TP1_proteomics_elmarrahi.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# TP 1 PROTEOMIQUE : ANALYSE DONNEES SHOTGUN\n",
    "## Auteure : Anissa EL MARRAHI, 5BIM"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "%matplotlib nbagg\n",
    "import matplotlib.pyplot as plt\n",
    "import numpy as np\n",
    "from scipy.stats import norm\n",
    "from xml.etree.ElementTree import parse, dump\n",
    "import pandas as pd"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/home/anissa/.local/lib/python3.6/site-packages/pandas/core/ops/array_ops.py:253: FutureWarning: elementwise comparison failed; returning scalar instead, but in the future will perform elementwise comparison\n",
      "  res_values = method(rvalues)\n"
     ]
    }
   ],
   "source": [
    "tcl = pd.read_csv(\"./data/TCL_wt1.tsv\",sep = '\\t')\n",
    "headers = tcl.columns \n",
    "\n",
    "for h in headers :\n",
    "    #tcl =  tcl[tcl[h] != '#VALEUR!']\n",
    "    tcl.drop(tcl.index[tcl[h] == '#VALEUR!'], inplace = True)\n",
    "tcl = tcl.dropna()\n",
    "tcl[\"Corrected Abundance ratio (1.53)\"] = tcl[\"Corrected Abundance ratio (1.53)\"].astype(float)\n",
    "tcl[\"Log2 Corrected Abundance Ratio\"] = tcl[\"Log2 Corrected Abundance Ratio\"].astype(float)\n",
    "tcl[\"Abundance Ratio Adj. P-Value: (127. T3 Tc WT) / (126. T0 WT)\"] = tcl[\"Abundance Ratio Adj. P-Value: (127. T3 Tc WT) / (126. T0 WT)\"].astype(float)\n",
    "tcl[\"-LOG10 Adj.P-val\"] = tcl[\"-LOG10 Adj.P-val\"].astype(float)\n",
    "#print(tcl)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "<ns0:entry xmlns:ns0=\"http://uniprot.org/uniprot\" created=\"1989-10-01\" dataset=\"Swiss-Prot\" modified=\"2020-08-12\" version=\"166\">\n",
      "<ns0:accession>P11446</ns0:accession>\n",
      "<ns0:accession>Q2M8Q3</ns0:accession>\n",
      "<ns0:name>ARGC_ECOLI</ns0:name>\n",
      "<ns0:protein>\n",
      "<ns0:recommendedName>\n",
      "<ns0:fullName evidence=\"1 4\">N-acetyl-gamma-glutamyl-phosphate reductase</ns0:fullName>\n",
      "<ns0:shortName evidence=\"1 4\">AGPR</ns0:shortName>\n",
      "<ns0:ecNumber evidence=\"1 2\">1.2.1.38</ns0:ecNumber>\n",
      "</ns0:recommendedName>\n",
      "<ns0:alternativeName>\n",
      "<ns0:fullName evidence=\"1 3\">N-acetyl-glutamate semialdehyde dehydrogenase</ns0:fullName>\n",
      "<ns0:shortName evidence=\"1 3\">NAGSA dehydrogenase</ns0:shortName>\n",
      "</ns0:alternativeName>\n",
      "</ns0:protein>\n",
      "<ns0:gene>\n",
      "<ns0:name evidence=\"1\" type=\"primary\">argC</ns0:name>\n",
      "<ns0:name type=\"ordered locus\">b3958</ns0:name>\n",
      "<ns0:name type=\"ordered locus\">JW3930</ns0:name>\n",
      "</ns0:gene>\n",
      "<ns0:organism>\n",
      "<ns0:name type=\"scientific\">Escherichia coli (strain K12)</ns0:name>\n",
      "<ns0:dbReference id=\"83333\" type=\"NCBI Taxonomy\" />\n",
      "<ns0:lineage>\n",
      "<ns0:taxon>Bacteria</ns0:taxon>\n",
      "<ns0:taxon>Proteobacteria</ns0:taxon>\n",
      "<ns0:taxon>Gammaproteobacteria</ns0:taxon>\n",
      "<ns0:taxon>Enterobacterales</ns0:taxon>\n",
      "<ns0:taxon>Enterobacteriaceae</ns0:taxon>\n",
      "<ns0:taxon>Escherichia</ns0:taxon>\n",
      "</ns0:lineage>\n",
      "</ns0:organism>\n",
      "<ns0:reference key=\"1\">\n",
      "<ns0:citation date=\"1988\" first=\"275\" last=\"283\" name=\"Gene\" type=\"journal article\" volume=\"68\">\n",
      "<ns0:title>Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Parsot C.\" />\n",
      "<ns0:person name=\"Boyen A.\" />\n",
      "<ns0:person name=\"Cohen G.N.\" />\n",
      "<ns0:person name=\"Glansdorff N.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"2851495\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1016/0378-1119(88)90030-3\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"2\">\n",
      "<ns0:citation date=\"1993\" first=\"5408\" last=\"5417\" name=\"Nucleic Acids Res.\" type=\"journal article\" volume=\"21\">\n",
      "<ns0:title>Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Blattner F.R.\" />\n",
      "<ns0:person name=\"Burland V.D.\" />\n",
      "<ns0:person name=\"Plunkett G. III\" />\n",
      "<ns0:person name=\"Sofia H.J.\" />\n",
      "<ns0:person name=\"Daniels D.L.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"8265357\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1093/nar/21.23.5408\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"3\">\n",
      "<ns0:citation date=\"1997\" first=\"1453\" last=\"1462\" name=\"Science\" type=\"journal article\" volume=\"277\">\n",
      "<ns0:title>The complete genome sequence of Escherichia coli K-12.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Blattner F.R.\" />\n",
      "<ns0:person name=\"Plunkett G. III\" />\n",
      "<ns0:person name=\"Bloch C.A.\" />\n",
      "<ns0:person name=\"Perna N.T.\" />\n",
      "<ns0:person name=\"Burland V.\" />\n",
      "<ns0:person name=\"Riley M.\" />\n",
      "<ns0:person name=\"Collado-Vides J.\" />\n",
      "<ns0:person name=\"Glasner J.D.\" />\n",
      "<ns0:person name=\"Rode C.K.\" />\n",
      "<ns0:person name=\"Mayhew G.F.\" />\n",
      "<ns0:person name=\"Gregor J.\" />\n",
      "<ns0:person name=\"Davis N.W.\" />\n",
      "<ns0:person name=\"Kirkpatrick H.A.\" />\n",
      "<ns0:person name=\"Goeden M.A.\" />\n",
      "<ns0:person name=\"Rose D.J.\" />\n",
      "<ns0:person name=\"Mau B.\" />\n",
      "<ns0:person name=\"Shao Y.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"9278503\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1126/science.277.5331.1453\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"4\">\n",
      "<ns0:citation date=\"2006\" first=\"E1\" last=\"E5\" name=\"Mol. Syst. Biol.\" type=\"journal article\" volume=\"2\">\n",
      "<ns0:title>Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Hayashi K.\" />\n",
      "<ns0:person name=\"Morooka N.\" />\n",
      "<ns0:person name=\"Yamamoto Y.\" />\n",
      "<ns0:person name=\"Fujita K.\" />\n",
      "<ns0:person name=\"Isono K.\" />\n",
      "<ns0:person name=\"Choi S.\" />\n",
      "<ns0:person name=\"Ohtsubo E.\" />\n",
      "<ns0:person name=\"Baba T.\" />\n",
      "<ns0:person name=\"Wanner B.L.\" />\n",
      "<ns0:person name=\"Mori H.\" />\n",
      "<ns0:person name=\"Horiuchi T.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"16738553\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1038/msb4100049\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / W3110 / ATCC 27325 / DSM 5911</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"5\">\n",
      "<ns0:citation date=\"1982\" first=\"8031\" last=\"8048\" name=\"Nucleic Acids Res.\" type=\"journal article\" volume=\"10\">\n",
      "<ns0:title>The regulatory region of the divergent argECBH operon in Escherichia coli K-12.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Piette J.\" />\n",
      "<ns0:person name=\"Cunin R.\" />\n",
      "<ns0:person name=\"Boyen A.\" />\n",
      "<ns0:person name=\"Charlier D.R.M.\" />\n",
      "<ns0:person name=\"Crabeel M.\" />\n",
      "<ns0:person name=\"van Vliet F.\" />\n",
      "<ns0:person name=\"Glansdorff N.\" />\n",
      "<ns0:person name=\"Squires C.\" />\n",
      "<ns0:person name=\"Squires C.L.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"6761650\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1093/nar/10.24.8031\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"6\">\n",
      "<ns0:citation date=\"1992\" first=\"2323\" last=\"2331\" name=\"J. Bacteriol.\" type=\"journal article\" volume=\"174\">\n",
      "<ns0:title>Structural and biochemical characterization of the Escherichia coli argE gene product.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Meinnel T.\" />\n",
      "<ns0:person name=\"Schmitt E.\" />\n",
      "<ns0:person name=\"Mechulam Y.\" />\n",
      "<ns0:person name=\"Blanquet S.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"1551850\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1128/jb.174.7.2323-2331.1992\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"7\">\n",
      "<ns0:citation date=\"1962\" first=\"491\" last=\"496\" name=\"Biochem. Biophys. Res. Commun.\" type=\"journal article\" volume=\"7\">\n",
      "<ns0:title>N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Baich A.\" />\n",
      "<ns0:person name=\"Vogel H.J.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"13863980\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1016/0006-291x(62)90342-x\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>FUNCTION</ns0:scope>\n",
      "<ns0:scope>CATALYTIC ACTIVITY</ns0:scope>\n",
      "<ns0:scope>PATHWAY</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>W / ATCC 11105 / DSM 1900</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:comment type=\"function\">\n",
      "<ns0:text evidence=\"1 2\">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"catalytic activity\">\n",
      "<ns0:reaction evidence=\"1 2\">\n",
      "<ns0:text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</ns0:text>\n",
      "<ns0:dbReference id=\"RHEA:21588\" type=\"Rhea\" />\n",
      "<ns0:dbReference id=\"CHEBI:15378\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"CHEBI:29123\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"CHEBI:43474\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"CHEBI:57783\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"CHEBI:57936\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"CHEBI:58349\" type=\"ChEBI\" />\n",
      "<ns0:dbReference id=\"1.2.1.38\" type=\"EC\" />\n",
      "</ns0:reaction>\n",
      "</ns0:comment>\n",
      "<ns0:comment evidence=\"1 5\" type=\"pathway\">\n",
      "<ns0:text>Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"subcellular location\">\n",
      "<ns0:subcellularLocation>\n",
      "<ns0:location evidence=\"1\">Cytoplasm</ns0:location>\n",
      "</ns0:subcellularLocation>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"similarity\">\n",
      "<ns0:text evidence=\"1 4\">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:dbReference evidence=\"1 2\" id=\"1.2.1.38\" type=\"EC\" />\n",
      "<ns0:dbReference id=\"M21446\" type=\"EMBL\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"AAA23477.1\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"U00006\" type=\"EMBL\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"AAC43064.1\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"U00096\" type=\"EMBL\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"AAC76940.1\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"AP009048\" type=\"EMBL\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"BAE77353.1\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"J01587\" type=\"EMBL\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"AAB59146.1\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"X55417\" type=\"EMBL\">\n",
      "<ns0:property type=\"status\" value=\"NOT_ANNOTATED_CDS\" />\n",
      "<ns0:property type=\"molecule type\" value=\"Genomic_DNA\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"JT0332\" type=\"PIR\">\n",
      "<ns0:property type=\"entry name\" value=\"RDECEP\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"NP_418393.1\" type=\"RefSeq\">\n",
      "<ns0:property type=\"nucleotide sequence ID\" value=\"NC_000913.3\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"WP_000935370.1\" type=\"RefSeq\">\n",
      "<ns0:property type=\"nucleotide sequence ID\" value=\"NZ_STEB01000037.1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"P11446\" type=\"SMR\" />\n",
      "<ns0:dbReference id=\"4262190\" type=\"BioGRID\">\n",
      "<ns0:property type=\"interactions\" value=\"6\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"852751\" type=\"BioGRID\">\n",
      "<ns0:property type=\"interactions\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"P11446\" type=\"IntAct\">\n",
      "<ns0:property type=\"interactions\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"511145.b3958\" type=\"STRING\" />\n",
      "<ns0:dbReference id=\"P11446\" type=\"PaxDb\" />\n",
      "<ns0:dbReference id=\"P11446\" type=\"PRIDE\" />\n",
      "<ns0:dbReference id=\"AAC76940\" type=\"EnsemblBacteria\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"AAC76940\" />\n",
      "<ns0:property type=\"gene ID\" value=\"b3958\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"BAE77353\" type=\"EnsemblBacteria\">\n",
      "<ns0:property type=\"protein sequence ID\" value=\"BAE77353\" />\n",
      "<ns0:property type=\"gene ID\" value=\"BAE77353\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"948455\" type=\"GeneID\" />\n",
      "<ns0:dbReference id=\"ecj:JW3930\" type=\"KEGG\" />\n",
      "<ns0:dbReference id=\"eco:b3958\" type=\"KEGG\" />\n",
      "<ns0:dbReference id=\"fig|1411691.4.peg.2747\" type=\"PATRIC\" />\n",
      "<ns0:dbReference id=\"EB0063\" type=\"EchoBASE\" />\n",
      "<ns0:dbReference id=\"COG0002\" type=\"eggNOG\">\n",
      "<ns0:property type=\"taxonomic scope\" value=\"Bacteria\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"CLU_006384_0_1_6\" type=\"HOGENOM\" />\n",
      "<ns0:dbReference id=\"P11446\" type=\"InParanoid\" />\n",
      "<ns0:dbReference id=\"K00145\" type=\"KO\" />\n",
      "<ns0:dbReference id=\"P11446\" type=\"PhylomeDB\" />\n",
      "<ns0:dbReference id=\"EcoCyc:N-ACETYLGLUTPREDUCT-MONOMER\" type=\"BioCyc\" />\n",
      "<ns0:dbReference id=\"ECOL316407:JW3930-MONOMER\" type=\"BioCyc\" />\n",
      "<ns0:dbReference id=\"MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER\" type=\"BioCyc\" />\n",
      "<ns0:dbReference id=\"1.2.1.38\" type=\"BRENDA\">\n",
      "<ns0:property type=\"organism ID\" value=\"2026\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"UPA00068\" type=\"UniPathway\">\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "<ns0:property type=\"reaction ID\" value=\"UER00108\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"PR:P11446\" type=\"PRO\" />\n",
      "<ns0:dbReference id=\"UP000000318\" type=\"Proteomes\">\n",
      "<ns0:property type=\"component\" value=\"Chromosome\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"UP000000625\" type=\"Proteomes\">\n",
      "<ns0:property type=\"component\" value=\"Chromosome\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0005737\" type=\"GO\">\n",
