    filter(casn %in% casn_keep)"},{"path":"https://github.com/NIEHS/GeoTox/articles/package_data.html","id":"countystate-boundaries","dir":"Articles","previous_headings":"","what":"County/State boundaries","title":"GeoTox Package Data","text":"Download cartographic boundary files counties states U.S. Census Bureau. geometry data North Carolina counties state included package data geo_tox_data$boundaries.","code":"county <- st_read(\"cb_2019_us_county_5m/cb_2019_us_county_5m.shp\") state <- st_read(\"cb_2019_us_state_5m/cb_2019_us_state_5m.shp\")  geo_tox_data$boundaries <- list(   county = county |>     filter(STATEFP == 37) |>     select(FIPS = GEOID, geometry),   state = state |>     filter(STATEFP == 37) |>     select(geometry) )"},{"path":"https://github.com/NIEHS/GeoTox/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Skylar Marvel. Author. David Reif. Author. Kyle Messier. Maintainer, author. Spatiotemporal Exposures Toxicology Group. Copyright holder.","code":""},{"path":"https://github.com/NIEHS/GeoTox/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Messier, P K, Reif, M D, Marvel, W S (2024). “GeoTox Package: Open-source software connecting spatiotemporal exposure individual population-level risk.” medRxiv. doi:10.1101/2024.09.23.24314096, https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1.full.pdf, https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1. Eccles, M K, Karmaus, L , Kleinstreuer, C N, Parham, Fred, Rider, V C, Wambaugh, F J, Messier, P K (2023). “geospatial modeling approach quantifying risk exposure environmental chemical mixtures via common molecular target.” Science Total Environment, 855, 158905.","code":"@Article{,   author = {{Messier} and Kyle P and {Reif} and David M and {Marvel} and Skylar W},   title = {The GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk},   journal = {medRxiv},   year = {2024},   doi = {10.1101/2024.09.23.24314096},   elocationid = {2024.09.23.24314096},   url = {https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1},   eprint = {https://www.medrxiv.org/content/10.1101/2024.09.23.24314096v1.full.pdf}, } @Article{,   author = {{Eccles} and Kristin M and {Karmaus} and Agnes L and {Kleinstreuer} and Nicole C and {Parham} and {Fred} and {Rider} and Cynthia V and {Wambaugh} and John F and {Messier} and Kyle P},   title = {A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target},   journal = {Science of The Total Environment},   volume = {855},   pages = {158905},   year = {2023},   publisher = {Elsevier}, }"},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"geotox-","dir":"","previous_headings":"","what":"Spatiotemporal Mixture Risk Assessment","title":"Spatiotemporal Mixture Risk Assessment","text":"GeoTox open-source R software package characterizing risk perturbing molecular targets involved adverse human health outcomes based exposure spatially-referenced stressor mixtures via GeoTox framework - otherwise known source--outcome-continuum modeling. package, methods, case-studies described Messier, Reif, Marvel, 2024, medRxiv-Preprint. GeoTox framework first described Eccles et al. geospatial modeling approach quantifying risk exposure environmental chemical mixtures via common molecular target. Sci Total Environ. 2023 Jan 10;855:158905.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Spatiotemporal Mixture Risk Assessment","text":"","code":"install.packages(\"GeoTox\")"},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"development-version","dir":"","previous_headings":"","what":"Development Version","title":"Spatiotemporal Mixture Risk Assessment","text":"development version can installed GitHub.","code":"#install.packages(\"pak\") pak::pak(\"NIEHS/GeoTox\")"},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Spatiotemporal Mixture Risk Assessment","text":"Figure 1 shows steps source--outcome-continuum GeoTox modeling framework capable GeoTox package. blue text nodes represent object green text, rounded nodes represent methodology function required go one next. GeoTox package uses R S3 object-oriented programming create GeoTox object. GeoTox object list contains information required run analysis including tracking exposure, assays, dose-response, geospatial referencing. Figure 1: Overview steps GeoTox framework","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"getting-started","dir":"","previous_headings":"","what":"Getting Started","title":"Spatiotemporal Mixture Risk Assessment","text":"Please refer introduction vignette detailed description use GeoTox.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Spatiotemporal Mixture Risk Assessment","text":"citation information, please refer CITATION file.","code":""},{"path":"https://github.com/NIEHS/GeoTox/index.html","id":"issues-and-contributions","dir":"","previous_headings":"","what":"Issues and Contributions","title":"Spatiotemporal Mixture Risk Assessment","text":"add edit functionality, open pull request main branch detailed description proposed changes. Pull requests must pass status checks, approved rejected GeoTox maintainers. Utilize GitHub issues notify authors bugs, questions, recommendations. Identify issue appropriate label help ensure timely response.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox-package.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","title":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","text":"Connecting spatiotemporal exposure individual population-level risk via source--outcome continuum modeling. package, methods, case-studies described Messier, Reif, Marvel (2024) doi:10.1101/2024.09.23.24314096  Eccles et al. (2023) doi:10.1016/j.scitotenv.2022.158905 .","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"GeoTox: Spatiotemporal Mixture Risk Assessment — GeoTox-package","text":"Maintainer: Kyle Messier kyle.messier@nih.gov (ORCID) Authors: Skylar Marvel skylar.marvel@nih.gov (ORCID) David Reif david.reif@nih.gov (ORCID) contributors: Spatiotemporal Exposures Toxicology Group [copyright holder]","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox S3 object — GeoTox","title":"GeoTox S3 object — GeoTox","text":"S3 object can used help organize data results GeoTox analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"GeoTox S3 object — GeoTox","text":"","code":"GeoTox()  # S3 method for class 'GeoTox' plot(x, type = c(\"resp\", \"hill\", \"exposure\", \"sensitivity\"), ...)"},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"GeoTox S3 object — GeoTox","text":"x GeoTox object. type type plot. ... arguments passed subsequent methods.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"GeoTox S3 object — GeoTox","text":"GeoTox S3 object","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/GeoTox.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"GeoTox S3 object — GeoTox","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  geoTox <- GeoTox() |>    # Set region and group boundaries (for plotting)   set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state) |>    # Simulate populations for each region   simulate_population(age           = split(geo_tox_data$age, ~FIPS)[idx],                       obesity       = geo_tox_data$obesity[idx, ],                       exposure      = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n             = n) |>    # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                      dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed)) |>   # Calculate response   calculate_response() |>   # Perform sensitivity analysis   sensitivity_analysis()  # Print GeoTox object geoTox #> GeoTox object #> Assays: 13 #> Chemicals: 20 #> Regions: 5 #> Population: 10 #> Data Fields: #>      Name            Class            Dim #>       age    list(integer)       5 x (10) #>        IR    list(numeric)       5 x (10) #>   obesity  list(character)       5 x (10) #>     C_ext     list(matrix)  5 x (10 x 21) #>      C_ss     list(matrix)  5 x (10 x 21) #> Computed Fields: #>          Name             Class            Dim #>         D_int      list(matrix)  5 x (10 x 21) #>     C_invitro      list(matrix)  5 x (10 x 21) #>          resp  list(data.frame)  5 x (130 x 6) #>   sensitivity        list(list)        5 x (5) #> Other Fields: par, boundaries, exposure, css_sensitivity, hill_params  # Plot hill fits plot(geoTox, type = \"hill\")  # Plot exposure data plot(geoTox, type = \"exposure\", ncol = 5)  # Plot response data plot(geoTox) #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up'  plot(geoTox, assays = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\")  # Plot sensitivity data plot(geoTox, type = \"sensitivity\") #> Warning: Multiple assays found, using first assay 'APR_HepG2_p53Act_24h_up' #> Warning: Removed 240 NA values #> Picking joint bandwidth of 0.204  plot(geoTox, type = \"sensitivity\", assay = \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") #> Picking joint bandwidth of 0.489"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"Calculate combined response multiple chemicals. calculates generalized concentration addition response, independent action response, hazard quotient","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"","code":"calc_concentration_response(   C_invitro,   hill_params,   max_mult = 1.5,   fixed = FALSE )"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"C_invitro vitro concentrations hill_params output fit_hill() max_mult upper bound multiplier max response fixed TRUE, sd = 0","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"list data frames","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_concentration_response.