README.md.bak

# Fragariyo: Hunting for Protein Fragments
###### Update: May 13th, 2024

## What is Top-Down Mass Spectrometry?
In Top-Down Mass Spectrometry protein or protein complexes are fragmented intact inside a mass spectrometer. Therefore, if there are specific combination of Post-Translationla Modifications or amino acid substitutions fragmentation will be obtined for each one (unfrotunatly, in bottom the resultatn digested mix of peptides precludes the determination of an specific protein from - a.k.a proteoform). For more details, see the publications below.

  - 2016 [Top-Down Review](https://www.annualreviews.org/content/journals/10.1146/annurev-anchem-071015-041550)
  - [Top-Down Proteomics and the Human Proteoform Project](https://www.science.org/doi/full/10.1126/sciadv.abk0734)
  
### Package Installation

#### 1. Download .exe file from [the release page](https://github.com/RuotoloLab/Fragariyo/releases) for the latests versions 
#### 2. Follow the installation prompts
#### 3. Press on icon and a Graphical User Interface (GUI) will appeared. 

### Terminal Fragmentation

#### 1. On the GUI select **Change Output Directory**