      "<ns0:property type=\"term\" value=\"C:cytoplasm\" />\n",
      "<ns0:property type=\"evidence\" value=\"ECO:0000501\" />\n",
      "<ns0:property type=\"project\" value=\"UniProtKB-SubCell\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0003942\" type=\"GO\">\n",
      "<ns0:property type=\"term\" value=\"F:N-acetyl-gamma-glutamyl-phosphate reductase activity\" />\n",
      "<ns0:property type=\"evidence\" value=\"ECO:0000314\" />\n",
      "<ns0:property type=\"project\" value=\"EcoCyc\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0051287\" type=\"GO\">\n",
      "<ns0:property type=\"term\" value=\"F:NAD binding\" />\n",
      "<ns0:property type=\"evidence\" value=\"ECO:0000501\" />\n",
      "<ns0:property type=\"project\" value=\"InterPro\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0046983\" type=\"GO\">\n",
      "<ns0:property type=\"term\" value=\"F:protein dimerization activity\" />\n",
      "<ns0:property type=\"evidence\" value=\"ECO:0000501\" />\n",
      "<ns0:property type=\"project\" value=\"InterPro\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0006526\" type=\"GO\">\n",
      "<ns0:property type=\"term\" value=\"P:arginine biosynthetic process\" />\n",
      "<ns0:property type=\"evidence\" value=\"ECO:0000314\" />\n",
      "<ns0:property type=\"project\" value=\"EcoCyc\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"MF_00150\" type=\"HAMAP\">\n",
      "<ns0:property type=\"entry name\" value=\"ArgC_type1\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"IPR023013\" type=\"InterPro\">\n",
      "<ns0:property type=\"entry name\" value=\"AGPR_AS\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"IPR000706\" type=\"InterPro\">\n",
      "<ns0:property type=\"entry name\" value=\"AGPR_type-1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"IPR036291\" type=\"InterPro\">\n",
      "<ns0:property type=\"entry name\" value=\"NAD(P)-bd_dom_sf\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"IPR000534\" type=\"InterPro\">\n",
      "<ns0:property type=\"entry name\" value=\"Semialdehyde_DH_NAD-bd\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"IPR012280\" type=\"InterPro\">\n",
      "<ns0:property type=\"entry name\" value=\"Semialdhyde_DH_dimer_dom\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"PF01118\" type=\"Pfam\">\n",
      "<ns0:property type=\"entry name\" value=\"Semialdhyde_dh\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"PF02774\" type=\"Pfam\">\n",
      "<ns0:property type=\"entry name\" value=\"Semialdhyde_dhC\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"SM00859\" type=\"SMART\">\n",
      "<ns0:property type=\"entry name\" value=\"Semialdhyde_dh\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"SSF51735\" type=\"SUPFAM\">\n",
      "<ns0:property type=\"entry name\" value=\"SSF51735\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"TIGR01850\" type=\"TIGRFAMs\">\n",
      "<ns0:property type=\"entry name\" value=\"argC\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"PS01224\" type=\"PROSITE\">\n",
      "<ns0:property type=\"entry name\" value=\"ARGC\" />\n",
      "<ns0:property type=\"match status\" value=\"1\" />\n",
      "</ns0:dbReference>\n",
      "<ns0:proteinExistence type=\"evidence at protein level\" />\n",
      "<ns0:keyword id=\"KW-0028\">Amino-acid biosynthesis</ns0:keyword>\n",
      "<ns0:keyword id=\"KW-0055\">Arginine biosynthesis</ns0:keyword>\n",
      "<ns0:keyword id=\"KW-0963\">Cytoplasm</ns0:keyword>\n",
      "<ns0:keyword id=\"KW-0521\">NADP</ns0:keyword>\n",
      "<ns0:keyword id=\"KW-0560\">Oxidoreductase</ns0:keyword>\n",
      "<ns0:keyword id=\"KW-1185\">Reference proteome</ns0:keyword>\n",
      "<ns0:feature description=\"N-acetyl-gamma-glutamyl-phosphate reductase\" id=\"PRO_0000112401\" type=\"chain\">\n",
      "<ns0:location>\n",
      "<ns0:begin position=\"1\" />\n",
      "<ns0:end position=\"334\" />\n",
      "</ns0:location>\n",
      "</ns0:feature>\n",
      "<ns0:feature evidence=\"1\" type=\"active site\">\n",
      "<ns0:location>\n",
      "<ns0:position position=\"154\" />\n",
      "</ns0:location>\n",
      "</ns0:feature>\n",
      "<ns0:evidence key=\"1\" type=\"ECO:0000255\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"MF_00150\" type=\"HAMAP-Rule\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"2\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"13863980\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"3\" type=\"ECO:0000303\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"2851495\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"4\" type=\"ECO:0000305\" />\n",
      "<ns0:evidence key=\"5\" type=\"ECO:0000305\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"13863980\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:sequence checksum=\"67AC195ECE1C4789\" length=\"334\" mass=\"35952\" modified=\"1989-10-01\" version=\"1\">MLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQVLQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI</ns0:sequence>\n",
      "</ns0:entry>\n"
     ]
    }
   ],
   "source": [
    "from xml.etree.ElementTree import parse, dump\n",
    "# Parse the E.Coli proteome XML Document\n",
    "tree = parse('data/uniprot-proteome_UP000000625.xml')\n",
    "root = tree.getroot()\n",
    "ns = '{http://uniprot.org/uniprot}' # MANDATORY PREFIX FOR ANY SEARCH within document\n",
    "# Store all entries aka proteins in a list of xml nodes\n",
    "proteins = root.findall(ns + 'entry')\n",
    "# Display the xml subtree of the first protein \n",
    "dump(proteins[0])\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "<ns0:entry xmlns:ns0=\"http://uniprot.org/uniprot\" created=\"1993-07-01\" dataset=\"Swiss-Prot\" modified=\"2020-08-12\" version=\"187\">\n",
      "<ns0:accession>P31224</ns0:accession>\n",
      "<ns0:accession>Q2MBW5</ns0:accession>\n",
      "<ns0:name>ACRB_ECOLI</ns0:name>\n",
      "<ns0:protein>\n",
      "<ns0:recommendedName>\n",
      "<ns0:fullName>Multidrug efflux pump subunit AcrB</ns0:fullName>\n",
      "</ns0:recommendedName>\n",
      "<ns0:alternativeName>\n",
      "<ns0:fullName>AcrAB-TolC multidrug efflux pump subunit AcrB</ns0:fullName>\n",
      "</ns0:alternativeName>\n",
      "<ns0:alternativeName>\n",
      "<ns0:fullName>Acridine resistance protein B</ns0:fullName>\n",
      "</ns0:alternativeName>\n",
      "</ns0:protein>\n",
      "<ns0:gene>\n",
      "<ns0:name type=\"primary\">acrB</ns0:name>\n",
      "<ns0:name type=\"synonym\">acrE</ns0:name>\n",
      "<ns0:name type=\"ordered locus\">b0462</ns0:name>\n",
      "<ns0:name type=\"ordered locus\">JW0451</ns0:name>\n",
      "</ns0:gene>\n",
      "<ns0:organism>\n",
      "<ns0:name type=\"scientific\">Escherichia coli (strain K12)</ns0:name>\n",
      "<ns0:dbReference id=\"83333\" type=\"NCBI Taxonomy\" />\n",
      "<ns0:lineage>\n",
      "<ns0:taxon>Bacteria</ns0:taxon>\n",
      "<ns0:taxon>Proteobacteria</ns0:taxon>\n",
      "<ns0:taxon>Gammaproteobacteria</ns0:taxon>\n",
      "<ns0:taxon>Enterobacterales</ns0:taxon>\n",
      "<ns0:taxon>Enterobacteriaceae</ns0:taxon>\n",
      "<ns0:taxon>Escherichia</ns0:taxon>\n",
      "</ns0:lineage>\n",
      "</ns0:organism>\n",
      "<ns0:reference key=\"1\">\n",
      "<ns0:citation date=\"1993-05\" db=\"EMBL/GenBank/DDBJ databases\" type=\"submission\">\n",
      "<ns0:title>Nucleotide sequence of the acrAB operon from Escherichia coli.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Xu J.\" />\n",
      "<ns0:person name=\"Bertrand K.P.\" />\n",
      "</ns0:authorList>\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"2\">\n",
      "<ns0:citation date=\"1993\" first=\"6299\" last=\"6313\" name=\"J. Bacteriol.\" type=\"journal article\" volume=\"175\">\n",
      "<ns0:title>Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Ma D.\" />\n",
      "<ns0:person name=\"Cook D.N.\" />\n",
      "<ns0:person name=\"Alberti M.\" />\n",
      "<ns0:person name=\"Pon N.G.\" />\n",
      "<ns0:person name=\"Nikaido H.\" />\n",
      "<ns0:person name=\"Hearst J.E.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"8407802\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1128/jb.175.19.6299-6313.1993\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / W4573</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"3\">\n",
      "<ns0:citation date=\"1997-01\" db=\"EMBL/GenBank/DDBJ databases\" type=\"submission\">\n",
      "<ns0:title>Sequence of minutes 4-25 of Escherichia coli.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Chung E.\" />\n",
      "<ns0:person name=\"Allen E.\" />\n",
      "<ns0:person name=\"Araujo R.\" />\n",
      "<ns0:person name=\"Aparicio A.M.\" />\n",
      "<ns0:person name=\"Davis K.\" />\n",
      "<ns0:person name=\"Duncan M.\" />\n",
      "<ns0:person name=\"Federspiel N.\" />\n",
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      "<ns0:person name=\"Kalman S.\" />\n",
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      "<ns0:person name=\"Schramm S.\" />\n",
      "<ns0:person name=\"Davis R.W.\" />\n",
      "</ns0:authorList>\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"4\">\n",
      "<ns0:citation date=\"1997\" first=\"1453\" last=\"1462\" name=\"Science\" type=\"journal article\" volume=\"277\">\n",
      "<ns0:title>The complete genome sequence of Escherichia coli K-12.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Blattner F.R.\" />\n",
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      "<ns0:person name=\"Riley M.\" />\n",
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      "<ns0:person name=\"Davis N.W.\" />\n",
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      "<ns0:person name=\"Shao Y.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"9278503\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1126/science.277.5331.1453\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"5\">\n",
      "<ns0:citation date=\"2006\" first=\"E1\" last=\"E5\" name=\"Mol. Syst. Biol.\" type=\"journal article\" volume=\"2\">\n",
      "<ns0:title>Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Hayashi K.\" />\n",
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      "<ns0:person name=\"Yamamoto Y.\" />\n",
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      "<ns0:person name=\"Choi S.\" />\n",
      "<ns0:person name=\"Ohtsubo E.\" />\n",
      "<ns0:person name=\"Baba T.\" />\n",
      "<ns0:person name=\"Wanner B.L.\" />\n",
      "<ns0:person name=\"Mori H.\" />\n",
      "<ns0:person name=\"Horiuchi T.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"16738553\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1038/msb4100049\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / W3110 / ATCC 27325 / DSM 5911</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"6\">\n",
      "<ns0:citation date=\"1995\" first=\"45\" last=\"55\" name=\"Mol. Microbiol.\" type=\"journal article\" volume=\"16\">\n",
      "<ns0:title>Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Ma D.\" />\n",
      "<ns0:person name=\"Cook D.N.\" />\n",
      "<ns0:person name=\"Alberti M.\" />\n",
      "<ns0:person name=\"Pon N.G.\" />\n",
      "<ns0:person name=\"Nikaido H.\" />\n",
      "<ns0:person name=\"Hearst J.E.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"7651136\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1111/j.1365-2958.1995.tb02390.x\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>CHARACTERIZATION</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"7\">\n",
      "<ns0:citation date=\"2000\" first=\"195\" last=\"200\" name=\"J. Biochem.\" type=\"journal article\" volume=\"128\">\n",
      "<ns0:title>Molecular construction of a multidrug exporter system, AcrAB: molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal sequence of AcrA.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Kawabe T.\" />\n",
      "<ns0:person name=\"Fujihira E.\" />\n",
      "<ns0:person name=\"Yamaguchi A.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"10920254\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1093/oxfordjournals.jbchem.a022741\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>INTERACTION WITH ACRA</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"8\">\n",
      "<ns0:citation date=\"2004\" first=\"697\" last=\"706\" name=\"Mol. Microbiol.\" type=\"journal article\" volume=\"53\">\n",
      "<ns0:title>Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.</ns0:title>\n",
      "<ns0:authorList>\n",
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      "<ns0:person name=\"Koronakis V.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"15228545\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1111/j.1365-2958.2004.04158.x\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>INTERACTION WITH ACRA AND TOLC</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "<ns0:scope>SUBCELLULAR LOCATION</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MC1061 / ATCC 53338 / DSM 7140</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"9\">\n",
      "<ns0:citation date=\"2005\" first=\"34409\" last=\"34419\" name=\"J. Biol. Chem.\" type=\"journal article\" volume=\"280\">\n",
      "<ns0:title>Protein complexes of the Escherichia coli cell envelope.</ns0:title>\n",
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      "</ns0:authorList>\n",
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      "<ns0:dbReference id=\"10.1074/jbc.m506479200\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "<ns0:scope>SUBCELLULAR LOCATION</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>BL21-DE3</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"10\">\n",
      "<ns0:citation date=\"2005\" first=\"1321\" last=\"1323\" name=\"Science\" type=\"journal article\" volume=\"308\">\n",
      "<ns0:title>Global topology analysis of the Escherichia coli inner membrane proteome.</ns0:title>\n",
      "<ns0:authorList>\n",
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      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"15919996\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1126/science.1109730\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>TOPOLOGY [LARGE SCALE ANALYSIS]</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"11\">\n",