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate the mixture response from one of three different approaches: IA, GCA, or Hazard Quotient — calc_concentration_response","text":"","code":"C_invitro <- list(   matrix(1:8 / 1e3, ncol = 2, dimnames = list(NULL, c(\"c1\", \"c2\"))),   matrix(9:16 / 1e3, ncol = 2, dimnames = list(NULL, c(\"c1\", \"c2\"))) ) hill_params <- fit_hill(   data.frame(chem = rep(c(\"c1\", \"c2\"), each = 3),              logc = c(-1, 0, 1, 0, 1, 2),              resp = c(10, 5, 0, 4, 2, 0) / 10),   chem = \"chem\" )  calc_concentration_response(C_invitro, hill_params) #> [[1]] #>   sample      GCA.Eff       IA.Eff  GCA.HQ.10   IA.HQ.10 #> 1      1 0.0076864671 0.0077364934 0.55601871 0.55600659 #> 2      2 0.0006767173 0.0006770262 0.01534725 0.01534744 #> 3      3 0.0722956637 0.0741979092 1.45744108 1.45745710 #> 4      4 0.0273376842 0.0274220130 0.39699362 0.39699367 #>  #> [[2]] #>   sample    GCA.Eff     IA.Eff GCA.HQ.10  IA.HQ.10 #> 1      1 0.18688743 0.18693404 3.7723954 3.7724269 #> 2      2 0.01226720 0.01227572 0.3474801 0.3474778 #> 3      3 0.01883785 0.01894890 1.7068482 1.7068523 #> 4      4 0.12791787 0.12799417 2.2230433 2.2230437 #>  calc_concentration_response(C_invitro, hill_params, fixed = TRUE) #> [[1]] #>   sample   GCA.Eff    IA.Eff GCA.HQ.10 IA.HQ.10 #> 1      1 0.2393398 0.2742427  13.49985     13.5 #> 2      2 0.3102525 0.3493325  23.39997     23.4 #> 3      3 0.3479706 0.3866123  33.29939     33.3 #> 4      4 0.3713827 0.4087487  43.19904     43.2 #>  #> [[2]] #>   sample   GCA.Eff    IA.Eff GCA.HQ.10 IA.HQ.10 #> 1      1 0.4200784 0.4517192  92.70122     92.7 #> 2      2 0.4246337 0.4554551 102.60133    102.6 #> 3      3 0.4284513 0.4585306 112.50143    112.5 #> 4      4 0.4316926 0.4611019 122.40154    122.4 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":null,"dir":"Reference","previous_headings":"","what":"Independent Action — calc_independent_action","title":"Independent Action — calc_independent_action","text":"Calculate independent action response set chemicals Hill concentration-response curves.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Independent Action — calc_independent_action","text":"","code":"calc_independent_action(conc, max, AC50, Emax, n = 1)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Independent Action — calc_independent_action","text":"conc concentrations regular space max maximal (asymptotic) responses AC50 concentrations half-maximal response Emax maximum mixture response n Hill coefficients (slopes)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Independent Action — calc_independent_action","text":"response value","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Independent Action — calc_independent_action","text":"concentration computed : $$   IA = E_{max} \\times   \\left(     1 - \\prod\\limits_{} \\left(1 - \\frac{x_i}{E_{max}}\\right)   \\right), $$ \\(x_i = hill\\_val(conc_i, max_i, AC50_i, n_i)\\) Hill model response function chemical.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_independent_action.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Independent Action — calc_independent_action","text":"","code":"n_chem <- 5 conc <- 10^sample(-1:4, n_chem, replace = TRUE) max <- 80 * runif(n_chem) AC50 <- 10^(5 * runif(n_chem) - 1) Emax <- 100  calc_independent_action(conc, max, AC50, Emax) #> [1] 79.86892"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate internal chemical dose — calc_internal_dose","title":"Calculate internal chemical dose — calc_internal_dose","text":"Estimate internal dose inhalation chemical given inhalation rate, time, body weight","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate internal chemical dose — calc_internal_dose","text":"","code":"calc_internal_dose(C_ext, IR, time = 1, BW = 1, scaling = 1)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate internal chemical dose — calc_internal_dose","text":"C_ext ambient chemical concentration \\(\\frac{mg}{m^3}\\) IR inhalation rate \\(\\frac{m^3}{day}\\) time total time \\(days\\) BW body weight \\(kg\\) scaling scaling factor encompassing required unit adjustments","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate internal chemical dose — calc_internal_dose","text":"list matrices containing internal chemical doses \\(\\frac{mg}{kg}\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate internal chemical dose — calc_internal_dose","text":"Input C_ext must matrix list matrices. Input IR must atomic vector list atomic vectors. time, BW scaling arguments scalars. internal dose calculated : $$D_{int} = \\frac{C_{ext} \\times IR \\times time}{BW} \\times scaling$$","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_internal_dose.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate internal chemical dose — calc_internal_dose","text":"","code":"# Single population C_ext <- matrix(1:15, ncol = 3) IR <- 1:5 calc_internal_dose(C_ext, IR) #> [[1]] #>      [,1] [,2] [,3] #> [1,]    1    6   11 #> [2,]    4   14   24 #> [3,]    9   24   39 #> [4,]   16   36   56 #> [5,]   25   50   75 #>   # Multiple populations C_ext <- list(   \"a\" = matrix(1:15 / 10, ncol = 3),   \"b\" = matrix(1:8, ncol = 2) ) IR <- list(1:5, 1:4 / 2) calc_internal_dose(C_ext, IR) #> $a #>      [,1] [,2] [,3] #> [1,]  0.1  0.6  1.1 #> [2,]  0.4  1.4  2.4 #> [3,]  0.9  2.4  3.9 #> [4,]  1.6  3.6  5.6 #> [5,]  2.5  5.0  7.5 #>  #> $b #>      [,1] [,2] #> [1,]  0.5  2.5 #> [2,]  2.0  6.0 #> [3,]  4.5 10.5 #> [4,]  8.0 16.0 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate in vitro concentration — calc_invitro_concentration","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"Estimate vitro equivalent plasma concentration given internal chemical dose steady-state plasma concentration.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"","code":"calc_invitro_concentration(D_int, C_ss = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"D_int internal chemical dose \\(\\frac{mg}{kg}\\) C_ss steady-state plasma concentration \\(\\frac{\\mu M}{mg / kg}\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"list matrices containing concentrations \\(\\mu M\\)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"Input D_int must matrix list matrices. Input C_ss must numeric atomic vector matrix, list types. vitro equivalent plasma concentration calculated : $$C_{plasma} = C_{ss} \\times D_{int}$$","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calc_invitro_concentration.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate in vitro concentration — calc_invitro_concentration","text":"","code":"# Single population D_int <- matrix(1:15, ncol = 3) C_ss <- 1:5 calc_invitro_concentration(D_int, C_ss) #> [[1]] #>      [,1] [,2] [,3] #> [1,]    1    6   11 #> [2,]    4   14   24 #> [3,]    9   24   39 #> [4,]   16   36   56 #> [5,]   25   50   75 #>   # Multiple populations D_int <- list(   \"a\" = matrix(1:15 / 10, ncol = 3),   \"b\" = matrix(1:8, ncol = 2) ) C_ss <- list(1:5, 1:4 / 2) calc_invitro_concentration(D_int, C_ss) #> $a #>      [,1] [,2] [,3] #> [1,]  0.1  0.6  1.1 #> [2,]  0.4  1.4  2.4 #> [3,]  0.9  2.4  3.9 #> [4,]  1.6  3.6  5.6 #> [5,]  2.5  5.0  7.5 #>  #> $b #>      [,1] [,2] #> [1,]  0.5  2.5 #> [2,]  2.0  6.0 #> [3,]  4.5 10.5 #> [4,]  8.0 16.0 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":null,"dir":"Reference","previous_headings":"","what":"Calculate response — calculate_response","title":"Calculate response — calculate_response","text":"Calculate mixture response GeoTox population data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Calculate response — calculate_response","text":"","code":"calculate_response(x, ...)"