covariate for CL

[Mannny-PK]

Dear Professor,
I have encountered a problem when I used Pmetrics, the details are as follows.
The code to run is as follows:
#Primary
CL0, 0.1,3
Q, 0.1,6
V, 1,60
Vp, 1,120

#Sec

Ke = CL/V

KCP = Q/V

KPC = Q/Vp

CL = CL0-0.05*ALB

C 32 is the mean alb in the population

#Cov

WT

CCR

ALB

AGE

APACHE

#Out
Y(1) = X(1)/V

#Err
G=5
0.1, 0.15, 0, 0

The run was failed.

[mnneely]

You might want to try moving the equations around in the #SEC block, so that CL is defined before it is used, i.e. make it the first equation. Not sure if that is the problem, but I’d start there. I also usually put the #COV block before the #SEC block if I’m using covariates in equations, although that should not be an issue. Unfortunately, I can’t read the Chinese characters in the screenshot, so I don’t know what it says. From: Mannny-PK ***@***.***> Date: Thursday, November 3, 2022 at 1:43 AM To: LAPKB/Pmetrics ***@***.***> Cc: Subscribed ***@***.***> Subject: [LAPKB/Pmetrics] covariate for CL (Discussion #109) Dear Professor, I have encountered a problem when I used Pmetrics, the details are as follows. The code to run is as follows: #Primary CL0, 0.1,3 Q, 0.1,6 V, 1,60 Vp, 1,120 #Sec Ke = CL/V KCP = Q/V KPC = Q/Vp CL = CL0-0.05*ALB C 32 is the mean alb in the population #Cov WT CCR ALB AGE APACHE #Out Y(1) = X(1)/V #Err G=5 0.1, 0.15, 0, 0 The run was failed. [??1]<https://urldefense.com/v3/__https:/user-images.githubusercontent.com/109020077/199678286-6b3cbbb5-6463-41ef-bea4-2fafa2de146b.png__;!!LIr3w8kk_Xxm!uTEp7Map9DyoK9w7l6I3A5efdtof2b9Qs639uxK26a_X4Z6992Yn4QIYun7xw-U9fql-pVuAmmeStlB6kvrENQo$> — Reply to this email directly, view it on GitHub<https://urldefense.com/v3/__https:/github.com/LAPKB/Pmetrics/discussions/109__;!!LIr3w8kk_Xxm!uTEp7Map9DyoK9w7l6I3A5efdtof2b9Qs639uxK26a_X4Z6992Yn4QIYun7xw-U9fql-pVuAmmeStlB6uJFNhS0$>, or unsubscribe<https://urldefense.com/v3/__https:/github.com/notifications/unsubscribe-auth/AB6CLTVQCCN6GLKV4B4IABTWGN3LJANCNFSM6AAAAAARV4NGXI__;!!LIr3w8kk_Xxm!uTEp7Map9DyoK9w7l6I3A5efdtof2b9Qs639uxK26a_X4Z6992Yn4QIYun7xw-U9fql-pVuAmmeStlB6BSntkfc$>. You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>

[Mannny-PK]

I reworked it based on your suggestion and it worked, thank you very much for your answer!