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      "<ns0:title>Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Aoki S.K.\" />\n",
      "<ns0:person name=\"Malinverni J.C.\" />\n",
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      "<ns0:person name=\"Thomas B.\" />\n",
      "<ns0:person name=\"Pamma R.\" />\n",
      "<ns0:person name=\"Trinh B.N.\" />\n",
      "<ns0:person name=\"Remers S.\" />\n",
      "<ns0:person name=\"Webb J.\" />\n",
      "<ns0:person name=\"Braaten B.A.\" />\n",
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      "<ns0:person name=\"Low D.A.\" />\n",
      "</ns0:authorList>\n",
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      "<ns0:dbReference id=\"10.1111/j.1365-2958.2008.06404.x\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>FUNCTION (MICROBIAL INFECTION)</ns0:scope>\n",
      "<ns0:scope>DISRUPTION PHENOTYPE</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MC4100</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"12\">\n",
      "<ns0:citation date=\"2012\" first=\"16696\" last=\"16701\" name=\"Proc. Natl. Acad. Sci. U.S.A.\" type=\"journal article\" volume=\"109\">\n",
      "<ns0:title>Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Hobbs E.C.\" />\n",
      "<ns0:person name=\"Yin X.\" />\n",
      "<ns0:person name=\"Paul B.J.\" />\n",
      "<ns0:person name=\"Astarita J.L.\" />\n",
      "<ns0:person name=\"Storz G.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"23010927\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1073/pnas.1210093109\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>FUNCTION</ns0:scope>\n",
      "<ns0:scope>INTERACTION WITH ACRZ</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "<ns0:scope>INDUCTION</ns0:scope>\n",
      "<ns0:scope>MUTAGENESIS OF HIS-526</ns0:scope>\n",
      "<ns0:source>\n",
      "<ns0:strain>K12 / MG1655 / ATCC 47076</ns0:strain>\n",
      "</ns0:source>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"13\">\n",
      "<ns0:citation date=\"2002\" first=\"587\" last=\"593\" name=\"Nature\" type=\"journal article\" volume=\"419\">\n",
      "<ns0:title>Crystal structure of bacterial multidrug efflux transporter AcrB.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Murakami S.\" />\n",
      "<ns0:person name=\"Nakashima R.\" />\n",
      "<ns0:person name=\"Yamashita E.\" />\n",
      "<ns0:person name=\"Yamaguchi A.\" />\n",
      "</ns0:authorList>\n",
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      "<ns0:dbReference id=\"10.1038/nature01050\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS)</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"14\">\n",
      "<ns0:citation date=\"2003\" first=\"976\" last=\"980\" name=\"Science\" type=\"journal article\" volume=\"300\">\n",
      "<ns0:title>Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Yu E.W.\" />\n",
      "<ns0:person name=\"McDermott G.\" />\n",
      "<ns0:person name=\"Zgurskaya H.I.\" />\n",
      "<ns0:person name=\"Nikaido H.\" />\n",
      "<ns0:person name=\"Koshland D.E. Jr.\" />\n",
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      "<ns0:dbReference id=\"10.1126/science.1083137\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>X-RAY CRYSTALLOGRAPHY (3.48 ANGSTROMS) IN COMPLEXES WITH SUBSTRATES</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"15\">\n",
      "<ns0:citation date=\"2006\" first=\"173\" last=\"179\" name=\"Nature\" type=\"journal article\" volume=\"443\">\n",
      "<ns0:title>Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Murakami S.\" />\n",
      "<ns0:person name=\"Nakashima R.\" />\n",
      "<ns0:person name=\"Yamashita E.\" />\n",
      "<ns0:person name=\"Matsumoto T.\" />\n",
      "<ns0:person name=\"Yamaguchi A.\" />\n",
      "</ns0:authorList>\n",
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      "<ns0:dbReference id=\"10.1038/nature05076\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "<ns0:scope>FUNCTION</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"16\">\n",
      "<ns0:citation date=\"2006\" first=\"1295\" last=\"1298\" name=\"Science\" type=\"journal article\" volume=\"313\">\n",
      "<ns0:title>Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Seeger M.A.\" />\n",
      "<ns0:person name=\"Schiefner A.\" />\n",
      "<ns0:person name=\"Eicher T.\" />\n",
      "<ns0:person name=\"Verrey F.\" />\n",
      "<ns0:person name=\"Diederichs K.\" />\n",
      "<ns0:person name=\"Pos K.M.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"16946072\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1126/science.1131542\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "<ns0:scope>FUNCTION</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:reference key=\"17\">\n",
      "<ns0:citation date=\"2007\" first=\"107\" last=\"113\" name=\"PLoS Biol.\" type=\"journal article\" volume=\"5\">\n",
      "<ns0:title>Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors.</ns0:title>\n",
      "<ns0:authorList>\n",
      "<ns0:person name=\"Sennhauser G.\" />\n",
      "<ns0:person name=\"Amstutz P.\" />\n",
      "<ns0:person name=\"Briand C.\" />\n",
      "<ns0:person name=\"Storchenegger O.\" />\n",
      "<ns0:person name=\"Gruetter M.G.\" />\n",
      "</ns0:authorList>\n",
      "<ns0:dbReference id=\"17194213\" type=\"PubMed\" />\n",
      "<ns0:dbReference id=\"10.1371/journal.pbio.0050007\" type=\"DOI\" />\n",
      "</ns0:citation>\n",
      "<ns0:scope>X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)</ns0:scope>\n",
      "<ns0:scope>FUNCTION</ns0:scope>\n",
      "<ns0:scope>SUBUNIT</ns0:scope>\n",
      "</ns0:reference>\n",
      "<ns0:comment type=\"function\">\n",
      "<ns0:text evidence=\"23 24 25 27\">AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"function\">\n",
      "<ns0:text evidence=\"26\">(Microbial infection) Involved in contact-dependent growth inhibition (CDI), acts downstream of BamA, the receptor for CDI. Its role in CDI is independent of the AcrA-AcrB-TolC efflux pump complex.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"subunit\">\n",
      "<ns0:text evidence=\"17 18 19 20 22 23 24 25 27\">Homotrimer, with large domains that extend into the periplasm, interacts with AcrA and TolC. AcrA may be required to stably link this protein and TolC. Interacts with AcrZ. Part of the AcrA-AcrB-AcrZ-TolC efflux pump.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"interaction\">\n",
      "<ns0:interactant intactId=\"EBI-551006\">\n",
      "<ns0:id>P31224</ns0:id>\n",
      "</ns0:interactant>\n",
      "<ns0:interactant intactId=\"EBI-551006\">\n",
      "<ns0:id>P31224</ns0:id>\n",
      "<ns0:label>acrB</ns0:label>\n",
      "</ns0:interactant>\n",
      "<ns0:organismsDiffer>false</ns0:organismsDiffer>\n",
      "<ns0:experiments>9</ns0:experiments>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"interaction\">\n",
      "<ns0:interactant intactId=\"EBI-551006\">\n",
      "<ns0:id>P31224</ns0:id>\n",
      "</ns0:interactant>\n",
      "<ns0:interactant intactId=\"EBI-6313593\">\n",
      "<ns0:id>P0AAW9</ns0:id>\n",
      "<ns0:label>acrZ</ns0:label>\n",
      "</ns0:interactant>\n",
      "<ns0:organismsDiffer>false</ns0:organismsDiffer>\n",
      "<ns0:experiments>7</ns0:experiments>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"interaction\">\n",
      "<ns0:interactant intactId=\"EBI-551006\">\n",
      "<ns0:id>P31224</ns0:id>\n",
      "</ns0:interactant>\n",
      "<ns0:interactant intactId=\"EBI-1130723\">\n",
      "<ns0:id>P0ADZ7</ns0:id>\n",
      "<ns0:label>yajC</ns0:label>\n",
      "</ns0:interactant>\n",
      "<ns0:organismsDiffer>false</ns0:organismsDiffer>\n",
      "<ns0:experiments>2</ns0:experiments>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"subcellular location\">\n",
      "<ns0:subcellularLocation>\n",
      "<ns0:location evidence=\"20 22\">Cell inner membrane</ns0:location>\n",
      "<ns0:topology evidence=\"20 22\">Multi-pass membrane protein</ns0:topology>\n",
      "</ns0:subcellularLocation>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"induction\">\n",
      "<ns0:text evidence=\"27\">Positively regulated by MarA, Rob and SoxS transcriptional regulators (at protein level).</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"disruption phenotype\">\n",
      "<ns0:text evidence=\"26\">Loss of susceptibility to contact-dependent growth inhibition (CDI); inhibiting cells still contact the target.</ns0:text>\n",
      "</ns0:comment>\n",
      "<ns0:comment type=\"similarity\">\n",
      "<ns0:text evidence=\"28\">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</ns0:text>\n",
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    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
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      "</ns0:dbReference>\n",
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      "</ns0:dbReference>\n",
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      "</ns0:dbReference>\n",
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      "<ns0:property type=\"term\" value=\"C:integral component of plasma membrane\" />\n",
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      "</ns0:dbReference>\n",
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      "<ns0:property type=\"evidence\" value=\"ECO:0007005\" />\n",
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      "</ns0:dbReference>\n",
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      "</ns0:dbReference>\n",
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      "</ns0:dbReference>\n",
      "<ns0:dbReference id=\"GO:0015562\" type=\"GO\">\n",
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      "</ns0:dbReference>\n",
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    {
     "name": "stdout",
     "output_type": "stream",
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      "</ns0:evidence>\n",
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      "</ns0:evidence>\n",
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      "<ns0:source>\n",
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      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"13\" type=\"ECO:0000244\">\n",
      "<ns0:source>\n",
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      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"14\" type=\"ECO:0000244\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"5YIL\" type=\"PDB\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"15\" type=\"ECO:0000244\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"6BAJ\" type=\"PDB\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"16\" type=\"ECO:0000244\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"6Q4P\" type=\"PDB\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"17\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"10920254\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"18\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"12374972\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"19\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
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      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"20\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"15228545\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"21\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"15919996\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"22\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"16079137\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"23\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"16915237\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"24\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"16946072\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"25\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"17194213\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"26\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"18761695\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"27\" type=\"ECO:0000269\">\n",
      "<ns0:source>\n",
      "<ns0:dbReference id=\"23010927\" type=\"PubMed\" />\n",
      "</ns0:source>\n",
      "</ns0:evidence>\n",
      "<ns0:evidence key=\"28\" type=\"ECO:0000305\" />\n",
      "<ns0:sequence checksum=\"19670E3C4CC29055\" length=\"1049\" mass=\"113574\" modified=\"1993-07-01\" version=\"1\">MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH</ns0:sequence>\n",
      "</ns0:entry>\n"
     ]
    }
   ],
   "source": [
    "# Find the xml subtree of a protein with accession \"P31224\"\n",
    "for entry in proteins:\n",
    "    accessions = entry.findall(ns+\"accession\")\n",
    "    for acc in accessions:\n",
    "        if acc.text == \"P31224\":\n",
    "            dump(entry)\n",
    "            break"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "\n",
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       "    } else if (typeof(MozWebSocket) !== 'undefined') {\n",
       "        return MozWebSocket;\n",
       "    } else {\n",
       "        alert('Your browser does not have WebSocket support. ' +\n",
       "              'Please try Chrome, Safari or Firefox ≥ 6. ' +\n",
       "              'Firefox 4 and 5 are also supported but you ' +\n",
       "              'have to enable WebSockets in about:config.');\n",
       "    };\n",
       "}\n",
       "\n",
       "mpl.figure = function(figure_id, websocket, ondownload, parent_element) {\n",
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       "        if (warnings) {\n",
       "            warnings.style.display = 'block';\n",
       "            warnings.textContent = (\n",
       "                \"This browser does not support binary websocket messages. \" +\n",
       "                    \"Performance may be slow.\");\n",
       "        }\n",
       "    }\n",
       "\n",
       "    this.imageObj = new Image();\n",
       "\n",
       "    this.context = undefined;\n",
       "    this.message = undefined;\n",
       "    this.canvas = undefined;\n",
       "    this.rubberband_canvas = undefined;\n",