},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Calculate response — calculate_response","text":"x GeoTox object ... additional arguments passed functions. See details.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Calculate response — calculate_response","text":"object additional fields added updated","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Calculate response — calculate_response","text":"Additional parameters include time, BW, scaling calc_internal_dose, max_mult calc_concentration_response.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/calculate_response.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Calculate response — calculate_response","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Response computations can now be done geoTox <- geoTox |> calculate_response()"},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute response sensitivity to parameter variation. — compute_sensitivity","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"Compute response sensitivity parameter variation.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"","code":"compute_sensitivity(   x,   vary = c(\"age\", \"obesity\", \"css_params\", \"fit_params\", \"C_ext\"),   max_mult = NULL )"},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"x GeoTox object. vary parameter vary. max_mult input calc_concentration_response step.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"output calc_concentration_response","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/compute_sensitivity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute response sensitivity to parameter variation. — compute_sensitivity","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Sensitivity computations can now be done age_resp <- geoTox |> compute_sensitivity() obesity_resp <- geoTox |> compute_sensitivity(vary = \"obesity\")"},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":null,"dir":"Reference","previous_headings":"","what":"Fit 2- or 3-parameter Hill model — fit_hill","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"Fit 2- 3-parameter Hill model","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"","code":"fit_hill(   x,   conc = \"logc\",   resp = \"resp\",   fixed_slope = TRUE,   chem = NULL,   assay = NULL )"},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"x data frame dose response data. conc column name base-10 log scaled concentration. resp column name response. fixed_slope TRUE, slope fixed 1. chem (optional) column name chemical identifiers. assay (optional) column name assay identifiers.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"data frame fit parameters.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"Optional chem assay identifiers can used fit multiple chemicals /assays. Returned columns tp top asymptote logAC50 50% response concentration. computation standard deviations two parameters fails, standard deviation set equal parameter estimate indicated respective imputed flag TRUE.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/fit_hill.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Fit 2- or 3-parameter Hill model — fit_hill","text":"","code":"# Multiple assays, multiple chemicals df <- geo_tox_data$dose_response fit_hill(df, assay = \"endp\", chem = \"casn\") #> # A tibble: 89 × 15 #>    assay  chem     tp  tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max #>    <chr>  <chr> <dbl>  <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl> #>  1 APR_H… 510-…  4.44  5.86     2.06      0.448     1        0   -0.398     2.30 #>  2 APR_H… 92-8…  2.14  0.945    2.05      0.271     1        0   -0.398     2.30 #>  3 APR_H… 95-9…  1.46  0.556    1.67      0.246     1        0   -0.699     2    #>  4 APR_H… 510-…  2.33  0.542    1.79      0.192     1        0   -0.398     2.30 #>  5 APR_H… 72-4…  1.93  1.93     1.95      1.95      1        0   -0.398     2.30 #>  6 APR_H… 92-8…  2.43  1.50     2.22      0.317     1        0   -0.398     2.30 #>  7 ATG_p… 87-8…  2.15  0.877    1.57      0.321     1        0   -1.30      2    #>  8 TOX21… 100-… 71.4  27.2      1.54      0.294     1        0   -3         2    #>  9 TOX21… 101-… 80.1  80.1      2.31      2.31      1        0   -3         1.95 #> 10 TOX21… 101-…  0     0        2.45      0.101     1        0   -3         1.95 #> # ℹ 79 more rows #> # ℹ 5 more variables: resp_min <dbl>, resp_max <dbl>, AIC <dbl>, #> #   tp.sd.imputed <lgl>, logAC50.sd.imputed <lgl>  # Single assay, multiple chemicals df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") fit_hill(df, chem = \"casn\") #> # A tibble: 7 × 14 #>   chem        tp  tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max #>   <chr>    <dbl>  <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl> #> 1 106-50-3  29.9  14.7     1.88     0.363      1        0    -3        1.90 #> 2 119-90-4  65.6  65.6     2.09     2.09       1        0    -2.70     2.30 #> 3 120-80-9 126.    8.29    1.54     0.0796     1        0    -2.70     2.30 #> 4 123-31-9 108.  108.      2.39     2.39       1        0    -2.70     2.30 #> 5 510-15-6  48.5   7.47    2.24     0.123      1        0    -2.70     2.30 #> 6 88-06-2   58.7  37.0     2.80     0.310      1        0    -2.70     2.30 #> 7 92-87-5   73.7   7.22    2.06     0.0863     1        0    -2.70     2.30 #> # ℹ 5 more variables: resp_min <dbl>, resp_max <dbl>, AIC <dbl>, #> #   tp.sd.imputed <lgl>, logAC50.sd.imputed <lgl>  # Single assay, single chemical df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",                 casn == \"510-15-6\") fit_hill(df) #> # A tibble: 1 × 13 #>      tp tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max resp_min #>   <dbl> <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl>    <dbl> #> 1  48.5  7.47    2.24      0.123     1        0    -2.70     2.30    -2.38 #> # ℹ 4 more variables: resp_max <dbl>, AIC <dbl>, tp.sd.imputed <lgl>, #> #   logAC50.sd.imputed <lgl> # 3-parameter Hill model fit_hill(df, fixed_slope = FALSE) #> # A tibble: 1 × 13 #>      tp tp.sd logAC50 logAC50.sd slope slope.sd logc_min logc_max resp_min #>   <dbl> <dbl>   <dbl>      <dbl> <dbl>    <dbl>    <dbl>    <dbl>    <dbl> #> 1  31.2  1.29    1.83     0.0173  4.02    0.864    -2.70     2.30    -2.38 #> # ℹ 4 more variables: resp_max <dbl>, AIC <dbl>, tp.sd.imputed <lgl>, #> #   logAC50.sd.imputed <lgl>"},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":null,"dir":"Reference","previous_headings":"","what":"GeoTox Data — geo_tox_data","title":"GeoTox Data — geo_tox_data","text":"Sample data use vignettes function examples. See Package Data vignette, vignette(\"package_data\", package = \"GeoTox\"), details data gathered.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"GeoTox Data — geo_tox_data","text":"","code":"geo_tox_data"},{"path":"https://github.com/NIEHS/GeoTox/reference/geo_tox_data.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"GeoTox Data — geo_tox_data","text":"list items: exposure 2019 AirToxScreen exposure concentrations subset chemicals North Carolina counties. dose_response Subset chemicals curated ICE cHTS active within set assays. age County population estimates 7/1/2019 North Carolina. obesity CDC PLACES obesity data North Carolina counties 2020. simulated_css Simulated steady-state plasma concentrations various age groups obesity status combinations. boundaries County state boundaries North Carolina 2019.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed Age — get_fixed_age","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"Get C_ss Data Fixed Age","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"","code":"get_fixed_age(simulated_css, age)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"list matrices containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_age.