       "    this.rubberband_context = undefined;\n",
       "    this.format_dropdown = undefined;\n",
       "\n",
       "    this.image_mode = 'full';\n",
       "\n",
       "    this.root = $('<div/>');\n",
       "    this._root_extra_style(this.root)\n",
       "    this.root.attr('style', 'display: inline-block');\n",
       "\n",
       "    $(parent_element).append(this.root);\n",
       "\n",
       "    this._init_header(this);\n",
       "    this._init_canvas(this);\n",
       "    this._init_toolbar(this);\n",
       "\n",
       "    var fig = this;\n",
       "\n",
       "    this.waiting = false;\n",
       "\n",
       "    this.ws.onopen =  function () {\n",
       "            fig.send_message(\"supports_binary\", {value: fig.supports_binary});\n",
       "            fig.send_message(\"send_image_mode\", {});\n",
       "            if (mpl.ratio != 1) {\n",
       "                fig.send_message(\"set_dpi_ratio\", {'dpi_ratio': mpl.ratio});\n",
       "            }\n",
       "            fig.send_message(\"refresh\", {});\n",
       "        }\n",
       "\n",
       "    this.imageObj.onload = function() {\n",
       "            if (fig.image_mode == 'full') {\n",
       "                // Full images could contain transparency (where diff images\n",
       "                // almost always do), so we need to clear the canvas so that\n",
       "                // there is no ghosting.\n",
       "                fig.context.clearRect(0, 0, fig.canvas.width, fig.canvas.height);\n",
       "            }\n",
       "            fig.context.drawImage(fig.imageObj, 0, 0);\n",
       "        };\n",
       "\n",
       "    this.imageObj.onunload = function() {\n",
       "        fig.ws.close();\n",
       "    }\n",
       "\n",
       "    this.ws.onmessage = this._make_on_message_function(this);\n",
       "\n",
       "    this.ondownload = ondownload;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_header = function() {\n",
       "    var titlebar = $(\n",
       "        '<div class=\"ui-dialog-titlebar ui-widget-header ui-corner-all ' +\n",
       "        'ui-helper-clearfix\"/>');\n",
       "    var titletext = $(\n",
       "        '<div class=\"ui-dialog-title\" style=\"width: 100%; ' +\n",
       "        'text-align: center; padding: 3px;\"/>');\n",
       "    titlebar.append(titletext)\n",
       "    this.root.append(titlebar);\n",
       "    this.header = titletext[0];\n",
       "}\n",
       "\n",
       "\n",
       "\n",
       "mpl.figure.prototype._canvas_extra_style = function(canvas_div) {\n",
       "\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype._root_extra_style = function(canvas_div) {\n",
       "\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_canvas = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var canvas_div = $('<div/>');\n",
       "\n",
       "    canvas_div.attr('style', 'position: relative; clear: both; outline: 0');\n",
       "\n",
       "    function canvas_keyboard_event(event) {\n",
       "        return fig.key_event(event, event['data']);\n",
       "    }\n",
       "\n",
       "    canvas_div.keydown('key_press', canvas_keyboard_event);\n",
       "    canvas_div.keyup('key_release', canvas_keyboard_event);\n",
       "    this.canvas_div = canvas_div\n",
       "    this._canvas_extra_style(canvas_div)\n",
       "    this.root.append(canvas_div);\n",
       "\n",
       "    var canvas = $('<canvas/>');\n",
       "    canvas.addClass('mpl-canvas');\n",
       "    canvas.attr('style', \"left: 0; top: 0; z-index: 0; outline: 0\")\n",
       "\n",
       "    this.canvas = canvas[0];\n",
       "    this.context = canvas[0].getContext(\"2d\");\n",
       "\n",
       "    var backingStore = this.context.backingStorePixelRatio ||\n",
       "\tthis.context.webkitBackingStorePixelRatio ||\n",
       "\tthis.context.mozBackingStorePixelRatio ||\n",
       "\tthis.context.msBackingStorePixelRatio ||\n",
       "\tthis.context.oBackingStorePixelRatio ||\n",
       "\tthis.context.backingStorePixelRatio || 1;\n",
       "\n",
       "    mpl.ratio = (window.devicePixelRatio || 1) / backingStore;\n",
       "\n",
       "    var rubberband = $('<canvas/>');\n",
       "    rubberband.attr('style', \"position: absolute; left: 0; top: 0; z-index: 1;\")\n",
       "\n",
       "    var pass_mouse_events = true;\n",
       "\n",
       "    canvas_div.resizable({\n",
       "        start: function(event, ui) {\n",
       "            pass_mouse_events = false;\n",
       "        },\n",
       "        resize: function(event, ui) {\n",
       "            fig.request_resize(ui.size.width, ui.size.height);\n",
       "        },\n",
       "        stop: function(event, ui) {\n",
       "            pass_mouse_events = true;\n",
       "            fig.request_resize(ui.size.width, ui.size.height);\n",
       "        },\n",
       "    });\n",
       "\n",
       "    function mouse_event_fn(event) {\n",
       "        if (pass_mouse_events)\n",
       "            return fig.mouse_event(event, event['data']);\n",
       "    }\n",
       "\n",
       "    rubberband.mousedown('button_press', mouse_event_fn);\n",
       "    rubberband.mouseup('button_release', mouse_event_fn);\n",
       "    // Throttle sequential mouse events to 1 every 20ms.\n",
       "    rubberband.mousemove('motion_notify', mouse_event_fn);\n",
       "\n",
       "    rubberband.mouseenter('figure_enter', mouse_event_fn);\n",
       "    rubberband.mouseleave('figure_leave', mouse_event_fn);\n",
       "\n",
       "    canvas_div.on(\"wheel\", function (event) {\n",
       "        event = event.originalEvent;\n",
       "        event['data'] = 'scroll'\n",
       "        if (event.deltaY < 0) {\n",
       "            event.step = 1;\n",
       "        } else {\n",
       "            event.step = -1;\n",
       "        }\n",
       "        mouse_event_fn(event);\n",
       "    });\n",
       "\n",
       "    canvas_div.append(canvas);\n",
       "    canvas_div.append(rubberband);\n",
       "\n",
       "    this.rubberband = rubberband;\n",
       "    this.rubberband_canvas = rubberband[0];\n",
       "    this.rubberband_context = rubberband[0].getContext(\"2d\");\n",
       "    this.rubberband_context.strokeStyle = \"#000000\";\n",
       "\n",
       "    this._resize_canvas = function(width, height) {\n",
       "        // Keep the size of the canvas, canvas container, and rubber band\n",
       "        // canvas in synch.\n",
       "        canvas_div.css('width', width)\n",
       "        canvas_div.css('height', height)\n",
       "\n",
       "        canvas.attr('width', width * mpl.ratio);\n",
       "        canvas.attr('height', height * mpl.ratio);\n",
       "        canvas.attr('style', 'width: ' + width + 'px; height: ' + height + 'px;');\n",
       "\n",
       "        rubberband.attr('width', width);\n",
       "        rubberband.attr('height', height);\n",
       "    }\n",
       "\n",
       "    // Set the figure to an initial 600x600px, this will subsequently be updated\n",
       "    // upon first draw.\n",
       "    this._resize_canvas(600, 600);\n",
       "\n",
       "    // Disable right mouse context menu.\n",
       "    $(this.rubberband_canvas).bind(\"contextmenu\",function(e){\n",
       "        return false;\n",
       "    });\n",
       "\n",
       "    function set_focus () {\n",
       "        canvas.focus();\n",
       "        canvas_div.focus();\n",
       "    }\n",
       "\n",
       "    window.setTimeout(set_focus, 100);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_toolbar = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var nav_element = $('<div/>');\n",
       "    nav_element.attr('style', 'width: 100%');\n",
       "    this.root.append(nav_element);\n",
       "\n",
       "    // Define a callback function for later on.\n",
       "    function toolbar_event(event) {\n",
       "        return fig.toolbar_button_onclick(event['data']);\n",
       "    }\n",
       "    function toolbar_mouse_event(event) {\n",
       "        return fig.toolbar_button_onmouseover(event['data']);\n",
       "    }\n",
       "\n",
       "    for(var toolbar_ind in mpl.toolbar_items) {\n",
       "        var name = mpl.toolbar_items[toolbar_ind][0];\n",
       "        var tooltip = mpl.toolbar_items[toolbar_ind][1];\n",
       "        var image = mpl.toolbar_items[toolbar_ind][2];\n",
       "        var method_name = mpl.toolbar_items[toolbar_ind][3];\n",
       "\n",
       "        if (!name) {\n",
       "            // put a spacer in here.\n",
       "            continue;\n",
       "        }\n",
       "        var button = $('<button/>');\n",
       "        button.addClass('ui-button ui-widget ui-state-default ui-corner-all ' +\n",
       "                        'ui-button-icon-only');\n",
       "        button.attr('role', 'button');\n",
       "        button.attr('aria-disabled', 'false');\n",
       "        button.click(method_name, toolbar_event);\n",
       "        button.mouseover(tooltip, toolbar_mouse_event);\n",
       "\n",
       "        var icon_img = $('<span/>');\n",
       "        icon_img.addClass('ui-button-icon-primary ui-icon');\n",
       "        icon_img.addClass(image);\n",
       "        icon_img.addClass('ui-corner-all');\n",
       "\n",
       "        var tooltip_span = $('<span/>');\n",
       "        tooltip_span.addClass('ui-button-text');\n",
       "        tooltip_span.html(tooltip);\n",
       "\n",
       "        button.append(icon_img);\n",
       "        button.append(tooltip_span);\n",
       "\n",
       "        nav_element.append(button);\n",
       "    }\n",
       "\n",
       "    var fmt_picker_span = $('<span/>');\n",
       "\n",
       "    var fmt_picker = $('<select/>');\n",
       "    fmt_picker.addClass('mpl-toolbar-option ui-widget ui-widget-content');\n",
       "    fmt_picker_span.append(fmt_picker);\n",
       "    nav_element.append(fmt_picker_span);\n",
       "    this.format_dropdown = fmt_picker[0];\n",
       "\n",
       "    for (var ind in mpl.extensions) {\n",
       "        var fmt = mpl.extensions[ind];\n",
       "        var option = $(\n",
       "            '<option/>', {selected: fmt === mpl.default_extension}).html(fmt);\n",
       "        fmt_picker.append(option);\n",
       "    }\n",
       "\n",
       "    // Add hover states to the ui-buttons\n",
       "    $( \".ui-button\" ).hover(\n",
       "        function() { $(this).addClass(\"ui-state-hover\");},\n",
       "        function() { $(this).removeClass(\"ui-state-hover\");}\n",
       "    );\n",
       "\n",
       "    var status_bar = $('<span class=\"mpl-message\"/>');\n",
       "    nav_element.append(status_bar);\n",
       "    this.message = status_bar[0];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.request_resize = function(x_pixels, y_pixels) {\n",
       "    // Request matplotlib to resize the figure. Matplotlib will then trigger a resize in the client,\n",
       "    // which will in turn request a refresh of the image.\n",
       "    this.send_message('resize', {'width': x_pixels, 'height': y_pixels});\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.send_message = function(type, properties) {\n",
       "    properties['type'] = type;\n",
       "    properties['figure_id'] = this.id;\n",
       "    this.ws.send(JSON.stringify(properties));\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.send_draw_message = function() {\n",
       "    if (!this.waiting) {\n",
       "        this.waiting = true;\n",
       "        this.ws.send(JSON.stringify({type: \"draw\", figure_id: this.id}));\n",
       "    }\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype.handle_save = function(fig, msg) {\n",
       "    var format_dropdown = fig.format_dropdown;\n",
       "    var format = format_dropdown.options[format_dropdown.selectedIndex].value;\n",
       "    fig.ondownload(fig, format);\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype.handle_resize = function(fig, msg) {\n",
       "    var size = msg['size'];\n",
       "    if (size[0] != fig.canvas.width || size[1] != fig.canvas.height) {\n",
       "        fig._resize_canvas(size[0], size[1]);\n",
       "        fig.send_message(\"refresh\", {});\n",
       "    };\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_rubberband = function(fig, msg) {\n",
       "    var x0 = msg['x0'] / mpl.ratio;\n",
       "    var y0 = (fig.canvas.height - msg['y0']) / mpl.ratio;\n",
       "    var x1 = msg['x1'] / mpl.ratio;\n",
       "    var y1 = (fig.canvas.height - msg['y1']) / mpl.ratio;\n",
       "    x0 = Math.floor(x0) + 0.5;\n",
       "    y0 = Math.floor(y0) + 0.5;\n",
       "    x1 = Math.floor(x1) + 0.5;\n",
       "    y1 = Math.floor(y1) + 0.5;\n",
       "    var min_x = Math.min(x0, x1);\n",
       "    var min_y = Math.min(y0, y1);\n",
       "    var width = Math.abs(x1 - x0);\n",
       "    var height = Math.abs(y1 - y0);\n",
       "\n",
       "    fig.rubberband_context.clearRect(\n",
       "        0, 0, fig.canvas.width / mpl.ratio, fig.canvas.height / mpl.ratio);\n",
       "\n",
       "    fig.rubberband_context.strokeRect(min_x, min_y, width, height);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_figure_label = function(fig, msg) {\n",
       "    // Updates the figure title.\n",
       "    fig.header.textContent = msg['label'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_cursor = function(fig, msg) {\n",
       "    var cursor = msg['cursor'];\n",
       "    switch(cursor)\n",
       "    {\n",
       "    case 0:\n",
       "        cursor = 'pointer';\n",
       "        break;\n",
       "    case 1:\n",
       "        cursor = 'default';\n",
       "        break;\n",
       "    case 2:\n",
       "        cursor = 'crosshair';\n",
       "        break;\n",
       "    case 3:\n",
       "        cursor = 'move';\n",
       "        break;\n",
       "    }\n",
       "    fig.rubberband_canvas.style.cursor = cursor;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_message = function(fig, msg) {\n",
       "    fig.message.textContent = msg['message'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_draw = function(fig, msg) {\n",
       "    // Request the server to send over a new figure.\n",
       "    fig.send_draw_message();\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_image_mode = function(fig, msg) {\n",
       "    fig.image_mode = msg['mode'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.updated_canvas_event = function() {\n",
       "    // Called whenever the canvas gets updated.\n",
       "    this.send_message(\"ack\", {});\n",
       "}\n",
       "\n",
       "// A function to construct a web socket function for onmessage handling.\n",
       "// Called in the figure constructor.\n",
       "mpl.figure.prototype._make_on_message_function = function(fig) {\n",
       "    return function socket_on_message(evt) {\n",
       "        if (evt.data instanceof Blob) {\n",
       "            /* FIXME: We get \"Resource interpreted as Image but\n",
       "             * transferred with MIME type text/plain:\" errors on\n",
       "             * Chrome.  But how to set the MIME type?  It doesn't seem\n",
       "             * to be part of the websocket stream */\n",
       "            evt.data.type = \"image/png\";\n",
       "\n",
       "            /* Free the memory for the previous frames */\n",
       "            if (fig.imageObj.src) {\n",
       "                (window.URL || window.webkitURL).revokeObjectURL(\n",
       "                    fig.imageObj.src);\n",
       "            }\n",
       "\n",
       "            fig.imageObj.src = (window.URL || window.webkitURL).createObjectURL(\n",
       "                evt.data);\n",
       "            fig.updated_canvas_event();\n",
       "            fig.waiting = false;\n",
       "            return;\n",
       "        }\n",
       "        else if (typeof evt.data === 'string' && evt.data.slice(0, 21) == \"data:image/png;base64\") {\n",
       "            fig.imageObj.src = evt.data;\n",
       "            fig.updated_canvas_event();\n",
       "            fig.waiting = false;\n",
       "            return;\n",
       "        }\n",
       "\n",
       "        var msg = JSON.parse(evt.data);\n",
       "        var msg_type = msg['type'];\n",
       "\n",
       "        // Call the  \"handle_{type}\" callback, which takes\n",
       "        // the figure and JSON message as its only arguments.\n",
       "        try {\n",
       "            var callback = fig[\"handle_\" + msg_type];\n",
       "        } catch (e) {\n",
       "            console.log(\"No handler for the '\" + msg_type + \"' message type: \", msg);\n",
       "            return;\n",
       "        }\n",
       "\n",
       "        if (callback) {\n",
       "            try {\n",
       "                // console.log(\"Handling '\" + msg_type + \"' message: \", msg);\n",
       "                callback(fig, msg);\n",
       "            } catch (e) {\n",
       "                console.log(\"Exception inside the 'handler_\" + msg_type + \"' callback:\", e, e.stack, msg);\n",
       "            }\n",
       "        }\n",
       "    };\n",
       "}\n",
       "\n",
       "// from http://stackoverflow.com/questions/1114465/getting-mouse-location-in-canvas\n",
       "mpl.findpos = function(e) {\n",
       "    //this section is from http://www.quirksmode.org/js/events_properties.html\n",
       "    var targ;\n",
       "    if (!e)\n",
       "        e = window.event;\n",
       "    if (e.target)\n",
       "        targ = e.target;\n",
       "    else if (e.srcElement)\n",
       "        targ = e.srcElement;\n",
       "    if (targ.nodeType == 3) // defeat Safari bug\n",
       "        targ = targ.parentNode;\n",
       "\n",
       "    // jQuery normalizes the pageX and pageY\n",
       "    // pageX,Y are the mouse positions relative to the document\n",
       "    // offset() returns the position of the element relative to the document\n",
       "    var x = e.pageX - $(targ).offset().left;\n",
       "    var y = e.pageY - $(targ).offset().top;\n",
       "\n",
       "    return {\"x\": x, \"y\": y};\n",
       "};\n",
       "\n",
       "/*\n",
       " * return a copy of an object with only non-object keys\n",
       " * we need this to avoid circular references\n",
       " * http://stackoverflow.com/a/24161582/3208463\n",
       " */\n",
       "function simpleKeys (original) {\n",
       "  return Object.keys(original).reduce(function (obj, key) {\n",
       "    if (typeof original[key] !== 'object')\n",
       "        obj[key] = original[key]\n",
       "    return obj;\n",
       "  }, {});\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.mouse_event = function(event, name) {\n",
       "    var canvas_pos = mpl.findpos(event)\n",
       "\n",
       "    if (name === 'button_press')\n",
       "    {\n",
       "        this.canvas.focus();\n",
       "        this.canvas_div.focus();\n",
       "    }\n",
       "\n",
       "    var x = canvas_pos.x * mpl.ratio;\n",
       "    var y = canvas_pos.y * mpl.ratio;\n",
       "\n",
       "    this.send_message(name, {x: x, y: y, button: event.button,\n",
       "                             step: event.step,\n",
       "                             guiEvent: simpleKeys(event)});\n",
       "\n",
       "    /* This prevents the web browser from automatically changing to\n",
       "     * the text insertion cursor when the button is pressed.  We want\n",
       "     * to control all of the cursor setting manually through the\n",
       "     * 'cursor' event from matplotlib */\n",
       "    event.preventDefault();\n",
       "    return false;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._key_event_extra = function(event, name) {\n",
       "    // Handle any extra behaviour associated with a key event\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.key_event = function(event, name) {\n",
       "\n",
       "    // Prevent repeat events\n",
       "    if (name == 'key_press')\n",
       "    {\n",
       "        if (event.which === this._key)\n",
       "            return;\n",
       "        else\n",
       "            this._key = event.which;\n",
       "    }\n",
       "    if (name == 'key_release')\n",
       "        this._key = null;\n",
       "\n",
       "    var value = '';\n",
       "    if (event.ctrlKey && event.which != 17)\n",
       "        value += \"ctrl+\";\n",
       "    if (event.altKey && event.which != 18)\n",
       "        value += \"alt+\";\n",
       "    if (event.shiftKey && event.which != 16)\n",
       "        value += \"shift+\";\n",
       "\n",
       "    value += 'k';\n",
       "    value += event.which.toString();\n",
       "\n",
       "    this._key_event_extra(event, name);\n",
       "\n",
       "    this.send_message(name, {key: value,\n",
       "                             guiEvent: simpleKeys(event)});\n",
       "    return false;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.toolbar_button_onclick = function(name) {\n",
       "    if (name == 'download') {\n",
       "        this.handle_save(this, null);\n",
       "    } else {\n",
       "        this.send_message(\"toolbar_button\", {name: name});\n",
       "    }\n",
       "};\n",
       "\n",
       "mpl.figure.prototype.toolbar_button_onmouseover = function(tooltip) {\n",
       "    this.message.textContent = tooltip;\n",
       "};\n",
       "mpl.toolbar_items = [[\"Home\", \"Reset original view\", \"fa fa-home icon-home\", \"home\"], [\"Back\", \"Back to previous view\", \"fa fa-arrow-left icon-arrow-left\", \"back\"], [\"Forward\", \"Forward to next view\", \"fa fa-arrow-right icon-arrow-right\", \"forward\"], [\"\", \"\", \"\", \"\"], [\"Pan\", \"Pan axes with left mouse, zoom with right\", \"fa fa-arrows icon-move\", \"pan\"], [\"Zoom\", \"Zoom to rectangle\", \"fa fa-square-o icon-check-empty\", \"zoom\"], [\"\", \"\", \"\", \"\"], [\"Download\", \"Download plot\", \"fa fa-floppy-o icon-save\", \"download\"]];\n",
       "\n",
       "mpl.extensions = [\"eps\", \"jpeg\", \"pdf\", \"png\", \"ps\", \"raw\", \"svg\", \"tif\"];\n",
       "\n",
       "mpl.default_extension = \"png\";var comm_websocket_adapter = function(comm) {\n",
       "    // Create a \"websocket\"-like object which calls the given IPython comm\n",
       "    // object with the appropriate methods. Currently this is a non binary\n",
       "    // socket, so there is still some room for performance tuning.\n",
       "    var ws = {};\n",
       "\n",
       "    ws.close = function() {\n",
       "        comm.close()\n",
       "    };\n",
       "    ws.send = function(m) {\n",
       "        //console.log('sending', m);\n",
       "        comm.send(m);\n",
       "    };\n",
       "    // Register the callback with on_msg.\n",
       "    comm.on_msg(function(msg) {\n",
       "        //console.log('receiving', msg['content']['data'], msg);\n",
       "        // Pass the mpl event to the overridden (by mpl) onmessage function.\n",
       "        ws.onmessage(msg['content']['data'])\n",
       "    });\n",
       "    return ws;\n",
       "}\n",
       "\n",
       "mpl.mpl_figure_comm = function(comm, msg) {\n",
       "    // This is the function which gets called when the mpl process\n",
       "    // starts-up an IPython Comm through the \"matplotlib\" channel.\n",
       "\n",
       "    var id = msg.content.data.id;\n",
       "    // Get hold of the div created by the display call when the Comm\n",
       "    // socket was opened in Python.\n",
       "    var element = $(\"#\" + id);\n",
       "    var ws_proxy = comm_websocket_adapter(comm)\n",
       "\n",
       "    function ondownload(figure, format) {\n",
       "        window.open(figure.imageObj.src);\n",
       "    }\n",
       "\n",
       "    var fig = new mpl.figure(id, ws_proxy,\n",
       "                           ondownload,\n",
       "                           element.get(0));\n",
       "\n",
       "    // Call onopen now - mpl needs it, as it is assuming we've passed it a real\n",
       "    // web socket which is closed, not our websocket->open comm proxy.\n",
       "    ws_proxy.onopen();\n",
       "\n",
       "    fig.parent_element = element.get(0);\n",
       "    fig.cell_info = mpl.find_output_cell(\"<div id='\" + id + \"'></div>\");\n",
       "    if (!fig.cell_info) {\n",
       "        console.error(\"Failed to find cell for figure\", id, fig);\n",
       "        return;\n",
       "    }\n",
       "\n",
       "    var output_index = fig.cell_info[2]\n",
       "    var cell = fig.cell_info[0];\n",
       "\n",
       "};\n",
       "\n",
       "mpl.figure.prototype.handle_close = function(fig, msg) {\n",
       "    var width = fig.canvas.width/mpl.ratio\n",
       "    fig.root.unbind('remove')\n",
       "\n",
       "    // Update the output cell to use the data from the current canvas.\n",
       "    fig.push_to_output();\n",
       "    var dataURL = fig.canvas.toDataURL();\n",
       "    // Re-enable the keyboard manager in IPython - without this line, in FF,\n",
       "    // the notebook keyboard shortcuts fail.\n",
       "    IPython.keyboard_manager.enable()\n",
       "    $(fig.parent_element).html('<img src=\"' + dataURL + '\" width=\"' + width + '\">');\n",
       "    fig.close_ws(fig, msg);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.close_ws = function(fig, msg){\n",
       "    fig.send_message('closing', msg);\n",
       "    // fig.ws.close()\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.push_to_output = function(remove_interactive) {\n",
       "    // Turn the data on the canvas into data in the output cell.\n",
       "    var width = this.canvas.width/mpl.ratio\n",
       "    var dataURL = this.canvas.toDataURL();\n",
       "    this.cell_info[1]['text/html'] = '<img src=\"' + dataURL + '\" width=\"' + width + '\">';\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.updated_canvas_event = function() {\n",
       "    // Tell IPython that the notebook contents must change.\n",
       "    IPython.notebook.set_dirty(true);\n",
       "    this.send_message(\"ack\", {});\n",
       "    var fig = this;\n",
       "    // Wait a second, then push the new image to the DOM so\n",
       "    // that it is saved nicely (might be nice to debounce this).\n",
       "    setTimeout(function () { fig.push_to_output() }, 1000);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_toolbar = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var nav_element = $('<div/>');\n",
       "    nav_element.attr('style', 'width: 100%');\n",
       "    this.root.append(nav_element);\n",
       "\n",
       "    // Define a callback function for later on.\n",
       "    function toolbar_event(event) {\n",
       "        return fig.toolbar_button_onclick(event['data']);\n",
       "    }\n",
       "    function toolbar_mouse_event(event) {\n",
       "        return fig.toolbar_button_onmouseover(event['data']);\n",
       "    }\n",
       "\n",
       "    for(var toolbar_ind in mpl.toolbar_items){\n",
       "        var name = mpl.toolbar_items[toolbar_ind][0];\n",
       "        var tooltip = mpl.toolbar_items[toolbar_ind][1];\n",
       "        var image = mpl.toolbar_items[toolbar_ind][2];\n",
       "        var method_name = mpl.toolbar_items[toolbar_ind][3];\n",
       "\n",
       "        if (!name) { continue; };\n",
       "\n",
       "        var button = $('<button class=\"btn btn-default\" href=\"#\" title=\"' + name + '\"><i class=\"fa ' + image + ' fa-lg\"></i></button>');\n",
       "        button.click(method_name, toolbar_event);\n",
       "        button.mouseover(tooltip, toolbar_mouse_event);\n",
       "        nav_element.append(button);\n",
       "    }\n",
       "\n",
       "    // Add the status bar.\n",
       "    var status_bar = $('<span class=\"mpl-message\" style=\"text-align:right; float: right;\"/>');\n",
       "    nav_element.append(status_bar);\n",
       "    this.message = status_bar[0];\n",
       "\n",
       "    // Add the close button to the window.\n",
       "    var buttongrp = $('<div class=\"btn-group inline pull-right\"></div>');\n",
       "    var button = $('<button class=\"btn btn-mini btn-primary\" href=\"#\" title=\"Stop Interaction\"><i class=\"fa fa-power-off icon-remove icon-large\"></i></button>');\n",