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed Age — get_fixed_age","text":"","code":"get_fixed_age(simulated_css = geo_tox_data$simulated_css,               age = list(c(25, 35, 55), c(15, 60))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  5.6245   6.656   2.3210  0.20555 0.10435  0.11010  0.35850  0.1832 #> [2,]  6.7320   8.194   3.0145  0.26055 0.13450  0.14015  0.48860  0.2070 #> [3,]  9.7745  10.615   3.7720  0.34805 0.18920  0.21190  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.2445   1.4985  0.84285   6.7105  0.30055  2.2450  3.4785  3.3765 #> [2,]  1.6280   1.9545  1.17400   7.3715  0.39220  2.7920  3.8750  4.4375 #> [3,]  2.2435   2.5475  1.44250   8.6155  0.53005  3.6225  4.6450  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  1.0200   1.3740   3.187  4.7235  2.6265 #> [2,]  1.2380   1.6265   3.648  5.8290  3.2970 #> [3,]  1.5575   2.1620   4.755  7.8175  4.3650 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4  63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.3915  4.7355   1.7015  0.16175 0.073885 0.089035  0.27315  0.1245 #> [2,]  9.7745 10.6150   3.7720  0.34805 0.189200 0.211900  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,] 0.97755   1.1135  0.68195   5.3505  0.20900  1.6395   2.781  2.6675 #> [2,] 2.24350   2.5475  1.44250   8.6155  0.53005  3.6225   4.645  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7936    1.023   2.194  3.9780  1.9685 #> [2,]  1.5575    2.162   4.755  7.8175  4.3650 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":null,"dir":"Reference","previous_headings":"","what":"Get Fixed C_ss Data — get_fixed_css","title":"Get Fixed C_ss Data — get_fixed_css","text":"Get C_ss values use sensitivity_analysis compute_sensitivity.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get Fixed C_ss Data — get_fixed_css","text":"","code":"get_fixed_css(simulated_css, age, obesity, C_ss)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get Fixed C_ss Data — get_fixed_css","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages. obesity list atomic vectors containing obesity status. C_ss list matrices containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get Fixed C_ss Data — get_fixed_css","text":"list matrices atomic vectors containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_css.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get Fixed C_ss Data — get_fixed_css","text":"","code":"# Define inputs age <- list(c(25, 35, 55),             c(15, 60)) obesity <- list(c(\"Obese\", \"Normal\", \"Obese\"),                 c(\"Normal\", \"Normal\")) C_ss <- sample_Css(simulated_css = geo_tox_data$simulated_css,                    age = age,                    obesity = obesity)  # Get fixed C_ss data get_fixed_css(simulated_css = geo_tox_data$simulated_css,               age = age,               obesity = obesity,               C_ss = C_ss) #> $age #> $age[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  5.6245   6.656   2.3210  0.20555 0.10435  0.11010  0.35850  0.1832 #> [2,]  6.7320   8.194   3.0145  0.26055 0.13450  0.14015  0.48860  0.2070 #> [3,]  9.7745  10.615   3.7720  0.34805 0.18920  0.21190  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.2445   1.4985  0.84285   6.7105  0.30055  2.2450  3.4785  3.3765 #> [2,]  1.6280   1.9545  1.17400   7.3715  0.39220  2.7920  3.8750  4.4375 #> [3,]  2.2435   2.5475  1.44250   8.6155  0.53005  3.6225  4.6450  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  1.0200   1.3740   3.187  4.7235  2.6265 #> [2,]  1.2380   1.6265   3.648  5.8290  3.2970 #> [3,]  1.5575   2.1620   4.755  7.8175  4.3650 #>  #> $age[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4  63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.3915  4.7355   1.7015  0.16175 0.073885 0.089035  0.27315  0.1245 #> [2,]  9.7745 10.6150   3.7720  0.34805 0.189200 0.211900  0.66345  0.2928 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,] 0.97755   1.1135  0.68195   5.3505  0.20900  1.6395   2.781  2.6675 #> [2,] 2.24350   2.5475  1.44250   8.6155  0.53005  3.6225   4.645  6.2555 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7936    1.023   2.194  3.9780  1.9685 #> [2,]  1.5575    2.162   4.755  7.8175  4.3650 #>  #>  #> $params #> $params[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   3.720 25.9000    4.800  0.07592 0.29870  0.23420   0.7295 0.14230 #> [2,]   2.488  0.8094   22.560  0.23280 0.05003  0.02254   0.2919 0.07566 #> [3,]   4.384  1.6220    1.325  0.12190 0.08474  0.06052   1.0870 0.11880 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.680    1.089   4.5530   21.360   0.3849  1.5030   2.979  20.780 #> [2,]   1.974    1.475   1.1020    1.717   0.3452  0.5761   2.150   1.355 #> [3,]   1.212    1.341   0.9264   11.510   0.2517  7.2560   2.450   2.109 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.7866   0.3238   2.186  0.9258  0.8813 #> [2,]  1.3160   1.0380   3.410  3.8810  1.5600 #> [3,]  1.0760   1.9520   4.217  5.9390  3.1460 #>  #> $params[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   2.276   2.578   0.4497   0.4456 0.07661   0.1058   0.2782  0.1107 #> [2,]  16.200   7.308   2.9800   0.5936 1.45200   0.1064   0.6615  0.1498 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  1.4790   0.5304   0.2464    5.750  0.08054   1.703  23.150   14.06 #> [2,]  0.5934   2.4130   0.6624    3.265  0.12990   4.181   1.659   14.13 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]   1.743   0.8955   1.574   8.728   2.302 #> [2,]   2.014   1.0190  10.580   3.001   1.525 #>  #>  #> $obesity #> $obesity[[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #> [2,]  4.4205  4.9300    1.849  0.16290  0.0820 0.088135   0.3035 0.12915 #> [3,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387  1.7780   2.953   2.757 #> [3,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 1.31000    1.758  3.8180  6.3620  3.6535 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [3,] 1.31000    1.758  3.8180  6.3620  3.6535 #>  #> $obesity[[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #> [2,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #>  #>  #> $other #> $other[[1]] #> [1] 2.588 2.588 2.588 #>  #> $other[[2]] #> [1] 1.381 1.381 #>  #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"Get C_ss Data Fixed Obesity Status","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"","code":"get_fixed_obesity(simulated_css, obesity)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). obesity list atomic vectors containing obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"list matrices containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_obesity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed Obesity Status — get_fixed_obesity","text":"","code":"get_fixed_obesity(simulated_css = geo_tox_data$simulated_css,                   obesity = list(c(\"Obese\", \"Normal\", \"Obese\"),                                  c(\"Normal\", \"Normal\"))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #> [2,]  4.4205  4.9300    1.849  0.16290  0.0820 0.088135   0.3035 0.12915 #> [3,]  7.4820  8.6775    2.965  0.28405  0.1432 0.153750   0.5077 0.22425 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387  1.7780   2.953   2.757 #> [3,]   1.726   2.0710   1.1730   7.3635   0.4089  2.9815   3.926   4.751 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 1.31000    1.758  3.8180  6.3620  3.6535 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [3,] 1.31000    1.758  3.8180  6.3620  3.6535 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #> [2,]  4.4205    4.93    1.849   0.1629   0.082 0.088135   0.3035 0.12915 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #> [2,]   1.037   1.2025   0.7162   5.8545   0.2387   1.778   2.953   2.757 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,] 0.80915    1.087  2.3715  3.7635  2.1955 #> [2,] 0.80915    1.087  2.3715  3.7635  2.1955 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":null,"dir":"Reference","previous_headings":"","what":"Get median C_ss Values — get_fixed_other","title":"Get median C_ss Values — get_fixed_other","text":"Get median C_ss Values","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get median C_ss Values — get_fixed_other","text":"","code":"get_fixed_other(C_ss)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get median C_ss Values — get_fixed_other","text":"C_ss list matrices containing C_ss data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get median C_ss Values — get_fixed_other","text":"list atomic vectors containing median C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_other.