       "    button.click(function (evt) { fig.handle_close(fig, {}); } );\n",
       "    button.mouseover('Stop Interaction', toolbar_mouse_event);\n",
       "    buttongrp.append(button);\n",
       "    var titlebar = this.root.find($('.ui-dialog-titlebar'));\n",
       "    titlebar.prepend(buttongrp);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._root_extra_style = function(el){\n",
       "    var fig = this\n",
       "    el.on(\"remove\", function(){\n",
       "\tfig.close_ws(fig, {});\n",
       "    });\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._canvas_extra_style = function(el){\n",
       "    // this is important to make the div 'focusable\n",
       "    el.attr('tabindex', 0)\n",
       "    // reach out to IPython and tell the keyboard manager to turn it's self\n",
       "    // off when our div gets focus\n",
       "\n",
       "    // location in version 3\n",
       "    if (IPython.notebook.keyboard_manager) {\n",
       "        IPython.notebook.keyboard_manager.register_events(el);\n",
       "    }\n",
       "    else {\n",
       "        // location in version 2\n",
       "        IPython.keyboard_manager.register_events(el);\n",
       "    }\n",
       "\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._key_event_extra = function(event, name) {\n",
       "    var manager = IPython.notebook.keyboard_manager;\n",
       "    if (!manager)\n",
       "        manager = IPython.keyboard_manager;\n",
       "\n",
       "    // Check for shift+enter\n",
       "    if (event.shiftKey && event.which == 13) {\n",
       "        this.canvas_div.blur();\n",
       "        // select the cell after this one\n",
       "        var index = IPython.notebook.find_cell_index(this.cell_info[0]);\n",
       "        IPython.notebook.select(index + 1);\n",
       "    }\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_save = function(fig, msg) {\n",
       "    fig.ondownload(fig, null);\n",
       "}\n",
       "\n",
       "\n",
       "mpl.find_output_cell = function(html_output) {\n",
       "    // Return the cell and output element which can be found *uniquely* in the notebook.\n",
       "    // Note - this is a bit hacky, but it is done because the \"notebook_saving.Notebook\"\n",
       "    // IPython event is triggered only after the cells have been serialised, which for\n",
       "    // our purposes (turning an active figure into a static one), is too late.\n",
       "    var cells = IPython.notebook.get_cells();\n",
       "    var ncells = cells.length;\n",
       "    for (var i=0; i<ncells; i++) {\n",
       "        var cell = cells[i];\n",
       "        if (cell.cell_type === 'code'){\n",
       "            for (var j=0; j<cell.output_area.outputs.length; j++) {\n",
       "                var data = cell.output_area.outputs[j];\n",
       "                if (data.data) {\n",
       "                    // IPython >= 3 moved mimebundle to data attribute of output\n",
       "                    data = data.data;\n",
       "                }\n",
       "                if (data['text/html'] == html_output) {\n",
       "                    return [cell, data, j];\n",
       "                }\n",
       "            }\n",
       "        }\n",
       "    }\n",
       "}\n",
       "\n",
       "// Register the function which deals with the matplotlib target/channel.\n",
       "// The kernel may be null if the page has been refreshed.\n",
       "if (IPython.notebook.kernel != null) {\n",
       "    IPython.notebook.kernel.comm_manager.register_target('matplotlib', mpl.mpl_figure_comm);\n",
       "}\n"
      ],
      "text/plain": [
       "<IPython.core.display.Javascript object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
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\" width=\"640\">"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "-0.63862621564433 0.47062451611275274\n"
     ]
    }
   ],
   "source": [
    "# histogramme les valeurs de Log2 Corrected Abundance Ratio\n",
    "import numpy as np\n",
    "from math import sqrt\n",
    "'''\n",
    "fig, ax = plt.sublplots()\n",
    "log2_abratio = tcl['Log2 Corrected Abundance Ratio'].tolist()\n",
    "ax.hist(log2_abratio, bins=n_bins)\n",
    "'''\n",
    "fig, ax = plt.subplots()\n",
    "log2_abratio = tcl['Log2 Corrected Abundance Ratio'].tolist()\n",
    "hist = ax.hist(log2_abratio, bins=100) # draw histogram\n",
    "mu = np.mean(log2_abratio)\n",
    "S_2 = np.std(log2_abratio)\n",
    "print(mu,S_2)\n",
    "\n",
    "\n",
    "x = np.linspace(min(log2_abratio), max(log2_abratio), 100) # generate PDF domain points\n",
    "dx = hist[1][1] - hist[1][0] # Get single value bar height\n",
    "scale = len(log2_abratio)*dx # scale accordingly\n",
    "ax.plot(x, norm.pdf(x, mu, S_2)*scale) # compute theoritical PDF and draw it\n",
    "ax.set_xlabel('Log2 Corrected Abundance Ratio')\n",
    "ax.set_ylabel('protein counts')\n",
    "ax.set_title('Histogram of the values of Log2 Corrected Abundance Ratio of the proteins')\n",
    "fig.savefig('histogram_log2FC.png')\n",
    "\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "1746\n"
     ]
    }
   ],
   "source": [
    "print(len(log2_abratio))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 50,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/javascript": [
       "/* Put everything inside the global mpl namespace */\n",
       "window.mpl = {};\n",
       "\n",
       "\n",
       "mpl.get_websocket_type = function() {\n",
       "    if (typeof(WebSocket) !== 'undefined') {\n",
       "        return WebSocket;\n",
       "    } else if (typeof(MozWebSocket) !== 'undefined') {\n",
       "        return MozWebSocket;\n",
       "    } else {\n",
       "        alert('Your browser does not have WebSocket support. ' +\n",
       "              'Please try Chrome, Safari or Firefox ≥ 6. ' +\n",
       "              'Firefox 4 and 5 are also supported but you ' +\n",
       "              'have to enable WebSockets in about:config.');\n",
       "    };\n",
       "}\n",
       "\n",
       "mpl.figure = function(figure_id, websocket, ondownload, parent_element) {\n",
       "    this.id = figure_id;\n",
       "\n",
       "    this.ws = websocket;\n",
       "\n",
       "    this.supports_binary = (this.ws.binaryType != undefined);\n",
       "\n",
       "    if (!this.supports_binary) {\n",
       "        var warnings = document.getElementById(\"mpl-warnings\");\n",
       "        if (warnings) {\n",
       "            warnings.style.display = 'block';\n",
       "            warnings.textContent = (\n",
       "                \"This browser does not support binary websocket messages. \" +\n",
       "                    \"Performance may be slow.\");\n",
       "        }\n",
       "    }\n",
       "\n",
       "    this.imageObj = new Image();\n",
       "\n",
       "    this.context = undefined;\n",
       "    this.message = undefined;\n",
       "    this.canvas = undefined;\n",
       "    this.rubberband_canvas = undefined;\n",
       "    this.rubberband_context = undefined;\n",
       "    this.format_dropdown = undefined;\n",
       "\n",
       "    this.image_mode = 'full';\n",
       "\n",
       "    this.root = $('<div/>');\n",
       "    this._root_extra_style(this.root)\n",
       "    this.root.attr('style', 'display: inline-block');\n",
       "\n",
       "    $(parent_element).append(this.root);\n",
       "\n",
       "    this._init_header(this);\n",
       "    this._init_canvas(this);\n",
       "    this._init_toolbar(this);\n",
       "\n",
       "    var fig = this;\n",
       "\n",
       "    this.waiting = false;\n",
       "\n",
       "    this.ws.onopen =  function () {\n",
       "            fig.send_message(\"supports_binary\", {value: fig.supports_binary});\n",
       "            fig.send_message(\"send_image_mode\", {});\n",
       "            if (mpl.ratio != 1) {\n",
       "                fig.send_message(\"set_dpi_ratio\", {'dpi_ratio': mpl.ratio});\n",
       "            }\n",
       "            fig.send_message(\"refresh\", {});\n",
       "        }\n",
       "\n",
       "    this.imageObj.onload = function() {\n",
       "            if (fig.image_mode == 'full') {\n",
       "                // Full images could contain transparency (where diff images\n",
       "                // almost always do), so we need to clear the canvas so that\n",
       "                // there is no ghosting.\n",
       "                fig.context.clearRect(0, 0, fig.canvas.width, fig.canvas.height);\n",
       "            }\n",
       "            fig.context.drawImage(fig.imageObj, 0, 0);\n",
       "        };\n",
       "\n",
       "    this.imageObj.onunload = function() {\n",
       "        fig.ws.close();\n",
       "    }\n",
       "\n",
       "    this.ws.onmessage = this._make_on_message_function(this);\n",
       "\n",
       "    this.ondownload = ondownload;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_header = function() {\n",
       "    var titlebar = $(\n",
       "        '<div class=\"ui-dialog-titlebar ui-widget-header ui-corner-all ' +\n",
       "        'ui-helper-clearfix\"/>');\n",
       "    var titletext = $(\n",
       "        '<div class=\"ui-dialog-title\" style=\"width: 100%; ' +\n",
       "        'text-align: center; padding: 3px;\"/>');\n",
       "    titlebar.append(titletext)\n",
       "    this.root.append(titlebar);\n",
       "    this.header = titletext[0];\n",
       "}\n",
       "\n",
       "\n",
       "\n",
       "mpl.figure.prototype._canvas_extra_style = function(canvas_div) {\n",
       "\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype._root_extra_style = function(canvas_div) {\n",
       "\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_canvas = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var canvas_div = $('<div/>');\n",
       "\n",
       "    canvas_div.attr('style', 'position: relative; clear: both; outline: 0');\n",
       "\n",
       "    function canvas_keyboard_event(event) {\n",
       "        return fig.key_event(event, event['data']);\n",
       "    }\n",
       "\n",
       "    canvas_div.keydown('key_press', canvas_keyboard_event);\n",
       "    canvas_div.keyup('key_release', canvas_keyboard_event);\n",
       "    this.canvas_div = canvas_div\n",
       "    this._canvas_extra_style(canvas_div)\n",
       "    this.root.append(canvas_div);\n",
       "\n",
       "    var canvas = $('<canvas/>');\n",
       "    canvas.addClass('mpl-canvas');\n",
       "    canvas.attr('style', \"left: 0; top: 0; z-index: 0; outline: 0\")\n",
       "\n",
       "    this.canvas = canvas[0];\n",
       "    this.context = canvas[0].getContext(\"2d\");\n",
       "\n",
       "    var backingStore = this.context.backingStorePixelRatio ||\n",
       "\tthis.context.webkitBackingStorePixelRatio ||\n",
       "\tthis.context.mozBackingStorePixelRatio ||\n",
       "\tthis.context.msBackingStorePixelRatio ||\n",
       "\tthis.context.oBackingStorePixelRatio ||\n",
       "\tthis.context.backingStorePixelRatio || 1;\n",
       "\n",
       "    mpl.ratio = (window.devicePixelRatio || 1) / backingStore;\n",
       "\n",
       "    var rubberband = $('<canvas/>');\n",
       "    rubberband.attr('style', \"position: absolute; left: 0; top: 0; z-index: 1;\")\n",
       "\n",
       "    var pass_mouse_events = true;\n",
       "\n",
       "    canvas_div.resizable({\n",
       "        start: function(event, ui) {\n",
       "            pass_mouse_events = false;\n",
       "        },\n",
       "        resize: function(event, ui) {\n",
       "            fig.request_resize(ui.size.width, ui.size.height);\n",
       "        },\n",
       "        stop: function(event, ui) {\n",
       "            pass_mouse_events = true;\n",
       "            fig.request_resize(ui.size.width, ui.size.height);\n",
       "        },\n",
       "    });\n",
       "\n",
       "    function mouse_event_fn(event) {\n",
       "        if (pass_mouse_events)\n",
       "            return fig.mouse_event(event, event['data']);\n",
       "    }\n",
       "\n",
       "    rubberband.mousedown('button_press', mouse_event_fn);\n",
       "    rubberband.mouseup('button_release', mouse_event_fn);\n",
       "    // Throttle sequential mouse events to 1 every 20ms.\n",
       "    rubberband.mousemove('motion_notify', mouse_event_fn);\n",
       "\n",
       "    rubberband.mouseenter('figure_enter', mouse_event_fn);\n",
       "    rubberband.mouseleave('figure_leave', mouse_event_fn);\n",
       "\n",
       "    canvas_div.on(\"wheel\", function (event) {\n",
       "        event = event.originalEvent;\n",
       "        event['data'] = 'scroll'\n",
       "        if (event.deltaY < 0) {\n",
       "            event.step = 1;\n",
       "        } else {\n",
       "            event.step = -1;\n",
       "        }\n",
       "        mouse_event_fn(event);\n",
       "    });\n",
       "\n",
       "    canvas_div.append(canvas);\n",
       "    canvas_div.append(rubberband);\n",
       "\n",
       "    this.rubberband = rubberband;\n",
       "    this.rubberband_canvas = rubberband[0];\n",
       "    this.rubberband_context = rubberband[0].getContext(\"2d\");\n",
       "    this.rubberband_context.strokeStyle = \"#000000\";\n",
       "\n",
       "    this._resize_canvas = function(width, height) {\n",
       "        // Keep the size of the canvas, canvas container, and rubber band\n",
       "        // canvas in synch.\n",
       "        canvas_div.css('width', width)\n",
       "        canvas_div.css('height', height)\n",
       "\n",
       "        canvas.attr('width', width * mpl.ratio);\n",
       "        canvas.attr('height', height * mpl.ratio);\n",
       "        canvas.attr('style', 'width: ' + width + 'px; height: ' + height + 'px;');\n",
       "\n",
       "        rubberband.attr('width', width);\n",
       "        rubberband.attr('height', height);\n",
       "    }\n",
       "\n",
       "    // Set the figure to an initial 600x600px, this will subsequently be updated\n",
       "    // upon first draw.\n",
       "    this._resize_canvas(600, 600);\n",