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get median C_ss Values — get_fixed_other","text":"","code":"# Generate input C_ss data age <- list(c(25, 35, 55),             c(15, 60)) obesity <- list(c(\"Obese\", \"Normal\", \"Obese\"),                 c(\"Normal\", \"Normal\")) C_ss <- sample_Css(simulated_css = geo_tox_data$simulated_css,                    age = age,                    obesity = obesity)  # Get median C_ss values get_fixed_other(C_ss) #> [[1]] #> [1] 2.45 2.45 2.45 #>  #> [[2]] #> [1] 1.6895 1.6895 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":null,"dir":"Reference","previous_headings":"","what":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"Get C_ss Data Fixed C_ss Generation Parameters","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"","code":"get_fixed_params(simulated_css, age)"},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vectors containing ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"list matrices containing C_ss values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/get_fixed_params.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get C_ss Data for Fixed C_ss Generation Parameters — get_fixed_params","text":"","code":"get_fixed_params(simulated_css = geo_tox_data$simulated_css,                  age = list(c(25, 35, 55), c(15, 60))) #> [[1]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   2.595  0.5459    1.782   0.2642 0.18630  0.03007   1.4080 0.09582 #> [2,]   3.543  1.0850    5.692   0.1298 0.03938  0.10010  13.7300 0.40390 #> [3,]   3.250  1.7390    9.401   0.2014 0.06880  0.02218   0.3102 0.17550 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  3.1200   0.3398   0.3828    6.138   0.6469  0.4783   6.558   3.050 #> [2,]  0.4771   1.6840   9.7810    3.915   0.6829 14.8500   4.514   3.637 #> [3,]  1.0180   5.4550   0.6603   11.830   0.2534  2.0280   3.349   3.140 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  0.5220    0.733   5.581   7.804  6.7490 #> [2,]  0.5415    3.464   3.815   7.185  1.9910 #> [3,]  0.2630    4.582   8.341   1.561  0.5831 #>  #> [[2]] #>      87-86-5 95-95-4 133-06-2 101-14-4 63-25-2 510-15-6 106-50-3 91-94-1 #> [1,]   1.794   15.08   0.4329   0.9152 0.04971  0.04314   0.7964 0.08704 #> [2,]  25.920    6.18   1.9380   0.1242 0.61000  0.10650   4.6570 0.05691 #>      84-74-2 120-80-9 100-02-7 119-90-4 123-31-9 60-11-7 95-80-7 88-06-2 #> [1,]  0.3507    2.951   1.8480    8.269   0.8545   0.858   5.395  2.5680 #> [2,]  0.8936    1.769   0.8127    2.375   0.1742   2.632  43.790  0.8412 #>      92-87-5 101-77-9 53-96-3 72-43-5 56-38-2 #> [1,]  3.0890   0.7562  0.9738   5.518  0.7429 #> [2,]  0.2205   2.3210  5.7920   3.051  2.9160 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":null,"dir":"Reference","previous_headings":"","what":"Hill model concentration — hill_conc","title":"Hill model concentration — hill_conc","text":"Calculate concentration regular space given response value.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Hill model concentration — hill_conc","text":"","code":"hill_conc(resp, max, AC50, n)"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Hill model concentration — hill_conc","text":"resp response value max maximal (asymptotic) response AC50 concentration half-maximal response n Hill coefficient (slope)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Hill model concentration — hill_conc","text":"concentration regular space","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Hill model concentration — hill_conc","text":"regular space version tcpl::tcplHillConc(). concentration computed : $$conc = AC50 * (\\frac{max}{resp} - 1)^{-1 / n}$$","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_conc.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Hill model concentration — hill_conc","text":"","code":"hill_conc(c(0.2, 0.5, 0.75), 1, 0.01, 1) #> [1] 0.0025 0.0100 0.0300 hill_conc(c(0.2, 0.5, 0.9), 1, c(0.1, 0.01, 0.001), 2) #> [1] 0.050 0.010 0.003"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":null,"dir":"Reference","previous_headings":"","what":"Hill model response — hill_val","title":"Hill model response — hill_val","text":"Calculate response given concentration regular space.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Hill model response — hill_val","text":"","code":"hill_val(conc, max, AC50, n)"},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Hill model response — hill_val","text":"conc concentration regular space max maximal (asymptotic) response AC50 concentration half-maximal response n Hill coefficient (slope)","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Hill model response — hill_val","text":"response value","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Hill model response — hill_val","text":"regular space version tcpl::tcplHillVal(). Hill model defined : $$resp = \\frac{max}{1 + (\\frac{AC50}{conc})^{n}}$$","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/hill_val.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Hill model response — hill_val","text":"","code":"hill_val(c(0.0025, 0.01, 0.03), 1, 0.01, 1) #> [1] 0.20 0.50 0.75 hill_val(c(0.05, 0.01, 0.003), 1, c(0.1, 0.01, 0.001), 2) #> [1] 0.2 0.5 0.9"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot exposure data. — plot_exposure","title":"Plot exposure data. — plot_exposure","text":"Plot exposure data.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot exposure data. — plot_exposure","text":"","code":"plot_exposure(   exposure,   region_boundary,   group_boundary = NULL,   chem_label = \"chnm\",   ncol = 2 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot exposure data. — plot_exposure","text":"exposure list exposure data named region label. region_boundary \"sf\" data.frame mapping features \"geometry\" column. Used color regions. group_boundary (optional) \"sf\" data.frame containing \"geometry\" column. Used draw outlines. chem_label label facet_wrap. ncol number columns wrap.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot exposure data. — plot_exposure","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_exposure.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot exposure data. — plot_exposure","text":"","code":"# Load package data exposure <- split(geo_tox_data$exposure, ~FIPS) region_boundary <- geo_tox_data$boundaries$county group_boundary <- geo_tox_data$boundaries$state  # Plot county exposure data # Use CASN as label to avoid long chemical names plot_exposure(exposure,               region_boundary,               chem_label = \"casn\",               ncol = 5)   # Add state boundaries plot_exposure(exposure,               region_boundary,               group_boundary = group_boundary,               chem_label = \"casn\",               ncol = 5)"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot Hill equation fits. — plot_hill","title":"Plot Hill equation fits. — plot_hill","text":"Plot Hill equation fits.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot Hill equation fits. — plot_hill","text":"","code":"plot_hill(hill_params, xlim = c(-1, 4))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot Hill equation fits. — plot_hill","text":"hill_params output fit_hill. xlim log-10 scaled concentration limits.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot Hill equation fits. — plot_hill","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_hill.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot Hill equation fits. — plot_hill","text":"","code":"# Multiple assays, multiple chemicals df <- geo_tox_data$dose_response plot_hill(fit_hill(df, assay = \"endp\", chem = \"casn\"))   # Single assay, multiple chemicals df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\") fig <- plot_hill(fit_hill(df, chem = \"casn\")) fig  # Modify plot fig + ggplot2::guides(color = ggplot2::guide_legend(title = \"Chemical\\nCASN\"))   # Single assay, single chemical df <- geo_tox_data$dose_response |>   dplyr::filter(endp == \"TOX21_H2AX_HTRF_CHO_Agonist_ratio\",                 casn == \"510-15-6\") plot_hill(fit_hill(df))  # 3-parameter Hill model plot_hill(fit_hill(df, fixed_slope = FALSE))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot response data — plot_resp","title":"Plot response data — plot_resp","text":"Plot response data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot response data — plot_resp","text":"","code":"plot_resp(   df,   region_boundary,   group_boundary = NULL,   assay_quantiles = c(Median = 0.5),   summary_quantiles = c(`10th percentile` = 0.1) )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot response data — plot_resp","text":"df output resp_quantiles. region_boundary \"sf\" data.frame mapping features \"geometry\" column. Used color map regions. group_boundary \"sf\" data.frame containing \"geometry\" column. Used draw outlines around groups regions. assay_quantiles named numeric vector assay quantile labels. summary_quantiles named numeric vector summary quantile labels.