       "\n",
       "    // Disable right mouse context menu.\n",
       "    $(this.rubberband_canvas).bind(\"contextmenu\",function(e){\n",
       "        return false;\n",
       "    });\n",
       "\n",
       "    function set_focus () {\n",
       "        canvas.focus();\n",
       "        canvas_div.focus();\n",
       "    }\n",
       "\n",
       "    window.setTimeout(set_focus, 100);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_toolbar = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var nav_element = $('<div/>');\n",
       "    nav_element.attr('style', 'width: 100%');\n",
       "    this.root.append(nav_element);\n",
       "\n",
       "    // Define a callback function for later on.\n",
       "    function toolbar_event(event) {\n",
       "        return fig.toolbar_button_onclick(event['data']);\n",
       "    }\n",
       "    function toolbar_mouse_event(event) {\n",
       "        return fig.toolbar_button_onmouseover(event['data']);\n",
       "    }\n",
       "\n",
       "    for(var toolbar_ind in mpl.toolbar_items) {\n",
       "        var name = mpl.toolbar_items[toolbar_ind][0];\n",
       "        var tooltip = mpl.toolbar_items[toolbar_ind][1];\n",
       "        var image = mpl.toolbar_items[toolbar_ind][2];\n",
       "        var method_name = mpl.toolbar_items[toolbar_ind][3];\n",
       "\n",
       "        if (!name) {\n",
       "            // put a spacer in here.\n",
       "            continue;\n",
       "        }\n",
       "        var button = $('<button/>');\n",
       "        button.addClass('ui-button ui-widget ui-state-default ui-corner-all ' +\n",
       "                        'ui-button-icon-only');\n",
       "        button.attr('role', 'button');\n",
       "        button.attr('aria-disabled', 'false');\n",
       "        button.click(method_name, toolbar_event);\n",
       "        button.mouseover(tooltip, toolbar_mouse_event);\n",
       "\n",
       "        var icon_img = $('<span/>');\n",
       "        icon_img.addClass('ui-button-icon-primary ui-icon');\n",
       "        icon_img.addClass(image);\n",
       "        icon_img.addClass('ui-corner-all');\n",
       "\n",
       "        var tooltip_span = $('<span/>');\n",
       "        tooltip_span.addClass('ui-button-text');\n",
       "        tooltip_span.html(tooltip);\n",
       "\n",
       "        button.append(icon_img);\n",
       "        button.append(tooltip_span);\n",
       "\n",
       "        nav_element.append(button);\n",
       "    }\n",
       "\n",
       "    var fmt_picker_span = $('<span/>');\n",
       "\n",
       "    var fmt_picker = $('<select/>');\n",
       "    fmt_picker.addClass('mpl-toolbar-option ui-widget ui-widget-content');\n",
       "    fmt_picker_span.append(fmt_picker);\n",
       "    nav_element.append(fmt_picker_span);\n",
       "    this.format_dropdown = fmt_picker[0];\n",
       "\n",
       "    for (var ind in mpl.extensions) {\n",
       "        var fmt = mpl.extensions[ind];\n",
       "        var option = $(\n",
       "            '<option/>', {selected: fmt === mpl.default_extension}).html(fmt);\n",
       "        fmt_picker.append(option);\n",
       "    }\n",
       "\n",
       "    // Add hover states to the ui-buttons\n",
       "    $( \".ui-button\" ).hover(\n",
       "        function() { $(this).addClass(\"ui-state-hover\");},\n",
       "        function() { $(this).removeClass(\"ui-state-hover\");}\n",
       "    );\n",
       "\n",
       "    var status_bar = $('<span class=\"mpl-message\"/>');\n",
       "    nav_element.append(status_bar);\n",
       "    this.message = status_bar[0];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.request_resize = function(x_pixels, y_pixels) {\n",
       "    // Request matplotlib to resize the figure. Matplotlib will then trigger a resize in the client,\n",
       "    // which will in turn request a refresh of the image.\n",
       "    this.send_message('resize', {'width': x_pixels, 'height': y_pixels});\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.send_message = function(type, properties) {\n",
       "    properties['type'] = type;\n",
       "    properties['figure_id'] = this.id;\n",
       "    this.ws.send(JSON.stringify(properties));\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.send_draw_message = function() {\n",
       "    if (!this.waiting) {\n",
       "        this.waiting = true;\n",
       "        this.ws.send(JSON.stringify({type: \"draw\", figure_id: this.id}));\n",
       "    }\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype.handle_save = function(fig, msg) {\n",
       "    var format_dropdown = fig.format_dropdown;\n",
       "    var format = format_dropdown.options[format_dropdown.selectedIndex].value;\n",
       "    fig.ondownload(fig, format);\n",
       "}\n",
       "\n",
       "\n",
       "mpl.figure.prototype.handle_resize = function(fig, msg) {\n",
       "    var size = msg['size'];\n",
       "    if (size[0] != fig.canvas.width || size[1] != fig.canvas.height) {\n",
       "        fig._resize_canvas(size[0], size[1]);\n",
       "        fig.send_message(\"refresh\", {});\n",
       "    };\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_rubberband = function(fig, msg) {\n",
       "    var x0 = msg['x0'] / mpl.ratio;\n",
       "    var y0 = (fig.canvas.height - msg['y0']) / mpl.ratio;\n",
       "    var x1 = msg['x1'] / mpl.ratio;\n",
       "    var y1 = (fig.canvas.height - msg['y1']) / mpl.ratio;\n",
       "    x0 = Math.floor(x0) + 0.5;\n",
       "    y0 = Math.floor(y0) + 0.5;\n",
       "    x1 = Math.floor(x1) + 0.5;\n",
       "    y1 = Math.floor(y1) + 0.5;\n",
       "    var min_x = Math.min(x0, x1);\n",
       "    var min_y = Math.min(y0, y1);\n",
       "    var width = Math.abs(x1 - x0);\n",
       "    var height = Math.abs(y1 - y0);\n",
       "\n",
       "    fig.rubberband_context.clearRect(\n",
       "        0, 0, fig.canvas.width / mpl.ratio, fig.canvas.height / mpl.ratio);\n",
       "\n",
       "    fig.rubberband_context.strokeRect(min_x, min_y, width, height);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_figure_label = function(fig, msg) {\n",
       "    // Updates the figure title.\n",
       "    fig.header.textContent = msg['label'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_cursor = function(fig, msg) {\n",
       "    var cursor = msg['cursor'];\n",
       "    switch(cursor)\n",
       "    {\n",
       "    case 0:\n",
       "        cursor = 'pointer';\n",
       "        break;\n",
       "    case 1:\n",
       "        cursor = 'default';\n",
       "        break;\n",
       "    case 2:\n",
       "        cursor = 'crosshair';\n",
       "        break;\n",
       "    case 3:\n",
       "        cursor = 'move';\n",
       "        break;\n",
       "    }\n",
       "    fig.rubberband_canvas.style.cursor = cursor;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_message = function(fig, msg) {\n",
       "    fig.message.textContent = msg['message'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_draw = function(fig, msg) {\n",
       "    // Request the server to send over a new figure.\n",
       "    fig.send_draw_message();\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_image_mode = function(fig, msg) {\n",
       "    fig.image_mode = msg['mode'];\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.updated_canvas_event = function() {\n",
       "    // Called whenever the canvas gets updated.\n",
       "    this.send_message(\"ack\", {});\n",
       "}\n",
       "\n",
       "// A function to construct a web socket function for onmessage handling.\n",
       "// Called in the figure constructor.\n",
       "mpl.figure.prototype._make_on_message_function = function(fig) {\n",
       "    return function socket_on_message(evt) {\n",
       "        if (evt.data instanceof Blob) {\n",
       "            /* FIXME: We get \"Resource interpreted as Image but\n",
       "             * transferred with MIME type text/plain:\" errors on\n",
       "             * Chrome.  But how to set the MIME type?  It doesn't seem\n",
       "             * to be part of the websocket stream */\n",
       "            evt.data.type = \"image/png\";\n",
       "\n",
       "            /* Free the memory for the previous frames */\n",
       "            if (fig.imageObj.src) {\n",
       "                (window.URL || window.webkitURL).revokeObjectURL(\n",
       "                    fig.imageObj.src);\n",
       "            }\n",
       "\n",
       "            fig.imageObj.src = (window.URL || window.webkitURL).createObjectURL(\n",
       "                evt.data);\n",
       "            fig.updated_canvas_event();\n",
       "            fig.waiting = false;\n",
       "            return;\n",
       "        }\n",
       "        else if (typeof evt.data === 'string' && evt.data.slice(0, 21) == \"data:image/png;base64\") {\n",
       "            fig.imageObj.src = evt.data;\n",
       "            fig.updated_canvas_event();\n",
       "            fig.waiting = false;\n",
       "            return;\n",
       "        }\n",
       "\n",
       "        var msg = JSON.parse(evt.data);\n",
       "        var msg_type = msg['type'];\n",
       "\n",
       "        // Call the  \"handle_{type}\" callback, which takes\n",
       "        // the figure and JSON message as its only arguments.\n",
       "        try {\n",
       "            var callback = fig[\"handle_\" + msg_type];\n",
       "        } catch (e) {\n",
       "            console.log(\"No handler for the '\" + msg_type + \"' message type: \", msg);\n",
       "            return;\n",
       "        }\n",
       "\n",
       "        if (callback) {\n",
       "            try {\n",
       "                // console.log(\"Handling '\" + msg_type + \"' message: \", msg);\n",
       "                callback(fig, msg);\n",
       "            } catch (e) {\n",
       "                console.log(\"Exception inside the 'handler_\" + msg_type + \"' callback:\", e, e.stack, msg);\n",
       "            }\n",
       "        }\n",
       "    };\n",
       "}\n",
       "\n",
       "// from http://stackoverflow.com/questions/1114465/getting-mouse-location-in-canvas\n",
       "mpl.findpos = function(e) {\n",
       "    //this section is from http://www.quirksmode.org/js/events_properties.html\n",
       "    var targ;\n",
       "    if (!e)\n",
       "        e = window.event;\n",
       "    if (e.target)\n",
       "        targ = e.target;\n",
       "    else if (e.srcElement)\n",
       "        targ = e.srcElement;\n",
       "    if (targ.nodeType == 3) // defeat Safari bug\n",
       "        targ = targ.parentNode;\n",
       "\n",
       "    // jQuery normalizes the pageX and pageY\n",
       "    // pageX,Y are the mouse positions relative to the document\n",
       "    // offset() returns the position of the element relative to the document\n",
       "    var x = e.pageX - $(targ).offset().left;\n",
       "    var y = e.pageY - $(targ).offset().top;\n",
       "\n",
       "    return {\"x\": x, \"y\": y};\n",
       "};\n",
       "\n",
       "/*\n",
       " * return a copy of an object with only non-object keys\n",
       " * we need this to avoid circular references\n",
       " * http://stackoverflow.com/a/24161582/3208463\n",
       " */\n",
       "function simpleKeys (original) {\n",
       "  return Object.keys(original).reduce(function (obj, key) {\n",
       "    if (typeof original[key] !== 'object')\n",
       "        obj[key] = original[key]\n",
       "    return obj;\n",
       "  }, {});\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.mouse_event = function(event, name) {\n",
       "    var canvas_pos = mpl.findpos(event)\n",
       "\n",
       "    if (name === 'button_press')\n",
       "    {\n",
       "        this.canvas.focus();\n",
       "        this.canvas_div.focus();\n",
       "    }\n",
       "\n",
       "    var x = canvas_pos.x * mpl.ratio;\n",
       "    var y = canvas_pos.y * mpl.ratio;\n",
       "\n",
       "    this.send_message(name, {x: x, y: y, button: event.button,\n",
       "                             step: event.step,\n",
       "                             guiEvent: simpleKeys(event)});\n",
       "\n",
       "    /* This prevents the web browser from automatically changing to\n",
       "     * the text insertion cursor when the button is pressed.  We want\n",
       "     * to control all of the cursor setting manually through the\n",
       "     * 'cursor' event from matplotlib */\n",
       "    event.preventDefault();\n",
       "    return false;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._key_event_extra = function(event, name) {\n",
       "    // Handle any extra behaviour associated with a key event\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.key_event = function(event, name) {\n",
       "\n",
       "    // Prevent repeat events\n",
       "    if (name == 'key_press')\n",
       "    {\n",
       "        if (event.which === this._key)\n",
       "            return;\n",
       "        else\n",
       "            this._key = event.which;\n",
       "    }\n",
       "    if (name == 'key_release')\n",
       "        this._key = null;\n",
       "\n",
       "    var value = '';\n",
       "    if (event.ctrlKey && event.which != 17)\n",
       "        value += \"ctrl+\";\n",
       "    if (event.altKey && event.which != 18)\n",
       "        value += \"alt+\";\n",
       "    if (event.shiftKey && event.which != 16)\n",
       "        value += \"shift+\";\n",
       "\n",
       "    value += 'k';\n",
       "    value += event.which.toString();\n",
       "\n",
       "    this._key_event_extra(event, name);\n",
       "\n",
       "    this.send_message(name, {key: value,\n",
       "                             guiEvent: simpleKeys(event)});\n",
       "    return false;\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.toolbar_button_onclick = function(name) {\n",
       "    if (name == 'download') {\n",
       "        this.handle_save(this, null);\n",
       "    } else {\n",
       "        this.send_message(\"toolbar_button\", {name: name});\n",