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot response data — plot_resp","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_resp.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot response data — plot_resp","text":"","code":"# Use example boundary data from package region_boundary <- geo_tox_data$boundaries$county group_boundary <- geo_tox_data$boundaries$state n <- nrow(region_boundary)  # Single assay quantile df <- data.frame(id = region_boundary$FIPS,                  metric = \"GCA.Eff\",                  assay_quantile = 0.5,                  value = runif(n)^3) # Default plot plot_resp(df, region_boundary)  # Add group boundary, a state border in this case plot_resp(df, region_boundary, group_boundary)  # Change quantile label plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"Q50\" = 0.5))   # Multiple assay quantiles df <- data.frame(id = rep(region_boundary$FIPS, 2),                  metric = \"GCA.Eff\",                  assay_quantile = rep(c(0.25, 0.75), each = n),                  value = c(runif(n)^3, runif(n)^3 + 0.15)) plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"Q25\" = 0.25, \"Q75\" = 0.75))   # Summary quantiles df <- data.frame(id = rep(region_boundary$FIPS, 4),                  assay_quantile = rep(rep(c(0.25, 0.75), each = n), 2),                  summary_quantile = rep(c(0.05, 0.95), each = n * 2),                  metric = \"GCA.Eff\",                  value = c(runif(n)^3, runif(n)^3 + 0.15,                            runif(n)^3 + 0.7, runif(n)^3 + 0.85)) plot_resp(df, region_boundary, group_boundary,           assay_quantiles = c(\"A_Q25\" = 0.25, \"A_Q75\" = 0.75),           summary_quantiles = c(\"S_Q05\" = 0.05, \"S_Q95\" = 0.95))"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot results of sensitivity analysis. — plot_sensitivity","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"Plot results sensitivity analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"","code":"plot_sensitivity(   x,   metric = \"GCA.Eff\",   assay = NULL,   y = \"\",   xlab = metric,   ylab = \"\" )"},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"x GeoTox object. metric metric plot. Valid choices \"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\", \"IA.HQ.10\". assay assay plot, multiple exist. y y value text bottom ridge plot. xlab x-axis label. ylab y-axis label.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"ggplot2 object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/plot_sensitivity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot results of sensitivity analysis. — plot_sensitivity","text":"","code":"# Required GeoTox fields are generated by first running [calculate_response] # and [sensitivity_analysis] on a GeoTox object. This will create the fields # `resp` and `sensitivity`. For this example, dummy data will be used. make_data <- function(n = 5, metric = \"GCA.Eff\") {   list(stats::setNames(data.frame(1:n, runif(n)),                        c(\"sample\", metric))) }  geoTox <- GeoTox() geoTox$resp <- make_data() geoTox$sensitivity <- list(age = make_data(),                            obesity = make_data(),                            css_params = make_data(),                            fit_params = make_data(),                            C_ext = make_data())  plot_sensitivity(geoTox) #> Picking joint bandwidth of 0.11"},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":null,"dir":"Reference","previous_headings":"","what":"Get response quantiles — resp_quantiles","title":"Get response quantiles — resp_quantiles","text":"Get response quantiles","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get response quantiles — resp_quantiles","text":"","code":"resp_quantiles(   resp,   metric = c(\"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\", \"IA.HQ.10\"),   assays = NULL,   assay_summary = FALSE,   assay_quantiles = c(Median = 0.5),   summary_quantiles = c(`10th percentile` = 0.1) )"},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get response quantiles — resp_quantiles","text":"resp calculated mixture response output calc_concentration_response. metric response metric, one \"GCA.Eff\", \"IA.Eff\", \"GCA.HQ.10\" \"IA.HQ.10\". assays assays summarize. NULL multiple assays exist, first assay used. assay_summary boolean indicating whether summarize across assays. assay_quantiles numeric vector assay quantiles. summary_quantiles numeric vector quantiles compute across assay quantiles.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get response quantiles — resp_quantiles","text":"data frame computed response quantiles.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Get response quantiles — resp_quantiles","text":"columns returned data frame vary based inputs. assays specified assay_summary FALSE, resulting data frame assay column. assay_summary TRUE, data frame summary_quantile column.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/resp_quantiles.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get response quantiles — resp_quantiles","text":"","code":"# Dummy response data resp <- list(   \"r1\" = data.frame(assay = c(\"a1\", \"a1\", \"a2\", \"a2\"),                     sample = c(1, 2, 1, 2),                     GCA.Eff = c(1, 2, 3, 4),                     IA.Eff = c(5, 6, 7, 8),                     \"GCA.HQ.10\" = c(9, 10, 11, 12),                     \"IA.HQ.10\" = c(13, 14, 15, 16)))  # Summarize single assay resp_quantiles(resp) #> Warning: Multiple assays found, using first assay 'a1' #> # A tibble: 1 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff            0.5   1.5 # Specify assay resp_quantiles(resp, assays = \"a1\") #> # A tibble: 1 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff            0.5   1.5 # Specify quantiles resp_quantiles(resp, assays = \"a1\", assay_quantiles = c(0.25, 0.75)) #> # A tibble: 2 × 5 #>   id    assay metric  assay_quantile value #>   <chr> <chr> <chr>            <dbl> <dbl> #> 1 r1    a1    GCA.Eff           0.25  1.25 #> 2 r1    a1    GCA.Eff           0.75  1.75 # Specify metric resp_quantiles(resp, assays = \"a1\", metric = \"IA.HQ.10\") #> # A tibble: 1 × 5 #>   id    assay metric   assay_quantile value #>   <chr> <chr> <chr>             <dbl> <dbl> #> 1 r1    a1    IA.HQ.10            0.5  13.5  # Summarize across assays resp_quantiles(resp, assay_summary = TRUE) #> Warning: There are only 2 assays. #> Consider using a larger number of assays for a more robust analysis. #> # A tibble: 1 × 5 #>   id    assay_quantile metric  summary_quantile value #>   <chr>          <dbl> <chr>              <dbl> <dbl> #> 1 r1               0.5 GCA.Eff              0.1   1.7 # Specify quantiles suppressWarnings(   resp_quantiles(resp,                  assay_summary = TRUE,                  assay_quantiles = c(0.25, 0.75),                  summary_quantiles = c(0.1, 0.9)) ) #> # A tibble: 4 × 5 #>   id    assay_quantile metric  summary_quantile value #>   <chr>          <dbl> <chr>              <dbl> <dbl> #> 1 r1              0.25 GCA.Eff              0.1  1.45 #> 2 r1              0.25 GCA.Eff              0.9  3.05 #> 3 r1              0.75 GCA.Eff              0.1  1.95 #> 4 r1              0.75 GCA.Eff              0.9  3.55"},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":null,"dir":"Reference","previous_headings":"","what":"Sample from pre-generated C_ss data — sample_Css","title":"Sample from pre-generated C_ss data — sample_Css","text":"Sample pre-generated C_ss data","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Sample from pre-generated C_ss data — sample_Css","text":"","code":"sample_Css(simulated_css, age, obesity)"},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Sample from pre-generated C_ss data — sample_Css","text":"simulated_css list pre-generated C_ss data, details see: vignette(\"package_data\", package = \"GeoTox\"). age list atomic vector ages. obesity list atomic vector obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Sample from pre-generated C_ss data — sample_Css","text":"list matrices containing C_ss values. Columns sorted consistent order across functions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sample_Css.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Sample from pre-generated C_ss data — sample_Css","text":"","code":"# Vector inputs sample_Css(geo_tox_data$simulated_css,            c(15, 25, 35),            c(\"Normal\", \"Obese\", \"Normal\")) #> [[1]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   0.4032  0.06119   0.4044  0.04516    3.125    1.505  0.08384   4.1070 #> [2,]   0.8511  0.40070   1.5170  0.20540    8.311    1.713  0.30070   0.8906 #> [3,]   0.6539  0.39460   0.3364  0.68070    1.555    3.633  0.42150   1.9910 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]  0.08366  0.6665   2.187   2.193 0.03733   3.545   2.067   5.036  0.7018 #> [2,]  0.07002  6.3640   1.945   4.409 0.21210   4.614   1.967   7.638 12.9700 #> [3,]  0.19310  3.7220   1.539   1.727 0.06266   4.898   0.985   9.054  1.5870 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,] 0.06077  0.3466   2.231  11.650 #> [2,] 0.19230  0.8108   1.401  17.550 #> [3,] 0.22590  2.6400   2.103   1.502 #>   # List inputs sample_Css(geo_tox_data$simulated_css,            list(c(34, 29), 55),            list(c(\"Obese\", \"Normal\"), \"Normal\")) #> [[1]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   2.1290   0.3820    3.652   0.2247    6.800   0.8395   0.6320    2.746 #> [2,]   0.6427   0.1391    2.175   0.2645    3.766   3.4160   0.4531    1.364 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]   0.4971   5.819   5.986   3.001 0.06565    4.73  1.1280   1.239   5.524 #> [2,]   0.1654   1.163   1.315   2.156 0.03879  265.30  0.9735   3.735   9.349 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,]  1.3720  1.2370   3.461   9.255 #> [2,]  0.0863  0.3199   4.240   5.488 #>  #> [[2]] #>      100-02-7 101-14-4 101-77-9 106-50-3 119-90-4 120-80-9 123-31-9 133-06-2 #> [1,]   0.4114   0.2184    1.091   0.4477    3.899   0.7356   0.8564    11.01 #>      510-15-6 53-96-3 56-38-2 60-11-7 63-25-2 72-43-5 84-74-2 87-86-5 88-06-2 #> [1,]  0.09589   4.414   3.463   3.304 0.09706   3.237   1.294   2.108   1.301 #>      91-94-1 92-87-5 95-80-7 95-95-4 #> [1,]  0.1822   2.242   1.932   1.595 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":null,"dir":"Reference","previous_headings":"","what":"Perform sensitivity analysis — sensitivity_analysis","title":"Perform sensitivity analysis — sensitivity_analysis","text":"Perform sensitivity analysis","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Perform sensitivity analysis — sensitivity_analysis","text":"","code":"sensitivity_analysis(x, max_mult = list(NULL, NULL, NULL, 1.2, NULL))"},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Perform sensitivity analysis — sensitivity_analysis","text":"x GeoTox object. max_mult numeric list length 5 step sensitivity analysis.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Perform sensitivity analysis — sensitivity_analysis","text":"GeoTox object added sensitivity field.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Perform sensitivity analysis — sensitivity_analysis","text":"wrapper function sequentially call compute_sensitivity function inputs age, obesity, css_params, fit_params, C_ext. results returned named list stored sensitivity field input GeoTox object. Values NULL max_mult input use default value stored GeoTox object (x$par$resp$max_mult). GeoTox object created initialized 1.5, can changed via calculate_response function directly object.","code":""},{"path":[]},{"path":"https://github.com/NIEHS/GeoTox/reference/sensitivity_analysis.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Perform sensitivity analysis — sensitivity_analysis","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object and populate required fields geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n) |>   # Estimated Hill parameters   set_hill_params(geo_tox_data$dose_response |>                     fit_hill(assay = \"endp\", chem = \"casn\") |>                     dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed))  # Sensitivity analysis can now be done geoTox <- geoTox |> sensitivity_analysis()"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":null,"dir":"Reference","previous_headings":"","what":"Set GeoTox boundaries — set_boundaries","title":"Set GeoTox boundaries — set_boundaries","text":"Set GeoTox boundaries","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Set GeoTox boundaries — set_boundaries","text":"","code":"set_boundaries(x, region = NULL, group = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Set GeoTox boundaries — set_boundaries","text":"x GeoTox object. region \"sf\" data.frame mapping features \"geometry\" column. Used coloring map regions. group \"sf\" data.frame containing \"geometry\" column. Used draw outlines around groups regions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Set GeoTox boundaries — set_boundaries","text":"GeoTox object boundaries set.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_boundaries.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Set GeoTox boundaries — set_boundaries","text":"","code":"geoTox <- GeoTox() |>    set_boundaries(region = geo_tox_data$boundaries$county,                  group  = geo_tox_data$boundaries$state)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":null,"dir":"Reference","previous_headings":"","what":"Set Hill parameters for a GeoTox object. — set_hill_params","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"Set Hill parameters GeoTox object.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"","code":"set_hill_params(x, hill_params)"},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"x GeoTox object. hill_params output fit_hill.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"GeoTox object Hill parameters set.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/set_hill_params.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Set Hill parameters for a GeoTox object. — set_hill_params","text":"","code":"hill_params <- geo_tox_data$dose_response |>   fit_hill(chem = \"casn\", assay = \"endp\") |>   dplyr::filter(!tp.sd.imputed, !logAC50.sd.imputed)  geoTox <- GeoTox() |>    set_hill_params(hill_params)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate ages — simulate_age","title":"Simulate ages — simulate_age","text":"Simulate ages","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate ages — simulate_age","text":"","code":"simulate_age(x, n = 1000)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate ages — simulate_age","text":"x data frame list data frames containing population data age groups. data frame must contain columns \"AGEGRP\" \"TOT_POP\". n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate ages — simulate_age","text":"List arrays containing simulated ages.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate ages — simulate_age","text":"data frame must contain 19 rows. first row represents total population age groups next 18 rows represent age groups 0 89 increments 5 years.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_age.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate ages — simulate_age","text":"","code":"# Single data frame x <- data.frame(AGEGRP = 0:18, TOT_POP = 0) # populate only age range 40-44, set population total of all ages x$TOT_POP[c(1, 10)] <- 100 simulate_age(x, 5) #> [[1]] #> [1] 41 40 40 40 44 #>   # List of 2 data frames y <- data.frame(AGEGRP = 0:18, TOT_POP = 0) # populate age ranges 5-9 and 50-54 y$TOT_POP[c(3, 12)] <- 10 # set population total for all age groups y$TOT_POP[1] <- sum(y$TOT_POP) simulate_age(list(x = x, y = y), 15) #> $x #>  [1] 44 41 41 44 44 40 42 41 44 41 42 42 41 44 43 #>  #> $y #>  [1]  8  9 53 53 52 51  7  7 50  6  5 51 54 51  7 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate external exposure — simulate_exposure","title":"Simulate external exposure — simulate_exposure","text":"Simulate external exposure","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate external exposure — simulate_exposure","text":"","code":"simulate_exposure(   x,   expos_mean = \"mean\",   expos_sd = \"sd\",   expos_label = \"casn\",   n = 1000 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate external exposure — simulate_exposure","text":"x data frame list data frames containing exposure data. expos_mean column name mean values. expos_sd column name standard deviations. expos_label column name labeling term, required x one row. n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate external exposure — simulate_exposure","text":"list matrices containing inhalation rates. Matrix columns named using values expos_label column one data frame row. Columns sorted consistent order across functions.