       "    }\n",
       "};\n",
       "\n",
       "mpl.figure.prototype.toolbar_button_onmouseover = function(tooltip) {\n",
       "    this.message.textContent = tooltip;\n",
       "};\n",
       "mpl.toolbar_items = [[\"Home\", \"Reset original view\", \"fa fa-home icon-home\", \"home\"], [\"Back\", \"Back to previous view\", \"fa fa-arrow-left icon-arrow-left\", \"back\"], [\"Forward\", \"Forward to next view\", \"fa fa-arrow-right icon-arrow-right\", \"forward\"], [\"\", \"\", \"\", \"\"], [\"Pan\", \"Pan axes with left mouse, zoom with right\", \"fa fa-arrows icon-move\", \"pan\"], [\"Zoom\", \"Zoom to rectangle\", \"fa fa-square-o icon-check-empty\", \"zoom\"], [\"\", \"\", \"\", \"\"], [\"Download\", \"Download plot\", \"fa fa-floppy-o icon-save\", \"download\"]];\n",
       "\n",
       "mpl.extensions = [\"eps\", \"jpeg\", \"pdf\", \"png\", \"ps\", \"raw\", \"svg\", \"tif\"];\n",
       "\n",
       "mpl.default_extension = \"png\";var comm_websocket_adapter = function(comm) {\n",
       "    // Create a \"websocket\"-like object which calls the given IPython comm\n",
       "    // object with the appropriate methods. Currently this is a non binary\n",
       "    // socket, so there is still some room for performance tuning.\n",
       "    var ws = {};\n",
       "\n",
       "    ws.close = function() {\n",
       "        comm.close()\n",
       "    };\n",
       "    ws.send = function(m) {\n",
       "        //console.log('sending', m);\n",
       "        comm.send(m);\n",
       "    };\n",
       "    // Register the callback with on_msg.\n",
       "    comm.on_msg(function(msg) {\n",
       "        //console.log('receiving', msg['content']['data'], msg);\n",
       "        // Pass the mpl event to the overridden (by mpl) onmessage function.\n",
       "        ws.onmessage(msg['content']['data'])\n",
       "    });\n",
       "    return ws;\n",
       "}\n",
       "\n",
       "mpl.mpl_figure_comm = function(comm, msg) {\n",
       "    // This is the function which gets called when the mpl process\n",
       "    // starts-up an IPython Comm through the \"matplotlib\" channel.\n",
       "\n",
       "    var id = msg.content.data.id;\n",
       "    // Get hold of the div created by the display call when the Comm\n",
       "    // socket was opened in Python.\n",
       "    var element = $(\"#\" + id);\n",
       "    var ws_proxy = comm_websocket_adapter(comm)\n",
       "\n",
       "    function ondownload(figure, format) {\n",
       "        window.open(figure.imageObj.src);\n",
       "    }\n",
       "\n",
       "    var fig = new mpl.figure(id, ws_proxy,\n",
       "                           ondownload,\n",
       "                           element.get(0));\n",
       "\n",
       "    // Call onopen now - mpl needs it, as it is assuming we've passed it a real\n",
       "    // web socket which is closed, not our websocket->open comm proxy.\n",
       "    ws_proxy.onopen();\n",
       "\n",
       "    fig.parent_element = element.get(0);\n",
       "    fig.cell_info = mpl.find_output_cell(\"<div id='\" + id + \"'></div>\");\n",
       "    if (!fig.cell_info) {\n",
       "        console.error(\"Failed to find cell for figure\", id, fig);\n",
       "        return;\n",
       "    }\n",
       "\n",
       "    var output_index = fig.cell_info[2]\n",
       "    var cell = fig.cell_info[0];\n",
       "\n",
       "};\n",
       "\n",
       "mpl.figure.prototype.handle_close = function(fig, msg) {\n",
       "    var width = fig.canvas.width/mpl.ratio\n",
       "    fig.root.unbind('remove')\n",
       "\n",
       "    // Update the output cell to use the data from the current canvas.\n",
       "    fig.push_to_output();\n",
       "    var dataURL = fig.canvas.toDataURL();\n",
       "    // Re-enable the keyboard manager in IPython - without this line, in FF,\n",
       "    // the notebook keyboard shortcuts fail.\n",
       "    IPython.keyboard_manager.enable()\n",
       "    $(fig.parent_element).html('<img src=\"' + dataURL + '\" width=\"' + width + '\">');\n",
       "    fig.close_ws(fig, msg);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.close_ws = function(fig, msg){\n",
       "    fig.send_message('closing', msg);\n",
       "    // fig.ws.close()\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.push_to_output = function(remove_interactive) {\n",
       "    // Turn the data on the canvas into data in the output cell.\n",
       "    var width = this.canvas.width/mpl.ratio\n",
       "    var dataURL = this.canvas.toDataURL();\n",
       "    this.cell_info[1]['text/html'] = '<img src=\"' + dataURL + '\" width=\"' + width + '\">';\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.updated_canvas_event = function() {\n",
       "    // Tell IPython that the notebook contents must change.\n",
       "    IPython.notebook.set_dirty(true);\n",
       "    this.send_message(\"ack\", {});\n",
       "    var fig = this;\n",
       "    // Wait a second, then push the new image to the DOM so\n",
       "    // that it is saved nicely (might be nice to debounce this).\n",
       "    setTimeout(function () { fig.push_to_output() }, 1000);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._init_toolbar = function() {\n",
       "    var fig = this;\n",
       "\n",
       "    var nav_element = $('<div/>');\n",
       "    nav_element.attr('style', 'width: 100%');\n",
       "    this.root.append(nav_element);\n",
       "\n",
       "    // Define a callback function for later on.\n",
       "    function toolbar_event(event) {\n",
       "        return fig.toolbar_button_onclick(event['data']);\n",
       "    }\n",
       "    function toolbar_mouse_event(event) {\n",
       "        return fig.toolbar_button_onmouseover(event['data']);\n",
       "    }\n",
       "\n",
       "    for(var toolbar_ind in mpl.toolbar_items){\n",
       "        var name = mpl.toolbar_items[toolbar_ind][0];\n",
       "        var tooltip = mpl.toolbar_items[toolbar_ind][1];\n",
       "        var image = mpl.toolbar_items[toolbar_ind][2];\n",
       "        var method_name = mpl.toolbar_items[toolbar_ind][3];\n",
       "\n",
       "        if (!name) { continue; };\n",
       "\n",
       "        var button = $('<button class=\"btn btn-default\" href=\"#\" title=\"' + name + '\"><i class=\"fa ' + image + ' fa-lg\"></i></button>');\n",
       "        button.click(method_name, toolbar_event);\n",
       "        button.mouseover(tooltip, toolbar_mouse_event);\n",
       "        nav_element.append(button);\n",
       "    }\n",
       "\n",
       "    // Add the status bar.\n",
       "    var status_bar = $('<span class=\"mpl-message\" style=\"text-align:right; float: right;\"/>');\n",
       "    nav_element.append(status_bar);\n",
       "    this.message = status_bar[0];\n",
       "\n",
       "    // Add the close button to the window.\n",
       "    var buttongrp = $('<div class=\"btn-group inline pull-right\"></div>');\n",
       "    var button = $('<button class=\"btn btn-mini btn-primary\" href=\"#\" title=\"Stop Interaction\"><i class=\"fa fa-power-off icon-remove icon-large\"></i></button>');\n",
       "    button.click(function (evt) { fig.handle_close(fig, {}); } );\n",
       "    button.mouseover('Stop Interaction', toolbar_mouse_event);\n",
       "    buttongrp.append(button);\n",
       "    var titlebar = this.root.find($('.ui-dialog-titlebar'));\n",
       "    titlebar.prepend(buttongrp);\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._root_extra_style = function(el){\n",
       "    var fig = this\n",
       "    el.on(\"remove\", function(){\n",
       "\tfig.close_ws(fig, {});\n",
       "    });\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._canvas_extra_style = function(el){\n",
       "    // this is important to make the div 'focusable\n",
       "    el.attr('tabindex', 0)\n",
       "    // reach out to IPython and tell the keyboard manager to turn it's self\n",
       "    // off when our div gets focus\n",
       "\n",
       "    // location in version 3\n",
       "    if (IPython.notebook.keyboard_manager) {\n",
       "        IPython.notebook.keyboard_manager.register_events(el);\n",
       "    }\n",
       "    else {\n",
       "        // location in version 2\n",
       "        IPython.keyboard_manager.register_events(el);\n",
       "    }\n",
       "\n",
       "}\n",
       "\n",
       "mpl.figure.prototype._key_event_extra = function(event, name) {\n",
       "    var manager = IPython.notebook.keyboard_manager;\n",
       "    if (!manager)\n",
       "        manager = IPython.keyboard_manager;\n",
       "\n",
       "    // Check for shift+enter\n",
       "    if (event.shiftKey && event.which == 13) {\n",
       "        this.canvas_div.blur();\n",
       "        // select the cell after this one\n",
       "        var index = IPython.notebook.find_cell_index(this.cell_info[0]);\n",
       "        IPython.notebook.select(index + 1);\n",
       "    }\n",
       "}\n",
       "\n",
       "mpl.figure.prototype.handle_save = function(fig, msg) {\n",
       "    fig.ondownload(fig, null);\n",
       "}\n",
       "\n",
       "\n",
       "mpl.find_output_cell = function(html_output) {\n",
       "    // Return the cell and output element which can be found *uniquely* in the notebook.\n",
       "    // Note - this is a bit hacky, but it is done because the \"notebook_saving.Notebook\"\n",
       "    // IPython event is triggered only after the cells have been serialised, which for\n",
       "    // our purposes (turning an active figure into a static one), is too late.\n",
       "    var cells = IPython.notebook.get_cells();\n",
       "    var ncells = cells.length;\n",
       "    for (var i=0; i<ncells; i++) {\n",
       "        var cell = cells[i];\n",
       "        if (cell.cell_type === 'code'){\n",
       "            for (var j=0; j<cell.output_area.outputs.length; j++) {\n",
       "                var data = cell.output_area.outputs[j];\n",
       "                if (data.data) {\n",
       "                    // IPython >= 3 moved mimebundle to data attribute of output\n",
       "                    data = data.data;\n",
       "                }\n",
       "                if (data['text/html'] == html_output) {\n",
       "                    return [cell, data, j];\n",
       "                }\n",
       "            }\n",
       "        }\n",
       "    }\n",
       "}\n",
       "\n",
       "// Register the function which deals with the matplotlib target/channel.\n",
       "// The kernel may be null if the page has been refreshed.\n",
       "if (IPython.notebook.kernel != null) {\n",
       "    IPython.notebook.kernel.comm_manager.register_target('matplotlib', mpl.mpl_figure_comm);\n",
       "}\n"
      ],
      "text/plain": [
       "<IPython.core.display.Javascript object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
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\" width=\"640\">"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# VOLCANO PLOT  LOG10 Adj p-val en fonction de log2 Corrected Abundance ratio\n",
    "fig, ax = plt.subplots()\n",
    "log10 = tcl['-LOG10 Adj.P-val'].tolist()\n",
    "ax.scatter(log2_abratio, log10,marker = 'o')\n",
    "#\n",
    "thresh_y = 3\n",
    "thresh_x = mu + (S_2)\n",
    "'''\n",
    "sur-abondance : mu + écart-type \n",
    "2 conditions : \n",
    "p-valeur <= 0.01\n",
    "FC >= mu + écart-type\n",
    "'''\n",
    "ax.plot(ax.get_xlim(),(thresh_y,thresh_y),color = 'black' ,linestyle = 'dashed', linewidth = 0.7)\n",
    "ax.plot((thresh_x,thresh_x),ax.get_ylim(),color = 'black', linestyle = 'dashed', linewidth = 0.7)\n",
    "ax.set_xlabel('Log2 Corrected Abundance Ratio')\n",
    "ax.set_ylabel('-LOG10 Adj.P-val')\n",
    "ax.set_title(\"Volcano Plot of Log10 of proteins' p-values Log2 Corrected Abundance Ratio \")\n",
    "fig.savefig('volcano_plot.png')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "['P0A8V6', 'P0A9Q1', 'P02358', 'P0ACF8', 'P62399', 'P0A905', 'P76506', 'P13036', 'P10384', 'P06971', 'P0A910', 'P06996', 'P76344', 'P02931']\n"
     ]
    }
   ],
   "source": [
    "tcl_abundant = tcl[tcl['-LOG10 Adj.P-val']>= 3]\n",
    "tcl_abundant = tcl_abundant[tcl_abundant['Log2 Corrected Abundance Ratio']>= mu + S_2]\n",
    "#tcl_abundant = tcl.loc[(tcl['-LOG10 Adj.P-val']>= 3 & (tcl['Log2 Corrected Abundance Ratio']>= mu + S_2)]\n",
    "#print(tcl_abundant)\n",
    "abund_prots = tcl_abundant[\"Accession\"].tolist()\n",
    "print(abund_prots)\n",
    "# IL y a donc 14 protéines abondantes"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {},
   "outputs": [],
   "source": [
    "def getGOterms(proteins, abundant_prot):\n",
    "    \"\"\"\n",
    "    Gets all GO terms related to each accession number in a given list in the reference xml file. GO terms are\n",
    "    conservated in a set returned by the function at the end\n",
    "    :@param proteins: xml tree containing all infos about a lot of proteins including GO terms\n",
    "    :@param abundant_prot: list of abundant proteins for which we'll search any GO terms (with their accession nb)\n",
    "    :@return: set of all the goterms\n",
    "    \"\"\"\n",
    "    goterms = []\n",
    "    nb_success=0\n",
    "    for entry in proteins:\n",
    "        accessions = entry.findall(ns+\"accession\")\n",
    "        for acc in accessions:\n",
    "            if acc.text in abundant_prot:\n",
    "                nb_success +=1\n",
    "                a = entry.iter()\n",
    "                for el in a:\n",
    "                    identif = el.items()\n",
    "                    if len(identif) == 2:\n",
    "                        if identif[0][1] == \"GO\":\n",
    "                            goterms.append(identif[1][1])\n",
    "    goterms_set = set(goterms)\n",
    "    print(nb_success)\n",
    "    return goterms_set"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "14\n",
      "82\n"
     ]
    }
   ],
   "source": [
    "all_goterms = getGOterms(proteins,abund_prots)\n",
    "print(len(all_goterms))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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