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_exposure.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate external exposure — simulate_exposure","text":"","code":"# Single data frame x <- data.frame(mean = 1:3, sd = (1:3) / 10, casn = letters[1:3]) simulate_exposure(x, n = 5) #> [[1]] #>              a        b        c #> [1,] 0.9589639 1.942589 2.451133 #> [2,] 0.8855310 2.023900 2.695203 #> [3,] 1.1057684 2.063064 2.496449 #> [4,] 1.2500731 2.162863 3.524906 #> [5,] 0.8554196 2.259877 3.247982 #>   # List of 2 data frames y <- data.frame(mean = 4:6, sd = 0.1, casn = letters[1:3]) simulate_exposure(list(loc1 = x, loc2 = y), n = 5) #> $loc1 #>              a        b        c #> [1,] 0.9985420 2.418962 2.889693 #> [2,] 1.0071619 1.904265 2.958021 #> [3,] 0.9372769 1.914698 3.174726 #> [4,] 0.9754153 2.018951 3.189433 #> [5,] 1.1182927 1.871831 2.871555 #>  #> $loc2 #>             a        b        c #> [1,] 3.949621 5.048086 6.059213 #> [2,] 3.949047 5.009067 5.847476 #> [3,] 3.938871 4.883739 5.957730 #> [4,] 4.050804 5.091922 5.960801 #> [5,] 4.057940 5.047837 6.006035 #>   # Input has custom column names z <- data.frame(ave = 1:3, stdev = (1:3) / 10, chnm = letters[1:3]) simulate_exposure(z,                   expos_mean = \"ave\",                   expos_sd = \"stdev\",                   expos_label = \"chnm\",                   n = 5) #> [[1]] #>              a        b        c #> [1,] 1.0068706 2.246875 2.465981 #> [2,] 1.1088794 2.286902 2.671737 #> [3,] 0.9603815 2.013617 3.227719 #> [4,] 0.9356854 2.088608 2.733121 #> [5,] 1.0065421 2.397329 2.783188 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate inhalation rates — simulate_inhalation_rate","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"Simulate inhalation rates","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"","code":"simulate_inhalation_rate(x, IR_params = NULL)"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"x atomic vector list atomic vectors containing ages. IR_params (optional) data frame columns \"age\", \"mean\" \"sd\". See details information.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"List atomic vectors containing inhalation rates.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"age column optional IR_params data frame ascending order represent lower value age groups corresponding mean sd values. provided, default values come Table 6.7 EPA's 2011 Exposure Factors Handbook using mean male female values.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_inhalation_rate.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate inhalation rates — simulate_inhalation_rate","text":"","code":"# Single atomic vector ages <- sample(1:100, 6, replace = TRUE) simulate_inhalation_rate(ages) #> [[1]] #> [1] 0.1625213 0.2281144 0.1786136 0.2349537 0.2106563 0.2596359 #>   # List of atomic vectors ages <- list(   sample(1:100, 5, replace = TRUE),   sample(1:100, 3, replace = TRUE) ) simulate_inhalation_rate(ages) #> [[1]] #> [1] 0.1971633 0.3031290 0.2993870 0.2280779 0.2170229 #>  #> [[2]] #> [1] 0.3514907 0.2375111 0.2301368 #>   # Custom IR_params IR_params <- data.frame(\"age\" = c(0, 20, 50),                         \"mean\" = c(0.5, 0.3, 0.2),                         \"sd\" = c(0.1, 0.06, 0.03)) simulate_inhalation_rate(c(15, 30, 65), IR_params) #> [[1]] #> [1] 0.3858133 0.2594459 0.1721599 #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate obesity status — simulate_obesity","title":"Simulate obesity status — simulate_obesity","text":"Simulate obesity status","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate obesity status — simulate_obesity","text":"","code":"simulate_obesity(   x,   obes_prev = \"OBESITY_CrudePrev\",   obes_sd = \"OBESITY_SD\",   obes_label = \"FIPS\",   n = 1000 )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate obesity status — simulate_obesity","text":"x data frame containing obesity data percentage 0 100. obes_prev column name prevalence. obes_sd column name standard deviation. obes_label column name labeling term, required x one row. n simulated sample size.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate obesity status — simulate_obesity","text":"List arrays containing simulated obesity status.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_obesity.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate obesity status — simulate_obesity","text":"","code":"# Input has default column names df <- data.frame(OBESITY_CrudePrev = c(20, 50, 80),                  OBESITY_SD = c(5, 5, 5),                  FIPS = letters[1:3]) simulate_obesity(df, n = 5) #> $a #> [1] \"Normal\" \"Normal\" \"Normal\" \"Normal\" \"Normal\" #>  #> $b #> [1] \"Normal\" \"Obese\"  \"Normal\" \"Normal\" \"Normal\" #>  #> $c #> [1] \"Obese\" \"Obese\" \"Obese\" \"Obese\" \"Obese\" #>   # Input has custom column names df <- data.frame(prev = c(20, 50, 80),                  sd = c(5, 5, 5),                  label = letters[1:3]) simulate_obesity(df,                  obes_prev = \"prev\",                  obes_sd = \"sd\",                  obes_label = \"label\",                  n = 5) #> $a #> [1] \"Normal\" \"Obese\"  \"Normal\" \"Normal\" \"Normal\" #>  #> $b #> [1] \"Normal\" \"Obese\"  \"Obese\"  \"Normal\" \"Obese\"  #>  #> $c #> [1] \"Obese\" \"Obese\" \"Obese\" \"Obese\" \"Obese\" #>"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":null,"dir":"Reference","previous_headings":"","what":"Simulate population data — simulate_population","title":"Simulate population data — simulate_population","text":"Simulate population data given input fields","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Simulate population data — simulate_population","text":"","code":"simulate_population(   x,   age = NULL,   obesity = NULL,   exposure = NULL,   simulated_css = NULL,   ... )"},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Simulate population data — simulate_population","text":"x GeoTox object. age input x function simulate_age. simulating ages, inhalation rate subsequently calculated using simulate_inhalation_rate. obesity input x function simulate_obesity. exposure input x function simulate_exposure. simulated_css input simulated_css functions sample_Css get_fixed_css. ... additional arguments passed functions. See details.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Simulate population data — simulate_population","text":"object simulated fields added.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Simulate population data — simulate_population","text":"Additional parameters include n sample size, IR_params simulate_inhalation_rate, obes_prev, obes_sd, obes_label simulate_obesity, expos_mean, expos_sd, expos_label simulate_exposure.","code":""},{"path":"https://github.com/NIEHS/GeoTox/reference/simulate_population.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Simulate population data — simulate_population","text":"","code":"# Use a subset of the package data for demonstration purposes set.seed(2357) n <- 10 # Population size m <- 5 # Number of regions idx <- if (m < 100) sample(1:100, m) else 1:100  # Create GeoTox object geoTox <- GeoTox() |>   # Simulate populations for each region   simulate_population(age = split(geo_tox_data$age, ~FIPS)[idx],                       obesity = geo_tox_data$obesity[idx, ],                       exposure = split(geo_tox_data$exposure, ~FIPS)[idx],                       simulated_css = geo_tox_data$simulated_css,                       n = n)"},{"path":"https://github.com/NIEHS/GeoTox/news/index.html","id":"geotox-020","dir":"Changelog","previous_headings":"","what":"GeoTox 0.2.0","title":"GeoTox 0.2.0","text":"CRAN release: 2024-11-15 Initial CRAN submission.","code":""}]
